Incidental Mutation 'R0836:Wrn'
| ID |
77919 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Wrn
|
| Ensembl Gene |
ENSMUSG00000031583 |
| Gene Name |
Werner syndrome RecQ like helicase |
| Synonyms |
|
| MMRRC Submission |
039015-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.301)
|
| Stock # |
R0836 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
33724412-33875555 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 33785034 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 446
(I446T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000147379
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000033990]
[ENSMUST00000033991]
[ENSMUST00000211498]
|
| AlphaFold |
O09053 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000033990
AA Change: I689T
PolyPhen 2
Score 0.909 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000033990
Gene: ENSMUSG00000031583
AA Change: I689T
| Domain | Start | End | E-Value | Type |
|---|
|
35EXOc
|
47 |
226 |
1e-47 |
SMART |
|
low complexity region
|
484 |
489 |
N/A |
INTRINSIC |
|
DEXDc
|
509 |
704 |
2.3e-28 |
SMART |
|
HELICc
|
743 |
824 |
3.7e-27 |
SMART |
|
RQC
|
923 |
1028 |
3.1e-28 |
SMART |
|
HRDC
|
1115 |
1194 |
1.5e-26 |
SMART |
|
low complexity region
|
1205 |
1216 |
N/A |
INTRINSIC |
|
Pfam:HTH_40
|
1222 |
1318 |
2.7e-9 |
PFAM |
|
low complexity region
|
1342 |
1356 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000033991
AA Change: I689T
PolyPhen 2
Score 0.909 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000033991
Gene: ENSMUSG00000031583
AA Change: I689T
| Domain | Start | End | E-Value | Type |
|---|
|
35EXOc
|
47 |
226 |
1.1e-47 |
SMART |
|
low complexity region
|
484 |
489 |
N/A |
INTRINSIC |
|
DEXDc
|
509 |
704 |
2.4e-28 |
SMART |
|
HELICc
|
743 |
824 |
3.7e-27 |
SMART |
|
Pfam:RecQ_Zn_bind
|
835 |
905 |
2.2e-8 |
PFAM |
|
RQC
|
923 |
1028 |
3.2e-28 |
SMART |
|
HRDC
|
1115 |
1194 |
1.5e-26 |
SMART |
|
low complexity region
|
1205 |
1216 |
N/A |
INTRINSIC |
|
Pfam:HTH_40
|
1223 |
1317 |
4.3e-10 |
PFAM |
|
low complexity region
|
1342 |
1356 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000211498
AA Change: I446T
PolyPhen 2
Score 0.910 (Sensitivity: 0.81; Specificity: 0.94)
|
| Meta Mutation Damage Score |
0.2107 |
| Coding Region Coverage |
- 1x: 99.6%
- 3x: 98.9%
- 10x: 96.9%
- 20x: 92.2%
|
| Validation Efficiency |
100% (102/102) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutants show enhanced frequency and variety of tumors in conjunction with Trp53 knockout alleles. Homozygotes also have an elevated frequency of somatic reversion of the pink-eyed dilution unstable mutation. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 99 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 3110082I17Rik |
A |
G |
5: 139,349,875 (GRCm39) |
V58A |
possibly damaging |
Het |
| 4932415M13Rik |
A |
T |
17: 54,031,374 (GRCm39) |
|
noncoding transcript |
Het |
| A930003A15Rik |
T |
C |
16: 19,702,622 (GRCm39) |
|
noncoding transcript |
Het |
| Abca8a |
A |
T |
11: 109,931,390 (GRCm39) |
D1253E |
possibly damaging |
Het |
| Acsm3 |
T |
C |
7: 119,376,323 (GRCm39) |
I350T |
possibly damaging |
Het |
| Adcy9 |
T |
C |
16: 4,237,135 (GRCm39) |
D92G |
possibly damaging |
Het |
| Aldh9a1 |
G |
A |
1: 167,177,824 (GRCm39) |
G7D |
