Mutagenetix > Incidental Mutation

Incidental Mutation 'R0836:Itgae'

77937

Institutional Source

Beutler Lab

Gene Symbol

Itgae

Ensembl Gene

ENSMUSG00000005947

Gene Name

integrin alpha E, epithelial-associated

Synonyms

CD103, alpha-E1

MMRRC Submission

039015-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0836 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

73090583-73147446 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 73129206 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 845 (M845L)

Ref Sequence

ENSEMBL: ENSMUSP00000099596 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000006101] [ENSMUST00000102537]

AlphaFold

Q60677

Predicted Effect

probably benign
Transcript: ENSMUST00000006101
AA Change: M845L

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000006101
Gene: ENSMUSG00000005947
AA Change: M845L

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Blast:Int_alpha	36	118	1e-24	BLAST
VWA	193	380	1.13e-39	SMART
Int_alpha	448	496	1.49e-3	SMART
Int_alpha	502	559	6.83e-12	SMART
Int_alpha	565	626	1.79e-15	SMART
Int_alpha	633	685	6.29e0	SMART
transmembrane domain	1115	1137	N/A	INTRINSIC
Pfam:Integrin_alpha	1138	1152	1.1e-6	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000102537
AA Change: M845L

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000099596
Gene: ENSMUSG00000005947
AA Change: M845L

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Blast:Int_alpha	36	118	5e-25	BLAST
VWA	193	380	1.13e-39	SMART
Int_alpha	448	496	1.49e-3	SMART
Int_alpha	502	559	6.83e-12	SMART
Int_alpha	565	626	1.79e-15	SMART
Int_alpha	633	685	6.29e0	SMART

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.6%
3x: 98.9%
10x: 96.9%
20x: 92.2%

