Incidental Mutation 'R0833:Plec'
ID 77675
Institutional Source Beutler Lab
Gene Symbol Plec
Ensembl Gene ENSMUSG00000022565
Gene Name plectin
Synonyms Plec1
MMRRC Submission 039012-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.782) question?
Stock # R0833 (G1)
Quality Score 217
Status Validated
Chromosome 15
Chromosomal Location 76055174-76115578 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) GGCAGCAG to GGCAGCAGCAG at 76066107 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000126936 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023226] [ENSMUST00000054449] [ENSMUST00000071869] [ENSMUST00000072692] [ENSMUST00000073418] [ENSMUST00000074834] [ENSMUST00000076442] [ENSMUST00000080857] [ENSMUST00000169108] [ENSMUST00000169714] [ENSMUST00000169438] [ENSMUST00000171562] [ENSMUST00000089610] [ENSMUST00000171634]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000023226
SMART Domains Protein: ENSMUSP00000023226
Gene: ENSMUSG00000022565

DomainStartEndE-ValueType
CH 44 143 4.57e-28 SMART
CH 160 258 3.52e-20 SMART
internal_repeat_2 293 375 1.47e-5 PROSPERO
internal_repeat_2 369 451 1.47e-5 PROSPERO
SPEC 516 613 3.08e-5 SMART
SPEC 616 716 1.29e-7 SMART
SPEC 722 884 3.01e0 SMART
low complexity region 963 977 N/A INTRINSIC
SPEC 980 1086 3.48e0 SMART
SPEC 1089 1200 7.63e-1 SMART
SPEC 1207 1367 2.59e-1 SMART
low complexity region 1371 1411 N/A INTRINSIC
low complexity region 1438 1455 N/A INTRINSIC
low complexity region 1468 1499 N/A INTRINSIC
low complexity region 1510 1559 N/A INTRINSIC
low complexity region 1601 1630 N/A INTRINSIC
low complexity region 1655 1680 N/A INTRINSIC
low complexity region 1718 1739 N/A INTRINSIC
low complexity region 1766 1830 N/A INTRINSIC
low complexity region 1846 1871 N/A INTRINSIC
low complexity region 1932 1946 N/A INTRINSIC
low complexity region 1960 1986 N/A INTRINSIC
low complexity region 2016 2050 N/A INTRINSIC
low complexity region 2056 2070 N/A INTRINSIC
low complexity region 2077 2105 N/A INTRINSIC
low complexity region 2114 2163 N/A INTRINSIC
low complexity region 2180 2195 N/A INTRINSIC
low complexity region 2283 2299 N/A INTRINSIC
low complexity region 2322 2340 N/A INTRINSIC
low complexity region 2391 2404 N/A INTRINSIC
low complexity region 2442 2472 N/A INTRINSIC
low complexity region 2525 2546 N/A INTRINSIC
low complexity region 2550 2565 N/A INTRINSIC
low complexity region 2567 2608 N/A INTRINSIC
PLEC 2647 2684 2.99e1 SMART
PLEC 2685 2722 4.49e-7 SMART
PLEC 2723 2760 4.49e-7 SMART
PLEC 2761 2798 3.54e-5 SMART
PLEC 2799 2836 3.27e-9 SMART
PLEC 2840 2874 6.31e-2 SMART
low complexity region 2945 2963 N/A INTRINSIC
PLEC 2975 3012 3.84e0 SMART
PLEC 3013 3050 1.59e-7 SMART
PLEC 3051 3088 3.54e-5 SMART
PLEC 3089 3126 8.64e-9 SMART
PLEC 3127 3164 1.53e-9 SMART
PLEC 3167 3202 2.18e2 SMART
low complexity region 3274 3293 N/A INTRINSIC
PLEC 3344 3381 3.22e-8 SMART
PLEC 3382 3419 7.82e-7 SMART
PLEC 3420 3457 1.9e-5 SMART
PLEC 3458 3495 7.01e-9 SMART
PLEC 3499 3533 3.38e-2 SMART
low complexity region 3545 3566 N/A INTRINSIC
low complexity region 3572 3582 N/A INTRINSIC
low complexity region 3615 3628 N/A INTRINSIC
PLEC 3679 3716 1.22e-8 SMART
PLEC 3717 3754 1.26e-10 SMART
PLEC 3755 3792 2.24e-7 SMART
PLEC 3793 3830 1.82e-7 SMART
PLEC 3834 3867 5.49e1 SMART
PLEC 3871 3904 3.2e2 SMART
PLEC 3922 3959 8.77e-10 SMART
PLEC 3960 3997 4.13e-6 SMART
PLEC 3998 4035 3.03e-4 SMART
PLEC 4036 4073 4.77e-11 SMART
PLEC 4077 4111 1.28e-2 SMART
PLEC 4124 4164 1.05e-7 SMART
low complexity region 4166 4176 N/A INTRINSIC
PLEC 4178 4215 1.73e1 SMART
low complexity region 4241 4256 N/A INTRINSIC
PLEC 4267 4304 3.65e-7 SMART
PLEC 4305 4342 9.99e-14 SMART
PLEC 4343 4380 4.71e-1 SMART
PLEC 4381 4418 2.44e-8 SMART
PLEC 4419 4456 2.87e-5 SMART
low complexity region 4466 4501 N/A INTRINSIC
low complexity region 4504 4530 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000054449
SMART Domains Protein: ENSMUSP00000057158
Gene: ENSMUSG00000022565

DomainStartEndE-ValueType
low complexity region 11 23 N/A INTRINSIC
CH 44 148 9.8e-28 SMART
CH 165 263 3.52e-20 SMART
internal_repeat_2 298 380 1.4e-5 PROSPERO
internal_repeat_2 374 456 1.4e-5 PROSPERO
SPEC 521 618 3.08e-5 SMART
SPEC 621 721 1.29e-7 SMART
SPEC 727 889 3.01e0 SMART
low complexity region 968 982 N/A INTRINSIC
SPEC 985 1091 3.48e0 SMART
SPEC 1094 1205 7.63e-1 SMART
SPEC 1212 1372 2.59e-1 SMART
low complexity region 1376 1416 N/A INTRINSIC
low complexity region 1443 1460 N/A INTRINSIC
low complexity region 1473 1504 N/A INTRINSIC
low complexity region 1515 1564 N/A INTRINSIC
low complexity region 1606 1635 N/A INTRINSIC
low complexity region 1660 1685 N/A INTRINSIC
low complexity region 1723 1744 N/A INTRINSIC
low complexity region 1771 1835 N/A INTRINSIC
low complexity region 1851 1876 N/A INTRINSIC
low complexity region 1937 1951 N/A INTRINSIC
low complexity region 1965 1991 N/A INTRINSIC
low complexity region 2021 2055 N/A INTRINSIC
low complexity region 2061 2075 N/A INTRINSIC
low complexity region 2082 2110 N/A INTRINSIC
low complexity region 2119 2168 N/A INTRINSIC
low complexity region 2185 2200 N/A INTRINSIC
low complexity region 2288 2304 N/A INTRINSIC
low complexity region 2327 2345 N/A INTRINSIC
low complexity region 2396 2409 N/A INTRINSIC
low complexity region 2447 2477 N/A INTRINSIC
low complexity region 2530 2551 N/A INTRINSIC
low complexity region 2555 2570 N/A INTRINSIC
low complexity region 2572 2613 N/A INTRINSIC
PLEC 2652 2689 2.99e1 SMART
PLEC 2690 2727 4.49e-7 SMART
PLEC 2728 2765 4.49e-7 SMART
PLEC 2766 2803 3.54e-5 SMART
PLEC 2804 2841 3.27e-9 SMART
PLEC 2845 2879 6.31e-2 SMART
low complexity region 2950 2968 N/A INTRINSIC
PLEC 2980 3017 3.84e0 SMART
PLEC 3018 3055 1.59e-7 SMART
PLEC 3056 3093 3.54e-5 SMART
PLEC 3094 3131 8.64e-9 SMART
PLEC 3132 3169 1.53e-9 SMART
PLEC 3172 3207 2.18e2 SMART
low complexity region 3279 3298 N/A INTRINSIC
PLEC 3349 3386 3.22e-8 SMART
PLEC 3387 3424 7.82e-7 SMART
PLEC 3425 3462 1.9e-5 SMART
PLEC 3463 3500 7.01e-9 SMART
PLEC 3504 3538 3.38e-2 SMART
low complexity region 3550 3571 N/A INTRINSIC
low complexity region 3577 3587 N/A INTRINSIC
low complexity region 3620 3633 N/A INTRINSIC
PLEC 3684 3721 1.22e-8 SMART
PLEC 3722 3759 1.26e-10 SMART
PLEC 3760 3797 2.24e-7 SMART
PLEC 3798 3835 1.82e-7 SMART
PLEC 3839 3872 5.49e1 SMART
PLEC 3876 3909 3.2e2 SMART
PLEC 3927 3964 8.77e-10 SMART
PLEC 3965 4002 4.13e-6 SMART
PLEC 4003 4040 3.03e-4 SMART
PLEC 4041 4078 4.77e-11 SMART
PLEC 4082 4116 1.28e-2 SMART
PLEC 4129 4169 1.05e-7 SMART
low complexity region 4171 4181 N/A INTRINSIC
PLEC 4183 4220 1.73e1 SMART
low complexity region 4246 4261 N/A INTRINSIC
PLEC 4272 4309 3.65e-7 SMART
PLEC 4310 4347 9.99e-14 SMART
PLEC 4348 4385 4.71e-1 SMART
PLEC 4386 4423 2.44e-8 SMART
PLEC 4424 4461 2.87e-5 SMART
low complexity region 4471 4506 N/A INTRINSIC
low complexity region 4509 4535 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000071869
SMART Domains Protein: ENSMUSP00000071765
Gene: ENSMUSG00000022565