probably benign |
Het |
| Alg14 |
A |
G |
3: 121,092,259 (GRCm39) |
H34R |
probably damaging |
Het |
| Ankrd27 |
A |
G |
7: 35,307,772 (GRCm39) |
N337S |
probably damaging |
Het |
| Apoa2 |
T |
A |
1: 171,052,948 (GRCm39) |
|
probably benign |
Het |
| Asphd2 |
A |
T |
5: 112,539,635 (GRCm39) |
L66H |
probably damaging |
Het |
| Astl |
T |
C |
2: 127,184,339 (GRCm39) |
F21L |
probably benign |
Het |
| Bptf |
C |
A |
11: 107,001,638 (GRCm39) |
|
probably null |
Het |
| Cacna2d4 |
C |
T |
6: 119,284,247 (GRCm39) |
R745W |
probably damaging |
Het |
| Cadps2 |
T |
C |
6: 23,328,775 (GRCm39) |
|
probably benign |
Het |
| Camk4 |
G |
T |
18: 33,072,507 (GRCm39) |
S20I |
unknown |
Het |
| Ccdc85a |
T |
A |
11: 28,533,296 (GRCm39) |
I83F |
probably damaging |
Het |
| Ccnt2 |
T |
A |
1: 127,730,131 (GRCm39) |
M336K |
probably benign |
Het |
| Cd209e |
G |
T |
8: 3,903,205 (GRCm39) |
D62E |
probably benign |
Het |
| Ceacam23 |
C |
A |
7: 17,638,906 (GRCm39) |
A301E |
possibly damaging |
Het |
| Ces1f |
A |
T |
8: 93,996,652 (GRCm39) |
S214T |
probably damaging |
Het |
| Cfap43 |
C |
A |
19: 47,804,285 (GRCm39) |
V304L |
probably benign |
Het |
| Col26a1 |
A |
G |
5: 136,794,154 (GRCm39) |
|
probably null |
Het |
| Cpa5 |
T |
C |
6: 30,623,210 (GRCm39) |
S124P |
probably damaging |
Het |
| Crtc1 |
A |
G |
8: 70,845,663 (GRCm39) |
V306A |
probably benign |
Het |
| D130043K22Rik |
G |
A |
13: 25,047,563 (GRCm39) |
|
probably benign |
Het |
| D17H6S53E |
A |
T |
17: 35,346,385 (GRCm39) |
|
probably null |
Het |
| Dmxl1 |
T |
C |
18: 49,966,215 (GRCm39) |
V20A |
probably damaging |
Het |
| Dnah11 |
G |
A |
12: 118,160,397 (GRCm39) |
A111V |
probably benign |
Het |
| Dyrk2 |
T |
C |
10: 118,697,027 (GRCm39) |
H77R |
probably benign |
Het |
| Epha3 |
A |
G |
16: 63,423,882 (GRCm39) |
|
probably benign |
Het |
| Epn2 |
T |
C |
11: 61,410,317 (GRCm39) |
N611S |
probably benign |
Het |
| Erich6 |
A |
C |
3: 58,526,365 (GRCm39) |
|
probably benign |
Het |
| Fam217b |
T |
C |
2: 178,062,782 (GRCm39) |
S249P |
probably benign |
Het |
| Fezf1 |
T |
C |
6: 23,246,998 (GRCm39) |
H278R |
probably benign |
Het |
| Fhod3 |
T |
A |
18: 25,199,275 (GRCm39) |
Y649N |
probably damaging |
Het |
| Ftdc2 |
G |
A |
16: 58,455,886 (GRCm39) |
S129L |
probably damaging |
Het |
| Grap |
T |
A |
11: 61,551,065 (GRCm39) |
D32E |
possibly damaging |
Het |
| Hipk1 |
A |
G |
3: 103,661,612 (GRCm39) |
S670P |
probably damaging |
Het |
| Iho1 |
A |
T |
9: 108,282,000 (GRCm39) |
C563S |
probably benign |
Het |
| Ilrun |
A |
T |
17: 28,005,112 (GRCm39) |
S148R |
probably damaging |
Het |
| Itga2 |
A |
G |
13: 114,993,215 (GRCm39) |
V800A |
probably damaging |
Het |
| Itgae |
A |
T |
11: 73,020,032 (GRCm39) |
M845L |
probably benign |
Het |
| Itgb5 |
A |
G |
16: 33,720,953 (GRCm39) |
K339R |
probably damaging |
Het |
| Itpka |
T |
A |
2: 119,581,312 (GRCm39) |
N448K |
probably damaging |
Het |
| Jak3 |
A |
C |
8: 72,136,622 (GRCm39) |
N643T |
probably damaging |
Het |
| Kcnd2 |
T |
A |
6: 21,727,328 (GRCm39) |
V627E |
probably damaging |
Het |
| Kcnd2 |
T |
C |
6: 21,726,238 (GRCm39) |
|
probably benign |
Het |
| Ktn1 |
A |
G |
14: 47,938,519 (GRCm39) |
|
probably null |
Het |
| Lamp1 |
T |
A |
8: 13,222,654 (GRCm39) |
F279L |
probably damaging |
Het |
| Macf1 |
A |
G |
