Incidental Mutation 'R0848:Or6c214'
ID 77435
Institutional Source Beutler Lab
Gene Symbol Or6c214
Ensembl Gene ENSMUSG00000050478
Gene Name olfactory receptor family 6 subfamily C member 214
Synonyms GA_x6K02T2PULF-11434134-11433199, Olfr807, MOR117-1
MMRRC Submission 039027-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R0848 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 129590382-129591317 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 129591077 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 81 (V81I)
Ref Sequence ENSEMBL: ENSMUSP00000150657 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059038] [ENSMUST00000213379] [ENSMUST00000217106]
AlphaFold Q8VGI9
Predicted Effect probably benign
Transcript: ENSMUST00000059038
AA Change: V81I

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000049924
Gene: ENSMUSG00000050478
AA Change: V81I

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 3.9e-45 PFAM
Pfam:7TM_GPCR_Srsx 33 302 3.4e-8 PFAM
Pfam:7tm_1 39 296 2.9e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213379
AA Change: V81I

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000217106
AA Change: V81I

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 94.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aass A T 6: 23,114,984 (GRCm39) H181Q probably damaging Het
Abca13 T A 11: 9,632,011 (GRCm39) L4977* probably null Het
Abca8a T A 11: 109,919,016 (GRCm39) Y1550F probably damaging Het
Actr2 C T 11: 20,022,584 (GRCm39) E296K probably benign Het
Agtpbp1 A T 13: 59,681,753 (GRCm39) probably benign Het
Anks1b A C 10: 89,906,987 (GRCm39) E268A probably damaging Het
C1rl A G 6: 124,485,465 (GRCm39) T279A probably benign Het
C5ar2 T C 7: 15,971,526 (GRCm39) T134A probably benign Het
Cdkl3 G A 11: 51,902,094 (GRCm39) R101Q probably damaging Het
Celsr2 A T 3: 108,321,654 (GRCm39) F386Y probably benign Het
Chd1 C T 17: 15,990,503 (GRCm39) P1685L probably damaging Het
Chrne G T 11: 70,506,239 (GRCm39) H402Q probably benign Het
Clvs1 A G 4: 9,282,003 (GRCm39) D149G possibly damaging Het
Cntnap5b T C 1: 100,182,888 (GRCm39) Y620H probably benign Het
Col6a1 A G 10: 76,549,458 (GRCm39) probably null Het
Cyp2d26 T A 15: 82,674,434 (GRCm39) I483F probably benign Het
Dlx6 C T 6: 6,863,665 (GRCm39) Q96* probably null Het
Dmac2l A T 12: 69,788,584 (GRCm39) H161L probably benign Het
Eif1a T A 18: 46,741,114 (GRCm39) N116K possibly damaging Het
Epb41l5 A T 1: 119,477,684 (GRCm39) C696S probably benign Het
Exoc7 A G 11: 116,186,074 (GRCm39) S376P possibly damaging Het
Fads1 C T 19: 10,160,429 (GRCm39) P5L probably benign Het
G3bp1 T C 11: 55,389,452 (GRCm39) F383L probably damaging Het
Gimap7 T C 6: 48,700,657 (GRCm39) I81T probably damaging Het
Gtf2a1l T C 17: 89,001,657 (GRCm39) V171A probably damaging Het
Hax1 A G 3: 89,902,940 (GRCm39) S253P probably damaging Het
Hsd3b5 A T 3: 98,526,671 (GRCm39) D258E probably damaging Het
Kcnb1 G T 2: 166,948,187 (GRCm39) F220L probably damaging Het
Kif1a T A 1: 92,947,620 (GRCm39) Y1708F probably damaging Het
Krt14 A T 11: 100,095,090 (GRCm39) I379N probably damaging Het
Lpxn A G 19: 12,781,401 (GRCm39) I40V probably benign Het
Lrp1 C T 10: 127,389,231 (GRCm39) probably null Het
Lyst G A 13: 13,809,515 (GRCm39) R395H probably benign Het
Mindy4 G A 6: 55,295,271 (GRCm39) W737* probably null Het
Mki67 C A 7: 135,302,772 (GRCm39) R754L probably benign Het
Morf4l1 A G 9: 89,982,502 (GRCm39) V144A probably benign Het
Mvb12a T C 8: 71,998,422 (GRCm39) S186P probably benign Het
Myrf G C 19: 10,195,526 (GRCm39) T428S probably benign Het
Nipal1 A G 5: 72,825,183 (GRCm39) N292S probably damaging Het
Nqo2 T G 13: 34,156,461 (GRCm39) probably null Het
Or14a256 T C 7: 86,264,848 (GRCm39) Y335C probably damaging Het
Or2d3b A G 7: 106,514,200 (GRCm39) K265R probably benign Het
Or5ak24 A T 2: 85,260,365 (GRCm39) N269K probably benign Het
Osbpl7 C A 11: 96,951,350 (GRCm39) P507Q probably damaging Het