DomainStartEndE-ValueType
CH 22 121 4.57e-28 SMART
CH 138 236 3.52e-20 SMART
internal_repeat_2 271 353 1.13e-5 PROSPERO
internal_repeat_2 347 429 1.13e-5 PROSPERO
SPEC 494 591 3.08e-5 SMART
SPEC 594 694 1.29e-7 SMART
SPEC 700 862 3.01e0 SMART
low complexity region 941 955 N/A INTRINSIC
SPEC 958 1064 3.48e0 SMART
SPEC 1067 1178 7.63e-1 SMART
SPEC 1185 1345 2.59e-1 SMART
low complexity region 1349 1389 N/A INTRINSIC
low complexity region 1416 1433 N/A INTRINSIC
low complexity region 1446 1477 N/A INTRINSIC
low complexity region 1488 1537 N/A INTRINSIC
low complexity region 1579 1608 N/A INTRINSIC
low complexity region 1633 1658 N/A INTRINSIC
low complexity region 1696 1717 N/A INTRINSIC
low complexity region 1744 1808 N/A INTRINSIC
low complexity region 1824 1849 N/A INTRINSIC
low complexity region 1910 1924 N/A INTRINSIC
low complexity region 1938 1964 N/A INTRINSIC
low complexity region 1994 2028 N/A INTRINSIC
low complexity region 2034 2048 N/A INTRINSIC
low complexity region 2055 2083 N/A INTRINSIC
low complexity region 2092 2141 N/A INTRINSIC
low complexity region 2158 2173 N/A INTRINSIC
low complexity region 2261 2277 N/A INTRINSIC
low complexity region 2300 2318 N/A INTRINSIC
low complexity region 2369 2382 N/A INTRINSIC
low complexity region 2420 2450 N/A INTRINSIC
low complexity region 2503 2524 N/A INTRINSIC
low complexity region 2528 2543 N/A INTRINSIC
low complexity region 2545 2586 N/A INTRINSIC
PLEC 2625 2662 2.99e1 SMART
PLEC 2663 2700 4.49e-7 SMART
PLEC 2701 2738 4.49e-7 SMART
PLEC 2739 2776 3.54e-5 SMART
PLEC 2777 2814 3.27e-9 SMART
PLEC 2818 2852 6.31e-2 SMART
low complexity region 2923 2941 N/A INTRINSIC
PLEC 2953 2990 3.84e0 SMART
PLEC 2991 3028 1.59e-7 SMART
PLEC 3029 3066 3.54e-5 SMART
PLEC 3067 3104 8.64e-9 SMART
PLEC 3105 3142 1.53e-9 SMART
PLEC 3145 3180 2.18e2 SMART
low complexity region 3252 3271 N/A INTRINSIC
PLEC 3322 3359 3.22e-8 SMART
PLEC 3360 3397 7.82e-7 SMART
PLEC 3398 3435 1.9e-5 SMART
PLEC 3436 3473 7.01e-9 SMART
PLEC 3477 3511 3.38e-2 SMART
low complexity region 3523 3544 N/A INTRINSIC
low complexity region 3550 3560 N/A INTRINSIC
low complexity region 3593 3606 N/A INTRINSIC
PLEC 3657 3694 1.22e-8 SMART
PLEC 3695 3732 1.26e-10 SMART
PLEC 3733 3770 2.24e-7 SMART
PLEC 3771 3808 1.82e-7 SMART
PLEC 3812 3845 5.49e1 SMART
PLEC 3849 3882 3.2e2 SMART
PLEC 3900 3937 8.77e-10 SMART
PLEC 3938 3975 4.13e-6 SMART
PLEC 3976 4013 3.03e-4 SMART
PLEC 4014 4051 4.77e-11 SMART
PLEC 4055 4089 1.28e-2 SMART
PLEC 4102 4142 1.05e-7 SMART
low complexity region 4144 4154 N/A INTRINSIC
PLEC 4156 4193 1.73e1 SMART
low complexity region 4219 4234 N/A INTRINSIC
PLEC 4245 4282 3.65e-7 SMART
PLEC 4283 4320 9.99e-14 SMART
PLEC 4321 4358 4.71e-1 SMART
PLEC 4359 4396 2.44e-8 SMART
PLEC 4397 4434 2.87e-5 SMART
low complexity region 4444 4479 N/A INTRINSIC
low complexity region 4482 4508 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000072692
SMART Domains Protein: ENSMUSP00000072478
Gene: ENSMUSG00000022565

DomainStartEndE-ValueType
CH 51 150 4.57e-28 SMART
CH 167 265 3.52e-20 SMART
internal_repeat_2 300 382 1.54e-5 PROSPERO
internal_repeat_2 376 458 1.54e-5 PROSPERO
SPEC 523 620 3.08e-5 SMART
SPEC 623 723 1.29e-7 SMART
SPEC 729 891 3.01e0 SMART
low complexity region 970 984 N/A INTRINSIC
SPEC 987 1093 3.48e0 SMART
SPEC 1096 1207 7.63e-1 SMART
SPEC 1214 1374 2.59e-1 SMART
low complexity region 1378 1418 N/A INTRINSIC
low complexity region 1445 1462 N/A INTRINSIC
low complexity region 1475 1506 N/A INTRINSIC
low complexity region 1517 1566 N/A INTRINSIC
low complexity region 1608 1637 N/A INTRINSIC
low complexity region 1662 1687 N/A INTRINSIC
low complexity region 1725 1746 N/A INTRINSIC
low complexity region 1773 1837 N/A INTRINSIC
low complexity region 1853 1878 N/A INTRINSIC
low complexity region 1939 1953 N/A INTRINSIC
low complexity region 1967 1993 N/A INTRINSIC
low complexity region 2023 2057 N/A INTRINSIC
low complexity region 2063 2077 N/A INTRINSIC
low complexity region 2084 2112 N/A INTRINSIC
low complexity region 2121 2170 N/A INTRINSIC
low complexity region 2187 2202 N/A INTRINSIC
low complexity region 2290 2306 N/A INTRINSIC
low complexity region 2329 2347 N/A INTRINSIC
low complexity region 2398 2411 N/A INTRINSIC
low complexity region 2449 2479 N/A INTRINSIC
low complexity region 2532 2553 N/A INTRINSIC
low complexity region 2557 2572 N/A INTRINSIC
low complexity region 2574 2615 N/A INTRINSIC
PLEC 2654 2691 2.99e1 SMART
PLEC 2692 2729 4.49e-7 SMART
PLEC 2730 2767 4.49e-7 SMART
PLEC 2768 2805 3.54e-5 SMART
PLEC 2806 2843 3.27e-9 SMART
PLEC 2847 2881 6.31e-2 SMART
low complexity region 2952 2970 N/A INTRINSIC
PLEC 2982 3019 3.84e0 SMART
PLEC 3020 3057 1.59e-7 SMART
PLEC 3058 3095 3.54e-5 SMART
PLEC 3096 3133 8.64e-9 SMART
PLEC 3134 3171 1.53e-9 SMART
PLEC 3174 3209 2.18e2 SMART
low complexity region 3281 3300 N/A INTRINSIC
PLEC 3351 3388 3.22e-8 SMART
PLEC 3389 3426 7.82e-7 SMART
PLEC 3427 3464 1.9e-5 SMART
PLEC 3465 3502 7.01e-9 SMART
PLEC 3506 3540 3.38e-2 SMART
low complexity region 3552 3573 N/A INTRINSIC
low complexity region 3579 3589 N/A INTRINSIC
low complexity region 3622 3635 N/A INTRINSIC
PLEC 3686 3723 1.22e-8 SMART
PLEC 3724 3761 1.26e-10 SMART
PLEC 3762 3799 2.24e-7 SMART
PLEC 3800 3837 1.82e-7 SMART
PLEC 3841 3874 5.49e1 SMART
PLEC 3878 3911 3.2e2 SMART
PLEC 3929 3966 8.77e-10 SMART
PLEC 3967 4004 4.13e-6 SMART
PLEC 4005 4042 3.03e-4 SMART
PLEC 4043 4080 4.77e-11 SMART
PLEC 4084 4118 1.28e-2 SMART
PLEC 4131 4171 1.05e-7 SMART
low complexity region 4173 4183 N/A INTRINSIC
PLEC 4185 4222 1.73e1 SMART
low complexity region 4248 4263 N/A INTRINSIC
PLEC 4274 4311 3.65e-7 SMART
PLEC 4312 4349 9.99e-14 SMART
PLEC 4350 4387 4.71e-1 SMART
PLEC 4388 4425 2.44e-8 SMART
PLEC 4426 4463 2.87e-5 SMART
low complexity region 4473 4508 N/A INTRINSIC
low complexity region 4511 4537 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000073418
SMART Domains Protein: ENSMUSP00000073124
Gene: ENSMUSG00000022565

DomainStartEndE-ValueType
Pfam:S10_plectin 7 101 6.3e-34 PFAM
CH 187 291 5e-30 SMART
CH 308 406 1.8e-22 SMART
internal_repeat_2 441 523 2.49e-5 PROSPERO
internal_repeat_2 517 599 2.49e-5 PROSPERO
SPEC 664 761 1.9e-7 SMART
SPEC 764 864 8.4e-10 SMART
SPEC 870 1032 1.9e-2 SMART
low complexity region 1111 1125 N/A INTRINSIC
SPEC 1128 1234 2.3e-2 SMART
SPEC 1237 1348 4.9e-3 SMART
SPEC 1355 1515 1.7e-3 SMART
low complexity region 1519 1559 N/A INTRINSIC
low complexity region 1586 1603 N/A INTRINSIC
low complexity region 1616 1647 N/A INTRINSIC
low complexity region 1658 1707 N/A INTRINSIC
low complexity region 1749 1778 N/A INTRINSIC
low complexity region 1803 1828 N/A INTRINSIC
low complexity region 1866 1887 N/A INTRINSIC
low complexity region 1914 1978 N/A INTRINSIC
low complexity region 1994 2019 N/A INTRINSIC
low complexity region 2080 2094 N/A INTRINSIC
low complexity region 2108 2134 N/A INTRINSIC
low complexity region 2164 2198 N/A INTRINSIC
low complexity region 2204 2218 N/A INTRINSIC
low complexity region 2225 2253 N/A INTRINSIC
low complexity region 2262 2311 N/A INTRINSIC
low complexity region 2328 2343 N/A INTRINSIC
low complexity region 2431 2447 N/A INTRINSIC
low complexity region 2470 2488 N/A INTRINSIC
low complexity region 2539 2552 N/A INTRINSIC
low complexity region 2590 2620 N/A INTRINSIC
low complexity region 2673 2694 N/A INTRINSIC
low complexity region 2698 2713 N/A INTRINSIC
low complexity region 2715 2756 N/A INTRINSIC
PLEC 2795 2832 1.9e-1 SMART
PLEC 2833 2870 2.8e-9 SMART
PLEC 2871 2908 2.8e-9 SMART
PLEC 2909 2946 2.3e-7 SMART
PLEC 2947 2984 2e-11 SMART
PLEC 2988 3022 4e-4 SMART
low complexity region 3093 3111 N/A INTRINSIC
PLEC 3123 3160 2.5e-2 SMART
PLEC 3161 3198 1.1e-9 SMART
PLEC 3199 3236 2.2e-7 SMART
PLEC 3237 3274 5.7e-11 SMART
PLEC 3275 3312 1e-11 SMART
PLEC 3315 3350 1.4e0 SMART
low complexity region 3422 3441 N/A INTRINSIC
PLEC 3492 3529 2.1e-10 SMART
PLEC 3530 3567 5.1e-9 SMART
PLEC 3568 3605 1.2e-7 SMART
PLEC 3606 3643 4.6e-11 SMART
PLEC 3647 3681 2.2e-4 SMART
low complexity region 3693 3714 N/A INTRINSIC
low complexity region 3720 3730 N/A INTRINSIC
low complexity region 3763 3776 N/A INTRINSIC
PLEC 3827 3864 8.1e-11 SMART
PLEC 3865 3902 7.9e-13 SMART
PLEC 3903 3940 1.5e-9 SMART
PLEC 3941 3978 1.2e-9 SMART
PLEC 3982 4015 3.6e-1 SMART
PLEC 4019 4052 2e0 SMART
PLEC 4070 4107 5.7e-12 SMART
PLEC 4108 4145 2.7e-8 SMART
PLEC 4146 4183 1.9e-6 SMART
PLEC 4184 4221 3e-13 SMART
PLEC 4225 4259 8.1e-5 SMART
PLEC 4272 4312 6.5e-10 SMART
low complexity region 4314 4324 N/A INTRINSIC
PLEC 4326 4363 1.1e-1 SMART
low complexity region 4389 4404 N/A INTRINSIC
PLEC 4415 4452 2.3e-9 SMART
PLEC 4453 4490 6.4e-16 SMART
PLEC 4491 4528 3.1e-3 SMART
PLEC 4529 4566 1.5e-10 SMART
PLEC 4567 4604 1.8e-7 SMART
low complexity region 4614 4649 N/A INTRINSIC
low complexity region 4652 4678 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000074834
SMART Domains Protein: ENSMUSP00000074383
Gene: ENSMUSG00000022565