4: 123,388,675 (GRCm39) |
|
probably null |
Het |
| Mark2 |
A |
G |
19: 7,263,189 (GRCm39) |
Y193H |
probably damaging |
Het |
| Mcrs1 |
T |
C |
15: 99,141,330 (GRCm39) |
|
probably benign |
Het |
| Mtnr1a |
A |
T |
8: 45,540,974 (GRCm39) |
I312F |
probably benign |
Het |
| Myom2 |
A |
T |
8: 15,182,924 (GRCm39) |
K1454* |
probably null |
Het |
| Nfkbia |
C |
A |
12: 55,537,561 (GRCm39) |
A211S |
probably damaging |
Het |
| Or52ae9 |
T |
C |
7: 103,390,132 (GRCm39) |
H105R |
probably damaging |
Het |
| Or56b1b |
T |
C |
7: 108,164,205 (GRCm39) |
T266A |
possibly damaging |
Het |
| Or8b1c |
A |
T |
9: 38,384,081 (GRCm39) |
I13F |
probably benign |
Het |
| Otog |
C |
T |
7: 45,918,786 (GRCm39) |
T954I |
possibly damaging |
Het |
| Phlpp2 |
A |
G |
8: 110,663,738 (GRCm39) |
T926A |
probably damaging |
Het |
| Plec |
GGCAGCAG |
GGCAGCAGCAG |
15: 76,066,107 (GRCm39) |
|
probably benign |
Het |
| Plekha5 |
T |
A |
6: 140,535,360 (GRCm39) |
|
probably benign |
Het |
| Pmch |
A |
G |
10: 87,927,086 (GRCm39) |
I30V |
probably benign |
Het |
| Ppat |
A |
C |
5: 77,070,348 (GRCm39) |
Y157D |
probably benign |
Het |
| Ppp1r16a |
C |
T |
15: 76,577,869 (GRCm39) |
Q328* |
probably null |
Het |
| Rab27b |
T |
C |
18: 70,120,112 (GRCm39) |
|
probably benign |
Het |
| Rapsn |
T |
C |
2: 90,867,153 (GRCm39) |
Y152H |
probably damaging |
Het |
| Rasd1 |
A |
T |
11: 59,855,379 (GRCm39) |
F85I |
probably damaging |
Het |
| Rbp3 |
T |
G |
14: 33,678,595 (GRCm39) |
S848A |
possibly damaging |
Het |
| Rgs1 |
A |
T |
1: 144,123,671 (GRCm39) |
S85T |
probably damaging |
Het |
| Rictor |
A |
G |
15: 6,793,759 (GRCm39) |
|
probably null |
Het |
| Rims1 |
T |
C |
1: 22,497,709 (GRCm39) |
|
probably null |
Het |
| Shc1 |
A |
G |
3: 89,330,276 (GRCm39) |
D70G |
probably damaging |
Het |
| Slc22a28 |
T |
C |
19: 8,094,197 (GRCm39) |
Y245C |
possibly damaging |
Het |
| Slc25a1 |
T |
A |
16: 17,745,300 (GRCm39) |
H78L |
probably benign |
Het |
| Slc30a7 |
T |
A |
3: 115,783,789 (GRCm39) |
|
probably null |
Het |
| Slc34a2 |
A |
G |
5: 53,225,049 (GRCm39) |
T397A |
probably benign |
Het |
| Slc51a |
T |
A |
16: 32,294,667 (GRCm39) |
T306S |
probably benign |
Het |
| Sorcs3 |
G |
A |
19: 48,475,833 (GRCm39) |
V231I |
probably benign |
Het |
| Sp100 |
A |
T |
1: 85,627,465 (GRCm39) |
I86L |
probably damaging |
Het |
| Spata31e5 |
A |
G |
1: 28,816,902 (GRCm39) |
S377P |
possibly damaging |
Het |
| Stard9 |
T |
G |
2: 120,527,480 (GRCm39) |
S1246A |
possibly damaging |
Het |
| Stxbp5 |
A |
T |
10: 9,740,843 (GRCm39) |
S116R |
probably damaging |
Het |
| Tas2r105 |
T |
C |
6: 131,664,393 (GRCm39) |
I12V |
probably benign |
Het |
| Tas2r121 |
A |
G |
6: 132,677,325 (GRCm39) |
S216P |
probably damaging |
Het |
| Tax1bp1 |
C |
T |
6: 52,718,925 (GRCm39) |
|
probably benign |
Het |
| Tcof1 |
T |
C |
18: 60,978,904 (GRCm39) |
D48G |
probably damaging |
Het |
| Tex24 |
A |
T |
8: 27,834,748 (GRCm39) |
H92L |
possibly damaging |
Het |
| Tgm3 |
C |
T |
2: 129,868,602 (GRCm39) |
|
probably benign |
Het |
| Thbs4 |
T |
G |
13: 92,894,546 (GRCm39) |
D659A |
probably damaging |
Het |
| Tmed11 |
A |
T |
5: 108,943,175 (GRCm39) |
M1K |
probably null |
Het |
| Tmpo |
A |
T |
10: 90,997,815 (GRCm39) |
C657* |
probably null |
Het |
| Unc5a |
C |
A |
13: 55,151,746 (GRCm39) |
N56K |
