Mutagenetix > Incidental Mutation

Incidental Mutation 'R0837:Vmn2r103'

78016

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r103

Ensembl Gene

ENSMUSG00000091771

Gene Name

vomeronasal 2, receptor 103

Synonyms

EG627636

MMRRC Submission

039016-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

R0837 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

19773363-19812536 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 19793927 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 327 (Y327C)

Ref Sequence

ENSEMBL: ENSMUSP00000126756 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172203]

AlphaFold

E9PWW0

Predicted Effect

probably damaging
Transcript: ENSMUST00000172203
AA Change: Y327C

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: Y327C

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	449	1.3e-37	PFAM
Pfam:NCD3G	509	562	3.5e-22	PFAM
Pfam:7tm_3	595	830	1.1e-51	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.4%
3x: 98.8%
10x: 97.4%
20x: 94.8%

Validation Efficiency

96% (44/46)

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930563I02Rik	T	C	14: 60,095,926 (GRCm38)		probably benign	Het
4930579C12Rik	A	G	9: 89,168,207 (GRCm38)		noncoding transcript	Het
Adam34	T	A	8: 43,651,500 (GRCm38)	K369N	probably benign	Het
Ap1g1	T	C	8: 109,851,065 (GRCm38)	W481R	probably damaging	Het
Bicdl1	G	A	5: 115,731,292 (GRCm38)	P26S	probably benign	Het
Cacna1c	A	T	6: 118,630,270 (GRCm38)	C1224*	probably null	Het
Cpsf2	C	T	12: 101,997,242 (GRCm38)		probably benign	Het
Cyp11b2	G	A	15: 74,853,641 (GRCm38)	R210W	probably damaging	Het
Dock7	C	T	4: 98,989,258 (GRCm38)	V1048I	probably benign	Het
Dync2h1	C	A	9: 7,077,979 (GRCm38)	A2908S	probably benign	Het
Elane	A	G	10: 79,887,108 (GRCm38)	D116G	probably damaging	Het
Epb41l2	C	T	10: 25,507,816 (GRCm38)	R153C	probably damaging	Het
Gucy2c	G	A	6: 136,722,420 (GRCm38)	P617L	probably damaging	Het
H2ac21	G	A	3: 96,220,123 (GRCm38)	A70T	probably damaging	Het
Kcnq4	T	A	4: 120,746,861 (GRCm38)	I106L	probably benign	Het
Man2b1	A	G	8: 85,096,829 (GRCm38)	N931D	possibly damaging	Het
Mthfs	A	G	9: 89,215,390 (GRCm38)	E100G	probably damaging	Het
Mto1	A	T	9: 78,473,790 (GRCm38)	I639F	probably damaging	Het
Myo15a	A	G	11: 60,487,251 (GRCm38)	E177G	probably damaging	Het
Naip5	T	A	13: 100,230,743 (GRCm38)	M282L	probably benign	Het
Or10aa1	A	G	1: 174,042,487 (GRCm38)	D179G	probably damaging	Het
Pik3c2g	G	A	6: 139,957,699 (GRCm38)		probably benign	Het
Prl7d1	T	A	13: 27,714,338 (GRCm38)	M64L	probably benign	Het
Prnp	A	T	2: 131,936,524 (GRCm38)	N32I	probably damaging	Het
Ptpn11	C	T	5: 121,149,111 (GRCm38)	V406I	probably benign	Het
Rab40c	G	A	17: 25,884,693 (GRCm38)	T151I	probably damaging	Het
Rb1cc1	T	A	1: 6,234,271 (GRCm38)		probably null	Het
Rnf145	T	C	11: 44,524,988 (GRCm38)	V10A	probably benign	Het
Rtn4rl2	T	C	2: 84,880,692 (GRCm38)	N70S	probably damaging	Het
Scaper	A	T	9: 55,859,042 (GRCm38)	C483*	probably null	Het
Sema4a	T	A	3: 88,453,098 (GRCm38)	Q58L	possibly damaging	Het
Slf1	T	C	13: 77,100,948 (GRCm38)		probably null	Het
Sycp1	G	T	3: 102,915,245 (GRCm38)	N364K	probably benign	Het
Tenm4	T	C	7: 96,896,275 (GRCm38)		probably benign	Het
Tnfaip2	A	G	12: 111,450,707 (GRCm38)	T537A	probably damaging	Het
Trappc12	A	G	12: 28,703,597 (GRCm38)	I573T	possibly damaging	Het
Ugt2b38	G	A	5: 87,411,773 (GRCm38)	T420I	probably damaging	Het
Ulk1	A	T	5: 110,789,545 (GRCm38)		probably benign	Het
Unc80	G	A	1: 66,648,944 (GRCm38)	C2367Y	possibly damaging	Het
Usp7	C	A	16: 8,703,502 (GRCm38)	G135C	probably damaging	Het
Vmn2r28	T	A	7: 5,488,027 (GRCm38)	H407L	probably damaging	Het
Zfp804a	A	C	2: 82,259,162 (GRCm38)	T1112P	probably damaging	Het
Zfr2	A	G	10: 81,245,408 (GRCm38)	K431E	probably damaging	Het
Zfy1	A	T	Y: 725,850 (GRCm38)	Y638*	probably null	Het

