Incidental Mutation 'R0828:Trpa1'
ID 78354
Institutional Source Beutler Lab
Gene Symbol Trpa1
Ensembl Gene ENSMUSG00000032769
Gene Name transient receptor potential cation channel, subfamily A, member 1
Synonyms ANKTM1
MMRRC Submission 039008-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.133) question?
Stock # R0828 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 14942872-14989086 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 14946108 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 1008 (V1008M)
Ref Sequence ENSEMBL: ENSMUSP00000043594 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041447]
AlphaFold Q8BLA8
Predicted Effect probably damaging
Transcript: ENSMUST00000041447
AA Change: V1008M

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000043594
Gene: ENSMUSG00000032769
AA Change: V1008M

DomainStartEndE-ValueType
ANK 63 94 1.01e2 SMART
ANK 98 127 9.7e-8 SMART
ANK 131 161 1.36e-2 SMART
ANK 165 194 5.45e-2 SMART
ANK 198 226 3.07e2 SMART
ANK 239 268 1.99e-4 SMART
ANK 272 302 1.33e2 SMART
ANK 309 338 4.19e-3 SMART
ANK 342 371 2.34e-1 SMART
ANK 413 442 3.41e-3 SMART
ANK 446 475 5.75e-1 SMART
ANK 482 511 4.1e-6 SMART
ANK 514 543 1.68e-2 SMART
ANK 548 577 4.97e-5 SMART
Blast:ANK 580 609 2e-11 BLAST
Pfam:Ion_trans 736 975 1.8e-11 PFAM
Meta Mutation Damage Score 0.1646 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.7%
  • 10x: 97.1%
  • 20x: 93.8%
Validation Efficiency 98% (59/60)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mutations in this gene result in altered nociception and neuron responses to isothiocyanate or thiosulfinate compounds like those found in mustard oil and garlic. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730522E02Rik C T 11: 25,602,020 (GRCm39) C70Y unknown Het
Abi3bp C T 16: 56,498,193 (GRCm39) T929I probably damaging Het
Adap2 C A 11: 80,056,490 (GRCm39) probably benign Het
Adgrg5 A G 8: 95,668,413 (GRCm39) probably null Het
Afdn C A 17: 14,124,260 (GRCm39) N1803K probably damaging Het
Alox12b T C 11: 69,057,132 (GRCm39) L451P possibly damaging Het
Ankrd26 T C 6: 118,510,434 (GRCm39) probably benign Het
Bcr A T 10: 74,993,039 (GRCm39) probably benign Het
Cacna1c T C 6: 118,734,347 (GRCm39) N300D probably benign Het
Camsap1 G T 2: 25,829,097 (GRCm39) Q876K probably damaging Het
Cdh10 A G 15: 18,986,837 (GRCm39) D356G possibly damaging Het
Cdipt T A 7: 126,576,092 (GRCm39) Y16N probably damaging Het
Cebpz T C 17: 79,233,411 (GRCm39) E772G probably benign Het
Cep350 A G 1: 155,828,992 (GRCm39) I304T probably benign Het
Chpt1 C A 10: 88,312,277 (GRCm39) G9V probably damaging Het
Col6a5 T A 9: 105,739,263 (GRCm39) probably null Het
Dock7 G T 4: 98,903,982 (GRCm39) P688T probably damaging Het
Ephb3 T A 16: 21,037,784 (GRCm39) probably benign Het
Fcgr2b T C 1: 170,788,599 (GRCm39) Y336C probably damaging Het
Flg2 A T 3: 93,110,639 (GRCm39) H889L unknown Het
Gucy2c C T 6: 136,686,746 (GRCm39) V806M probably damaging Het
Hmgxb3 T A 18: 61,304,426 (GRCm39) I55F probably damaging Het