Validation Efficiency

100% (102/102)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit reductions in the numbers of intestinal and vaginal intraepithelial lymphocytes and of T lymphocytes of the lamina propria. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 99 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3110082I17Rik	A	G	5: 139,364,120 (GRCm38)	V58A	possibly damaging	Het
4932415M13Rik	A	T	17: 53,724,346 (GRCm38)		noncoding transcript	Het
A930003A15Rik	T	C	16: 19,883,872 (GRCm38)		noncoding transcript	Het
Abca8a	A	T	11: 110,040,564 (GRCm38)	D1253E	possibly damaging	Het
Acsm3	T	C	7: 119,777,100 (GRCm38)	I350T	possibly damaging	Het
Adcy9	T	C	16: 4,419,271 (GRCm38)	D92G	possibly damaging	Het
Aldh9a1	G	A	1: 167,350,255 (GRCm38)	G7D	probably benign	Het
Alg14	A	G	3: 121,298,610 (GRCm38)	H34R	probably damaging	Het
Ankrd27	A	G	7: 35,608,347 (GRCm38)	N337S	probably damaging	Het
Apoa2	T	A	1: 171,225,379 (GRCm38)		probably benign	Het
Asphd2	A	T	5: 112,391,769 (GRCm38)	L66H	probably damaging	Het
Astl	T	C	2: 127,342,419 (GRCm38)	F21L	probably benign	Het
Bptf	C	A	11: 107,110,812 (GRCm38)		probably null	Het
Cacna2d4	C	T	6: 119,307,286 (GRCm38)	R745W	probably damaging	Het
Cadps2	T	C	6: 23,328,776 (GRCm38)		probably benign	Het
Camk4	G	T	18: 32,939,454 (GRCm38)	S20I	unknown	Het
Ccdc36	A	T	9: 108,404,801 (GRCm38)	C563S	probably benign	Het
Ccdc85a	T	A	11: 28,583,296 (GRCm38)	I83F	probably damaging	Het
Ccnt2	T	A	1: 127,802,394 (GRCm38)	M336K	probably benign	Het
Cd209e	G	T	8: 3,853,205 (GRCm38)	D62E	probably benign	Het
Ces1f	A	T	8: 93,270,024 (GRCm38)	S214T	probably damaging	Het
Cfap43	C	A	19: 47,815,846 (GRCm38)	V304L	probably benign	Het
Col26a1	A	G	5: 136,765,300 (GRCm38)		probably null	Het
Cpa5	T	C	6: 30,623,211 (GRCm38)	S124P	probably damaging	Het
Crtc1	A	G	8: 70,393,013 (GRCm38)	V306A	probably benign	Het
D130043K22Rik	G	A	13: 24,863,580 (GRCm38)		probably benign	Het
D17H6S53E	A	T	17: 35,127,409 (GRCm38)		probably null	Het
D17Wsu92e	A	T	17: 27,786,138 (GRCm38)	S148R	probably damaging	Het
Dmxl1	T	C	18: 49,833,148 (GRCm38)	V20A	probably damaging	Het
Dnah11	G	A	12: 118,196,662 (GRCm38)	A111V	probably benign	Het
Dyrk2	T	C	10: 118,861,122 (GRCm38)	H77R	probably benign	Het
E330017A01Rik	G	A	16: 58,635,523 (GRCm38)	S129L	probably damaging	Het
Epha3	A	G	16: 63,603,519 (GRCm38)		probably benign	Het
Epn2	T	C	11: 61,519,491 (GRCm38)	N611S	probably benign	Het
Erich6	A	C	3: 58,618,944 (GRCm38)		probably benign	Het
Fam217b	T	C	2: 178,420,989 (GRCm38)	S249P	probably benign	Het
Fezf1	T	C	6: 23,246,999 (GRCm38)	H278R	probably benign	Het
Fhod3	T	A	18: 25,066,218 (GRCm38)	Y649N	probably damaging	Het
Gm5155	C	A	7: 17,904,981 (GRCm38)	A301E	possibly damaging	Het
Gm597	A	G	1: 28,777,821 (GRCm38)	S377P	possibly damaging	Het
Grap	T	A	11: 61,660,239 (GRCm38)	D32E	possibly damaging	Het
Hipk1	A	G	3: 103,754,296 (GRCm38)	S670P	probably damaging	Het
Itga2	A	G	13: 114,856,679 (GRCm38)	V800A	probably damaging	Het
Itgb5	A	G	16: 33,900,583 (GRCm38)	K339R	probably damaging	Het
Itpka	T	A	2: 119,750,831 (GRCm38)	N448K	probably damaging	Het
Jak3	A	C	8: 71,683,978 (GRCm38)	N643T	probably damaging	Het
