Incidental Mutation 'R0837:Zfp804a'
ID 77976
Institutional Source Beutler Lab
Gene Symbol Zfp804a
Ensembl Gene ENSMUSG00000070866
Gene Name zinc finger protein 804A
Synonyms C630007C17Rik
MMRRC Submission 039016-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.198) question?
Stock # R0837 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 81883566-82090223 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 82089506 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Proline at position 1112 (T1112P)
Ref Sequence ENSEMBL: ENSMUSP00000041941 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047527]
AlphaFold A2AKY4
Predicted Effect probably damaging
Transcript: ENSMUST00000047527
AA Change: T1112P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000041941
Gene: ENSMUSG00000070866
AA Change: T1112P

DomainStartEndE-ValueType
ZnF_C2H2 57 81 7.29e0 SMART
low complexity region 588 595 N/A INTRINSIC
low complexity region 801 808 N/A INTRINSIC
low complexity region 1012 1029 N/A INTRINSIC
low complexity region 1061 1077 N/A INTRINSIC
low complexity region 1168 1191 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127187
Meta Mutation Damage Score 0.1055 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.4%
  • 20x: 94.8%
Validation Efficiency 96% (44/46)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a zinc finger binding protein. Polymorphisms in this gene, especially rs1344706, are thought to confer increased susceptibility to schizophrenia, bipolar disorder, and heroin addiciton. [provided by RefSeq, Nov 2015]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930563I02Rik T C 14: 60,333,375 (GRCm39) probably benign Het
4930579C12Rik A G 9: 89,050,260 (GRCm39) noncoding transcript Het
Adam34 T A 8: 44,104,537 (GRCm39) K369N probably benign Het
Ap1g1 T C 8: 110,577,697 (GRCm39) W481R probably damaging Het
Bicdl1 G A 5: 115,869,351 (GRCm39) P26S probably benign Het
Cacna1c A T 6: 118,607,231 (GRCm39) C1224* probably null Het
Cpsf2 C T 12: 101,963,501 (GRCm39) probably benign Het
Cyp11b2 G A 15: 74,725,490 (GRCm39) R210W probably damaging Het
Dock7 C T 4: 98,877,495 (GRCm39) V1048I probably benign Het
Dync2h1 C A 9: 7,077,979 (GRCm39) A2908S probably benign Het
Elane A G 10: 79,722,942 (GRCm39) D116G probably damaging Het
Epb41l2 C T 10: 25,383,714 (GRCm39) R153C probably damaging Het
Gucy2c G A 6: 136,699,418 (GRCm39) P617L probably damaging Het
H2ac21 G A 3: 96,127,439 (GRCm39) A70T probably damaging Het
Kcnq4 T A 4: 120,604,058 (GRCm39) I106L probably benign Het
Man2b1 A G 8: 85,823,458 (GRCm39) N931D possibly damaging Het
Mthfs A G 9: 89,097,443 (GRCm39) E100G probably damaging Het
Mto1 A T 9: 78,381,072 (GRCm39) I639F probably damaging Het
Myo15a A G 11: 60,378,077 (GRCm39) E177G probably damaging Het
Naip5 T A 13: 100,367,251 (GRCm39) M282L probably benign Het
Or10aa1 A G 1: 173,870,053 (GRCm39) D179G probably damaging Het
Pik3c2g G A 6: 139,903,425 (GRCm39) probably benign Het