Igsf9b T A 9: 27,230,901 (GRCm39) Y301* probably null Het
Il12rb2 C T 6: 67,333,691 (GRCm39) R196H probably benign Het
Itgam T C 7: 127,715,677 (GRCm39) probably null Het
Klhl25 T C 7: 75,515,943 (GRCm39) V283A probably damaging Het
Klhl5 T C 5: 65,320,135 (GRCm39) L423P probably damaging Het
Krt6a T C 15: 101,602,271 (GRCm39) N138S probably damaging Het
Lrba A T 3: 86,515,677 (GRCm39) probably null Het
Map4k5 T C 12: 69,852,100 (GRCm39) T828A probably damaging Het
Marchf8 T A 6: 116,382,639 (GRCm39) M434K probably benign Het
Mink1 C T 11: 70,500,971 (GRCm39) Q743* probably null Het
Mrgpra3 T C 7: 47,239,884 (GRCm39) N14S probably benign Het
Mroh7 T C 4: 106,557,073 (GRCm39) S808G probably damaging Het
Msi1 T C 5: 115,568,953 (GRCm39) probably null Het
Nrap A G 19: 56,333,990 (GRCm39) Y874H probably damaging Het
Nup205 T C 6: 35,171,501 (GRCm39) F455L probably benign Het
Or2t1 G T 14: 14,328,800 (GRCm38) V230L probably benign Het
Piwil2 A G 14: 70,613,466 (GRCm39) V894A probably damaging Het
Polr1c A G 17: 46,555,990 (GRCm39) S173P probably damaging Het
Pphln1-ps1 A G 16: 13,495,669 (GRCm39) Y256C probably damaging Het
Prep C T 10: 45,031,621 (GRCm39) A564V probably benign Het
Rab3gap1 T C 1: 127,865,922 (GRCm39) probably benign Het
Rcc1 G C 4: 132,063,136 (GRCm39) probably benign Het
Scn11a T A 9: 119,584,073 (GRCm39) D1514V probably benign Het
Setdb1 G A 3: 95,246,171 (GRCm39) P584S probably damaging Het
Slc12a7 A G 13: 73,936,771 (GRCm39) I144V probably benign Het
Slc45a4 T C 15: 73,458,665 (GRCm39) M295V probably benign Het
Slco1a1 T A 6: 141,867,565 (GRCm39) D456V possibly damaging Het
Sspo G T 6: 48,475,668 (GRCm39) C4928F probably damaging Het
St6galnac1 T A 11: 116,659,823 (GRCm39) K163N probably benign Het
Tcp11l1 A T 2: 104,530,181 (GRCm39) probably benign Het
Tns1 T A 1: 73,958,825 (GRCm39) I1715F probably damaging Het
Ttc28 A G 5: 111,371,312 (GRCm39) E587G probably damaging Het
Ubr4 T C 4: 139,177,864 (GRCm39) probably benign Het
Ugcg C T 4: 59,207,798 (GRCm39) P46S probably benign Het
Usp8 G A 2: 126,584,034 (GRCm39) probably benign Het
Zfc3h1 G T 10: 115,237,612 (GRCm39) A464S possibly damaging Het
Zfp106 T C 2: 120,366,084 (GRCm39) I108V probably benign Het
Other mutations in Trpa1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00801:Trpa1 APN 1 14,961,557 (GRCm39) missense probably damaging 0.97
IGL00937:Trpa1 APN 1 14,950,501 (GRCm39) splice site probably benign
IGL00957:Trpa1 APN 1 14,951,892 (GRCm39) missense probably damaging 0.99
IGL01307:Trpa1 APN 1 14,966,771 (GRCm39) missense probably benign 0.23
IGL01336:Trpa1 APN 1 14,957,104 (GRCm39) splice site probably benign
IGL01408:Trpa1 APN 1 14,959,637 (GRCm39) missense probably benign 0.03
IGL01504:Trpa1 APN 1 14,952,443 (GRCm39) missense possibly damaging 0.79
IGL01543:Trpa1 APN 1 14,970,300 (GRCm39) missense probably damaging 1.00
IGL01609:Trpa1 APN 1 14,982,607 (GRCm39) missense probably damaging 0.99
IGL01895:Trpa1 APN 1 14,957,867 (GRCm39) missense possibly damaging 0.87