Pcdhb1 G A 18: 37,400,475 (GRCm39) G809S probably benign Het
Pcm1 T C 8: 41,735,720 (GRCm39) V846A probably damaging Het
Phf3 A G 1: 30,902,253 (GRCm39) L20P probably damaging Het
Pih1d1 A G 7: 44,807,041 (GRCm39) T58A probably damaging Het
Plekhn1 A G 4: 156,308,021 (GRCm39) probably null Het
Plvap A T 8: 71,959,526 (GRCm39) L422Q probably damaging Het
Polq C T 16: 36,882,492 (GRCm39) A1273V probably benign Het
Prelid2 T A 18: 42,068,289 (GRCm39) I51F probably damaging Het
Ptpn18 G A 1: 34,501,783 (GRCm39) D8N probably damaging Het
Ptpra T A 2: 130,360,911 (GRCm39) F190Y probably damaging Het
Pus7l A G 15: 94,438,393 (GRCm39) S151P probably benign Het
Rsph6a G A 7: 18,791,595 (GRCm39) D255N probably benign Het
Serpinb6c A T 13: 34,083,288 (GRCm39) V42D probably damaging Het
Slc7a13 A G 4: 19,818,866 (GRCm39) N22S probably benign Het
Snx5 G A 2: 144,095,726 (GRCm39) R312C probably damaging Het
Stard9 T C 2: 120,526,304 (GRCm39) S854P probably damaging Het
Syne2 AAGAG AAGAGAGAG 12: 76,144,733 (GRCm39) probably null Het
Syne2 AGAGTGAG AGAGTGAGTGAG 12: 76,144,734 (GRCm39) probably null Het
Tlr12 A G 4: 128,510,084 (GRCm39) I722T probably benign Het
Tmem101 A T 11: 102,046,692 (GRCm39) M59K possibly damaging Het
Trim34a C T 7: 103,910,331 (GRCm39) R378C probably benign Het
Trim35 T A 14: 66,546,574 (GRCm39) M447K probably benign Het
Trps1 C A 15: 50,524,945 (GRCm39) S704I possibly damaging Het
Vmn1r231 T A 17: 21,110,433 (GRCm39) S161C probably damaging Het
Vps13a A C 19: 16,676,261 (GRCm39) N1237K probably damaging Het
Zfp619 G T 7: 39,185,983 (GRCm39) C671F probably damaging Het
Other mutations in Or6c214
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02586:Or6c214 APN 10 129,590,524 (GRCm39) missense possibly damaging 0.87
IGL03031:Or6c214 APN 10 129,591,238 (GRCm39) missense possibly damaging 0.94
R0691:Or6c214 UTSW 10 129,591,271 (GRCm39) missense probably damaging 1.00
R0988:Or6c214 UTSW 10 129,590,866 (GRCm39) missense probably benign 0.03
R1880:Or6c214 UTSW 10 129,591,290 (GRCm39) missense probably benign 0.09
R1894:Or6c214 UTSW 10 129,590,943 (GRCm39) nonsense probably null
R1935:Or6c214 UTSW 10 129,590,584 (GRCm39) missense probably damaging 1.00
R2513:Or6c214 UTSW 10 129,591,021 (GRCm39) missense probably damaging 1.00
R4201:Or6c214 UTSW 10 129,590,497 (GRCm39) missense probably damaging 1.00
R4643:Or6c214 UTSW 10 129,590,824 (GRCm39) missense probably damaging 1.00
R4651:Or6c214 UTSW 10 129,591,287 (GRCm39) missense probably benign
R4652:Or6c214 UTSW 10 129,591,287 (GRCm39) missense probably benign
R4797:Or6c214 UTSW 10 129,590,390 (GRCm39) missense probably benign 0.06
R5337:Or6c214 UTSW 10 129,590,403 (GRCm39) nonsense probably null
R5597:Or6c214 UTSW 10 129,590,755 (GRCm39) missense probably damaging 1.00
R6310:Or6c214 UTSW 10 129,590,528 (GRCm39) missense probably benign 0.04
R6442:Or6c214 UTSW 10 129,591,277 (GRCm39) missense probably damaging 1.00
R6443:Or6c214 UTSW 10 129,591,277 (GRCm39) missense probably damaging 1.00
R6642:Or6c214 UTSW 10 129,591,232 (GRCm39) missense probably damaging 1.00
R7660:Or6c214 UTSW 10 129,590,432 (GRCm39) nonsense probably null
R7862:Or6c214 UTSW 10 129,591,224 (GRCm39) missense probably benign 0.00
R9052:Or6c214 UTSW 10 129,591,094 (GRCm39) missense possibly damaging 0.75
R9091:Or6c214 UTSW 10 129,591,148 (GRCm39) missense probably damaging 0.98
R9270:Or6c214 UTSW 10 129,591,148 (GRCm39) missense probably damaging 0.98
R9703:Or6c214 UTSW 10 129,591,286 (GRCm39) missense possibly damaging 0.57
Z1088:Or6c214 UTSW 10 129,591,208 (GRCm39) missense possibly damaging 0.77
Z1176:Or6c214 UTSW 10 129,590,693 (GRCm39) missense possibly damaging 0.93
Z1176:Or6c214 UTSW 10 129,590,557 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGGCAGATCGCAAACACAGCAATTA -3'
(R):5'- TCTGGGATTGACAGAAGACCCAAAGT -3'

Sequencing Primer
(F):5'- CAGCAATGTACAGACTCTGTTGTTC -3'
(R):5'- GACCCAAAGTGGCAAATTGTAATC -3'
Posted On 2013-10-16