Prl7d1 T A 13: 27,898,321 (GRCm39) M64L probably benign Het
Prnp A T 2: 131,778,444 (GRCm39) N32I probably damaging Het
Ptpn11 C T 5: 121,287,174 (GRCm39) V406I probably benign Het
Rab40c G A 17: 26,103,667 (GRCm39) T151I probably damaging Het
Rb1cc1 T A 1: 6,304,495 (GRCm39) probably null Het
Rnf145 T C 11: 44,415,815 (GRCm39) V10A probably benign Het
Rtn4rl2 T C 2: 84,711,036 (GRCm39) N70S probably damaging Het
Scaper A T 9: 55,766,326 (GRCm39) C483* probably null Het
Sema4a T A 3: 88,360,405 (GRCm39) Q58L possibly damaging Het
Slf1 T C 13: 77,249,067 (GRCm39) probably null Het
Sycp1 G T 3: 102,822,561 (GRCm39) N364K probably benign Het
Tenm4 T C 7: 96,545,482 (GRCm39) probably benign Het
Tnfaip2 A G 12: 111,417,141 (GRCm39) T537A probably damaging Het
Trappc12 A G 12: 28,753,596 (GRCm39) I573T possibly damaging Het
Ugt2b38 G A 5: 87,559,632 (GRCm39) T420I probably damaging Het
Ulk1 A T 5: 110,937,411 (GRCm39) probably benign Het
Unc80 G A 1: 66,688,103 (GRCm39) C2367Y possibly damaging Het
Usp7 C A 16: 8,521,366 (GRCm39) G135C probably damaging Het
Vmn2r103 A G 17: 20,014,189 (GRCm39) Y327C probably damaging Het
Vmn2r28 T A 7: 5,491,026 (GRCm39) H407L probably damaging Het
Zfr2 A G 10: 81,081,242 (GRCm39) K431E probably damaging Het
Zfy1 A T Y: 725,850 (GRCm39) Y638* probably null Het
Other mutations in Zfp804a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00466:Zfp804a APN 2 81,884,219 (GRCm39) missense probably benign 0.30
IGL02011:Zfp804a APN 2 82,087,035 (GRCm39) missense probably damaging 1.00
IGL02218:Zfp804a APN 2 82,089,546 (GRCm39) missense probably damaging 1.00
IGL02645:Zfp804a APN 2 81,884,220 (GRCm39) missense possibly damaging 0.94
PIT4431001:Zfp804a UTSW 2 82,089,536 (GRCm39) missense probably benign 0.04
R0027:Zfp804a UTSW 2 82,087,544 (GRCm39) missense probably damaging 1.00
R0167:Zfp804a UTSW 2 82,086,860 (GRCm39) missense probably damaging 1.00
R0437:Zfp804a UTSW 2 81,884,135 (GRCm39) start codon destroyed probably null 0.08
R0521:Zfp804a UTSW 2 82,089,761 (GRCm39) nonsense probably null
R0546:Zfp804a UTSW 2 82,089,264 (GRCm39) missense possibly damaging 0.91
R0609:Zfp804a UTSW 2 82,087,932 (GRCm39) missense probably damaging 1.00
R0694:Zfp804a UTSW 2 81,884,148 (GRCm39) missense probably damaging 1.00
R0947:Zfp804a UTSW 2 82,089,062 (GRCm39) missense possibly damaging 0.58
R1103:Zfp804a UTSW 2 82,087,844 (GRCm39) missense probably damaging 0.99
R1168:Zfp804a UTSW 2 82,087,041 (GRCm39) missense probably benign 0.43
R1365:Zfp804a UTSW 2 82,087,590 (GRCm39) missense probably benign 0.00
R1377:Zfp804a UTSW 2 82,088,841 (GRCm39) missense probably benign 0.39
R1501:Zfp804a UTSW 2 82,066,143 (GRCm39) missense probably damaging 1.00
R1526:Zfp804a UTSW 2 82,088,532 (GRCm39) missense probably benign
R1585:Zfp804a UTSW 2 81,884,095 (GRCm39) start gained probably benign
R1674:Zfp804a UTSW 2 82,089,168 (GRCm39) missense probably benign 0.35
R2058:Zfp804a UTSW 2 82,087,710 (GRCm39) missense probably benign 0.00