Other mutations in Vmn2r103

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00333:Vmn2r103	APN	17	19,793,102 (GRCm38)	missense	probably damaging	0.98
IGL00939:Vmn2r103	APN	17	19,794,965 (GRCm38)	missense	probably benign	0.00
IGL01120:Vmn2r103	APN	17	19,792,997 (GRCm38)	missense	probably benign	0.06
IGL01403:Vmn2r103	APN	17	19,792,967 (GRCm38)	missense	probably benign
IGL01404:Vmn2r103	APN	17	19,812,434 (GRCm38)	missense	probably damaging	1.00
IGL01713:Vmn2r103	APN	17	19,794,068 (GRCm38)	missense	probably damaging	1.00
IGL01802:Vmn2r103	APN	17	19,799,208 (GRCm38)	missense	probably benign
IGL02251:Vmn2r103	APN	17	19,793,969 (GRCm38)	missense	possibly damaging	0.84
IGL02466:Vmn2r103	APN	17	19,773,369 (GRCm38)	missense	probably benign
IGL02555:Vmn2r103	APN	17	19,811,611 (GRCm38)	missense	probably damaging	1.00
IGL02668:Vmn2r103	APN	17	19,794,127 (GRCm38)	missense	probably benign	0.03
IGL02715:Vmn2r103	APN	17	19,793,956 (GRCm38)	missense	probably damaging	0.97
IGL02735:Vmn2r103	APN	17	19,812,248 (GRCm38)	missense	probably benign	0.27
IGL03101:Vmn2r103	APN	17	19,773,520 (GRCm38)	missense	probably damaging	0.98
R0003:Vmn2r103	UTSW	17	19,811,979 (GRCm38)	missense	probably damaging	0.99
R0052:Vmn2r103	UTSW	17	19,811,641 (GRCm38)	missense	probably benign	0.01
R0375:Vmn2r103	UTSW	17	19,793,464 (GRCm38)	missense	probably benign	0.12
R0375:Vmn2r103	UTSW	17	19,792,859 (GRCm38)	missense	probably benign	0.06
R0755:Vmn2r103	UTSW	17	19,773,568 (GRCm38)	missense	probably benign	0.01
R1345:Vmn2r103	UTSW	17	19,794,247 (GRCm38)	missense	probably damaging	1.00
R1396:Vmn2r103	UTSW	17	19,792,968 (GRCm38)	missense	probably benign
R1488:Vmn2r103	UTSW	17	19,793,660 (GRCm38)	missense	probably damaging	0.97
R1533:Vmn2r103	UTSW	17	19,773,400 (GRCm38)	missense	probably benign	0.01
R1590:Vmn2r103	UTSW	17	19,794,234 (GRCm38)	missense	probably benign
R1928:Vmn2r103	UTSW	17	19,811,767 (GRCm38)	missense	possibly damaging	0.95
R1942:Vmn2r103	UTSW	17	19,812,300 (GRCm38)	missense	probably benign	0.02
R2071:Vmn2r103	UTSW	17	19,793,794 (GRCm38)	missense	probably benign
R2219:Vmn2r103	UTSW	17	19,793,647 (GRCm38)	missense	probably damaging	1.00
R2442:Vmn2r103	UTSW	17	19,773,531 (GRCm38)	missense	probably benign	0.00
R2889:Vmn2r103	UTSW	17	19,793,600 (GRCm38)	missense	probably damaging	1.00
R3762:Vmn2r103	UTSW	17	19,812,149 (GRCm38)	missense	probably damaging	0.98
R4014:Vmn2r103	UTSW	17	19,793,604 (GRCm38)	missense	possibly damaging	0.67
R4331:Vmn2r103	UTSW	17	19,794,233 (GRCm38)	missense	probably benign	0.00
R4630:Vmn2r103	UTSW	17	19,793,696 (GRCm38)	missense	probably benign	0.04
R4631:Vmn2r103	UTSW	17	19,793,696 (GRCm38)	missense	probably benign	0.04
R4632:Vmn2r103	UTSW	17	19,793,696 (GRCm38)	missense	probably benign	0.04