DomainStartEndE-ValueType
CH 35 134 4.57e-28 SMART
CH 151 249 3.52e-20 SMART
internal_repeat_2 284 366 1.19e-5 PROSPERO
internal_repeat_2 360 442 1.19e-5 PROSPERO
SPEC 507 604 3.08e-5 SMART
SPEC 607 707 1.29e-7 SMART
SPEC 713 875 3.01e0 SMART
low complexity region 954 968 N/A INTRINSIC
SPEC 971 1077 3.48e0 SMART
SPEC 1080 1191 7.63e-1 SMART
SPEC 1198 1358 2.59e-1 SMART
low complexity region 1362 1402 N/A INTRINSIC
low complexity region 1429 1446 N/A INTRINSIC
low complexity region 1459 1490 N/A INTRINSIC
low complexity region 1501 1550 N/A INTRINSIC
low complexity region 1592 1621 N/A INTRINSIC
low complexity region 1646 1671 N/A INTRINSIC
low complexity region 1709 1730 N/A INTRINSIC
low complexity region 1757 1821 N/A INTRINSIC
low complexity region 1837 1862 N/A INTRINSIC
low complexity region 1923 1937 N/A INTRINSIC
low complexity region 1951 1977 N/A INTRINSIC
low complexity region 2007 2041 N/A INTRINSIC
low complexity region 2047 2061 N/A INTRINSIC
low complexity region 2068 2096 N/A INTRINSIC
low complexity region 2105 2154 N/A INTRINSIC
low complexity region 2171 2186 N/A INTRINSIC
low complexity region 2274 2290 N/A INTRINSIC
low complexity region 2313 2331 N/A INTRINSIC
low complexity region 2382 2395 N/A INTRINSIC
low complexity region 2433 2463 N/A INTRINSIC
low complexity region 2516 2537 N/A INTRINSIC
low complexity region 2541 2556 N/A INTRINSIC
low complexity region 2558 2599 N/A INTRINSIC
PLEC 2638 2675 2.99e1 SMART
PLEC 2676 2713 4.49e-7 SMART
PLEC 2714 2751 4.49e-7 SMART
PLEC 2752 2789 3.54e-5 SMART
PLEC 2790 2827 3.27e-9 SMART
PLEC 2831 2865 6.31e-2 SMART
low complexity region 2936 2954 N/A INTRINSIC
PLEC 2966 3003 3.84e0 SMART
PLEC 3004 3041 1.59e-7 SMART
PLEC 3042 3079 3.54e-5 SMART
PLEC 3080 3117 8.64e-9 SMART
PLEC 3118 3155 1.53e-9 SMART
PLEC 3158 3193 2.18e2 SMART
low complexity region 3265 3284 N/A INTRINSIC
PLEC 3335 3372 3.22e-8 SMART
PLEC 3373 3410 7.82e-7 SMART
PLEC 3411 3448 1.9e-5 SMART
PLEC 3449 3486 7.01e-9 SMART
PLEC 3490 3524 3.38e-2 SMART
low complexity region 3536 3557 N/A INTRINSIC
low complexity region 3563 3573 N/A INTRINSIC
low complexity region 3606 3619 N/A INTRINSIC
PLEC 3670 3707 1.22e-8 SMART
PLEC 3708 3745 1.26e-10 SMART
PLEC 3746 3783 2.24e-7 SMART
PLEC 3784 3821 1.82e-7 SMART
PLEC 3825 3858 5.49e1 SMART
PLEC 3862 3895 3.2e2 SMART
PLEC 3913 3950 8.77e-10 SMART
PLEC 3951 3988 4.13e-6 SMART
PLEC 3989 4026 3.03e-4 SMART
PLEC 4027 4064 4.77e-11 SMART
PLEC 4068 4102 1.28e-2 SMART
PLEC 4115 4155 1.05e-7 SMART
low complexity region 4157 4167 N/A INTRINSIC
PLEC 4169 4206 1.73e1 SMART
low complexity region 4232 4247 N/A INTRINSIC
PLEC 4258 4295 3.65e-7 SMART
PLEC 4296 4333 9.99e-14 SMART
PLEC 4334 4371 4.71e-1 SMART
PLEC 4372 4409 2.44e-8 SMART
PLEC 4410 4447 2.87e-5 SMART
low complexity region 4457 4492 N/A INTRINSIC
low complexity region 4495 4521 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000076442
SMART Domains Protein: ENSMUSP00000075772
Gene: ENSMUSG00000022565

DomainStartEndE-ValueType
Pfam:S10_plectin 7 104 2.3e-37 PFAM
CH 187 286 4.57e-28 SMART
CH 303 401 3.52e-20 SMART
internal_repeat_2 436 518 2.42e-5 PROSPERO
internal_repeat_2 512 594 2.42e-5 PROSPERO
SPEC 659 756 3.08e-5 SMART
SPEC 759 859 1.29e-7 SMART
SPEC 865 1027 3.01e0 SMART
low complexity region 1106 1120 N/A INTRINSIC
SPEC 1123 1229 3.48e0 SMART
SPEC 1232 1343 7.63e-1 SMART
SPEC 1350 1510 2.59e-1 SMART
low complexity region 1514 1554 N/A INTRINSIC
low complexity region 1581 1598 N/A INTRINSIC
low complexity region 1611 1642 N/A INTRINSIC
low complexity region 1653 1702 N/A INTRINSIC
low complexity region 1744 1773 N/A INTRINSIC
low complexity region 1798 1823 N/A INTRINSIC
low complexity region 1861 1882 N/A INTRINSIC
low complexity region 1909 1973 N/A INTRINSIC
low complexity region 1989 2014 N/A INTRINSIC
low complexity region 2075 2089 N/A INTRINSIC
low complexity region 2103 2129 N/A INTRINSIC
low complexity region 2159 2193 N/A INTRINSIC
low complexity region 2199 2213 N/A INTRINSIC
low complexity region 2220 2248 N/A INTRINSIC
low complexity region 2257 2306 N/A INTRINSIC
low complexity region 2323 2338 N/A INTRINSIC
low complexity region 2426 2442 N/A INTRINSIC
low complexity region 2465 2483 N/A INTRINSIC
low complexity region 2534 2547 N/A INTRINSIC
low complexity region 2585 2615 N/A INTRINSIC
low complexity region 2668 2689 N/A INTRINSIC
low complexity region 2693 2708 N/A INTRINSIC
low complexity region 2710 2751 N/A INTRINSIC
PLEC 2790 2827 2.99e1 SMART
PLEC 2828 2865 4.49e-7 SMART
PLEC 2866 2903 4.49e-7 SMART
PLEC 2904 2941 3.54e-5 SMART
PLEC 2942 2979 3.27e-9 SMART
PLEC 2983 3017 6.31e-2 SMART
low complexity region 3088 3106 N/A INTRINSIC
PLEC 3118 3155 3.84e0 SMART
PLEC 3156 3193 1.59e-7 SMART
PLEC 3194 3231 3.54e-5 SMART
PLEC 3232 3269 8.64e-9 SMART
PLEC 3270 3307 1.53e-9 SMART
PLEC 3310 3345 2.18e2 SMART
low complexity region 3417 3436 N/A INTRINSIC
PLEC 3487 3524 3.22e-8 SMART
PLEC 3525 3562 7.82e-7 SMART
PLEC 3563 3600 1.9e-5 SMART
PLEC 3601 3638 7.01e-9 SMART
PLEC 3642 3676 3.38e-2 SMART
low complexity region 3688 3709 N/A INTRINSIC
low complexity region 3715 3725 N/A INTRINSIC
low complexity region 3758 3771 N/A INTRINSIC
PLEC 3822 3859 1.22e-8 SMART
PLEC 3860 3897 1.26e-10 SMART
PLEC 3898 3935 2.24e-7 SMART
PLEC 3936 3973 1.82e-7 SMART
PLEC 3977 4010 5.49e1 SMART
PLEC 4014 4047 3.2e2 SMART
PLEC 4065 4102 8.77e-10 SMART
PLEC 4103 4140 4.13e-6 SMART
PLEC 4141 4178 3.03e-4 SMART
PLEC 4179 4216 4.77e-11 SMART
PLEC 4220 4254 1.28e-2 SMART
PLEC 4267 4307 1.05e-7 SMART
low complexity region 4309 4319 N/A INTRINSIC
PLEC 4321 4358 1.73e1 SMART
low complexity region 4384 4399 N/A INTRINSIC
PLEC 4410 4447 3.65e-7 SMART
PLEC 4448 4485 9.99e-14 SMART
PLEC 4486 4523 4.71e-1 SMART
PLEC 4524 4561 2.44e-8 SMART
PLEC 4562 4599 2.87e-5 SMART
low complexity region 4609 4644 N/A INTRINSIC
low complexity region 4647 4673 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000080857
SMART Domains Protein: ENSMUSP00000079668
Gene: ENSMUSG00000022565

