Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00091:Vmn2r118'

777

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r118

Ensembl Gene

ENSMUSG00000091504

Gene Name

vomeronasal 2, receptor 118

Synonyms

EG383258, Vmn2r119, EG668547

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.141) question?

Stock #

IGL00091

Quality Score

Status

Chromosome

Chromosomal Location

55592341-55624672 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 55592708 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 732 (E732G)

Ref Sequence

ENSEMBL: ENSMUSP00000131128 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168440]

AlphaFold

E9Q1C1

Predicted Effect

probably damaging
Transcript: ENSMUST00000168440
AA Change: E732G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000131128
Gene: ENSMUSG00000091504
AA Change: E732G

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	142	470	4.6e-27	PFAM
Pfam:NCD3G	513	566	2.6e-20	PFAM
Pfam:7tm_3	599	834	5.9e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abraxas2	A	T	7: 132,883,428	Y400F	probably benign	Het
Adamts8	C	A	9: 30,953,500	T429K	probably damaging	Het
Adgrv1	C	T	13: 81,578,101	D602N	probably damaging	Het
Ano7	A	T	1: 93,402,166	H775L	probably benign	Het
Apoo-ps	A	T	13: 107,414,634		noncoding transcript	Het
Arid2	T	C	15: 96,372,302	V1432A	probably benign	Het
Atoh1	T	C	6: 64,729,584	S88P	possibly damaging	Het
C130050O18Rik	A	G	5: 139,414,846	E218G	probably damaging	Het
Cacna2d1	T	A	5: 16,212,944	F155L	probably damaging	Het
Car4	C	T	11: 84,965,767	P294S	probably damaging	Het
Cyp1a2	G	T	9: 57,682,069	S154*	probably null	Het
Cyp3a25	A	T	5: 146,001,463	Y68*	probably null	Het
Dmbt1	C	A	7: 131,079,540		probably benign	Het
Dnajc22	T	A	15: 99,101,178	F81L	possibly damaging	Het
Eml5	G	A	12: 98,873,209		probably benign	Het
Fpgs	A	T	2: 32,686,547		probably benign	Het
Gab2	T	C	7: 97,302,443	S537P	possibly damaging	Het
Gmds	G	A	13: 32,234,390	S37L	probably damaging	Het
Ipo13	T	C	4: 117,903,405	E626G	probably benign	Het
Kcng1	T	C	2: 168,268,764	H160R	probably benign	Het
Lama3	A	G	18: 12,580,292	T1608A	probably benign	Het
Lama4	A	C	10: 39,072,805	S855R	probably damaging	Het
Ltbp1	C	T	17: 75,225,338	H454Y	probably damaging	Het
Map3k14	C	A	11: 103,227,579	G594C	probably damaging	Het
Mcph1	A	G	8: 18,632,620	N591S	possibly damaging	Het
Moxd1	G	A	10: 24,279,864	V289I	probably damaging	Het
Mptx2	T	G	1: 173,274,888	N78T	probably damaging	Het
Muc4	G	A	16: 32,754,086	G1321R	probably benign	Het
Muc6	A	C	7: 141,638,584	S2059A	probably benign	Het
Nup50	T	A	15: 84,935,404	F293Y	probably benign	Het
Ogn	A	G	13: 49,621,038	Y219C	probably damaging	Het
Pdia3	T	C	2: 121,414,178	L47P	probably damaging	Het
Piwil4	A	T	9: 14,703,097	D786E	probably damaging	Het
Pspc1	A	G	14: 56,771,711	L222P	probably damaging	Het
Ptchd3	T	A	11: 121,831,146	Y282N	probably damaging	Het
Reln	C	A	5: 22,039,565	G805V	possibly damaging	Het
Serpini2	T	C	3: 75,249,242	Y327C	probably damaging	Het
Spire2	A	G	8: 123,354,059	D14G	probably damaging	Het
Stab2	A	T	10: 86,869,206		probably null	Het
Timeless	T	C	10: 128,241,708	L219P	probably damaging	Het
Tmem63a	C	T	1: 180,963,088	T437M	probably damaging	Het
Tslp	A	G	18: 32,815,395		probably benign	Het
Ttbk2	C	A	2: 120,748,833	G534*	probably null	Het
Uggt1	T	C	1: 36,179,552		probably benign	Het
Zfhx2	G	A	14: 55,066,565	P1321S	possibly damaging	Het
Zfp58	A	G	13: 67,490,995	V459A	probably benign	Het
Zfp831	T	C	2: 174,645,658	S709P	possibly damaging	Het

