Incidental Mutation 'P0037:Wdr95'
ID 7755
Institutional Source Beutler Lab
Gene Symbol Wdr95
Ensembl Gene ENSMUSG00000029658
Gene Name WD40 repeat domain 95
Synonyms 4930434E21Rik
MMRRC Submission 038286-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # P0037 (G1)
Quality Score
Status Validated
Chromosome 5
Chromosomal Location 149452144-149535359 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 149511536 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 412 (N412S)
Ref Sequence ENSEMBL: ENSMUSP00000144385 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000110502] [ENSMUST00000201525] [ENSMUST00000202902]
AlphaFold D3Z7A8
Predicted Effect probably benign
Transcript: ENSMUST00000110502
AA Change: N270S

PolyPhen 2 Score 0.153 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000106128
Gene: ENSMUSG00000029658
AA Change: N270S

DomainStartEndE-ValueType
Pfam:WD40 4 28 3.3e-3 PFAM
WD40 32 71 4.38e-5 SMART
WD40 120 159 3.27e-4 SMART
WD40 162 203 1.71e-7 SMART
WD40 206 249 3.57e0 SMART
WD40 263 301 1.7e-2 SMART
Blast:WD40 315 363 3e-14 BLAST
Blast:WD40 367 408 4e-13 BLAST
WD40 421 460 2.01e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000121108
AA Change: N412S

PolyPhen 2 Score 0.268 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000113092
Gene: ENSMUSG00000029658
AA Change: N412S

DomainStartEndE-ValueType
Blast:WD40 44 83 9e-11 BLAST
WD40 132 170 1.61e-3 SMART
WD40 174 213 4.38e-5 SMART
WD40 262 301 3.27e-4 SMART
WD40 304 345 1.71e-7 SMART
WD40 348 391 3.57e0 SMART
WD40 405 443 1.7e-2 SMART
Blast:WD40 457 505 3e-14 BLAST
Blast:WD40 509 550 4e-13 BLAST
WD40 563 602 2.01e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000201525
SMART Domains Protein: ENSMUSP00000144234
Gene: ENSMUSG00000029658

DomainStartEndE-ValueType
WD40 104 143 2e-6 SMART
WD40 146 187 1.1e-9 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202635
Predicted Effect probably benign
Transcript: ENSMUST00000202902
AA Change: N412S

PolyPhen 2 Score 0.268 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000144385
Gene: ENSMUSG00000029658
AA Change: N412S