DomainStartEndE-ValueType
CH 3 101 3.52e-20 SMART
internal_repeat_2 136 218 8.51e-6 PROSPERO
internal_repeat_2 212 294 8.51e-6 PROSPERO
SPEC 359 456 3.08e-5 SMART
SPEC 459 559 1.29e-7 SMART
SPEC 565 727 3.01e0 SMART
low complexity region 806 820 N/A INTRINSIC
SPEC 823 929 3.48e0 SMART
SPEC 932 1043 7.63e-1 SMART
SPEC 1050 1210 2.59e-1 SMART
low complexity region 1214 1254 N/A INTRINSIC
low complexity region 1281 1298 N/A INTRINSIC
low complexity region 1311 1342 N/A INTRINSIC
low complexity region 1353 1402 N/A INTRINSIC
low complexity region 1444 1473 N/A INTRINSIC
low complexity region 1498 1523 N/A INTRINSIC
low complexity region 1561 1582 N/A INTRINSIC
low complexity region 1609 1673 N/A INTRINSIC
low complexity region 1689 1714 N/A INTRINSIC
low complexity region 1775 1789 N/A INTRINSIC
low complexity region 1803 1829 N/A INTRINSIC
low complexity region 1859 1893 N/A INTRINSIC
low complexity region 1899 1913 N/A INTRINSIC
low complexity region 1920 1948 N/A INTRINSIC
low complexity region 1957 2006 N/A INTRINSIC
low complexity region 2023 2038 N/A INTRINSIC
low complexity region 2126 2142 N/A INTRINSIC
low complexity region 2165 2183 N/A INTRINSIC
low complexity region 2234 2247 N/A INTRINSIC
low complexity region 2285 2315 N/A INTRINSIC
low complexity region 2368 2389 N/A INTRINSIC
low complexity region 2393 2408 N/A INTRINSIC
low complexity region 2410 2451 N/A INTRINSIC
PLEC 2490 2527 2.99e1 SMART
PLEC 2528 2565 4.49e-7 SMART
PLEC 2566 2603 4.49e-7 SMART
PLEC 2604 2641 3.54e-5 SMART
PLEC 2642 2679 3.27e-9 SMART
PLEC 2683 2717 6.31e-2 SMART
low complexity region 2788 2806 N/A INTRINSIC
PLEC 2818 2855 3.84e0 SMART
PLEC 2856 2893 1.59e-7 SMART
PLEC 2894 2931 3.54e-5 SMART
PLEC 2932 2969 8.64e-9 SMART
PLEC 2970 3007 1.53e-9 SMART
PLEC 3010 3045 2.18e2 SMART
low complexity region 3117 3136 N/A INTRINSIC
PLEC 3187 3224 3.22e-8 SMART
PLEC 3225 3262 7.82e-7 SMART
PLEC 3263 3300 1.9e-5 SMART
PLEC 3301 3338 7.01e-9 SMART
PLEC 3342 3376 3.38e-2 SMART
low complexity region 3388 3409 N/A INTRINSIC
low complexity region 3415 3425 N/A INTRINSIC
low complexity region 3458 3471 N/A INTRINSIC
PLEC 3522 3559 1.22e-8 SMART
PLEC 3560 3597 1.26e-10 SMART
PLEC 3598 3635 2.24e-7 SMART
PLEC 3636 3673 1.82e-7 SMART
PLEC 3677 3710 5.49e1 SMART
PLEC 3714 3747 3.2e2 SMART
PLEC 3765 3802 8.77e-10 SMART
PLEC 3803 3840 4.13e-6 SMART
PLEC 3841 3878 3.03e-4 SMART
PLEC 3879 3916 4.77e-11 SMART
PLEC 3920 3954 1.28e-2 SMART
PLEC 3967 4007 1.05e-7 SMART
low complexity region 4009 4019 N/A INTRINSIC
PLEC 4021 4058 1.73e1 SMART
low complexity region 4084 4099 N/A INTRINSIC
PLEC 4110 4147 3.65e-7 SMART
PLEC 4148 4185 9.99e-14 SMART
PLEC 4186 4223 4.71e-1 SMART
PLEC 4224 4261 2.44e-8 SMART
PLEC 4262 4299 2.87e-5 SMART
low complexity region 4309 4344 N/A INTRINSIC
low complexity region 4347 4373 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000169108
SMART Domains Protein: ENSMUSP00000126068
Gene: ENSMUSG00000022565

DomainStartEndE-ValueType
CH 12 111 4.57e-28 SMART
CH 128 226 3.52e-20 SMART
internal_repeat_2 261 343 1.31e-5 PROSPERO
internal_repeat_2 337 419 1.31e-5 PROSPERO
SPEC 484 581 3.08e-5 SMART
SPEC 584 684 1.29e-7 SMART
SPEC 690 852 3.01e0 SMART
low complexity region 931 945 N/A INTRINSIC
SPEC 948 1054 3.48e0 SMART
SPEC 1057 1168 7.63e-1 SMART
SPEC 1175 1335 2.59e-1 SMART
low complexity region 1339 1379 N/A INTRINSIC
low complexity region 1406 1423 N/A INTRINSIC
low complexity region 1436 1467 N/A INTRINSIC
low complexity region 1478 1527 N/A INTRINSIC
low complexity region 1569 1598 N/A INTRINSIC
low complexity region 1623 1648 N/A INTRINSIC
low complexity region 1686 1707 N/A INTRINSIC
low complexity region 1734 1798 N/A INTRINSIC
low complexity region 1814 1839 N/A INTRINSIC
low complexity region 1900 1914 N/A INTRINSIC
low complexity region 1928 1954 N/A INTRINSIC
low complexity region 1984 2018 N/A INTRINSIC
low complexity region 2024 2038 N/A INTRINSIC
low complexity region 2045 2073 N/A INTRINSIC
low complexity region 2082 2131 N/A INTRINSIC
low complexity region 2148 2163 N/A INTRINSIC
low complexity region 2251 2267 N/A INTRINSIC
low complexity region 2290 2308 N/A INTRINSIC
low complexity region 2359 2372 N/A INTRINSIC
low complexity region 2410 2440 N/A INTRINSIC
low complexity region 2493 2514 N/A INTRINSIC
low complexity region 2518 2533 N/A INTRINSIC
low complexity region 2535 2576 N/A INTRINSIC
PLEC 2615 2652 2.99e1 SMART
PLEC 2653 2690 4.49e-7 SMART
PLEC 2691 2728 4.49e-7 SMART
PLEC 2729 2766 3.54e-5 SMART
PLEC 2767 2804 3.27e-9 SMART
PLEC 2808 2842 6.31e-2 SMART
low complexity region 2913 2931 N/A INTRINSIC
PLEC 2943 2980 3.84e0 SMART
PLEC 2981 3018 1.59e-7 SMART
PLEC 3019 3056 3.54e-5 SMART
PLEC 3057 3094 8.64e-9 SMART
PLEC 3095 3132 1.53e-9 SMART
PLEC 3135 3170 2.18e2 SMART
low complexity region 3242 3261 N/A INTRINSIC
PLEC 3312 3349 3.22e-8 SMART
PLEC 3350 3387 7.82e-7 SMART
PLEC 3388 3425 1.9e-5 SMART
PLEC 3426 3463 7.01e-9 SMART
PLEC 3467 3501 3.38e-2 SMART
low complexity region 3513 3534 N/A INTRINSIC
low complexity region 3540 3550 N/A INTRINSIC
low complexity region 3583 3596 N/A INTRINSIC
PLEC 3647 3684 1.22e-8 SMART
PLEC 3685 3722 1.26e-10 SMART
PLEC 3723 3760 2.24e-7 SMART
PLEC 3761 3798 1.82e-7 SMART
PLEC 3802 3835 5.49e1 SMART
PLEC 3839 3872 3.2e2 SMART
PLEC 3890 3927 8.77e-10 SMART
PLEC 3928 3965 4.13e-6 SMART
PLEC 3966 4003 3.03e-4 SMART
PLEC 4004 4041 4.77e-11 SMART
PLEC 4045 4079 1.28e-2 SMART
PLEC 4092 4132 1.05e-7 SMART
low complexity region 4134 4144 N/A INTRINSIC
PLEC 4146 4183 1.73e1 SMART
low complexity region 4209 4224 N/A INTRINSIC
PLEC 4235 4272 3.65e-7 SMART
PLEC 4273 4310 9.99e-14 SMART
PLEC 4311 4348 4.71e-1 SMART
PLEC 4349 4386 2.44e-8 SMART
PLEC 4387 4424 2.87e-5 SMART
low complexity region 4434 4469 N/A INTRINSIC
low complexity region 4472 4498 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000169714
SMART Domains Protein: ENSMUSP00000126526
Gene: ENSMUSG00000022565

DomainStartEndE-ValueType
low complexity region 11 23 N/A INTRINSIC
CH 44 143 4.57e-28 SMART
CH 160 258 3.52e-20 SMART
internal_repeat_2 293 375 1.36e-5 PROSPERO
internal_repeat_2 369 451 1.36e-5 PROSPERO
SPEC 516 613 3.08e-5 SMART
SPEC 616 716 1.29e-7 SMART
SPEC 722 884 3.01e0 SMART
low complexity region 963 977 N/A INTRINSIC
SPEC 980 1086 3.48e0 SMART
SPEC 1089 1200 7.63e-1 SMART
SPEC 1207 1367 2.59e-1 SMART
low complexity region 1371 1411 N/A INTRINSIC
low complexity region 1438 1455 N/A INTRINSIC
low complexity region 1468 1499 N/A INTRINSIC
low complexity region 1510 1559 N/A INTRINSIC
low complexity region 1601 1630 N/A INTRINSIC
low complexity region 1655 1680 N/A INTRINSIC
low complexity region 1718 1739 N/A INTRINSIC
low complexity region 1766 1830 N/A INTRINSIC
low complexity region 1846 1871 N/A INTRINSIC
low complexity region 1932 1946 N/A INTRINSIC
low complexity region 1960 1986 N/A INTRINSIC
low complexity region 2016 2050 N/A INTRINSIC
low complexity region 2056 2070 N/A INTRINSIC
low complexity region 2077 2105 N/A INTRINSIC
low complexity region 2114 2163 N/A INTRINSIC
low complexity region 2180 2195 N/A INTRINSIC
low complexity region 2283 2299 N/A INTRINSIC
low complexity region 2322 2340 N/A INTRINSIC
low complexity region 2391 2404 N/A INTRINSIC
low complexity region 2442 2472 N/A INTRINSIC
low complexity region 2525 2546 N/A INTRINSIC
low complexity region 2550 2565 N/A INTRINSIC
low complexity region 2567 2608 N/A INTRINSIC
PLEC 2647 2684 2.99e1 SMART
PLEC 2685 2722 4.49e-7 SMART
PLEC 2723 2760 4.49e-7 SMART
PLEC 2761 2798 3.54e-5 SMART
PLEC 2799 2836 3.27e-9 SMART
PLEC 2840 2874 6.31e-2 SMART
low complexity region 2945 2963 N/A INTRINSIC
PLEC 2975 3012 3.84e0 SMART
PLEC 3013 3050 1.59e-7 SMART
PLEC 3051 3088 3.54e-5 SMART
PLEC 3089 3126 8.64e-9 SMART
PLEC 3127 3164 1.53e-9 SMART
PLEC 3167 3202 2.18e2 SMART
low complexity region 3274 3293 N/A INTRINSIC
PLEC 3344 3381 3.22e-8 SMART
PLEC 3382 3419 7.82e-7 SMART
PLEC 3420 3457 1.9e-5 SMART
PLEC 3458 3495 7.01e-9 SMART
PLEC 3499 3533 3.38e-2 SMART
low complexity region 3545 3566 N/A INTRINSIC
low complexity region 3572 3582 N/A INTRINSIC
low complexity region 3615 3628 N/A INTRINSIC
PLEC 3679 3716 1.22e-8 SMART
PLEC 3717 3754 1.26e-10 SMART
PLEC 3755 3792 2.24e-7 SMART
PLEC 3793 3830 1.82e-7 SMART
PLEC 3834 3867 5.49e1 SMART
PLEC 3871 3904 3.2e2 SMART
PLEC 3922 3959 8.77e-10 SMART
PLEC 3960 3997 4.13e-6 SMART
PLEC 3998 4035 3.03e-4 SMART
PLEC 4036 4073 4.77e-11 SMART
PLEC 4077 4111 1.28e-2 SMART
PLEC 4124 4164 1.05e-7 SMART
low complexity region 4166 4176 N/A INTRINSIC
PLEC 4178 4215 1.73e1 SMART
low complexity region 4241 4256 N/A INTRINSIC
PLEC 4267 4304 3.65e-7 SMART
PLEC 4305 4342 9.99e-14 SMART
PLEC 4343 4380 4.71e-1 SMART
PLEC 4381 4418 2.44e-8 SMART
PLEC 4419 4456 2.87e-5 SMART
low complexity region 4466 4501 N/A INTRINSIC
low complexity region 4504 4530 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000169438
SMART Domains Protein: ENSMUSP00000127261
Gene: ENSMUSG00000022565

