Incidental Mutation 'R0846:Fos'
ID |
77381 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Fos
|
Ensembl Gene |
ENSMUSG00000021250 |
Gene Name |
FBJ osteosarcoma oncogene |
Synonyms |
D12Rfj1, cFos, c-fos |
MMRRC Submission |
039025-MU
|
Accession Numbers |
|
Essential gene? |
Essential
(E-score: 1.000)
|
Stock # |
R0846 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
12 |
Chromosomal Location |
85520664-85524047 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
C to T
at 85522457 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Threonine to Isoleucine
at position 162
(T162I)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000021674
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021674]
|
AlphaFold |
P01101 |
PDB Structure |
Crystal structure of the bZIP heterodimeric complex MafB:cFos bound to DNA [X-RAY DIFFRACTION]
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000021674
AA Change: T162I
PolyPhen 2
Score 0.957 (Sensitivity: 0.78; Specificity: 0.95)
|
SMART Domains |
Protein: ENSMUSP00000021674 Gene: ENSMUSG00000021250 AA Change: T162I
Domain | Start | End | E-Value | Type |
low complexity region
|
12 |
26 |
N/A |
INTRINSIC |
BRLZ
|
135 |
199 |
1.77e-15 |
SMART |
low complexity region
|
277 |
288 |
N/A |
INTRINSIC |
low complexity region
|
324 |
338 |
N/A |
INTRINSIC |
low complexity region
|
362 |
374 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000134311
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000136122
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000140525
|
Coding Region Coverage |
- 1x: 99.6%
- 3x: 98.8%
- 10x: 96.2%
- 20x: 90.2%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008] PHENOTYPE: Null mutants are growth-retarded, most dying perinatally. Survivors have osteopetrosis and abnormal tooth eruption, gametogenesis, hemopoiesis, behavior and photoreceptor apoptosis. Hippocampal-specific mutants have seizures and highly excitable neurons. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 37 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aak1 |
T |
C |
6: 86,936,071 (GRCm39) |
|
probably benign |
Het |
Adgrv1 |
G |
A |
13: 81,627,861 (GRCm39) |
R3667* |
probably null |
Het |
Adh5 |
T |
G |
3: 138,156,835 (GRCm39) |
C174G |
probably damaging |
Het |
Cap1 |
A |
C |
4: 122,756,692 (GRCm39) |
|
probably null |
Het |
Caps2 |
G |
A |
10: 112,051,490 (GRCm39) |
R587H |
probably damaging |
Het |
Ccn1 |
T |
A |
3: 145,353,525 (GRCm39) |
M346L |
possibly damaging |
Het |
Cdo1 |
A |
G |
18: 46,848,812 (GRCm39) |
V142A |
probably damaging |
Het |
Chuk |
T |
C |
19: 44,079,467 (GRCm39) |
T345A |
probably damaging |
Het |
Cobll1 |
T |
C |
2: 64,932,409 (GRCm39) |
|
probably null |
Het |
Col1a2 |
G |
A |
6: 4,518,822 (GRCm39) |
|
probably benign |
Het |
Cop1 |
T |
C |
1: 159,147,386 (GRCm39) |
Y571H |
probably benign |
Het |
Cstpp1 |
T |
A |
2: 91,214,182 (GRCm39) |
T58S |
probably damaging |
Het |
Dcc |
A |
G |
18: 71,959,283 (GRCm39) |
V163A |
probably benign |
Het |
Dnah11 |
G |
T |
12: 117,897,585 (GRCm39) |