possibly damaging |
Het |
| Urb1 |
T |
C |
16: 90,592,336 (GRCm39) |
D308G |
possibly damaging |
Het |
| Vav3 |
A |
G |
3: 109,554,995 (GRCm39) |
N81S |
possibly damaging |
Het |
| Vmn2r108 |
A |
T |
17: 20,691,721 (GRCm39) |
D267E |
probably benign |
Het |
| Vmn2r17 |
A |
T |
5: 109,575,822 (GRCm39) |
H231L |
possibly damaging |
Het |
| Zfp266 |
G |
A |
9: 20,411,095 (GRCm39) |
H361Y |
probably damaging |
Het |
|
| Other mutations in Wrn |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00659:Wrn
|
APN |
8 |
33,812,405 (GRCm39) |
splice site |
probably benign |
|
|
IGL00661:Wrn
|
APN |
8 |
33,809,173 (GRCm39) |
splice site |
probably benign |
|
|
IGL01472:Wrn
|
APN |
8 |
33,819,200 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01544:Wrn
|
APN |
8 |
33,814,554 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01599:Wrn
|
APN |
8 |
33,731,039 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL01688:Wrn
|
APN |
8 |
33,800,730 (GRCm39) |
splice site |
probably benign |
|
|
IGL01916:Wrn
|
APN |
8 |
33,747,252 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL01925:Wrn
|
APN |
8 |
33,809,208 (GRCm39) |
missense |
probably benign |
0.42 |
|
IGL02068:Wrn
|
APN |
8 |
33,800,777 (GRCm39) |
missense |
probably benign |
0.38 |
|
IGL02084:Wrn
|
APN |
8 |
33,775,207 (GRCm39) |
missense |
probably benign |
|
|
IGL02167:Wrn
|
APN |
8 |
33,807,583 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02230:Wrn
|
APN |
8 |
33,807,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02717:Wrn
|
APN |
8 |
33,833,601 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02982:Wrn
|
APN |
8 |
33,833,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03030:Wrn
|
APN |
8 |
33,738,989 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03088:Wrn
|
APN |
8 |
33,758,851 (GRCm39) |
splice site |
probably benign |
|
|
IGL03179:Wrn
|
APN |
8 |
33,800,734 (GRCm39) |
splice site |
probably null |
|
|
IGL03306:Wrn
|
APN |
8 |
33,826,149 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0004:Wrn
|
UTSW |
8 |
33,807,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0190:Wrn
|
UTSW |
8 |
33,731,011 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0441:Wrn
|
UTSW |
8 |
33,758,778 (GRCm39) |
missense |
probably benign |
0.24 |
|
R0463:Wrn
|
UTSW |
8 |
33,770,843 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R0538:Wrn
|
UTSW |
8 |
33,826,119 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0682:Wrn
|
UTSW |
8 |
33,757,848 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0729:Wrn
|
UTSW |
8 |
33,738,946 (GRCm39) |
splice site |
probably null |
|
|
R0744:Wrn
|
UTSW |
8 |
33,785,034 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1168:Wrn
|
UTSW |
8 |
33,806,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1301:Wrn
|
UTSW |
8 |
33,782,714 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1352:Wrn
|
UTSW |
8 |
33,784,944 (GRCm39) |
missense |
probably benign |
0.25 |
|
R1396:Wrn
|
UTSW |
8 |
33,758,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1432:Wrn
|
UTSW |
8 |
33,809,169 (GRCm39) |
splice site |
probably benign |
|
|
R1523:Wrn
|
UTSW |
8 |
33,782,744 (GRCm39) |
missense |
probably benign |
0.23 |
|
R1625:Wrn
|
UTSW |
8 |
33,819,158 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1664:Wrn