DomainStartEndE-ValueType
CH 3 101 3.52e-20 SMART
internal_repeat_2 136 218 8.51e-6 PROSPERO
internal_repeat_2 212 294 8.51e-6 PROSPERO
SPEC 359 456 3.08e-5 SMART
SPEC 459 559 1.29e-7 SMART
SPEC 565 727 3.01e0 SMART
low complexity region 806 820 N/A INTRINSIC
SPEC 823 929 3.48e0 SMART
SPEC 932 1043 7.63e-1 SMART
SPEC 1050 1210 2.59e-1 SMART
low complexity region 1214 1254 N/A INTRINSIC
low complexity region 1281 1298 N/A INTRINSIC
low complexity region 1311 1342 N/A INTRINSIC
low complexity region 1353 1402 N/A INTRINSIC
low complexity region 1444 1473 N/A INTRINSIC
low complexity region 1498 1523 N/A INTRINSIC
low complexity region 1561 1582 N/A INTRINSIC
low complexity region 1609 1673 N/A INTRINSIC
low complexity region 1689 1714 N/A INTRINSIC
low complexity region 1775 1789 N/A INTRINSIC
low complexity region 1803 1829 N/A INTRINSIC
low complexity region 1859 1893 N/A INTRINSIC
low complexity region 1899 1913 N/A INTRINSIC
low complexity region 1920 1948 N/A INTRINSIC
low complexity region 1957 2006 N/A INTRINSIC
low complexity region 2023 2038 N/A INTRINSIC
low complexity region 2126 2142 N/A INTRINSIC
low complexity region 2165 2183 N/A INTRINSIC
low complexity region 2234 2247 N/A INTRINSIC
low complexity region 2285 2315 N/A INTRINSIC
low complexity region 2368 2389 N/A INTRINSIC
low complexity region 2393 2408 N/A INTRINSIC
low complexity region 2410 2451 N/A INTRINSIC
PLEC 2490 2527 2.99e1 SMART
PLEC 2528 2565 4.49e-7 SMART
PLEC 2566 2603 4.49e-7 SMART
PLEC 2604 2641 3.54e-5 SMART
PLEC 2642 2679 3.27e-9 SMART
PLEC 2683 2717 6.31e-2 SMART
low complexity region 2788 2806 N/A INTRINSIC
PLEC 2818 2855 3.84e0 SMART
PLEC 2856 2893 1.59e-7 SMART
PLEC 2894 2931 3.54e-5 SMART
PLEC 2932 2969 8.64e-9 SMART
PLEC 2970 3007 1.53e-9 SMART
PLEC 3010 3045 2.18e2 SMART
low complexity region 3117 3136 N/A INTRINSIC
PLEC 3187 3224 3.22e-8 SMART
PLEC 3225 3262 7.82e-7 SMART
PLEC 3263 3300 1.9e-5 SMART
PLEC 3301 3338 7.01e-9 SMART
PLEC 3342 3376 3.38e-2 SMART
low complexity region 3388 3409 N/A INTRINSIC
low complexity region 3415 3425 N/A INTRINSIC
low complexity region 3458 3471 N/A INTRINSIC
PLEC 3522 3559 1.22e-8 SMART
PLEC 3560 3597 1.26e-10 SMART
PLEC 3598 3635 2.24e-7 SMART
PLEC 3636 3673 1.82e-7 SMART
PLEC 3677 3710 5.49e1 SMART
PLEC 3714 3747 3.2e2 SMART
PLEC 3765 3802 8.77e-10 SMART
PLEC 3803 3840 4.13e-6 SMART
PLEC 3841 3878 3.03e-4 SMART
PLEC 3879 3916 4.77e-11 SMART
PLEC 3920 3954 1.28e-2 SMART
PLEC 3967 4007 1.05e-7 SMART
low complexity region 4009 4019 N/A INTRINSIC
PLEC 4021 4058 1.73e1 SMART
low complexity region 4084 4099 N/A INTRINSIC
PLEC 4110 4147 3.65e-7 SMART
PLEC 4148 4185 9.99e-14 SMART
PLEC 4186 4223 4.71e-1 SMART
PLEC 4224 4261 2.44e-8 SMART
PLEC 4262 4299 2.87e-5 SMART
low complexity region 4309 4344 N/A INTRINSIC
low complexity region 4347 4373 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000171562
SMART Domains Protein: ENSMUSP00000129543
Gene: ENSMUSG00000022565

DomainStartEndE-ValueType
CH 3 101 3.52e-20 SMART
internal_repeat_2 136 218 8.51e-6 PROSPERO
internal_repeat_2 212 294 8.51e-6 PROSPERO
SPEC 359 456 3.08e-5 SMART
SPEC 459 559 1.29e-7 SMART
SPEC 565 727 3.01e0 SMART
low complexity region 806 820 N/A INTRINSIC
SPEC 823 929 3.48e0 SMART
SPEC 932 1043 7.63e-1 SMART
SPEC 1050 1210 2.59e-1 SMART
low complexity region 1214 1254 N/A INTRINSIC
low complexity region 1281 1298 N/A INTRINSIC
low complexity region 1311 1342 N/A INTRINSIC
low complexity region 1353 1402 N/A INTRINSIC
low complexity region 1444 1473 N/A INTRINSIC
low complexity region 1498 1523 N/A INTRINSIC
low complexity region 1561 1582 N/A INTRINSIC
low complexity region 1609 1673 N/A INTRINSIC
low complexity region 1689 1714 N/A INTRINSIC
low complexity region 1775 1789 N/A INTRINSIC
low complexity region 1803 1829 N/A INTRINSIC
low complexity region 1859 1893 N/A INTRINSIC
low complexity region 1899 1913 N/A INTRINSIC
low complexity region 1920 1948 N/A INTRINSIC
low complexity region 1957 2006 N/A INTRINSIC
low complexity region 2023 2038 N/A INTRINSIC
low complexity region 2126 2142 N/A INTRINSIC
low complexity region 2165 2183 N/A INTRINSIC
low complexity region 2234 2247 N/A INTRINSIC
low complexity region 2285 2315 N/A INTRINSIC
low complexity region 2368 2389 N/A INTRINSIC
low complexity region 2393 2408 N/A INTRINSIC
low complexity region 2410 2451 N/A INTRINSIC
PLEC 2490 2527 2.99e1 SMART
PLEC 2528 2565 4.49e-7 SMART
PLEC 2566 2603 4.49e-7 SMART
PLEC 2604 2641 3.54e-5 SMART
PLEC 2642 2679 3.27e-9 SMART
PLEC 2683 2717 6.31e-2 SMART
low complexity region 2788 2806 N/A INTRINSIC
PLEC 2818 2855 3.84e0 SMART
PLEC 2856 2893 1.59e-7 SMART
PLEC 2894 2931 3.54e-5 SMART
PLEC 2932 2969 8.64e-9 SMART
PLEC 2970 3007 1.53e-9 SMART
PLEC 3010 3045 2.18e2 SMART
low complexity region 3117 3136 N/A INTRINSIC
PLEC 3187 3224 3.22e-8 SMART
PLEC 3225 3262 7.82e-7 SMART
PLEC 3263 3300 1.9e-5 SMART
PLEC 3301 3338 7.01e-9 SMART
PLEC 3342 3376 3.38e-2 SMART
low complexity region 3388 3409 N/A INTRINSIC
low complexity region 3415 3425 N/A INTRINSIC
low complexity region 3458 3471 N/A INTRINSIC
PLEC 3522 3559 1.22e-8 SMART
PLEC 3560 3597 1.26e-10 SMART
PLEC 3598 3635 2.24e-7 SMART
PLEC 3636 3673 1.82e-7 SMART
PLEC 3677 3710 5.49e1 SMART
PLEC 3714 3747 3.2e2 SMART
PLEC 3765 3802 8.77e-10 SMART
PLEC 3803 3840 4.13e-6 SMART
PLEC 3841 3878 3.03e-4 SMART
PLEC 3879 3916 4.77e-11 SMART
PLEC 3920 3954 1.28e-2 SMART
PLEC 3967 4007 1.05e-7 SMART
low complexity region 4009 4019 N/A INTRINSIC
PLEC 4021 4058 1.73e1 SMART
low complexity region 4084 4099 N/A INTRINSIC
PLEC 4110 4147 3.65e-7 SMART
PLEC 4148 4185 9.99e-14 SMART
PLEC 4186 4223 4.71e-1 SMART
PLEC 4224 4261 2.44e-8 SMART
PLEC 4262 4299 2.87e-5 SMART
low complexity region 4309 4344 N/A INTRINSIC
low complexity region 4347 4373 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000089610
SMART Domains Protein: ENSMUSP00000087037
Gene: ENSMUSG00000022565

