Incidental Mutation 'P0038:Cdh13'
ID |
7730 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Cdh13
|
Ensembl Gene |
ENSMUSG00000031841 |
Gene Name |
cadherin 13 |
Synonyms |
T-cadherin, 4932416G01Rik, Tcad |
MMRRC Submission |
038287-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
P0038 (G1)
|
Quality Score |
|
Status
|
Validated
|
Chromosome |
8 |
Chromosomal Location |
119010472-120051660 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to A
at 119401843 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Valine to Methionine
at position 82
(V82M)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000113527
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000117160]
|
AlphaFold |
Q9WTR5 |
PDB Structure |
Crystal Structure of mouse T-cadherin EC1 EC2 [X-RAY DIFFRACTION]
Crystal structure of mouse T-cadherin EC1 [X-RAY DIFFRACTION]
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000117160
AA Change: V82M
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000113527 Gene: ENSMUSG00000031841 AA Change: V82M
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
Cadherin_pro
|
26 |
112 |
1.04e-17 |
SMART |
CA
|
160 |
243 |
1.49e-18 |
SMART |
CA
|
267 |
361 |
1.84e-23 |
SMART |
CA
|
383 |
476 |
8.75e-16 |
SMART |
CA
|
499 |
583 |
2.36e-21 |
SMART |
CA
|
604 |
687 |
5.93e-2 |
SMART |
low complexity region
|
695 |
714 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000123567
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000129548
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000142551
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000145849
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000148836
|
Meta Mutation Damage Score |
0.6467 |
Coding Region Coverage |
- 1x: 79.6%
- 3x: 69.7%
- 10x: 40.2%
- 20x: 18.1%
|
Validation Efficiency |
86% (80/93) |
MGI Phenotype |
FUNCTION: This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. This gene is highly expressed in the vasculature including endothelial cells, smooth muscle cells and pericytes, where the encoded protein binds to adiponectin and has been implicated in the modulation of angiogenesis. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Nov 2015] PHENOTYPE: Mice homozygous for a null allele exhibit decreased retinal neovascularization and increased adiponectin levels. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 16 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Atad2b |
C |
A |
12: 5,004,536 (GRCm39) |
|
probably benign |
Het |
Atmin |
T |
A |
8: 117,683,775 (GRCm39) |
C478* |
probably null |
Het |
Dip2c |
A |
C |
13: 9,697,018 (GRCm39) |
T1310P |
probably damaging |
Het |
Eral1 |
A |
T |
11: 77,966,847 (GRCm39) |
D189E |
probably damaging |
Het |
Fstl5 |
A |
G |
3: 76,052,369 (GRCm39) |
Y33C |
probably damaging |
Het |
Gjb4 |
A |
T |
4: 127,245,293 (GRCm39) |
V216D |
probably benign |
Het |
Lars2 |
T |
C |
9: 123,206,842 (GRCm39) |
V103A |
probably damaging |
Het |
Mfsd12 |
C |
T |
10: 81,198,052 (GRCm39) |
T311I |
probably benign |
Het |
Mtrex |
A |
C |
13: 113,047,513 (GRCm39) |
Y277* |
probably null |
Het |
Paf1 |
T |
C |
7: 28,096,350 (GRCm39) |
|
probably null |
Het |
Rfc1 |
T |
C |
5: 65,445,304 (GRCm39) |
T435A |
probably damaging |
Het |
Siglec1 |
T |
C |
2: 130,923,359 (GRCm39) |
N462S |
probably benign |
Het |
Tnks1bp1 |
C |
T |
2: 84,892,755 (GRCm39) |
T232I |
probably benign |
Het |
Trpc6 |
A |
T |
9: 8,649,512 (GRCm39) |
N574I |
possibly damaging |
Het |
Ttll7 |
T |
C |
3: 146,650,939 (GRCm39) |
