Incidental Mutation 'R0830:Cyp2g1'
| ID |
77487 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cyp2g1
|
| Ensembl Gene |
ENSMUSG00000049685 |
| Gene Name |
cytochrome P450, family 2, subfamily g, polypeptide 1 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0830 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
26508352-26520622 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 26514216 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Arginine
at position 274
(K274R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000047150
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000040944]
|
| AlphaFold |
Q9WV19 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000040944
AA Change: K274R
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000047150
Gene: ENSMUSG00000049685
AA Change: K274R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
12 |
23 |
N/A |
INTRINSIC |
|
Pfam:p450
|
34 |
491 |
4e-150 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000205273
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.4%
- 10x: 96.0%
- 20x: 90.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for disruptions in this gene display an essentially normal phenotype. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 41 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700056E22Rik |
C |
T |
1: 183,765,624 (GRCm39) |
R145H |
probably damaging |
Het |
| Adam26a |
C |
T |
8: 44,021,439 (GRCm39) |
V684I |
probably benign |
Het |
| Alk |
T |
C |
17: 72,910,195 (GRCm39) |
I170M |
probably benign |
Het |
| Apc2 |
T |
C |
10: 80,151,239 (GRCm39) |
Y2069H |
probably damaging |
Het |
| Aspm |
A |
G |
1: 139,401,992 (GRCm39) |
T1219A |
probably damaging |
Het |
| Bnip1 |
T |
C |
17: 27,008,679 (GRCm39) |
S94P |
probably benign |
Het |
| Cftr |
A |
G |
6: 18,270,224 (GRCm39) |
I805V |
probably benign |
Het |
| Col25a1 |
T |
A |
3: 130,378,375 (GRCm39) |
D609E |
probably damaging |
Het |
| Cplane1 |
T |
A |
15: 8,276,669 (GRCm39) |
V2771E |
unknown |
Het |
| D5Ertd579e |
G |
A |
5: 36,771,101 (GRCm39) |
T1098I |
probably damaging |
Het |
| Ddx39a |
T |
A |
8: 84,446,452 (GRCm39) |
C74S |
possibly damaging |
Het |
| E2f3 |
C |
T |
13: 30,169,543 (GRCm39) |
A37T |
probably benign |
Het |
| Emilin2 |
A |
G |
17: 71,580,815 (GRCm39) |
M637T |
probably benign |
Het |
| Exosc7 |
T |
C |
9: 122,948,358 (GRCm39) |
L93P |
probably benign |
Het |
| F2 |
T |
C |
2: 91,460,545 (GRCm39) |
E316G |
probably benign |
Het |
| Fat4 |
A |
C |
3: 39,053,258 (GRCm39) |
Q4084P |
probably benign |
Het |
| Flywch1 |
T |
C |
17: 23,981,344 (GRCm39) |
K160E |
probably benign |
Het |
| Foxi2 |
A |
G |
7: 135,013,459 (GRCm39) |
T230A |
probably benign |
Het |
| Fthl17a |
A |
G |
X: 84,313,679 (GRCm39) |
N154S |
possibly damaging |
Het |
| Hykk |
G |
A |
9: 54,844,601 (GRCm39) |
R222Q |
probably damaging |
Het |
| Il18rap |
T |
A |
1: 40,582,150 (GRCm39) |
V357E |
probably damaging |
Het |
| Ing4 |
A |
G |
6: 125,020,923 (GRCm39) |
E15G |
probably damaging |
Het |
| Irak1 |
T |
C |
X: 73,060,189 (GRCm39) |
D679G |
probably damaging |
Het |
| Itga1 |
T |
C |
13: 115,143,568 (GRCm39) |
E321G |
probably benign |
Het |
| Nudt1 |
T |
A |
5: 140,321,076 (GRCm39) |
|
probably null |
Het |
| Nup58 |
A |
G |
14: 60,480,931 (GRCm39) |
F138S |
probably damaging |
Het |
| Or10al6 |
A |
T |
17: 38,082,804 (GRCm39) |
M87L |
probably damaging |
Het |
| Or2a5 |
G |
T |
6: 42,873,532 (GRCm39) |
W49L |
probably benign |
Het |
| Pllp |
T |
C |
8: 95,406,103 (GRCm39) |
Y60C |
probably damaging |
Het |
| Pnpla7 |
T |
C |
2: 24,887,267 (GRCm39) |
V37A |
probably damaging |
Het |
| Poglut3 |
T |
G |
9: 53,302,011 (GRCm39) |