IGL02449:Trpa1 APN 1 14,968,381 (GRCm39) missense probably damaging 1.00
IGL02936:Trpa1 APN 1 14,946,193 (GRCm39) splice site probably null
fear-2 UTSW 1 14,961,527 (GRCm39) critical splice donor site probably null
petrified UTSW 1 14,954,340 (GRCm39) missense probably damaging 1.00
R0008:Trpa1 UTSW 1 14,973,439 (GRCm39) missense possibly damaging 0.53
R0008:Trpa1 UTSW 1 14,973,439 (GRCm39) missense possibly damaging 0.53
R0317:Trpa1 UTSW 1 14,951,856 (GRCm39) missense probably benign 0.03
R0454:Trpa1 UTSW 1 14,955,972 (GRCm39) critical splice donor site probably null
R0944:Trpa1 UTSW 1 14,982,585 (GRCm39) splice site probably null
R0962:Trpa1 UTSW 1 14,968,387 (GRCm39) missense possibly damaging 0.61
R1025:Trpa1 UTSW 1 14,974,407 (GRCm39) missense probably benign 0.01
R1035:Trpa1 UTSW 1 14,961,527 (GRCm39) critical splice donor site probably null
R1134:Trpa1 UTSW 1 14,951,972 (GRCm39) missense possibly damaging 0.95
R1278:Trpa1 UTSW 1 14,988,947 (GRCm39) critical splice donor site probably null
R1497:Trpa1 UTSW 1 14,956,036 (GRCm39) missense probably benign 0.30
R1617:Trpa1 UTSW 1 14,943,899 (GRCm39) missense probably damaging 1.00
R1800:Trpa1 UTSW 1 14,944,648 (GRCm39) missense probably benign 0.04
R1856:Trpa1 UTSW 1 14,969,612 (GRCm39) nonsense probably null
R1886:Trpa1 UTSW 1 14,959,649 (GRCm39) missense probably benign 0.00
R2004:Trpa1 UTSW 1 14,976,207 (GRCm39) missense possibly damaging 0.83
R2152:Trpa1 UTSW 1 14,969,625 (GRCm39) missense probably damaging 1.00
R2172:Trpa1 UTSW 1 14,951,880 (GRCm39) missense probably benign 0.01
R2198:Trpa1 UTSW 1 14,980,970 (GRCm39) missense probably benign
R2221:Trpa1 UTSW 1 14,973,480 (GRCm39) missense probably null 0.12
R2223:Trpa1 UTSW 1 14,973,480 (GRCm39) missense probably null 0.12
R2307:Trpa1 UTSW 1 14,982,605 (GRCm39) missense probably benign 0.00
R2338:Trpa1 UTSW 1 14,954,469 (GRCm39) missense probably damaging 0.97
R2698:Trpa1 UTSW 1 14,976,222 (GRCm39) missense probably damaging 1.00
R2872:Trpa1 UTSW 1 14,957,844 (GRCm39) missense probably damaging 1.00
R2872:Trpa1 UTSW 1 14,957,844 (GRCm39) missense probably damaging 1.00
R2873:Trpa1 UTSW 1 14,957,844 (GRCm39) missense probably damaging 1.00
R2874:Trpa1 UTSW 1 14,957,844 (GRCm39) missense probably damaging 1.00
R3418:Trpa1 UTSW 1 14,944,605 (GRCm39) missense probably benign 0.01
R3419:Trpa1 UTSW 1 14,944,605 (GRCm39) missense probably benign 0.01
R3796:Trpa1 UTSW 1 14,963,488 (GRCm39) missense possibly damaging 0.74
R3799:Trpa1 UTSW 1 14,963,488 (GRCm39) missense possibly damaging 0.74
R4238:Trpa1 UTSW 1 14,954,340 (GRCm39) missense probably damaging 1.00
R4320:Trpa1 UTSW 1 14,944,676 (GRCm39) missense probably benign 0.00
R4591:Trpa1 UTSW 1 14,952,332 (GRCm39) splice site probably null
R4834:Trpa1 UTSW 1 14,966,747 (GRCm39) missense possibly damaging 0.72
R4991:Trpa1 UTSW 1 14,980,970 (GRCm39) missense probably benign 0.00
R4999:Trpa1 UTSW 1 14,946,085 (GRCm39) missense probably benign 0.05
R5038:Trpa1 UTSW 1 14,981,090 (GRCm39) missense probably damaging 1.00