|
UTSW |
8 |
33,770,794 (GRCm39) |
splice site |
probably null |
|
|
R1773:Wrn
|
UTSW |
8 |
33,833,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1864:Wrn
|
UTSW |
8 |
33,778,892 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1868:Wrn
|
UTSW |
8 |
33,747,249 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2011:Wrn
|
UTSW |
8 |
33,726,432 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2075:Wrn
|
UTSW |
8 |
33,812,357 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2091:Wrn
|
UTSW |
8 |
33,757,853 (GRCm39) |
missense |
probably benign |
|
|
R2213:Wrn
|
UTSW |
8 |
33,747,043 (GRCm39) |
missense |
probably benign |
0.05 |
|
R2255:Wrn
|
UTSW |
8 |
33,819,230 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2276:Wrn
|
UTSW |
8 |
33,814,584 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3177:Wrn
|
UTSW |
8 |
33,807,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3277:Wrn
|
UTSW |
8 |
33,807,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3779:Wrn
|
UTSW |
8 |
33,731,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3827:Wrn
|
UTSW |
8 |
33,814,548 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4111:Wrn
|
UTSW |
8 |
33,842,183 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4392:Wrn
|
UTSW |
8 |
33,741,860 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4458:Wrn
|
UTSW |
8 |
33,785,026 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4650:Wrn
|
UTSW |
8 |
33,745,537 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4656:Wrn
|
UTSW |
8 |
33,826,019 (GRCm39) |
splice site |
probably null |
|
|
R4657:Wrn
|
UTSW |
8 |
33,826,019 (GRCm39) |
splice site |
probably null |
|
|
R4667:Wrn
|
UTSW |
8 |
33,814,366 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4735:Wrn
|
UTSW |
8 |
33,775,250 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4933:Wrn
|
UTSW |
8 |
33,812,371 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5104:Wrn
|
UTSW |
8 |
33,757,895 (GRCm39) |
splice site |
probably null |
|
|
R5166:Wrn
|
UTSW |
8 |
33,842,100 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5279:Wrn
|
UTSW |
8 |
33,731,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5400:Wrn
|
UTSW |
8 |
33,784,945 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5575:Wrn
|
UTSW |
8 |
33,826,158 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5695:Wrn
|
UTSW |
8 |
33,814,346 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5729:Wrn
|
UTSW |
8 |
33,758,806 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6044:Wrn
|
UTSW |
8 |
33,726,457 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6139:Wrn
|
UTSW |
8 |
33,843,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6158:Wrn
|
UTSW |
8 |
33,809,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6192:Wrn
|
UTSW |
8 |
33,774,682 (GRCm39) |
missense |
probably benign |
0.12 |
|
R6243:Wrn
|
UTSW |
8 |
33,774,682 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6354:Wrn
|
UTSW |
8 |
33,833,666 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6429:Wrn
|
UTSW |
8 |
33,833,024 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6490:Wrn
|
UTSW |
8 |
33,809,248 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6529:Wrn
|
UTSW |
8 |
33,826,004 (GRCm39) |
splice site |
probably null |
|
|
R6535:Wrn
