Incidental Mutation 'R0837:Vmn2r103'
ID 78016
Institutional Source Beutler Lab
Gene Symbol Vmn2r103
Ensembl Gene ENSMUSG00000091771
Gene Name vomeronasal 2, receptor 103
Synonyms EG627636
MMRRC Submission 039016-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R0837 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 19773363-19812536 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 19793927 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 327 (Y327C)
Ref Sequence ENSEMBL: ENSMUSP00000126756 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000172203]
AlphaFold E9PWW0
Predicted Effect probably damaging
Transcript: ENSMUST00000172203
AA Change: Y327C

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: Y327C

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:ANF_receptor 82 449 1.3e-37 PFAM
Pfam:NCD3G 509 562 3.5e-22 PFAM
Pfam:7tm_3 595 830 1.1e-51 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.4%
  • 20x: 94.8%
Validation Efficiency 96% (44/46)
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930563I02Rik T C 14: 60,095,926 (GRCm38) probably benign Het
4930579C12Rik A G 9: 89,168,207 (GRCm38) noncoding transcript Het
Adam34 T A 8: 43,651,500 (GRCm38) K369N probably benign Het
Ap1g1 T C 8: 109,851,065 (GRCm38) W481R probably damaging Het
Bicdl1 G A 5: 115,731,292 (GRCm38) P26S probably benign Het
Cacna1c A T 6: 118,630,270 (GRCm38) C1224* probably null Het
Cpsf2 C T 12: 101,997,242 (GRCm38) probably benign Het
Cyp11b2 G A 15: 74,853,641 (GRCm38) R210W probably damaging Het
Dock7 C T 4: 98,989,258 (GRCm38) V1048I probably benign Het
Dync2h1 C A 9: 7,077,979 (GRCm38) A2908S probably benign Het
Elane A G 10: 79,887,108 (GRCm38) D116G probably damaging Het
Epb41l2 C T 10: 25,507,816 (GRCm38) R153C probably damaging Het
Gucy2c G A 6: 136,722,420 (GRCm38) P617L probably damaging Het
H2ac21 G A 3: 96,220,123 (GRCm38) A70T probably damaging Het
Kcnq4 T A 4: 120,746,861 (GRCm38) I106L probably benign Het
Man2b1 A G 8: 85,096,829 (GRCm38) N931D possibly damaging Het
Mthfs A G 9: 89,215,390 (GRCm38) E100G probably damaging Het
Mto1 A T 9: 78,473,790 (GRCm38) I639F probably damaging Het
Myo15a A G 11: 60,487,251 (GRCm38) E177G probably damaging Het
Naip5 T A 13: 100,230,743 (GRCm38) M282L probably benign Het
Or10aa1 A G 1: 174,042,487 (GRCm38) D179G probably damaging Het
Pik3c2g G A 6: 139,957,699 (GRCm38) probably benign Het
Prl7d1 T A 13: 27,714,338 (GRCm38) M64L probably benign Het
Prnp A T 2: 131,936,524 (GRCm38) N32I probably damaging Het
Ptpn11 C T 5: 121,149,111 (GRCm38) V406I probably benign Het
Rab40c G A 17: 25,884,693 (GRCm38) T151I probably damaging Het
Rb1cc1 T A 1: 6,234,271 (GRCm38) probably null Het
Rnf145 T C 11: 44,524,988 (GRCm38) V10A probably benign Het
Rtn4rl2 T C 2: 84,880,692 (GRCm38) N70S probably damaging Het
Scaper A T 9: 55,859,042 (GRCm38) C483* probably null Het
Sema4a T A 3: 88,453,098 (GRCm38) Q58L possibly damaging Het
Slf1 T C 13: 77,100,948 (GRCm38) probably null Het
Sycp1 G T 3: 102,915,245 (GRCm38) N364K probably benign Het
Tenm4 T C 7: 96,896,275 (GRCm38) probably benign Het