L32R |
probably damaging |
Het |
| Psme4 |
A |
G |
11: 30,757,797 (GRCm39) |
H310R |
possibly damaging |
Het |
| Rasl10b |
G |
A |
11: 83,308,665 (GRCm39) |
|
probably null |
Het |
| Sash1 |
C |
T |
10: 8,605,673 (GRCm39) |
V906M |
probably benign |
Het |
| Scn1a |
A |
T |
2: 66,130,128 (GRCm39) |
I1212K |
probably damaging |
Het |
| Stbd1 |
A |
T |
5: 92,752,989 (GRCm39) |
S160C |
probably benign |
Het |
| Tex29 |
T |
C |
8: 11,904,157 (GRCm39) |
V99A |
probably benign |
Het |
| Tg |
A |
T |
15: 66,596,993 (GRCm39) |
N79I |
probably damaging |
Het |
| Tie1 |
T |
C |
4: 118,339,860 (GRCm39) |
D389G |
probably damaging |
Het |
| Vmn1r178 |
A |
G |
7: 23,593,452 (GRCm39) |
T167A |
possibly damaging |
Het |
| Xkr4 |
C |
T |
1: 3,740,968 (GRCm39) |
G202S |
possibly damaging |
Het |
|
| Other mutations in Cyp2g1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01134:Cyp2g1
|
APN |
7 |
26,509,256 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01137:Cyp2g1
|
APN |
7 |
26,513,684 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL02052:Cyp2g1
|
APN |
7 |
26,513,719 (GRCm39) |
splice site |
probably benign |
|
|
IGL02338:Cyp2g1
|
APN |
7 |
26,514,229 (GRCm39) |
splice site |
probably benign |
|
|
IGL02452:Cyp2g1
|
APN |
7 |
26,510,871 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL02523:Cyp2g1
|
APN |
7 |
26,518,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03165:Cyp2g1
|
APN |
7 |
26,509,201 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03230:Cyp2g1
|
APN |
7 |
26,518,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4472001:Cyp2g1
|
UTSW |
7 |
26,513,619 (GRCm39) |
missense |
probably benign |
0.28 |
|
R0106:Cyp2g1
|
UTSW |
7 |
26,513,607 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0106:Cyp2g1
|
UTSW |
7 |
26,513,607 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0380:Cyp2g1
|
UTSW |
7 |
26,513,720 (GRCm39) |
splice site |
probably benign |
|
|
R0697:Cyp2g1
|
UTSW |
7 |
26,514,152 (GRCm39) |
nonsense |
probably null |
|
|
R1660:Cyp2g1
|
UTSW |
7 |
26,509,107 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R2093:Cyp2g1
|
UTSW |
7 |
26,518,858 (GRCm39) |
missense |
probably benign |
0.35 |
|
R2131:Cyp2g1
|
UTSW |
7 |
26,520,135 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4606:Cyp2g1
|
UTSW |
7 |
26,513,579 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5030:Cyp2g1
|
UTSW |
7 |
26,520,226 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5574:Cyp2g1
|
UTSW |
7 |
26,520,165 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5877:Cyp2g1
|
UTSW |
7 |
26,516,065 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R6745:Cyp2g1
|
UTSW |
7 |
26,513,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7040:Cyp2g1
|
UTSW |
7 |
26,520,184 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7223:Cyp2g1
|
UTSW |
7 |
26,514,057 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7934:Cyp2g1
|
UTSW |
7 |
26,518,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8112:Cyp2g1
|
UTSW |
7 |
26,518,886 (GRCm39) |
missense |
probably benign |
|
|
R8177:Cyp2g1
|
UTSW |
7 |
26,518,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8194:Cyp2g1
|
UTSW |
7 |
26,514,159 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9043:Cyp2g1
|
UTSW |
7 |
26,509,256 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9406:Cyp2g1
|
UTSW |
7 |
26,518,910 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9441:Cyp2g1
|
UTSW |
7 |
26,514,060 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
X0067:Cyp2g1
|
UTSW |
7 |
26,520,187 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
| Predicted Primers |
|
| Posted On |
2013-10-16 |
Incidental Mutation