Kcnd2	T	C	6: 21,726,239 (GRCm38)		probably benign	Het
Kcnd2	T	A	6: 21,727,329 (GRCm38)	V627E	probably damaging	Het
Ktn1	A	G	14: 47,701,062 (GRCm38)		probably null	Het
Lamp1	T	A	8: 13,172,654 (GRCm38)	F279L	probably damaging	Het
Macf1	A	G	4: 123,494,882 (GRCm38)		probably null	Het
Mark2	A	G	19: 7,285,824 (GRCm38)	Y193H	probably damaging	Het
Mcrs1	T	C	15: 99,243,449 (GRCm38)		probably benign	Het
Mtnr1a	A	T	8: 45,087,937 (GRCm38)	I312F	probably benign	Het
Myom2	A	T	8: 15,132,924 (GRCm38)	K1454*	probably null	Het
Nfkbia	C	A	12: 55,490,776 (GRCm38)	A211S	probably damaging	Het
Olfr504	T	C	7: 108,564,998 (GRCm38)	T266A	possibly damaging	Het
Olfr629	T	C	7: 103,740,925 (GRCm38)	H105R	probably damaging	Het
Olfr905	A	T	9: 38,472,785 (GRCm38)	I13F	probably benign	Het
Otog	C	T	7: 46,269,362 (GRCm38)	T954I	possibly damaging	Het
Phlpp2	A	G	8: 109,937,106 (GRCm38)	T926A	probably damaging	Het
Plec	GGCAGCAG	GGCAGCAGCAG	15: 76,181,907 (GRCm38)		probably benign	Het
Plekha5	T	A	6: 140,589,634 (GRCm38)		probably benign	Het
Pmch	A	G	10: 88,091,224 (GRCm38)	I30V	probably benign	Het
Ppat	A	C	5: 76,922,501 (GRCm38)	Y157D	probably benign	Het
Ppp1r16a	C	T	15: 76,693,669 (GRCm38)	Q328*	probably null	Het
Rab27b	T	C	18: 69,987,041 (GRCm38)		probably benign	Het
Rapsn	T	C	2: 91,036,808 (GRCm38)	Y152H	probably damaging	Het
Rasd1	A	T	11: 59,964,553 (GRCm38)	F85I	probably damaging	Het
Rbp3	T	G	14: 33,956,638 (GRCm38)	S848A	possibly damaging	Het
Rgs1	A	T	1: 144,247,933 (GRCm38)	S85T	probably damaging	Het
Rictor	A	G	15: 6,764,278 (GRCm38)		probably null	Het
Rims1	T	C	1: 22,427,459 (GRCm38)		probably null	Het
Shc1	A	G	3: 89,422,969 (GRCm38)	D70G	probably damaging	Het
Slc22a28	T	C	19: 8,116,833 (GRCm38)	Y245C	possibly damaging	Het
Slc25a1	T	A	16: 17,927,436 (GRCm38)	H78L	probably benign	Het
Slc30a7	T	A	3: 115,990,140 (GRCm38)		probably null	Het
Slc34a2	A	G	5: 53,067,707 (GRCm38)	T397A	probably benign	Het
Slc51a	T	A	16: 32,475,849 (GRCm38)	T306S	probably benign	Het
Sorcs3	G	A	19: 48,487,394 (GRCm38)	V231I	probably benign	Het
Sp100	A	T	1: 85,699,744 (GRCm38)	I86L	probably damaging	Het
Stard9	T	G	2: 120,696,999 (GRCm38)	S1246A	possibly damaging	Het
Stxbp5	A	T	10: 9,865,099 (GRCm38)	S116R	probably damaging	Het
Tas2r105	T	C	6: 131,687,430 (GRCm38)	I12V	probably benign	Het
Tas2r121	A	G	6: 132,700,362 (GRCm38)	S216P	probably damaging	Het
Tax1bp1	C	T	6: 52,741,940 (GRCm38)		probably benign	Het
Tcof1	T	C	18: 60,845,832 (GRCm38)	D48G	probably damaging	Het
Tex24	A	T	8: 27,344,720 (GRCm38)	H92L	possibly damaging	Het
Tgm3	C	T	2: 130,026,682 (GRCm38)		probably benign	Het
Thbs4	T	G	13: 92,758,038 (GRCm38)	D659A	probably damaging	Het
Tmed11	A	T	5: 108,795,309 (GRCm38)	M1K	probably null	Het
Tmpo	A	T	10: 91,161,953 (GRCm38)	C657*	probably null	Het
Unc5a	C	A	13: 55,003,933 (GRCm38)	N56K	possibly damaging	Het
Urb1	T	C	16: 90,795,448 (GRCm38)	D308G	possibly damaging	Het
Vav3	A	G	3: 109,647,679 (GRCm38)	N81S	possibly damaging	Het
Vmn2r108	A	T	17: 20,471,459 (GRCm38)	D267E	probably benign	Het
Vmn2r17	A	T	5: 109,427,956 (GRCm38)	H231L	possibly damaging	Het
Wrn	A	G	8: 33,295,006 (GRCm38)	I446T	possibly damaging	Het
Zfp266	G	A	9: 20,499,799 (GRCm38)	H361Y	probably damaging	Het