Tnfaip2 A G 12: 111,450,707 (GRCm38) T537A probably damaging Het
Trappc12 A G 12: 28,703,597 (GRCm38) I573T possibly damaging Het
Ugt2b38 G A 5: 87,411,773 (GRCm38) T420I probably damaging Het
Ulk1 A T 5: 110,789,545 (GRCm38) probably benign Het
Unc80 G A 1: 66,648,944 (GRCm38) C2367Y possibly damaging Het
Usp7 C A 16: 8,703,502 (GRCm38) G135C probably damaging Het
Vmn2r28 T A 7: 5,488,027 (GRCm38) H407L probably damaging Het
Zfp804a A C 2: 82,259,162 (GRCm38) T1112P probably damaging Het
Zfr2 A G 10: 81,245,408 (GRCm38) K431E probably damaging Het
Zfy1 A T Y: 725,850 (GRCm38) Y638* probably null Het
Other mutations in Vmn2r103
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00333:Vmn2r103 APN 17 19,793,102 (GRCm38) missense probably damaging 0.98
IGL00939:Vmn2r103 APN 17 19,794,965 (GRCm38) missense probably benign 0.00
IGL01120:Vmn2r103 APN 17 19,792,997 (GRCm38) missense probably benign 0.06
IGL01403:Vmn2r103 APN 17 19,792,967 (GRCm38) missense probably benign
IGL01404:Vmn2r103 APN 17 19,812,434 (GRCm38) missense probably damaging 1.00
IGL01713:Vmn2r103 APN 17 19,794,068 (GRCm38) missense probably damaging 1.00
IGL01802:Vmn2r103 APN 17 19,799,208 (GRCm38) missense probably benign
IGL02251:Vmn2r103 APN 17 19,793,969 (GRCm38) missense possibly damaging 0.84
IGL02466:Vmn2r103 APN 17 19,773,369 (GRCm38) missense probably benign
IGL02555:Vmn2r103 APN 17 19,811,611 (GRCm38) missense probably damaging 1.00
IGL02668:Vmn2r103 APN 17 19,794,127 (GRCm38) missense probably benign 0.03
IGL02715:Vmn2r103 APN 17 19,793,956 (GRCm38) missense probably damaging 0.97
IGL02735:Vmn2r103 APN 17 19,812,248 (GRCm38) missense probably benign 0.27
IGL03101:Vmn2r103 APN 17 19,773,520 (GRCm38) missense probably damaging 0.98
R0003:Vmn2r103 UTSW 17 19,811,979 (GRCm38) missense probably damaging 0.99
R0052:Vmn2r103 UTSW 17 19,811,641 (GRCm38) missense probably benign 0.01
R0375:Vmn2r103 UTSW 17 19,793,464 (GRCm38) missense probably benign 0.12
R0375:Vmn2r103 UTSW 17 19,792,859 (GRCm38) missense probably benign 0.06
R0755:Vmn2r103 UTSW 17 19,773,568 (GRCm38) missense probably benign 0.01
R1345:Vmn2r103 UTSW 17 19,794,247 (GRCm38) missense probably damaging 1.00
R1396:Vmn2r103 UTSW 17 19,792,968 (GRCm38) missense probably benign
R1488:Vmn2r103 UTSW 17 19,793,660 (GRCm38) missense probably damaging 0.97
R1533:Vmn2r103 UTSW 17 19,773,400 (GRCm38) missense probably benign 0.01
R1590:Vmn2r103 UTSW 17 19,794,234 (GRCm38) missense probably benign
R1928:Vmn2r103 UTSW 17 19,811,767 (GRCm38) missense possibly damaging 0.95
R1942:Vmn2r103 UTSW 17 19,812,300 (GRCm38) missense probably benign 0.02
R2071:Vmn2r103 UTSW 17 19,793,794 (GRCm38) missense probably benign
R2219:Vmn2r103 UTSW 17 19,793,647 (GRCm38) missense probably damaging 1.00
R2442:Vmn2r103 UTSW 17 19,773,531 (GRCm38) missense probably benign 0.00
R2889:Vmn2r103 UTSW 17 19,793,600 (GRCm38) missense probably damaging 1.00
R3762:Vmn2r103 UTSW 17 19,812,149 (GRCm38) missense probably damaging 0.98
R4014:Vmn2r103 UTSW 17 19,793,604 (GRCm38) missense possibly damaging 0.67