DomainStartEndE-ValueType
low complexity region 16 28 N/A INTRINSIC
low complexity region 40 54 N/A INTRINSIC
CH 73 189 1.46e-26 SMART
CH 206 304 3.52e-20 SMART
internal_repeat_2 339 421 1.38e-5 PROSPERO
internal_repeat_2 415 497 1.38e-5 PROSPERO
SPEC 562 659 3.08e-5 SMART
SPEC 662 762 1.29e-7 SMART
SPEC 768 930 3.01e0 SMART
low complexity region 1009 1023 N/A INTRINSIC
SPEC 1026 1132 3.48e0 SMART
SPEC 1135 1246 7.63e-1 SMART
SPEC 1253 1413 2.59e-1 SMART
low complexity region 1417 1457 N/A INTRINSIC
low complexity region 1484 1501 N/A INTRINSIC
low complexity region 1514 1545 N/A INTRINSIC
low complexity region 1556 1605 N/A INTRINSIC
low complexity region 1647 1676 N/A INTRINSIC
low complexity region 1701 1726 N/A INTRINSIC
low complexity region 1764 1785 N/A INTRINSIC
low complexity region 1812 1876 N/A INTRINSIC
low complexity region 1892 1917 N/A INTRINSIC
low complexity region 1978 1992 N/A INTRINSIC
low complexity region 2006 2032 N/A INTRINSIC
low complexity region 2062 2096 N/A INTRINSIC
low complexity region 2102 2116 N/A INTRINSIC
low complexity region 2123 2151 N/A INTRINSIC
low complexity region 2160 2209 N/A INTRINSIC
low complexity region 2226 2241 N/A INTRINSIC
low complexity region 2329 2345 N/A INTRINSIC
low complexity region 2368 2386 N/A INTRINSIC
low complexity region 2437 2450 N/A INTRINSIC
low complexity region 2488 2518 N/A INTRINSIC
low complexity region 2571 2592 N/A INTRINSIC
low complexity region 2596 2611 N/A INTRINSIC
low complexity region 2613 2654 N/A INTRINSIC
PLEC 2693 2730 2.99e1 SMART
PLEC 2731 2768 4.49e-7 SMART
PLEC 2769 2806 4.49e-7 SMART
PLEC 2807 2844 3.54e-5 SMART
PLEC 2845 2882 3.27e-9 SMART
PLEC 2886 2920 6.31e-2 SMART
low complexity region 2991 3009 N/A INTRINSIC
PLEC 3021 3058 3.84e0 SMART
PLEC 3059 3096 1.59e-7 SMART
PLEC 3097 3134 3.54e-5 SMART
PLEC 3135 3172 8.64e-9 SMART
PLEC 3173 3210 1.53e-9 SMART
PLEC 3213 3248 2.18e2 SMART
low complexity region 3320 3339 N/A INTRINSIC
PLEC 3390 3427 3.22e-8 SMART
PLEC 3428 3465 7.82e-7 SMART
PLEC 3466 3503 1.9e-5 SMART
PLEC 3504 3541 7.01e-9 SMART
PLEC 3545 3579 3.38e-2 SMART
low complexity region 3591 3612 N/A INTRINSIC
low complexity region 3618 3628 N/A INTRINSIC
low complexity region 3661 3674 N/A INTRINSIC
PLEC 3725 3762 1.22e-8 SMART
PLEC 3763 3800 1.26e-10 SMART
PLEC 3801 3838 2.24e-7 SMART
PLEC 3839 3876 1.82e-7 SMART
PLEC 3880 3913 5.49e1 SMART
PLEC 3917 3950 3.2e2 SMART
PLEC 3968 4005 8.77e-10 SMART
PLEC 4006 4043 4.13e-6 SMART
PLEC 4044 4081 3.03e-4 SMART
PLEC 4082 4119 4.77e-11 SMART
PLEC 4123 4157 1.28e-2 SMART
PLEC 4170 4210 1.05e-7 SMART
low complexity region 4212 4222 N/A INTRINSIC
PLEC 4224 4261 1.73e1 SMART
low complexity region 4287 4302 N/A INTRINSIC
PLEC 4313 4350 3.65e-7 SMART
PLEC 4351 4388 9.99e-14 SMART
PLEC 4389 4426 4.71e-1 SMART
PLEC 4427 4464 2.44e-8 SMART
PLEC 4465 4502 2.87e-5 SMART
low complexity region 4512 4547 N/A INTRINSIC
low complexity region 4550 4576 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000165210
SMART Domains Protein: ENSMUSP00000130048
Gene: ENSMUSG00000022565

DomainStartEndE-ValueType
SPEC 21 183 3.01e0 SMART
low complexity region 262 276 N/A INTRINSIC
SPEC 279 385 1.83e0 SMART
SPEC 388 499 7.63e-1 SMART
SPEC 506 634 8.96e-2 SMART
low complexity region 640 652 N/A INTRINSIC
coiled coil region 670 784 N/A INTRINSIC
PLEC 819 856 2.99e1 SMART
PLEC 857 894 4.49e-7 SMART
PLEC 895 932 4.49e-7 SMART
PLEC 933 970 3.54e-5 SMART
PLEC 971 1008 3.27e-9 SMART
PLEC 1012 1046 6.31e-2 SMART
low complexity region 1117 1135 N/A INTRINSIC
PLEC 1147 1184 3.84e0 SMART
PLEC 1185 1222 1.59e-7 SMART
PLEC 1223 1260 3.54e-5 SMART
PLEC 1261 1298 8.64e-9 SMART
PLEC 1299 1336 1.53e-9 SMART
PLEC 1339 1374 2.18e2 SMART
low complexity region 1446 1465 N/A INTRINSIC
PLEC 1516 1553 3.22e-8 SMART
PLEC 1554 1591 7.82e-7 SMART
PLEC 1592 1629 1.9e-5 SMART
Pfam:Plectin 1631 1646 3.1e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000171634
SMART Domains Protein: ENSMUSP00000126936
Gene: ENSMUSG00000022565