|
UTSW |
8 |
33,826,131 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7001:Wrn
|
UTSW |
8 |
33,842,157 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7114:Wrn
|
UTSW |
8 |
33,775,149 (GRCm39) |
frame shift |
probably null |
|
|
R7198:Wrn
|
UTSW |
8 |
33,814,346 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7200:Wrn
|
UTSW |
8 |
33,812,376 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7227:Wrn
|
UTSW |
8 |
33,738,974 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7299:Wrn
|
UTSW |
8 |
33,782,746 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7374:Wrn
|
UTSW |
8 |
33,758,939 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7402:Wrn
|
UTSW |
8 |
33,738,994 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7404:Wrn
|
UTSW |
8 |
33,738,994 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7405:Wrn
|
UTSW |
8 |
33,738,994 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7464:Wrn
|
UTSW |
8 |
33,826,024 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7474:Wrn
|
UTSW |
8 |
33,819,209 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7609:Wrn
|
UTSW |
8 |
33,800,741 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R7729:Wrn
|
UTSW |
8 |
33,814,454 (GRCm39) |
missense |
probably benign |
0.21 |
|
R7830:Wrn
|
UTSW |
8 |
33,759,082 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7998:Wrn
|
UTSW |
8 |
33,782,671 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8239:Wrn
|
UTSW |
8 |
33,819,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8262:Wrn
|
UTSW |
8 |
33,814,274 (GRCm39) |
missense |
probably benign |
0.07 |
|
R8410:Wrn
|
UTSW |
8 |
33,759,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8480:Wrn
|
UTSW |
8 |
33,778,796 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8530:Wrn
|
UTSW |
8 |
33,770,852 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8540:Wrn
|
UTSW |
8 |
33,842,154 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8708:Wrn
|
UTSW |
8 |
33,782,671 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8783:Wrn
|
UTSW |
8 |
33,826,041 (GRCm39) |
missense |
probably null |
1.00 |
|
R8870:Wrn
|
UTSW |
8 |
33,819,220 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8876:Wrn
|
UTSW |
8 |
33,814,422 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9050:Wrn
|
UTSW |
8 |
33,833,021 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9329:Wrn
|
UTSW |
8 |
33,731,006 (GRCm39) |
missense |
probably benign |
|
|
R9595:Wrn
|
UTSW |
8 |
33,758,961 (GRCm39) |
missense |
probably benign |
|
|
R9621:Wrn
|
UTSW |
8 |
33,814,301 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9623:Wrn
|
UTSW |
8 |
33,774,644 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9797:Wrn
|
UTSW |
8 |
33,758,950 (GRCm39) |
missense |
probably benign |
0.02 |
|
RF010:Wrn
|
UTSW |
8 |
33,778,793 (GRCm39) |
missense |
probably benign |
0.13 |
|
X0017:Wrn
|
UTSW |
8 |
33,770,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Wrn
|
UTSW |
8 |
33,824,237 (GRCm39) |
missense |
probably damaging |
0.98 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCTCTGCCCTTGCAAAATACAAATGCT -3'
(R):5'- TGTGTCAGAAGACAGTGAGAAGTCAATG -3'
Sequencing Primer
(F):5'- agaccaagcccctaccc -3'
(R):5'- GTCAATGCGCCTTTTAAACG -3'
|
| Posted On |
2013-10-16 |
Incidental Mutation