R2146:Zfp804a UTSW 2 82,089,008 (GRCm39) missense probably benign 0.02
R2149:Zfp804a UTSW 2 82,089,008 (GRCm39) missense probably benign 0.02
R2171:Zfp804a UTSW 2 82,087,527 (GRCm39) missense possibly damaging 0.77
R2307:Zfp804a UTSW 2 82,087,201 (GRCm39) missense probably benign 0.04
R2398:Zfp804a UTSW 2 82,089,013 (GRCm39) missense possibly damaging 0.95
R2496:Zfp804a UTSW 2 82,066,188 (GRCm39) missense probably damaging 1.00
R2504:Zfp804a UTSW 2 82,087,863 (GRCm39) missense probably benign 0.00
R2919:Zfp804a UTSW 2 82,066,160 (GRCm39) missense probably damaging 1.00
R2943:Zfp804a UTSW 2 82,066,223 (GRCm39) missense probably damaging 1.00
R3116:Zfp804a UTSW 2 82,089,761 (GRCm39) missense probably damaging 1.00
R4170:Zfp804a UTSW 2 82,083,832 (GRCm39) missense probably damaging 1.00
R4393:Zfp804a UTSW 2 82,087,265 (GRCm39) missense probably benign 0.43
R4701:Zfp804a UTSW 2 82,086,926 (GRCm39) missense probably damaging 1.00
R4771:Zfp804a UTSW 2 82,088,286 (GRCm39) missense probably benign 0.01
R4793:Zfp804a UTSW 2 82,066,186 (GRCm39) missense probably damaging 1.00
R5523:Zfp804a UTSW 2 82,089,339 (GRCm39) missense probably damaging 1.00
R5526:Zfp804a UTSW 2 82,088,934 (GRCm39) missense probably benign 0.00
R5961:Zfp804a UTSW 2 82,088,346 (GRCm39) missense probably benign
R6181:Zfp804a UTSW 2 82,087,486 (GRCm39) missense probably damaging 1.00
R6209:Zfp804a UTSW 2 82,088,462 (GRCm39) missense probably damaging 1.00
R6325:Zfp804a UTSW 2 82,087,382 (GRCm39) missense possibly damaging 0.80
R7147:Zfp804a UTSW 2 82,088,531 (GRCm39) missense probably benign 0.00
R7229:Zfp804a UTSW 2 82,088,969 (GRCm39) missense probably benign 0.04
R7666:Zfp804a UTSW 2 82,089,404 (GRCm39) nonsense probably null
R7910:Zfp804a UTSW 2 82,086,917 (GRCm39) missense probably damaging 1.00
R8256:Zfp804a UTSW 2 81,884,193 (GRCm39) missense probably damaging 0.99
R8669:Zfp804a UTSW 2 82,088,106 (GRCm39) missense probably damaging 1.00
R8738:Zfp804a UTSW 2 82,089,450 (GRCm39) missense probably damaging 1.00
R8749:Zfp804a UTSW 2 82,087,919 (GRCm39) missense probably benign 0.18
R8751:Zfp804a UTSW 2 82,066,190 (GRCm39) missense probably damaging 0.96
R8828:Zfp804a UTSW 2 82,089,459 (GRCm39) missense possibly damaging 0.74
R8834:Zfp804a UTSW 2 82,089,441 (GRCm39) missense possibly damaging 0.76
R8924:Zfp804a UTSW 2 82,088,747 (GRCm39) missense probably benign 0.03
R8982:Zfp804a UTSW 2 82,066,172 (GRCm39) missense probably damaging 1.00
R9459:Zfp804a UTSW 2 82,089,753 (GRCm39) missense probably damaging 1.00
R9570:Zfp804a UTSW 2 82,088,844 (GRCm39) missense probably benign 0.22
X0064:Zfp804a UTSW 2 82,066,167 (GRCm39) missense probably damaging 1.00
Z1177:Zfp804a UTSW 2 82,088,907 (GRCm39) missense probably benign 0.25
Predicted Primers PCR Primer
(F):5'- TCCATTGCCTTTACCAGAGCAAGC -3'
(R):5'- TGATTGGCATCTGAGGAGAAGCAAC -3'

Sequencing Primer
(F):5'- ATCTACCATGTGAGGTCTACCAG -3'
(R):5'- TCTGAGGAGAAGCAACCAAAGC -3'
Posted On 2013-10-16