R5055:Trpa1 UTSW 1 14,946,183 (GRCm39) missense probably damaging 1.00
R5158:Trpa1 UTSW 1 14,951,885 (GRCm39) missense probably benign 0.01
R5193:Trpa1 UTSW 1 14,946,141 (GRCm39) missense possibly damaging 0.92
R5558:Trpa1 UTSW 1 14,968,492 (GRCm39) missense probably damaging 1.00
R5578:Trpa1 UTSW 1 14,957,232 (GRCm39) missense probably damaging 1.00
R5680:Trpa1 UTSW 1 14,946,078 (GRCm39) missense probably benign 0.00
R5738:Trpa1 UTSW 1 14,946,174 (GRCm39) missense probably damaging 1.00
R5801:Trpa1 UTSW 1 14,968,302 (GRCm39) missense probably damaging 1.00
R5945:Trpa1 UTSW 1 14,968,359 (GRCm39) missense probably benign 0.03
R6092:Trpa1 UTSW 1 14,959,710 (GRCm39) missense probably damaging 1.00
R6776:Trpa1 UTSW 1 14,982,601 (GRCm39) missense probably benign
R7126:Trpa1 UTSW 1 14,960,648 (GRCm39) missense probably benign 0.00
R7154:Trpa1 UTSW 1 14,952,457 (GRCm39) missense possibly damaging 0.46
R7175:Trpa1 UTSW 1 14,963,431 (GRCm39) missense possibly damaging 0.90
R7258:Trpa1 UTSW 1 14,973,473 (GRCm39) missense probably damaging 1.00
R7358:Trpa1 UTSW 1 14,968,334 (GRCm39) missense probably damaging 1.00
R7412:Trpa1 UTSW 1 14,954,422 (GRCm39) missense probably benign 0.43
R7639:Trpa1 UTSW 1 14,957,137 (GRCm39) missense probably benign 0.00
R7740:Trpa1 UTSW 1 14,982,625 (GRCm39) missense possibly damaging 0.72
R7815:Trpa1 UTSW 1 14,974,486 (GRCm39) missense probably benign 0.01
R7854:Trpa1 UTSW 1 14,951,918 (GRCm39) missense probably benign 0.00
R8112:Trpa1 UTSW 1 14,974,490 (GRCm39) missense probably benign
R8217:Trpa1 UTSW 1 14,957,247 (GRCm39) missense probably damaging 0.97
R8711:Trpa1 UTSW 1 14,980,998 (GRCm39) missense probably damaging 1.00
R8834:Trpa1 UTSW 1 14,963,528 (GRCm39) missense possibly damaging 0.60
R8907:Trpa1 UTSW 1 14,963,563 (GRCm39) missense probably damaging 1.00
R8907:Trpa1 UTSW 1 14,959,664 (GRCm39) missense probably benign 0.00
R9058:Trpa1 UTSW 1 14,959,618 (GRCm39) missense probably damaging 1.00
R9135:Trpa1 UTSW 1 14,952,435 (GRCm39) missense probably damaging 1.00
R9261:Trpa1 UTSW 1 14,963,465 (GRCm39) missense probably damaging 1.00
R9266:Trpa1 UTSW 1 14,980,953 (GRCm39) critical splice donor site probably null
R9287:Trpa1 UTSW 1 14,956,040 (GRCm39) nonsense probably null
R9323:Trpa1 UTSW 1 14,968,564 (GRCm39) missense probably benign 0.01
R9379:Trpa1 UTSW 1 14,966,739 (GRCm39) missense possibly damaging 0.64
R9497:Trpa1 UTSW 1 14,989,026 (GRCm39) missense probably benign 0.02
R9616:Trpa1 UTSW 1 14,989,077 (GRCm39) start gained probably benign
R9666:Trpa1 UTSW 1 14,973,455 (GRCm39) missense possibly damaging 0.67
X0028:Trpa1 UTSW 1 14,960,644 (GRCm39) missense probably benign 0.16
Z1176:Trpa1 UTSW 1 14,968,574 (GRCm39) missense probably damaging 1.00
Z1176:Trpa1 UTSW 1 14,961,530 (GRCm39) missense possibly damaging 0.80
Z1176:Trpa1 UTSW 1 14,951,916 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTAAAGCAGCCTCATCTACCTGCC -3'
(R):5'- GAAGACAACCTAGTCAGCTCGCTC -3'

Sequencing Primer
(F):5'- CATATGCTGCTGTGCATGAAC -3'
(R):5'- TTGAGACACGGGAATCCATT -3'
Posted On 2013-10-16