N3548K |
probably damaging |
Het |
Ehhadh |
G |
T |
16: 21,592,247 (GRCm39) |
S152* |
probably null |
Het |
Fitm2 |
T |
C |
2: 163,311,734 (GRCm39) |
T160A |
probably benign |
Het |
Fsd2 |
T |
C |
7: 81,190,145 (GRCm39) |
I546V |
probably benign |
Het |
Gal3st2c |
T |
C |
1: 93,934,669 (GRCm39) |
V19A |
possibly damaging |
Het |
Gorasp2 |
T |
A |
2: 70,521,298 (GRCm39) |
S443T |
probably benign |
Het |
Klf4 |
G |
A |
4: 55,530,191 (GRCm39) |
H307Y |
probably damaging |
Het |
Ldc1 |
A |
C |
4: 130,115,417 (GRCm39) |
S44A |
probably benign |
Het |
Mark3 |
A |
G |
12: 111,593,658 (GRCm39) |
D230G |
possibly damaging |
Het |
Mnat1 |
T |
G |
12: 73,170,706 (GRCm39) |
|
probably null |
Het |
Or5m9b |
T |
C |
2: 85,905,510 (GRCm39) |
L142P |
possibly damaging |
Het |
Otogl |
T |
G |
10: 107,608,157 (GRCm39) |
T2073P |
probably benign |
Het |
Pdxdc1 |
A |
C |
16: 13,672,257 (GRCm39) |
|
probably null |
Het |
Pkhd1l1 |
T |
C |
15: 44,358,993 (GRCm39) |
S401P |
probably damaging |
Het |
Polr1a |
T |
C |
6: 71,901,627 (GRCm39) |
Y262H |
probably damaging |
Het |
Pramel19 |
A |
T |
4: 101,798,447 (GRCm39) |
K139N |
probably benign |
Het |
Scamp4 |
T |
C |
10: 80,450,537 (GRCm39) |
F205L |
probably benign |
Het |
Scn1a |
C |
T |
2: 66,155,099 (GRCm39) |
S620N |
probably benign |
Het |
Scn7a |
C |
T |
2: 66,527,944 (GRCm39) |
D849N |
possibly damaging |
Het |
Slc17a8 |
T |
C |
10: 89,442,596 (GRCm39) |
D79G |
possibly damaging |
Het |
Sync |
A |
G |
4: 129,187,897 (GRCm39) |
S310G |
probably benign |
Het |
Tbc1d9b |
A |
C |
11: 50,062,148 (GRCm39) |
I1219L |
probably benign |
Het |
Vmn1r47 |
T |
A |
6: 89,999,657 (GRCm39) |
M263K |
probably benign |
Het |
Zfp773 |
A |
T |
7: 7,135,691 (GRCm39) |
C302S |
probably damaging |
Het |
|
Other mutations in Fos |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00897:Fos
|
APN |
12 |
85,523,120 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03088:Fos
|
APN |
12 |
85,522,630 (GRCm39) |
missense |
possibly damaging |
0.79 |
R0653:Fos
|
UTSW |
12 |
85,522,790 (GRCm39) |
missense |
probably benign |
0.16 |
R4700:Fos
|
UTSW |
12 |
85,522,936 (GRCm39) |
missense |
probably benign |
|
R6306:Fos
|
UTSW |
12 |
85,522,460 (GRCm39) |
missense |
probably damaging |
1.00 |
R7154:Fos
|
UTSW |
12 |
85,520,931 (GRCm39) |
missense |
probably benign |
0.00 |
R7528:Fos
|
UTSW |
12 |
85,522,432 (GRCm39) |
missense |
probably damaging |
1.00 |
R7577:Fos
|
UTSW |
12 |
85,521,871 (GRCm39) |
missense |
probably benign |
|
R7853:Fos
|
UTSW |
12 |
85,522,792 (GRCm39) |
missense |
probably benign |
0.01 |
R8443:Fos
|
UTSW |
12 |
85,522,466 (GRCm39) |
missense |
probably damaging |
1.00 |
R8486:Fos
|
UTSW |
12 |
85,522,805 (GRCm39) |
missense |
probably benign |
0.25 |
R8953:Fos
|
UTSW |
12 |
85,522,826 (GRCm39) |
missense |
probably benign |
0.13 |
|
Predicted Primers |
PCR Primer
(F):5'- ATCACACTCTGCCTGCCAACTG -3'
(R):5'- AGACATCTCCTCTGGGAAGCCAAG -3'
Sequencing Primer
(F):5'- GGTTAGAAAAACTGCTTCACCG -3'
(R):5'- GATTGGCAATCTCAGTCTGCAAC -3'
|
Posted On |
2013-10-16 |