R4331:Vmn2r103 UTSW 17 19,794,233 (GRCm38) missense probably benign 0.00
R4630:Vmn2r103 UTSW 17 19,793,696 (GRCm38) missense probably benign 0.04
R4631:Vmn2r103 UTSW 17 19,793,696 (GRCm38) missense probably benign 0.04
R4632:Vmn2r103 UTSW 17 19,793,696 (GRCm38) missense probably benign 0.04
R4660:Vmn2r103 UTSW 17 19,811,815 (GRCm38) missense probably damaging 1.00
R4801:Vmn2r103 UTSW 17 19,795,076 (GRCm38) missense probably benign 0.06
R4802:Vmn2r103 UTSW 17 19,795,076 (GRCm38) missense probably benign 0.06
R4931:Vmn2r103 UTSW 17 19,811,769 (GRCm38) missense probably benign 0.01
R4995:Vmn2r103 UTSW 17 19,773,511 (GRCm38) missense probably benign 0.14
R5309:Vmn2r103 UTSW 17 19,793,034 (GRCm38) missense probably benign 0.01
R5312:Vmn2r103 UTSW 17 19,793,034 (GRCm38) missense probably benign 0.01
R5329:Vmn2r103 UTSW 17 19,812,171 (GRCm38) missense probably damaging 1.00
R5611:Vmn2r103 UTSW 17 19,793,642 (GRCm38) missense probably damaging 0.99
R5684:Vmn2r103 UTSW 17 19,792,989 (GRCm38) missense probably benign 0.02
R5715:Vmn2r103 UTSW 17 19,794,939 (GRCm38) missense probably benign 0.17
R5907:Vmn2r103 UTSW 17 19,812,453 (GRCm38) missense possibly damaging 0.67
R6029:Vmn2r103 UTSW 17 19,794,216 (GRCm38) nonsense probably null
R6114:Vmn2r103 UTSW 17 19,812,325 (GRCm38) missense probably damaging 0.99
R6285:Vmn2r103 UTSW 17 19,812,144 (GRCm38) missense probably benign
R6292:Vmn2r103 UTSW 17 19,793,604 (GRCm38) missense possibly damaging 0.67
R6334:Vmn2r103 UTSW 17 19,794,082 (GRCm38) missense probably damaging 0.97
R6501:Vmn2r103 UTSW 17 19,811,904 (GRCm38) missense probably benign 0.29
R6710:Vmn2r103 UTSW 17 19,811,977 (GRCm38) missense probably damaging 1.00
R6774:Vmn2r103 UTSW 17 19,773,511 (GRCm38) missense probably benign 0.14
R6981:Vmn2r103 UTSW 17 19,793,477 (GRCm38) missense probably benign 0.00
R7768:Vmn2r103 UTSW 17 19,812,052 (GRCm38) missense probably damaging 0.99
R7816:Vmn2r103 UTSW 17 19,794,214 (GRCm38) missense probably benign 0.06
R7885:Vmn2r103 UTSW 17 19,793,123 (GRCm38) missense probably benign 0.25
R8002:Vmn2r103 UTSW 17 19,799,249 (GRCm38) missense probably damaging 1.00
R8031:Vmn2r103 UTSW 17 19,793,497 (GRCm38) missense probably benign 0.00
R8140:Vmn2r103 UTSW 17 19,811,796 (GRCm38) missense probably damaging 1.00
R8186:Vmn2r103 UTSW 17 19,811,943 (GRCm38) missense probably damaging 1.00
R8559:Vmn2r103 UTSW 17 19,812,384 (GRCm38) missense probably benign 0.01
R9413:Vmn2r103 UTSW 17 19,811,896 (GRCm38) missense possibly damaging 0.54
R9591:Vmn2r103 UTSW 17 19,811,659 (GRCm38) missense possibly damaging 0.70
R9652:Vmn2r103 UTSW 17 19,793,765 (GRCm38) missense probably benign 0.01
R9680:Vmn2r103 UTSW 17 19,799,263 (GRCm38) nonsense probably null
R9743:Vmn2r103 UTSW 17 19,812,213 (GRCm38) missense probably damaging 1.00
Z1088:Vmn2r103 UTSW 17 19,795,047 (GRCm38) missense probably benign 0.08
Predicted Primers PCR Primer
(F):5'- TGATCCCAGCCACATGGACTTCAC -3'
(R):5'- CTGCAAATCACTTATGCCAGAGTGC -3'

Sequencing Primer
(F):5'- AGCCACATGGACTTCACATTTTG -3'
(R):5'- ACAGTAGAAAGGTTATTACCTGCC -3'
Posted On 2013-10-16