Other mutations in Vmn2r118

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00976:Vmn2r118	APN	17	55593204	missense	probably damaging	1.00
IGL01419:Vmn2r118	APN	17	55593000	missense	probably benign	0.01
IGL01796:Vmn2r118	APN	17	55608585	missense	probably benign	0.30
IGL01799:Vmn2r118	APN	17	55592990	missense	probably damaging	1.00
IGL02002:Vmn2r118	APN	17	55592619	missense	probably damaging	1.00
IGL02075:Vmn2r118	APN	17	55610517	missense	probably benign	0.18
IGL02172:Vmn2r118	APN	17	55624598	missense	probably benign	0.00
IGL02529:Vmn2r118	APN	17	55610870	missense	possibly damaging	0.58
IGL02712:Vmn2r118	APN	17	55592655	missense	probably benign	0.21
IGL03096:Vmn2r118	APN	17	55607996	missense	probably damaging	1.00
R0306:Vmn2r118	UTSW	17	55608616	missense	possibly damaging	0.89
R0329:Vmn2r118	UTSW	17	55610717	missense	probably damaging	1.00
R0330:Vmn2r118	UTSW	17	55610717	missense	probably damaging	1.00
R0396:Vmn2r118	UTSW	17	55608643	missense	probably benign	0.00
R0411:Vmn2r118	UTSW	17	55611021	splice site	probably benign
R0513:Vmn2r118	UTSW	17	55610970	nonsense	probably null
R0627:Vmn2r118	UTSW	17	55610772	missense	probably benign	0.01
R0638:Vmn2r118	UTSW	17	55608466	missense	probably benign	0.03
R1328:Vmn2r118	UTSW	17	55608620	missense	probably benign	0.01
R1366:Vmn2r118	UTSW	17	55593237	nonsense	probably null
R1465:Vmn2r118	UTSW	17	55610935	missense	probably benign	0.33
R1465:Vmn2r118	UTSW	17	55610935	missense	probably benign	0.33
R1511:Vmn2r118	UTSW	17	55608496	nonsense	probably null
R1515:Vmn2r118	UTSW	17	55610643	missense	probably benign	0.25
R1550:Vmn2r118	UTSW	17	55608083	missense	probably damaging	1.00
R1779:Vmn2r118	UTSW	17	55611530	missense	probably benign	0.03
R1834:Vmn2r118	UTSW	17	55592456	missense	probably damaging	1.00
R1840:Vmn2r118	UTSW	17	55610406	nonsense	probably null
R1854:Vmn2r118	UTSW	17	55611556	missense	possibly damaging	0.57
R1967:Vmn2r118	UTSW	17	55592882	missense	probably damaging	1.00
R1976:Vmn2r118	UTSW	17	55592925	missense	probably damaging	1.00
R2308:Vmn2r118	UTSW	17	55624650	missense	probably benign	0.33
R3700:Vmn2r118	UTSW	17	55608421	missense	possibly damaging	0.68
R4334:Vmn2r118	UTSW	17	55610347	missense	possibly damaging	0.58
R4647:Vmn2r118	UTSW	17	55610665	missense	probably damaging	1.00
R4709:Vmn2r118	UTSW	17	55610860	missense	probably damaging	1.00
R4805:Vmn2r118	UTSW	17	55592581	missense	probably damaging	1.00
R4858:Vmn2r118	UTSW	17	55592894	missense	probably damaging	0.98
R5384:Vmn2r118	UTSW	17	55611565	missense	probably benign	0.00
R5385:Vmn2r118	UTSW	17	55611565	missense	probably benign	0.00
R5664:Vmn2r118	UTSW	17	55592765	missense	possibly damaging	0.46
R5740:Vmn2r118	UTSW	17	55593103	missense	probably benign	0.00
R5927:Vmn2r118	UTSW	17	55624494	missense	probably benign	0.04
R6143:Vmn2r118	UTSW	17	55592871	missense	possibly damaging	0.92
R6513:Vmn2r118	UTSW	17	55608093	missense	probably damaging	1.00
R6573:Vmn2r118	UTSW	17	55592996	missense	probably damaging	1.00
R6760:Vmn2r118	UTSW	17	55592714	missense	possibly damaging	0.92
R6794:Vmn2r118	UTSW	17	55592348	missense	possibly damaging	0.48
R6929:Vmn2r118	UTSW	17	55610440	missense	probably benign	0.01
R7201:Vmn2r118	UTSW	17	55608496	nonsense	probably null
R7539:Vmn2r118	UTSW	17	55592853	missense	probably damaging	0.98
R7836:Vmn2r118	UTSW	17	55593242	missense	probably damaging	0.99
R8179:Vmn2r118	UTSW	17	55608484	missense	probably benign	0.36
R8248:Vmn2r118	UTSW	17	55610936	missense	probably benign	0.18
R8347:Vmn2r118	UTSW	17	55610423	missense	possibly damaging	0.94
R8415:Vmn2r118	UTSW	17	55608057	missense	probably benign	0.08
R8428:Vmn2r118	UTSW	17	55608642	missense	probably benign	0.33
R8917:Vmn2r118	UTSW	17	55610216	missense	possibly damaging	0.82
R8993:Vmn2r118	UTSW	17	55610835	missense	possibly damaging	0.72
R9038:Vmn2r118	UTSW	17	55611649	missense	probably damaging	1.00
R9155:Vmn2r118	UTSW	17	55610207	missense	probably null	0.83
R9603:Vmn2r118	UTSW	17	55592837	missense	probably damaging	1.00
R9742:Vmn2r118	UTSW	17	55611009	missense	probably damaging	0.98
R9749:Vmn2r118	UTSW	17	55608415	critical splice donor site	probably null
R9792:Vmn2r118	UTSW	17	55592496	missense	probably damaging	0.99
R9793:Vmn2r118	UTSW	17	55592496	missense	probably damaging	0.99
R9795:Vmn2r118	UTSW	17	55592496	missense	probably damaging	0.99
X0022:Vmn2r118	UTSW	17	55593218	missense	probably damaging	1.00
Z1176:Vmn2r118	UTSW	17	55610655	nonsense	probably null

Posted On

2011-07-12