DomainStartEndE-ValueType
Pfam:S10_plectin 7 104 9.5e-38 PFAM
CH 187 291 9.8e-28 SMART
CH 308 406 3.52e-20 SMART
PDB:2ODU|A 420 651 1e-150 PDB
Blast:SPEC 430 533 2e-61 BLAST
SPEC 664 761 3.08e-5 SMART
SPEC 764 864 1.29e-7 SMART
coiled coil region 899 934 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.3%
  • 20x: 94.6%
Validation Efficiency 100% (97/97)
MGI Phenotype FUNCTION: Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, 17499243). Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010, this locus was named plectin 1 (symbol PLEC1 in human; Plec1 in mouse and rat) and the gene product had been referred to as "hemidesmosomal protein 1" or "plectin 1, intermediate filament binding 500kDa". These names were superseded by plectin. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail (PMID: 10556294, 14559777), revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms. Eleven exons (1-1j) have been identified that alternatively splice directly into a common exon 2 which is the first exon to encode plectin's highly conserved actin binding domain (ABD). Three additional exons (-1, 0a, and 0) splice into an alternative first coding exon (1c), and two additional exons (2alpha and 3alpha) are optionally spliced within the exons encoding the acting binding domain (exons 2-8). Analysis of the human locus has identified eight of the eleven alternative 5' exons found in mouse and rat (PMID: 14672974); exons 1i, 1j and 1h have not been confirmed in human. Furthermore, isoforms lacking the central rod domain encoded by exon 31 have been detected in mouse (PMID:10556294), rat (PMID: 9177781), and human (PMID: 11441066, 10780662, 20052759). It has been shown that the short alternative amino-terminal sequences encoded by the different first exons direct the targeting of the various isoforms to distinct subcellular locations (PMID: 14559777). As the expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development (PMID: 10556294, 12542521, 17389230) it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms, as if custom-made for specific requirements of the particular cells. Concordantly, individual isoforms were found to carry out distinct and specific functions (PMID: 14559777, 12542521, 18541706). In 1996, a number of groups reported that patients suffering from epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) lacked plectin expression in skin and muscle tissues due to defects in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687, 8696340). Two other subtypes of plectin-related EBS have been described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of plectin-related diseases see PMID: 15810881, 19945614. Mutations in the plectin gene related to human diseases should be named based on the position in NM_000445 (human variant 1, isoform 1c), unless the mutation is located within one of the other alternative first exons, in which case the position in the respective Reference Sequence should be used. [provided by RefSeq, Aug 2011]
PHENOTYPE: Targeted mutations of this gene result in neonatal death, skin blistering, impaired myofibril integrity, reduced hemidesmosome number, and disintegration of intercalated disks in the heart. Mice lacking isoform 1 are viable with no skin blistering but leukocyte recruitment to wounds is impaired. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 93 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700113H08Rik T C 10: 87,000,931 (GRCm39) L41P probably damaging Het
3110082I17Rik A G 5: 139,349,875 (GRCm39) V58A possibly damaging Het
4932415M13Rik A T 17: 54,031,374 (GRCm39) noncoding transcript Het
Aldh1a7 C T 19: 20,679,607 (GRCm39) V390M probably damaging Het
Alg14 A G 3: 121,092,259 (GRCm39) H34R probably damaging Het
Ankrd27 A G 7: 35,307,772 (GRCm39) N337S probably damaging Het
Apoa2 T A 1: 171,052,948 (GRCm39) probably benign Het
Arl2 T G 19: 6,186,052 (GRCm39) K126T probably damaging Het
Ascc3 T C 10: 50,721,762 (GRCm39) W2072R probably benign Het
Astl T C 2: 127,184,339 (GRCm39) F21L probably benign Het
Asxl3 A G 18: 22,649,097 (GRCm39) D362G probably damaging Het
Bdp1 A T 13: 100,172,333 (GRCm39) H2094Q probably benign Het
Cacna2d4 C T 6: 119,284,247 (GRCm39) R745W probably damaging Het
Ccdc85a T A 11: 28,533,296 (GRCm39) I83F probably damaging Het
Ccnt2 T A 1: 127,730,131 (GRCm39) M336K probably benign Het
Cd226 A C 18: 89,225,144 (GRCm39) probably benign Het
Ceacam23 C A 7: 17,638,906 (GRCm39) A301E possibly damaging Het
Ces1f A T 8: 93,996,652 (GRCm39) S214T probably damaging Het
Clip1 T C 5: 123,768,784 (GRCm39) D605G probably benign Het
Col26a1 A G 5: 136,794,154 (GRCm39) probably null Het
Crtc1 A G 8: 70,845,663 (GRCm39) V306A probably benign Het
D130043K22Rik G A 13: 25,047,563 (GRCm39) probably benign Het
D17H6S53E A T 17: 35,346,385 (GRCm39) probably null Het
Dnah11 G A 12: 118,160,397 (GRCm39) A111V probably benign Het
Dyrk2 T C 10: 118,697,027 (GRCm39) H77R probably benign Het
Epha3 A G 16: 63,423,882 (GRCm39) probably benign Het
Epn2 T C 11: 61,410,317 (GRCm39) N611S probably benign Het
Erich6 A C 3: 58,526,365 (GRCm39) probably benign Het
Fam217b T C 2: 178,062,782 (GRCm39) S249P probably benign Het
Fam219b A G 9: 57,445,299 (GRCm39) probably benign Het
Fryl A T 5: 73,246,424 (GRCm39) probably benign Het
Ftdc2 G A 16: 58,455,886 (GRCm39) S129L probably damaging Het
Gm14496 T C 2: 181,638,059 (GRCm39) W378R probably damaging Het
Gm57858 A G 3: 36,074,362 (GRCm39) probably benign Het
Gm8674 A T 13: 50,058,611 (GRCm39) noncoding transcript Het
Grap T A 11: 61,551,065 (GRCm39) D32E possibly damaging Het
Grk2 C A 19: 4,339,385 (GRCm39) L428F probably damaging Het
Grm8 T A 6: 27,363,178 (GRCm39) E779V probably damaging Het
Hipk1 A G 3: 103,661,612 (GRCm39) S670P probably damaging Het
Ilrun A T 17: 28,005,112 (GRCm39) S148R probably damaging Het
Itgae A T 11: 73,020,032 (GRCm39) M845L probably benign Het
Itih1 A T 14: 30,663,512 (GRCm39) V164E probably damaging Het
Itpka T A 2: 119,581,312 (GRCm39) N448K probably damaging Het
Jak3 A C 8: 72,136,622 (GRCm39) N643T probably damaging Het
Lrfn5 A C 12: 61,886,454 (GRCm39) T81P probably damaging Het
Lrrc45 T A 11: 120,609,019 (GRCm39) probably null Het
Marchf6 T C 15: 31,480,437 (GRCm39) Y562C probably benign Het
Mcrs1 T C 15: 99,141,330 (GRCm39) probably benign Het
Meis1 G A 11: 18,831,767 (GRCm39) H424Y possibly damaging Het
Mst1r A G 9: 107,791,975 (GRCm39) N837S probably benign Het
Mst1r G A 9: 107,790,366 (GRCm39) V660I probably benign Het
Mthfd2l T C 5: 91,094,801 (GRCm39) V90A probably damaging Het
Mtnr1a A T 8: 45,540,974 (GRCm39) I312F probably benign Het
Or10g3b T C 14: 52,586,835 (GRCm39) I223V probably benign Het
Or51g1 C A 7: 102,634,043 (GRCm39) L109F possibly damaging Het
Or8b12b T C 9: 37,684,372 (GRCm39) V139A probably benign Het
Otog C T 7: 45,918,786 (GRCm39) T954I possibly damaging Het
Pdcd6 A G 13: 74,464,443 (GRCm39) probably benign Het
Phlpp2 A G 8: 110,663,738 (GRCm39) T926A probably damaging Het
Plekha5 T A 6: 140,535,360 (GRCm39) probably benign Het
Ppp1r16a C T 15: 76,577,869 (GRCm39) Q328* probably null Het
Pramel18 G A 4: 101,767,294 (GRCm39) C181Y probably damaging Het
Pramel23 A T 4: 143,425,056 (GRCm39) M129K probably benign Het
Rab27b T C 18: 70,120,112 (GRCm39) probably benign Het
Rapsn T C 2: 90,867,153 (GRCm39) Y152H probably damaging Het
Rasd1 A T 11: 59,855,379 (GRCm39) F85I probably damaging Het
Rgs1 A T 1: 144,123,671 (GRCm39) S85T probably damaging Het
Samd9l T C 6: 3,372,725 (GRCm39) E1512G possibly damaging Het
Sgsm1 C T 5: 113,427,050 (GRCm39) A127T probably benign Het
Shc1 A G 3: 89,330,276 (GRCm39) D70G probably damaging Het
Slc26a1 T A 5: 108,821,389 (GRCm39) T167S probably benign Het
Slc26a7 A T 4: 14,593,873 (GRCm39) Y81N probably damaging Het
Slc2a12 T C 10: 22,577,915 (GRCm39) probably benign Het
Slc30a7 T A 3: 115,783,789 (GRCm39) probably null Het
Slc44a5 T C 3: 153,971,111 (GRCm39) S654P probably damaging Het
Stard9 T G 2: 120,527,480 (GRCm39) S1246A possibly damaging Het
Stxbp5 A T 10: 9,740,843 (GRCm39) S116R probably damaging Het
Syvn1 C T 19: 6,102,483 (GRCm39) P517L probably benign Het
Tas2r105 T C 6: 131,664,393 (GRCm39) I12V probably benign Het
Tas2r121 A G 6: 132,677,325 (GRCm39) S216P probably damaging Het
Tcof1 T C 18: 60,978,904 (GRCm39) D48G probably damaging Het
Tgm3 C T 2: 129,868,602 (GRCm39) probably benign Het
Tle2 T C 10: 81,424,781 (GRCm39) F667L probably damaging Het
Tnfaip3 C A 10: 18,878,697 (GRCm39) A704S probably benign Het
Trabd2b A G 4: 114,437,519 (GRCm39) Q232R probably benign Het
Ttc28 T A 5: 111,378,947 (GRCm39) I1144N probably damaging Het
Ucp3 T A 7: 100,128,748 (GRCm39) C25* probably null Het
Ugt3a1 A G 15: 9,370,236 (GRCm39) D460G probably damaging Het
Urb1 T C 16: 90,592,336 (GRCm39) D308G possibly damaging Het
Ush1g G T 11: 115,209,694 (GRCm39) R167S possibly damaging Het
Vav3 A G 3: 109,554,995 (GRCm39) N81S possibly damaging Het
Vmn2r108 A T 17: 20,691,721 (GRCm39) D267E probably benign Het
Zng1 A G 19: 24,918,203 (GRCm39) probably benign Het
Other mutations in Plec
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00791:Plec APN 15 76,057,137 (GRCm39) missense probably damaging 1.00
IGL01375:Plec APN 15 76,060,640 (GRCm39) missense probably damaging 1.00
IGL01432:Plec APN 15 76,074,728 (GRCm39) missense probably damaging 1.00
IGL01444:Plec APN 15 76,063,497 (GRCm39) missense possibly damaging 0.46
IGL01548:Plec APN 15 76,073,458 (GRCm39) missense probably benign 0.00
IGL01750:Plec APN 15 76,057,589 (GRCm39) missense probably damaging 1.00
IGL01828:Plec APN 15 76,067,955 (GRCm39) missense probably damaging 1.00
IGL01940:Plec APN 15 76,064,529 (GRCm39) missense probably damaging 1.00
IGL02049:Plec APN 15 76,063,149 (GRCm39) missense probably damaging 1.00
IGL02052:Plec APN 15 76,064,541 (GRCm39) missense probably damaging 1.00
IGL02114:Plec APN 15 76,057,748 (GRCm39) missense probably damaging 1.00
IGL02141:Plec APN 15 76,059,815 (GRCm39) missense probably damaging 1.00
IGL02162:Plec APN 15 76,064,360 (GRCm39) missense probably benign 0.01
IGL02227:Plec APN 15 76,056,474 (GRCm39) missense probably damaging 1.00
IGL02449:Plec APN 15 76,070,963 (GRCm39) missense possibly damaging 0.93
IGL02450:Plec APN 15 76,075,515 (GRCm39) missense probably damaging 1.00
IGL02454:Plec APN 15 76,075,231 (GRCm39) missense probably damaging 0.96
IGL02488:Plec APN 15 76,063,359 (GRCm39) missense possibly damaging 0.92
IGL02490:Plec APN 15 76,073,463 (GRCm39) missense probably damaging 1.00
IGL02494:Plec APN 15 76,060,979 (GRCm39) missense probably damaging 1.00
IGL02869:Plec APN 15 76,065,516 (GRCm39) missense probably damaging 1.00
IGL02900:Plec APN 15 76,070,414 (GRCm39) missense probably damaging 1.00
IGL03059:Plec APN 15 76,059,968 (GRCm39) missense probably damaging 1.00
IGL03091:Plec APN 15 76,073,503 (GRCm39) missense possibly damaging 0.58
IGL03094:Plec APN 15 76,075,519 (GRCm39) missense probably damaging 1.00
R0013:Plec UTSW 15 76,062,446 (GRCm39) missense probably damaging 0.96
R0076:Plec UTSW 15 76,075,614 (GRCm39) splice site probably benign
R0092:Plec UTSW 15 76,067,943 (GRCm39) missense probably benign 0.05
R0106:Plec UTSW 15 76,060,518 (GRCm39) missense probably damaging 1.00
R0111:Plec UTSW 15 76,062,846 (GRCm39) missense probably damaging 1.00
R0212:Plec UTSW 15 76,075,505 (GRCm39) nonsense probably null
R0329:Plec UTSW 15 76,075,618 (GRCm39) critical splice donor site probably null