Other mutations in Itgae

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00424:Itgae	APN	11	73,145,635 (GRCm38)	missense	probably benign	0.17
IGL00472:Itgae	APN	11	73,113,694 (GRCm38)	missense	probably benign	0.06
IGL00821:Itgae	APN	11	73,123,148 (GRCm38)	missense	probably damaging	1.00
IGL01625:Itgae	APN	11	73,119,437 (GRCm38)	missense	probably benign	0.00
IGL01639:Itgae	APN	11	73,119,378 (GRCm38)	missense	probably benign	0.00
IGL01743:Itgae	APN	11	73,111,759 (GRCm38)	missense	probably benign	0.02
IGL01911:Itgae	APN	11	73,116,137 (GRCm38)	missense	probably damaging	1.00
IGL01949:Itgae	APN	11	73,118,184 (GRCm38)	missense	probably benign	0.29
IGL02149:Itgae	APN	11	73,103,894 (GRCm38)	missense	probably benign	0.04
IGL02179:Itgae	APN	11	73,134,018 (GRCm38)	missense	probably benign	0.06
IGL02231:Itgae	APN	11	73,090,622 (GRCm38)	missense	possibly damaging	0.88
IGL02292:Itgae	APN	11	73,118,535 (GRCm38)	missense	probably damaging	0.98
IGL02378:Itgae	APN	11	73,118,121 (GRCm38)	missense	probably benign	0.00
IGL02525:Itgae	APN	11	73,130,951 (GRCm38)	missense	probably damaging	0.98
IGL02576:Itgae	APN	11	73,118,505 (GRCm38)	missense	possibly damaging	0.95
IGL02729:Itgae	APN	11	73,118,203 (GRCm38)	splice site	probably benign
IGL02859:Itgae	APN	11	73,114,867 (GRCm38)	missense	probably damaging	1.00
IGL03074:Itgae	APN	11	73,125,310 (GRCm38)	missense	probably benign	0.00
IGL03107:Itgae	APN	11	73,113,601 (GRCm38)	missense	probably damaging	1.00
IGL03264:Itgae	APN	11	73,115,574 (GRCm38)	missense	possibly damaging	0.73
IGL03272:Itgae	APN	11	73,133,854 (GRCm38)	splice site	probably null
IGL03352:Itgae	APN	11	73,131,730 (GRCm38)	missense	probably damaging	1.00
R0134:Itgae	UTSW	11	73,111,342 (GRCm38)	missense	probably benign	0.00
R0225:Itgae	UTSW	11	73,111,342 (GRCm38)	missense	probably benign	0.00
R0320:Itgae	UTSW	11	73,130,999 (GRCm38)	missense	possibly damaging	0.74
R0344:Itgae	UTSW	11	73,118,147 (GRCm38)	missense	probably benign	0.13
R0403:Itgae	UTSW	11	73,123,183 (GRCm38)	missense	possibly damaging	0.89
R0631:Itgae	UTSW	11	73,114,907 (GRCm38)	missense	probably damaging	1.00
R0833:Itgae	UTSW	11	73,129,206 (GRCm38)	missense	probably benign	0.02
R0973:Itgae	UTSW	11	73,138,509 (GRCm38)	nonsense	probably null
R1231:Itgae	UTSW	11	73,119,379 (GRCm38)	missense	probably benign	0.02
R1389:Itgae	UTSW	11	73,125,362 (GRCm38)	missense	probably damaging	1.00
R1433:Itgae	UTSW	11	73,115,592 (GRCm38)	missense	probably damaging	1.00
R1534:Itgae	UTSW	11	73,145,605 (GRCm38)	missense	possibly damaging	0.58
R1833:Itgae	UTSW	11	73,117,162 (GRCm38)	missense	possibly damaging	0.94
R1914:Itgae	UTSW	11	73,118,643 (GRCm38)	splice site	probably benign
R1915:Itgae	UTSW	11	73,118,643 (GRCm38)	splice site	probably benign
R2061:Itgae	UTSW	11	73,118,622 (GRCm38)	missense	probably benign	0.00
R2380:Itgae	UTSW	11	73,145,569 (GRCm38)	missense	probably benign	0.00
R2435:Itgae	UTSW	11	73,121,937 (GRCm38)	nonsense	probably null
R2680:Itgae	UTSW	11	73,114,926 (GRCm38)	missense	probably damaging	1.00
R2886:Itgae	UTSW	11	73,140,687 (GRCm38)	missense	probably benign	0.04
R3873:Itgae	UTSW	11	73,113,616 (GRCm38)	missense	probably damaging	1.00
R3923:Itgae	UTSW	11	73,116,143 (GRCm38)	missense	probably damaging	0.99
R4010:Itgae	UTSW	11	73,111,339 (GRCm38)	missense	probably benign	0.00