R4660:Vmn2r103	UTSW	17	19,811,815 (GRCm38)	missense	probably damaging	1.00
R4801:Vmn2r103	UTSW	17	19,795,076 (GRCm38)	missense	probably benign	0.06
R4802:Vmn2r103	UTSW	17	19,795,076 (GRCm38)	missense	probably benign	0.06
R4931:Vmn2r103	UTSW	17	19,811,769 (GRCm38)	missense	probably benign	0.01
R4995:Vmn2r103	UTSW	17	19,773,511 (GRCm38)	missense	probably benign	0.14
R5309:Vmn2r103	UTSW	17	19,793,034 (GRCm38)	missense	probably benign	0.01
R5312:Vmn2r103	UTSW	17	19,793,034 (GRCm38)	missense	probably benign	0.01
R5329:Vmn2r103	UTSW	17	19,812,171 (GRCm38)	missense	probably damaging	1.00
R5611:Vmn2r103	UTSW	17	19,793,642 (GRCm38)	missense	probably damaging	0.99
R5684:Vmn2r103	UTSW	17	19,792,989 (GRCm38)	missense	probably benign	0.02
R5715:Vmn2r103	UTSW	17	19,794,939 (GRCm38)	missense	probably benign	0.17
R5907:Vmn2r103	UTSW	17	19,812,453 (GRCm38)	missense	possibly damaging	0.67
R6029:Vmn2r103	UTSW	17	19,794,216 (GRCm38)	nonsense	probably null
R6114:Vmn2r103	UTSW	17	19,812,325 (GRCm38)	missense	probably damaging	0.99
R6285:Vmn2r103	UTSW	17	19,812,144 (GRCm38)	missense	probably benign
R6292:Vmn2r103	UTSW	17	19,793,604 (GRCm38)	missense	possibly damaging	0.67
R6334:Vmn2r103	UTSW	17	19,794,082 (GRCm38)	missense	probably damaging	0.97
R6501:Vmn2r103	UTSW	17	19,811,904 (GRCm38)	missense	probably benign	0.29
R6710:Vmn2r103	UTSW	17	19,811,977 (GRCm38)	missense	probably damaging	1.00
R6774:Vmn2r103	UTSW	17	19,773,511 (GRCm38)	missense	probably benign	0.14
R6981:Vmn2r103	UTSW	17	19,793,477 (GRCm38)	missense	probably benign	0.00
R7768:Vmn2r103	UTSW	17	19,812,052 (GRCm38)	missense	probably damaging	0.99
R7816:Vmn2r103	UTSW	17	19,794,214 (GRCm38)	missense	probably benign	0.06
R7885:Vmn2r103	UTSW	17	19,793,123 (GRCm38)	missense	probably benign	0.25
R8002:Vmn2r103	UTSW	17	19,799,249 (GRCm38)	missense	probably damaging	1.00
R8031:Vmn2r103	UTSW	17	19,793,497 (GRCm38)	missense	probably benign	0.00
R8140:Vmn2r103	UTSW	17	19,811,796 (GRCm38)	missense	probably damaging	1.00
R8186:Vmn2r103	UTSW	17	19,811,943 (GRCm38)	missense	probably damaging	1.00
R8559:Vmn2r103	UTSW	17	19,812,384 (GRCm38)	missense	probably benign	0.01
R9413:Vmn2r103	UTSW	17	19,811,896 (GRCm38)	missense	possibly damaging	0.54
R9591:Vmn2r103	UTSW	17	19,811,659 (GRCm38)	missense	possibly damaging	0.70
R9652:Vmn2r103	UTSW	17	19,793,765 (GRCm38)	missense	probably benign	0.01
R9680:Vmn2r103	UTSW	17	19,799,263 (GRCm38)	nonsense	probably null
R9743:Vmn2r103	UTSW	17	19,812,213 (GRCm38)	missense	probably damaging	1.00
Z1088:Vmn2r103	UTSW	17	19,795,047 (GRCm38)	missense	probably benign	0.08

Predicted Primers

PCR Primer
(F):5'- TGATCCCAGCCACATGGACTTCAC -3'
(R):5'- CTGCAAATCACTTATGCCAGAGTGC -3'

Sequencing Primer
(F):5'- AGCCACATGGACTTCACATTTTG -3'
(R):5'- ACAGTAGAAAGGTTATTACCTGCC -3'

Posted On

2013-10-16