R0330:Plec UTSW 15 76,075,618 (GRCm39) critical splice donor site probably null
R0334:Plec UTSW 15 76,062,206 (GRCm39) missense probably damaging 0.99
R0345:Plec UTSW 15 76,061,367 (GRCm39) missense probably damaging 1.00
R0457:Plec UTSW 15 76,061,801 (GRCm39) missense probably damaging 1.00
R0507:Plec UTSW 15 76,056,983 (GRCm39) missense probably damaging 1.00
R0531:Plec UTSW 15 76,061,498 (GRCm39) missense probably benign 0.11
R0578:Plec UTSW 15 76,061,084 (GRCm39) missense probably damaging 1.00
R0594:Plec UTSW 15 76,056,453 (GRCm39) missense probably damaging 1.00
R0632:Plec UTSW 15 76,057,611 (GRCm39) missense probably damaging 1.00
R0670:Plec UTSW 15 76,090,160 (GRCm39) missense probably damaging 0.99
R0742:Plec UTSW 15 76,056,983 (GRCm39) missense probably damaging 1.00
R0836:Plec UTSW 15 76,066,107 (GRCm39) unclassified probably benign
R0863:Plec UTSW 15 76,058,280 (GRCm39) nonsense probably null
R0948:Plec UTSW 15 76,089,887 (GRCm39) missense probably benign
R1163:Plec UTSW 15 76,068,038 (GRCm39) missense possibly damaging 0.90
R1437:Plec UTSW 15 76,073,481 (GRCm39) missense probably damaging 0.99
R1466:Plec UTSW 15 76,070,108 (GRCm39) missense possibly damaging 0.88
R1466:Plec UTSW 15 76,070,108 (GRCm39) missense possibly damaging 0.88
R1518:Plec UTSW 15 76,072,401 (GRCm39) missense probably damaging 0.99
R1584:Plec UTSW 15 76,070,108 (GRCm39) missense possibly damaging 0.88
R1649:Plec UTSW 15 76,090,011 (GRCm39) missense possibly damaging 0.50
R1728:Plec UTSW 15 76,061,892 (GRCm39) nonsense probably null
R1729:Plec UTSW 15 76,061,892 (GRCm39) nonsense probably null
R1734:Plec UTSW 15 76,070,418 (GRCm39) missense probably damaging 0.99
R1736:Plec UTSW 15 76,070,418 (GRCm39) missense probably damaging 0.99
R1738:Plec UTSW 15 76,070,418 (GRCm39) missense probably damaging 0.99
R1744:Plec UTSW 15 76,070,418 (GRCm39) missense probably damaging 0.99
R1819:Plec UTSW 15 76,064,106 (GRCm39) missense probably damaging 1.00
R1850:Plec UTSW 15 76,072,432 (GRCm39) missense probably benign 0.39
R1901:Plec UTSW 15 76,059,751 (GRCm39) missense probably damaging 0.98
R1902:Plec UTSW 15 76,059,751 (GRCm39) missense probably damaging 0.98
R1969:Plec UTSW 15 76,073,372 (GRCm39) missense probably damaging 1.00
R1991:Plec UTSW 15 76,057,743 (GRCm39) missense probably damaging 1.00
R2049:Plec UTSW 15 76,067,374 (GRCm39) missense probably benign 0.39
R2069:Plec UTSW 15 76,073,126 (GRCm39) missense probably benign 0.10
R2103:Plec UTSW 15 76,057,743 (GRCm39) missense probably damaging 1.00
R2140:Plec UTSW 15 76,067,374 (GRCm39) missense probably benign 0.39
R2142:Plec UTSW 15 76,067,374 (GRCm39) missense probably benign 0.39
R2234:Plec UTSW 15 76,061,147 (GRCm39) missense probably damaging 1.00
R2240:Plec UTSW 15 76,090,250 (GRCm39) missense probably damaging 1.00
R2762:Plec UTSW 15 76,056,486 (GRCm39) missense probably damaging 1.00
R2924:Plec UTSW 15 76,062,452 (GRCm39) missense probably damaging 1.00
R2925:Plec UTSW 15 76,062,452 (GRCm39) missense probably damaging 1.00
R2973:Plec UTSW 15 76,072,961 (GRCm39) missense probably damaging 1.00
R2974:Plec UTSW 15 76,072,961 (GRCm39) missense probably damaging 1.00
R4125:Plec UTSW 15 76,056,962 (GRCm39) missense probably damaging 1.00
R4156:Plec UTSW 15 76,056,453 (GRCm39) missense probably damaging 1.00
R4161:Plec UTSW 15 76,063,851 (GRCm39) missense possibly damaging 0.92
R4179:Plec UTSW 15 76,064,415 (GRCm39) missense possibly damaging 0.76
R4180:Plec UTSW 15 76,064,415 (GRCm39) missense possibly damaging 0.76
R4222:Plec UTSW 15 76,061,519 (GRCm39) missense probably damaging 1.00
R4373:Plec UTSW 15 76,067,317 (GRCm39) missense probably damaging 0.99
R4513:Plec UTSW 15 76,070,418 (GRCm39) missense probably damaging 0.99
R4546:Plec UTSW 15 76,065,757 (GRCm39) missense probably benign 0.07
R4577:Plec UTSW 15 76,068,269 (GRCm39) missense possibly damaging 0.55
R4584:Plec UTSW 15 76,115,406 (GRCm39) missense possibly damaging 0.89
R4619:Plec UTSW 15 76,076,382 (GRCm39) missense probably benign 0.00
R4624:Plec UTSW 15 76,059,335 (GRCm39) missense probably damaging 1.00
R4680:Plec UTSW 15 76,064,775 (GRCm39) missense unknown
R4690:Plec UTSW 15 76,058,456 (GRCm39) missense probably damaging 1.00
R4713:Plec UTSW 15 76,065,267 (GRCm39) missense unknown
R4927:Plec UTSW 15 76,061,162 (GRCm39) missense probably damaging 1.00
R4980:Plec UTSW 15 76,090,065 (GRCm39) missense probably damaging 0.97
R4980:Plec UTSW 15 76,077,495 (GRCm39) nonsense probably null
R5141:Plec UTSW 15 76,074,733 (GRCm39) missense probably damaging 1.00
R5191:Plec UTSW 15 76,059,365 (GRCm39) missense probably damaging 1.00
R5214:Plec UTSW 15 76,061,921 (GRCm39) missense probably damaging 1.00
R5260:Plec UTSW 15 76,060,824 (GRCm39) missense probably damaging 1.00
R5276:Plec UTSW 15 76,057,638 (GRCm39) missense probably damaging 1.00
R5291:Plec UTSW 15 76,058,211 (GRCm39) missense probably damaging 1.00
R5293:Plec UTSW 15 76,083,783 (GRCm39) missense probably benign
R5498:Plec UTSW 15 76,061,654 (GRCm39) missense probably damaging 1.00
R5617:Plec UTSW 15 76,058,732 (GRCm39) missense probably damaging 1.00
R5668:Plec UTSW 15 76,074,666 (GRCm39) missense possibly damaging 0.71
R5684:Plec UTSW 15 76,089,796 (GRCm39) critical splice donor site probably null
R5698:Plec UTSW 15 76,083,808 (GRCm39) missense probably benign 0.06
R5707:Plec UTSW 15 76,083,871 (GRCm39) intron probably benign
R5753:Plec UTSW 15 76,057,620 (GRCm39) missense probably damaging 1.00
R5762:Plec UTSW 15 76,063,455 (GRCm39) missense probably damaging 1.00
R5976:Plec UTSW 15 76,073,237 (GRCm39) missense probably damaging 1.00
R5995:Plec UTSW 15 76,070,105 (GRCm39) missense probably damaging 1.00
R6013:Plec UTSW 15 76,073,510 (GRCm39) missense possibly damaging 0.65
R6050:Plec UTSW 15 76,072,458 (GRCm39) missense probably damaging 1.00
R6172:Plec UTSW 15 76,056,576 (GRCm39) missense probably damaging 0.99
R6272:Plec UTSW 15 76,059,053 (GRCm39) missense probably damaging 1.00
R6375:Plec UTSW 15 76,061,840 (GRCm39) missense probably damaging 1.00
R6466:Plec UTSW 15 76,062,084 (GRCm39) missense probably benign 0.03
R6528:Plec UTSW 15 76,058,630 (GRCm39) missense probably damaging 1.00
R6586:Plec UTSW 15 76,059,287 (GRCm39) missense probably damaging 1.00
R6652:Plec UTSW 15 76,063,974 (GRCm39) missense probably damaging 0.97
R6657:Plec UTSW 15 76,062,356 (GRCm39) missense possibly damaging 0.74
R6679:Plec UTSW 15 76,058,015 (GRCm39) missense probably damaging 1.00
R6734:Plec UTSW 15 76,078,603 (GRCm39) missense probably damaging 1.00
R6795:Plec UTSW 15 76,064,338 (GRCm39) missense probably damaging 1.00
R6855:Plec UTSW 15 76,070,818 (GRCm39) missense probably damaging 0.99
R6908:Plec UTSW 15 76,070,081 (GRCm39) nonsense probably null
R6957:Plec UTSW 15 76,070,414 (GRCm39) missense probably damaging 1.00
R6984:Plec UTSW 15 76,059,527 (GRCm39) missense probably damaging 1.00
R7017:Plec UTSW 15 76,057,741 (GRCm39) missense probably damaging 1.00
R7043:Plec UTSW 15 76,093,328 (GRCm39) unclassified probably benign
R7068:Plec UTSW 15 76,061,969 (GRCm39) missense probably damaging 1.00
R7133:Plec UTSW 15 76,060,227 (GRCm39) missense possibly damaging 0.95
R7183:Plec UTSW 15 76,089,905 (GRCm39) missense unknown
R7221:Plec UTSW 15 76,059,974 (GRCm39) missense probably damaging 0.97
R7247:Plec UTSW 15 76,061,543 (GRCm39) missense probably damaging 1.00
R7272:Plec UTSW 15 76,059,153 (GRCm39) missense possibly damaging 0.84
R7346:Plec UTSW 15 76,082,178 (GRCm39) critical splice donor site probably null
R7375:Plec UTSW 15 76,061,555 (GRCm39) missense possibly damaging 0.89
R7396:Plec UTSW 15 76,059,089 (GRCm39) missense probably damaging 1.00
R7505:Plec UTSW 15 76,065,394 (GRCm39) missense unknown
R7530:Plec UTSW 15 76,069,844 (GRCm39) missense unknown
R7576:Plec UTSW 15 76,071,946 (GRCm39) missense unknown
R7585:Plec UTSW 15 76,057,632 (GRCm39) missense probably damaging 1.00
R7627:Plec UTSW 15 76,061,594 (GRCm39) missense probably damaging 1.00
R7630:Plec UTSW 15 76,074,816 (GRCm39) splice site probably null
R7695:Plec UTSW 15 76,068,055 (GRCm39) nonsense probably null
R7697:Plec UTSW 15 76,065,885 (GRCm39) missense unknown
R7718:Plec UTSW 15 76,061,639 (GRCm39) missense probably damaging 1.00
R7762:Plec UTSW 15 76,067,823 (GRCm39) missense unknown
R7775:Plec UTSW 15 76,061,135 (GRCm39) missense probably damaging 1.00
R7778:Plec UTSW 15 76,061,135 (GRCm39) missense probably damaging 1.00
R7785:Plec UTSW 15 76,090,029 (GRCm39) missense unknown
R7787:Plec UTSW 15 76,083,811 (GRCm39) missense unknown
R7839:Plec UTSW 15 76,060,583 (GRCm39) missense probably damaging 1.00
R7893:Plec UTSW 15 76,056,732 (GRCm39) missense possibly damaging 0.57
R8036:Plec UTSW 15 76,063,380 (GRCm39) missense possibly damaging 0.46
R8079:Plec UTSW 15 76,063,750 (GRCm39) nonsense probably null
R8132:Plec UTSW 15 76,074,773 (GRCm39) missense unknown
R8139:Plec UTSW 15 76,058,510 (GRCm39) missense probably damaging 0.99
R8214:Plec UTSW 15 76,076,484 (GRCm39) missense unknown
R8220:Plec UTSW 15 76,062,497 (GRCm39) missense possibly damaging 0.94
R8222:Plec UTSW 15 76,063,374 (GRCm39) missense possibly damaging 0.94
R8303:Plec UTSW 15 76,073,466 (GRCm39) missense unknown
R8471:Plec UTSW 15 76,070,620 (GRCm39) missense probably damaging 1.00
R8670:Plec UTSW 15 76,061,726 (GRCm39) missense probably damaging 1.00
R8711:Plec UTSW 15 76,059,531 (GRCm39) missense probably benign 0.45
R8765:Plec UTSW 15 76,066,045 (GRCm39) missense unknown
R8896:Plec UTSW 15 76,078,560 (GRCm39) missense unknown
R8897:Plec UTSW 15 76,057,598 (GRCm39) missense probably damaging 1.00
R8951:Plec UTSW 15 76,067,310 (GRCm39) nonsense probably null
R9008:Plec UTSW 15 76,060,232 (GRCm39) missense probably damaging 1.00
R9081:Plec UTSW 15 76,059,908 (GRCm39) missense probably damaging 0.98
R9085:Plec UTSW 15 76,057,275 (GRCm39) missense probably damaging 1.00
R9153:Plec UTSW 15 76,064,725 (GRCm39) missense unknown
R9198:Plec UTSW 15 76,069,937 (GRCm39) missense unknown
R9207:Plec UTSW 15 76,058,117 (GRCm39) missense probably damaging 1.00
R9235:Plec UTSW 15 76,059,701 (GRCm39) missense probably damaging 1.00
R9276:Plec UTSW 15 76,060,445 (GRCm39) missense probably benign 0.42
R9424:Plec UTSW 15 76,115,377 (GRCm39) missense probably benign 0.00
R9428:Plec UTSW 15 76,067,721 (GRCm39) critical splice donor site probably null
R9451:Plec UTSW 15 76,067,987 (GRCm39) missense unknown
R9511:Plec UTSW 15 76,058,897 (GRCm39) missense probably damaging 1.00
R9521:Plec UTSW 15 76,062,924 (GRCm39) missense possibly damaging 0.83
R9528:Plec UTSW 15 76,061,033 (GRCm39) missense possibly damaging 0.89
R9566:Plec UTSW 15 76,062,790 (GRCm39) missense possibly damaging 0.66
R9576:Plec UTSW 15 76,115,377 (GRCm39) missense probably benign 0.00
R9605:Plec UTSW 15 76,065,213 (GRCm39) missense unknown
R9643:Plec UTSW 15 76,058,177 (GRCm39) missense probably damaging 0.99
R9649:Plec UTSW 15 76,067,153 (GRCm39) missense unknown
U24488:Plec UTSW 15 76,061,930 (GRCm39) missense probably benign 0.15
X0028:Plec UTSW 15 76,057,435 (GRCm39) missense probably damaging 1.00
X0061:Plec UTSW 15 76,059,099 (GRCm39) missense probably damaging 1.00
Z1177:Plec UTSW 15 76,065,407 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- CTACACGGATCTCTTCCTCAATGCG -3'
(R):5'- GTAGAATTCAGGCAGGACTGTGGTG -3'

Sequencing Primer
(F):5'- GCAGCTCCTCTTGGATGC -3'
(R):5'- GGCTGCTATGCTCGCTG -3'
Posted On 2013-10-16