Incidental Mutation 'R0820:Dock11'
ID 78145
Institutional Source Beutler Lab
Gene Symbol Dock11
Ensembl Gene ENSMUSG00000031093
Gene Name dedicator of cytokinesis 11
Synonyms 5033414A21Rik, Zizimin2
MMRRC Submission 039000-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.234) question?
Stock # R0820 (G1)
Quality Score 222
Status Not validated
Chromosome X
Chromosomal Location 35152485-35340215 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 35283688 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Histidine at position 1102 (R1102H)
Ref Sequence ENSEMBL: ENSMUSP00000110921 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033419] [ENSMUST00000115266]
AlphaFold A2AF47
Predicted Effect probably damaging
Transcript: ENSMUST00000033419
AA Change: R1273H

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000033419
Gene: ENSMUSG00000031093
AA Change: R1273H

DomainStartEndE-ValueType
Pfam:DUF3398 52 145 4.2e-39 PFAM
PH 166 274 1.4e-17 SMART
Blast:PH 329 440 4e-58 BLAST
Pfam:DOCK-C2 636 827 2.4e-53 PFAM
low complexity region 1254 1270 N/A INTRINSIC
Pfam:DHR-2 1510 2029 7.3e-210 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000115266
AA Change: R1102H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000110921
Gene: ENSMUSG00000031093
AA Change: R1102H

DomainStartEndE-ValueType
PH 1 90 6.82e-7 SMART
Blast:PH 145 256 5e-58 BLAST
Pfam:DOCK-C2 451 644 1.3e-60 PFAM
low complexity region 1083 1099 N/A INTRINSIC
low complexity region 1521 1529 N/A INTRINSIC
Pfam:Ded_cyto 1681 1858 1.2e-68 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140175
Meta Mutation Damage Score 0.2849 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.5%
  • 10x: 96.2%
  • 20x: 90.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 3 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Trappc9 G A 15: 72,897,816 (GRCm39) R377W probably damaging Het
Vmn1r215 A G 13: 23,260,124 (GRCm39) M55V probably benign Het
Other mutations in Dock11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00536:Dock11 APN X 35,258,087 (GRCm39) missense probably benign 0.15
IGL00650:Dock11 APN X 35,270,246 (GRCm39) splice site probably benign
IGL00769:Dock11 APN X 35,267,715 (GRCm39) missense possibly damaging 0.74
IGL00963:Dock11 APN X 35,296,035 (GRCm39) missense possibly damaging 0.63
IGL01389:Dock11 APN X 35,256,701 (GRCm39) missense probably benign 0.43
IGL01410:Dock11 APN X 35,301,296 (GRCm39) missense probably damaging 1.00
IGL01519:Dock11 APN X 35,227,006 (GRCm39) missense probably benign
IGL02023:Dock11 APN X 35,232,422 (GRCm39) missense probably benign 0.09
IGL02253:Dock11 APN X 35,304,781 (GRCm39) missense probably damaging 1.00
IGL02416:Dock11 APN X 35,283,739 (GRCm39) missense probably damaging 0.97
IGL02583:Dock11 APN X 35,270,370 (GRCm39) missense possibly damaging 0.48
IGL03014:Dock11 APN X 35,310,699 (GRCm39) splice site probably benign
IGL03037:Dock11 APN X 35,310,699 (GRCm39) splice site probably benign
IGL03065:Dock11 APN X 35,310,699 (GRCm39) splice site probably benign
IGL03277:Dock11 APN X 35,277,603 (GRCm39) missense probably benign 0.32
R0816:Dock11 UTSW X 35,283,688 (GRCm39) missense probably damaging 1.00
R0819:Dock11 UTSW X 35,283,688 (GRCm39) missense probably damaging 1.00
R1430:Dock11 UTSW X 35,333,565 (GRCm39) missense probably benign 0.00
R1512:Dock11 UTSW X 35,283,688 (GRCm39) missense probably damaging 1.00
Z1088:Dock11 UTSW X 35,266,186 (GRCm39) missense probably benign 0.01
Z1176:Dock11 UTSW X 35,248,501 (GRCm39) missense possibly damaging 0.69
Predicted Primers PCR Primer
(F):5'- GATACTGTAGCAATGAAGACTCAGCCC -3'
(R):5'- CTGACTCCAGACAATACCAGTGATGC -3'

Sequencing Primer
(F):5'- TGAAGACTCAGCCCATTTACCTG -3'
(R):5'- TGCTATAGAGACAATGACTGACTCC -3'
Posted On 2013-10-16