Incidental Mutation 'R0837:Olfr433'
ID 77975
Institutional Source Beutler Lab
Gene Symbol Olfr433
Ensembl Gene ENSMUSG00000045381
Gene Name olfactory receptor 433
Synonyms GA_x6K02T2P20D-21133014-21132070, MOR123-1
MMRRC Submission 039016-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R0837 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 174040705-174044411 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 174042487 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 179 (D179G)
Ref Sequence ENSEMBL: ENSMUSP00000149005 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052975] [ENSMUST00000214690]
AlphaFold Q7TRV9
Predicted Effect probably damaging
Transcript: ENSMUST00000052975
AA Change: D179G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000056772
Gene: ENSMUSG00000045381
AA Change: D179G

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 4.6e-51 PFAM
Pfam:7TM_GPCR_Srsx 35 170 2.9e-8 PFAM
Pfam:7tm_1 41 289 1.3e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214690
AA Change: D179G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.4%
  • 20x: 94.8%
Validation Efficiency 96% (44/46)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930563I02Rik T C 14: 60,095,926 (GRCm38) probably benign Het
4930579C12Rik A G 9: 89,168,207 (GRCm38) noncoding transcript Het
Adam34 T A 8: 43,651,500 (GRCm38) K369N probably benign Het
Ap1g1 T C 8: 109,851,065 (GRCm38) W481R probably damaging Het
Bicdl1 G A 5: 115,731,292 (GRCm38) P26S probably benign Het
Cacna1c A T 6: 118,630,270 (GRCm38) C1224* probably null Het
Cpsf2 C T 12: 101,997,242 (GRCm38) probably benign Het
Cyp11b2 G A 15: 74,853,641 (GRCm38) R210W probably damaging Het
Dock7 C T 4: 98,989,258 (GRCm38) V1048I probably benign Het
Dync2h1 C A 9: 7,077,979 (GRCm38) A2908S probably benign Het
Elane A G 10: 79,887,108 (GRCm38) D116G probably damaging Het
Epb41l2 C T 10: 25,507,816 (GRCm38) R153C probably damaging Het
Gucy2c G A 6: 136,722,420 (GRCm38) P617L probably damaging Het
Hist2h2ab G A 3: 96,220,123 (GRCm38) A70T probably damaging Het
Kcnq4 T A 4: 120,746,861 (GRCm38) I106L probably benign Het
Man2b1 A G 8: 85,096,829 (GRCm38) N931D possibly damaging Het
Mthfs A G 9: 89,215,390 (GRCm38) E100G probably damaging Het
Mto1 A T 9: 78,473,790 (GRCm38) I639F probably damaging Het
Myo15 A G 11: 60,487,251 (GRCm38) E177G probably damaging Het
Naip5 T A 13: 100,230,743 (GRCm38) M282L probably benign Het
Pik3c2g G A 6: 139,957,699 (GRCm38) probably benign Het
Prl7d1 T A 13: 27,714,338 (GRCm38) M64L probably benign Het
Prnp A T 2: 131,936,524 (GRCm38) N32I probably damaging Het
Ptpn11 C T 5: 121,149,111 (GRCm38) V406I probably benign Het
Rab40c G A 17: 25,884,693 (GRCm38) T151I probably damaging Het
Rb1cc1 T A 1: 6,234,271 (GRCm38) probably null Het
Rnf145 T C 11: 44,524,988 (GRCm38) V10A probably benign Het
Rtn4rl2 T C 2: 84,880,692 (GRCm38) N70S probably damaging Het
Scaper A T 9: 55,859,042 (GRCm38) C483* probably null Het
Sema4a T A 3: 88,453,098 (GRCm38) Q58L possibly damaging Het
Slf1 T C 13: 77,100,948 (GRCm38) probably null Het
Sycp1 G T 3: 102,915,245 (GRCm38) N364K probably benign Het
Tenm4 T C 7: 96,896,275 (GRCm38) probably benign Het
Tnfaip2 A G 12: 111,450,707 (GRCm38) T537A probably damaging Het
Trappc12 A G 12: 28,703,597 (GRCm38) I573T possibly damaging Het
Ugt2b38 G A 5: 87,411,773 (GRCm38) T420I probably damaging Het
Ulk1 A T 5: 110,789,545 (GRCm38) probably benign Het
Unc80 G A 1: 66,648,944 (GRCm38) C2367Y possibly damaging Het
Usp7 C A 16: 8,703,502 (GRCm38) G135C probably damaging Het
Vmn2r103 A G 17: 19,793,927 (GRCm38) Y327C probably damaging Het
Vmn2r28 T A 7: 5,488,027 (GRCm38) H407L probably damaging Het
Zfp804a A C 2: 82,259,162 (GRCm38) T1112P probably damaging Het
Zfr2 A G 10: 81,245,408 (GRCm38) K431E probably damaging Het
Zfy1 A T Y: 725,850 (GRCm38) Y638* probably null Het
Other mutations in Olfr433
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01760:Olfr433 APN 1 174,042,625 (GRCm38) missense probably damaging 0.99
IGL02369:Olfr433 APN 1 174,041,973 (GRCm38) missense possibly damaging 0.64
IGL03256:Olfr433 APN 1 174,042,208 (GRCm38) missense probably damaging 1.00
IGL03297:Olfr433 APN 1 174,042,117 (GRCm38) missense probably benign 0.00
R1583:Olfr433 UTSW 1 174,042,480 (GRCm38) missense probably benign 0.11
R1974:Olfr433 UTSW 1 174,042,588 (GRCm38) missense probably damaging 1.00
R2280:Olfr433 UTSW 1 174,042,521 (GRCm38) missense probably benign 0.00
R2897:Olfr433 UTSW 1 174,042,133 (GRCm38) missense probably damaging 1.00
R3022:Olfr433 UTSW 1 174,042,084 (GRCm38) missense probably benign 0.13
R4478:Olfr433 UTSW 1 174,042,616 (GRCm38) missense probably benign 0.00
R6364:Olfr433 UTSW 1 174,042,212 (GRCm38) missense possibly damaging 0.80
R6588:Olfr433 UTSW 1 174,042,278 (GRCm38) missense probably benign 0.01
R7343:Olfr433 UTSW 1 174,042,853 (GRCm38) missense probably damaging 0.98
R7409:Olfr433 UTSW 1 174,042,533 (GRCm38) missense probably benign 0.02
R7714:Olfr433 UTSW 1 174,042,334 (GRCm38) missense probably benign 0.00
R7788:Olfr433 UTSW 1 174,042,084 (GRCm38) missense probably benign 0.13
R8982:Olfr433 UTSW 1 174,042,622 (GRCm38) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TATCTCCTCACACTGGCAGGGAAC -3'
(R):5'- CTGCTCTGAGGTGAACCCACATAC -3'

Sequencing Primer
(F):5'- CATGACCGAGTGCTACCTGTTAG -3'
(R):5'- GAAGCATAGAACAGTGCAACC -3'
Posted On 2013-10-16