DomainStartEndE-ValueType
Blast:WD40 44 83 9e-11 BLAST
WD40 132 170 1.61e-3 SMART
WD40 174 213 4.38e-5 SMART
WD40 262 301 3.27e-4 SMART
WD40 304 345 1.71e-7 SMART
WD40 348 391 3.57e0 SMART
WD40 405 443 1.7e-2 SMART
Blast:WD40 457 505 3e-14 BLAST
Blast:WD40 509 550 4e-13 BLAST
WD40 563 602 2.01e-4 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 81.9%
  • 3x: 74.9%
  • 10x: 53.1%
  • 20x: 30.8%
Validation Efficiency 70% (70/100)
Allele List at MGI
Other mutations in this stock
Total: 11 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Angpt2 A G 8: 18,764,259 (GRCm39) probably benign Het
Arih1 A G 9: 59,313,076 (GRCm39) V1A possibly damaging Het
Cntn3 T C 6: 102,186,235 (GRCm39) D584G probably damaging Het
Dnah10 G A 5: 124,895,056 (GRCm39) W3471* probably null Het
Mmrn2 G A 14: 34,125,022 (GRCm39) V868M probably damaging Het
Pcdh7 G T 5: 58,070,590 (GRCm39) E1089D probably benign Het
Setd1b T C 5: 123,303,984 (GRCm39) probably benign Het
Tex15 T C 8: 34,071,608 (GRCm39) I2385T probably benign Het
Trpm7 T C 2: 126,658,677 (GRCm39) probably benign Het
Wdr87-ps A G 7: 29,233,039 (GRCm39) noncoding transcript Het
Zmiz2 T C 11: 6,353,885 (GRCm39) I755T probably damaging Het
Other mutations in Wdr95
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00429:Wdr95 APN 5 149,518,709 (GRCm39) critical splice acceptor site probably benign 0.00
IGL02352:Wdr95 APN 5 149,504,084 (GRCm39) missense probably damaging 0.99
IGL02359:Wdr95 APN 5 149,504,084 (GRCm39) missense probably damaging 0.99
IGL02478:Wdr95 APN 5 149,519,786 (GRCm39) missense probably benign 0.02
IGL03078:Wdr95 APN 5 149,535,062 (GRCm39) missense possibly damaging 0.63
IGL03201:Wdr95 APN 5 149,505,352 (GRCm39) splice site probably null
R0115:Wdr95 UTSW 5 149,487,855 (GRCm39) missense probably damaging 1.00
R0538:Wdr95 UTSW 5 149,504,271 (GRCm39) missense probably damaging 1.00
R0606:Wdr95 UTSW 5 149,511,595 (GRCm39) missense probably damaging 1.00
R0723:Wdr95 UTSW 5 149,497,513 (GRCm39) missense probably damaging 1.00
R1104:Wdr95 UTSW 5 149,529,802 (GRCm39) missense probably benign 0.00
R1233:Wdr95 UTSW 5 149,518,829 (GRCm39) missense probably benign 0.00
R1233:Wdr95 UTSW 5 149,505,323 (GRCm39) missense possibly damaging 0.61
R1344:Wdr95 UTSW 5 149,511,563 (GRCm39) missense probably damaging 1.00
R1513:Wdr95 UTSW 5 149,522,759 (GRCm39) missense probably benign 0.00
R1623:Wdr95 UTSW 5 149,497,581 (GRCm39) missense probably damaging 1.00
R1633:Wdr95 UTSW 5 149,516,637 (GRCm39) missense probably damaging 0.98
R1664:Wdr95 UTSW 5 149,518,752 (GRCm39) missense probably damaging 0.98
R1686:Wdr95 UTSW 5 149,516,566 (GRCm39) missense probably damaging 1.00
R1741:Wdr95 UTSW 5 149,518,861 (GRCm39) splice site probably null
R1750:Wdr95 UTSW 5 149,505,351 (GRCm39) splice site probably null
R1774:Wdr95 UTSW 5 149,487,857 (GRCm39) nonsense probably null
R1831:Wdr95 UTSW 5 149,475,891 (GRCm39) missense probably damaging 1.00
R1838:Wdr95 UTSW 5 149,522,831 (GRCm39) missense probably benign 0.00
R1907:Wdr95 UTSW 5 149,475,891 (GRCm39) missense probably damaging 1.00
R2019:Wdr95 UTSW 5 149,497,613 (GRCm39) splice site probably benign
R2063:Wdr95 UTSW 5 149,502,627 (GRCm39) splice site probably null
R2392:Wdr95 UTSW 5 149,504,135 (GRCm39) missense probably benign 0.03
R2863:Wdr95 UTSW 5 149,505,321 (GRCm39) nonsense probably null
R4116:Wdr95 UTSW 5 149,521,040 (GRCm39) missense probably benign 0.02
R4237:Wdr95 UTSW 5 149,486,802 (GRCm39) nonsense probably null
R4420:Wdr95 UTSW 5 149,456,131 (GRCm39) missense probably damaging 0.99
R4639:Wdr95 UTSW 5 149,505,279 (GRCm39) splice site probably benign
R4824:Wdr95 UTSW 5 149,518,797 (GRCm39) missense probably damaging 1.00
R4911:Wdr95 UTSW 5 149,535,157 (GRCm39) nonsense probably null
R5016:Wdr95 UTSW 5 149,468,266 (GRCm39) missense probably benign 0.00
R5458:Wdr95 UTSW 5 149,487,879 (GRCm39) missense probably damaging 1.00
R5486:Wdr95 UTSW 5 149,519,795 (GRCm39) nonsense probably null
R5613:Wdr95 UTSW 5 149,507,935 (GRCm39) missense probably damaging 1.00
R5906:Wdr95 UTSW 5 149,487,692 (GRCm39) missense possibly damaging 0.50
R5956:Wdr95 UTSW 5 149,517,947 (GRCm39) missense probably benign 0.00
R6309:Wdr95 UTSW 5 149,504,268 (GRCm39) critical splice acceptor site probably null
R6867:Wdr95 UTSW 5 149,504,388 (GRCm39) splice site probably null
R6964:Wdr95 UTSW 5 149,505,315 (GRCm39) missense probably damaging 1.00
R7008:Wdr95 UTSW 5 149,535,005 (GRCm39) missense probably benign 0.00
R7208:Wdr95 UTSW 5 149,518,836 (GRCm39) missense probably benign 0.02
R7309:Wdr95 UTSW 5 149,529,758 (GRCm39) missense probably benign 0.01
R7504:Wdr95 UTSW 5 149,505,311 (GRCm39) missense probably damaging 0.99
R7660:Wdr95 UTSW 5 149,517,945 (GRCm39) missense possibly damaging 0.86
R7997:Wdr95 UTSW 5 149,502,622 (GRCm39) critical splice donor site probably null
R8084:Wdr95 UTSW 5 149,511,598 (GRCm39) missense probably damaging 1.00
R8356:Wdr95 UTSW 5 149,502,572 (GRCm39) missense probably damaging 1.00
R8456:Wdr95 UTSW 5 149,502,572 (GRCm39) missense probably damaging 1.00
R8523:Wdr95 UTSW 5 149,497,461 (GRCm39) missense probably damaging 1.00
R8682:Wdr95 UTSW 5 149,518,752 (GRCm39) missense possibly damaging 0.94
R9451:Wdr95 UTSW 5 149,504,165 (GRCm39) missense probably benign 0.01
R9453:Wdr95 UTSW 5 149,475,917 (GRCm39) missense probably damaging 0.99
R9779:Wdr95 UTSW 5 149,505,293 (GRCm39) missense probably benign 0.01
X0024:Wdr95 UTSW 5 149,511,632 (GRCm39) missense possibly damaging 0.81
Z1176:Wdr95 UTSW 5 149,489,901 (GRCm39) missense probably benign 0.34
Z1177:Wdr95 UTSW 5 149,468,241 (GRCm39) missense probably damaging 0.98
Posted On 2012-10-29