F700L |
possibly damaging |
Het |
Zc3hav1 |
G |
A |
6: 38,309,469 (GRCm39) |
T451M |
probably damaging |
Het |
|
Other mutations in Cdh13 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00539:Cdh13
|
APN |
8 |
120,039,245 (GRCm39) |
missense |
possibly damaging |
0.87 |
IGL00659:Cdh13
|
APN |
8 |
120,039,406 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01662:Cdh13
|
APN |
8 |
119,401,916 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01719:Cdh13
|
APN |
8 |
119,401,927 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02148:Cdh13
|
APN |
8 |
119,925,697 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02157:Cdh13
|
APN |
8 |
119,232,410 (GRCm39) |
missense |
possibly damaging |
0.68 |
IGL02188:Cdh13
|
APN |
8 |
119,578,500 (GRCm39) |
missense |
probably benign |
0.08 |
IGL02490:Cdh13
|
APN |
8 |
119,822,062 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02851:Cdh13
|
APN |
8 |
119,401,897 (GRCm39) |
missense |
probably benign |
0.32 |
IGL02958:Cdh13
|
APN |
8 |
120,039,460 (GRCm39) |
missense |
possibly damaging |
0.90 |
IGL03085:Cdh13
|
APN |
8 |
120,015,463 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03230:Cdh13
|
APN |
8 |
119,969,056 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03280:Cdh13
|
APN |
8 |
120,040,873 (GRCm39) |
missense |
probably damaging |
1.00 |
K3955:Cdh13
|
UTSW |
8 |
119,401,843 (GRCm39) |
missense |
probably damaging |
0.99 |
R0398:Cdh13
|
UTSW |
8 |
120,040,786 (GRCm39) |
missense |
probably damaging |
1.00 |
R2156:Cdh13
|
UTSW |
8 |
119,963,703 (GRCm39) |
missense |
probably damaging |
1.00 |
R3415:Cdh13
|
UTSW |
8 |
119,401,946 (GRCm39) |
missense |
probably benign |
0.35 |
R4243:Cdh13
|
UTSW |
8 |
119,968,996 (GRCm39) |
missense |
probably damaging |
1.00 |
R4839:Cdh13
|
UTSW |
8 |
119,578,587 (GRCm39) |
nonsense |
probably null |
|
R4851:Cdh13
|
UTSW |
8 |
119,484,129 (GRCm39) |
missense |
possibly damaging |
0.75 |
R5129:Cdh13
|
UTSW |
8 |
119,821,954 (GRCm39) |
missense |
probably damaging |
1.00 |
R5453:Cdh13
|
UTSW |
8 |
119,925,706 (GRCm39) |
missense |
probably damaging |
1.00 |
R5607:Cdh13
|
UTSW |
8 |
119,484,213 (GRCm39) |
missense |
probably benign |
|
R5608:Cdh13
|
UTSW |
8 |
119,484,213 (GRCm39) |
missense |
probably benign |
|
R5610:Cdh13
|
UTSW |
8 |
119,578,462 (GRCm39) |
missense |
possibly damaging |
0.95 |
R6035:Cdh13
|
UTSW |
8 |
119,232,437 (GRCm39) |
missense |
probably benign |
0.03 |
R6035:Cdh13
|
UTSW |
8 |
119,232,437 (GRCm39) |
missense |
probably benign |
0.03 |
R6556:Cdh13
|
UTSW |
8 |
119,694,926 (GRCm39) |
missense |
probably damaging |
0.99 |
R7124:Cdh13
|
UTSW |
8 |
119,694,912 (GRCm39) |
missense |
probably damaging |
1.00 |
R7349:Cdh13
|
UTSW |
8 |
119,969,097 (GRCm39) |
missense |
probably damaging |
0.97 |
R7418:Cdh13
|
UTSW |
8 |
120,039,264 (GRCm39) |
missense |
probably damaging |
1.00 |
R7679:Cdh13
|
UTSW |
8 |
119,963,658 (GRCm39) |
missense |
probably benign |
0.29 |
R7807:Cdh13
|
UTSW |
8 |
119,010,594 (GRCm39) |
start codon destroyed |
probably null |
0.77 |
R8777:Cdh13
|
UTSW |
8 |
119,963,706 (GRCm39) |
critical splice donor site |
probably null |
|
R8777-TAIL:Cdh13
|
UTSW |
8 |
119,963,706 (GRCm39) |
critical splice donor site |
probably null |
|
R9175:Cdh13
|
UTSW |
8 |
119,968,968 (GRCm39) |
missense |
probably damaging |
1.00 |
R9481:Cdh13
|
UTSW |
8 |
119,963,676 (GRCm39) |
missense |
|
|
X0025:Cdh13
|
UTSW |
8 |
119,232,418 (GRCm39) |
missense |
probably benign |
0.28 |
|
Posted On |
2012-10-29 |