R4059:Itgae	UTSW	11	73,112,134 (GRCm38)	missense	probably benign
R4212:Itgae	UTSW	11	73,119,352 (GRCm38)	missense	probably benign
R4213:Itgae	UTSW	11	73,119,352 (GRCm38)	missense	probably benign
R4691:Itgae	UTSW	11	73,119,519 (GRCm38)	nonsense	probably null
R4736:Itgae	UTSW	11	73,114,880 (GRCm38)	missense	possibly damaging	0.79
R5152:Itgae	UTSW	11	73,130,995 (GRCm38)	missense	probably damaging	1.00
R5201:Itgae	UTSW	11	73,110,556 (GRCm38)	missense	probably benign	0.00
R5307:Itgae	UTSW	11	73,145,638 (GRCm38)	missense	probably benign	0.00
R5362:Itgae	UTSW	11	73,111,849 (GRCm38)	missense	probably damaging	1.00
R5448:Itgae	UTSW	11	73,133,908 (GRCm38)	critical splice donor site	probably null
R5645:Itgae	UTSW	11	73,129,248 (GRCm38)	missense	probably damaging	1.00
R5672:Itgae	UTSW	11	73,145,551 (GRCm38)	missense	possibly damaging	0.96
R6079:Itgae	UTSW	11	73,115,574 (GRCm38)	missense	possibly damaging	0.73
R6138:Itgae	UTSW	11	73,115,574 (GRCm38)	missense	possibly damaging	0.73
R6226:Itgae	UTSW	11	73,140,757 (GRCm38)	missense	probably benign	0.11
R6244:Itgae	UTSW	11	73,145,601 (GRCm38)	missense	probably damaging	0.96
R6326:Itgae	UTSW	11	73,131,693 (GRCm38)	missense	possibly damaging	0.88
R6332:Itgae	UTSW	11	73,111,402 (GRCm38)	splice site	probably null
R6502:Itgae	UTSW	11	73,145,592 (GRCm38)	missense	probably benign	0.10
R6825:Itgae	UTSW	11	73,118,496 (GRCm38)	missense	possibly damaging	0.89
R7016:Itgae	UTSW	11	73,119,516 (GRCm38)	missense	probably damaging	0.99
R7020:Itgae	UTSW	11	73,111,369 (GRCm38)	missense	probably damaging	1.00
R7069:Itgae	UTSW	11	73,116,143 (GRCm38)	missense	probably damaging	0.99
R7132:Itgae	UTSW	11	73,111,358 (GRCm38)	missense	possibly damaging	0.93
R7473:Itgae	UTSW	11	73,140,678 (GRCm38)	missense	possibly damaging	0.87
R7599:Itgae	UTSW	11	73,121,960 (GRCm38)	missense	possibly damaging	0.62
R7637:Itgae	UTSW	11	73,113,631 (GRCm38)	missense	probably damaging	1.00
R7763:Itgae	UTSW	11	73,123,269 (GRCm38)	critical splice donor site	probably null
R7829:Itgae	UTSW	11	73,138,792 (GRCm38)	missense	probably benign
R7860:Itgae	UTSW	11	73,120,273 (GRCm38)	critical splice acceptor site	probably null
R7978:Itgae	UTSW	11	73,134,087 (GRCm38)	missense	probably damaging	0.98
R8197:Itgae	UTSW	11	73,120,384 (GRCm38)	missense	probably benign
R8911:Itgae	UTSW	11	73,113,621 (GRCm38)	missense	probably damaging	1.00
R9155:Itgae	UTSW	11	73,125,263 (GRCm38)	missense	possibly damaging	0.94
R9284:Itgae	UTSW	11	73,121,926 (GRCm38)	missense	probably benign	0.25
R9355:Itgae	UTSW	11	73,116,080 (GRCm38)	missense	probably damaging	1.00
R9414:Itgae	UTSW	11	73,111,803 (GRCm38)	missense	possibly damaging	0.59
R9595:Itgae	UTSW	11	73,125,356 (GRCm38)	missense	probably damaging	0.99
R9618:Itgae	UTSW	11	73,120,345 (GRCm38)	missense	possibly damaging	0.78
U15987:Itgae	UTSW	11	73,115,574 (GRCm38)	missense	possibly damaging	0.73
X0024:Itgae	UTSW	11	73,111,376 (GRCm38)	missense	probably benign	0.01
Z1186:Itgae	UTSW	11	73,103,887 (GRCm38)	missense	possibly damaging	0.74
Z1186:Itgae	UTSW	11	73,134,127 (GRCm38)	missense	probably benign	0.36
Z1186:Itgae	UTSW	11	73,121,957 (GRCm38)	missense	probably benign	0.00
Z1186:Itgae	UTSW	11	73,121,931 (GRCm38)	missense	probably benign	0.00
Z1186:Itgae	UTSW	11	73,118,087 (GRCm38)	missense	probably benign	0.01
Z1186:Itgae	UTSW	11	73,115,640 (GRCm38)	missense	probably benign
Z1186:Itgae	UTSW	11	73,103,960 (GRCm38)	missense	probably damaging	1.00
Z1187:Itgae	UTSW	11	73,103,887 (GRCm38)	missense	possibly damaging	0.74
Z1187:Itgae	UTSW	11	73,103,960 (GRCm38)	missense	probably damaging	1.00
Z1187:Itgae	UTSW	11	73,115,640 (GRCm38)	missense	probably benign
Z1187:Itgae	UTSW	11	73,118,087 (GRCm38)	missense	probably benign	0.01
Z1187:Itgae	UTSW	11	73,121,931 (GRCm38)	missense	probably benign	0.00
Z1187:Itgae	UTSW	11	73,121,957 (GRCm38)	missense	probably benign	0.00
Z1187:Itgae	UTSW	11	73,134,127 (GRCm38)	missense	probably benign	0.36
Z1188:Itgae	UTSW	11	73,103,887 (GRCm38)	missense	possibly damaging	0.74
Z1188:Itgae	UTSW	11	73,134,127 (GRCm38)	missense	probably benign	0.36
Z1188:Itgae	UTSW	11	73,121,957 (GRCm38)	missense	probably benign	0.00
Z1188:Itgae	UTSW	11	73,121,931 (GRCm38)	missense	probably benign	0.00
Z1188:Itgae	UTSW	11	73,118,087 (GRCm38)	missense	probably benign	0.01
Z1188:Itgae	UTSW	11	73,115,640 (GRCm38)	missense	probably benign
Z1188:Itgae	UTSW	11	73,103,960 (GRCm38)	missense	probably damaging	1.00
Z1189:Itgae	UTSW	11	73,103,887 (GRCm38)	missense	possibly damaging	0.74
Z1189:Itgae	UTSW	11	73,134,127 (GRCm38)	missense	probably benign	0.36
Z1189:Itgae	UTSW	11	73,121,957 (GRCm38)	missense	probably benign	0.00
Z1189:Itgae	UTSW	11	73,121,931 (GRCm38)	missense	probably benign	0.00
Z1189:Itgae	UTSW	11	73,118,087 (GRCm38)	missense	probably benign	0.01
Z1189:Itgae	UTSW	11	73,115,640 (GRCm38)	missense	probably benign
Z1189:Itgae	UTSW	11	73,103,960 (GRCm38)	missense	probably damaging	1.00
Z1190:Itgae	UTSW	11	73,134,127 (GRCm38)	missense	probably benign	0.36
Z1190:Itgae	UTSW	11	73,121,957 (GRCm38)	missense	probably benign	0.00
Z1190:Itgae	UTSW	11	73,121,931 (GRCm38)	missense	probably benign	0.00
Z1190:Itgae	UTSW	11	73,118,087 (GRCm38)	missense	probably benign	0.01
Z1190:Itgae	UTSW	11	73,115,640 (GRCm38)	missense	probably benign
Z1190:Itgae	UTSW	11	73,103,960 (GRCm38)	missense	probably damaging	1.00
Z1190:Itgae	UTSW	11	73,103,887 (GRCm38)	missense	possibly damaging	0.74
Z1191:Itgae	UTSW	11	73,134,127 (GRCm38)	missense	probably benign	0.36
Z1191:Itgae	UTSW	11	73,121,957 (GRCm38)	missense	probably benign	0.00
Z1191:Itgae	UTSW	11	73,121,931 (GRCm38)	missense	probably benign	0.00
Z1191:Itgae	UTSW	11	73,118,087 (GRCm38)	missense	probably benign	0.01
Z1191:Itgae	UTSW	11	73,115,640 (GRCm38)	missense	probably benign
Z1191:Itgae	UTSW	11	73,103,960 (GRCm38)	missense	probably damaging	1.00
Z1191:Itgae	UTSW	11	73,103,887 (GRCm38)	missense	possibly damaging	0.74
Z1192:Itgae	UTSW	11	73,121,957 (GRCm38)	missense	probably benign	0.00
Z1192:Itgae	UTSW	11	73,121,931 (GRCm38)	missense	probably benign	0.00
Z1192:Itgae	UTSW	11	73,118,087 (GRCm38)	missense	probably benign	0.01
Z1192:Itgae	UTSW	11	73,115,640 (GRCm38)	missense	probably benign
Z1192:Itgae	UTSW	11	73,103,960 (GRCm38)	missense	probably damaging	1.00
Z1192:Itgae	UTSW	11	73,103,887 (GRCm38)	missense	possibly damaging	0.74
Z1192:Itgae	UTSW	11	73,134,127 (GRCm38)	missense	probably benign	0.36

Predicted Primers

PCR Primer
(F):5'- AGCTAGGGGTCCAGCTCTGTTAAG -3'
(R):5'- CGTCAATCGCTATGCCTGTACTGC -3'

Sequencing Primer
(F):5'- gttcaatacccagcaaccac -3'
(R):5'- CTATGCCTGTACTGCATGGGG -3'

Posted On

2013-10-16