Incidental Mutation 'R0829:Lrrc74b'
ID 78445
Institutional Source Beutler Lab
Gene Symbol Lrrc74b
Ensembl Gene ENSMUSG00000022759
Gene Name leucine rich repeat containing 74B
Synonyms 4930451C15Rik
MMRRC Submission 039009-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.117) question?
Stock # R0829 (G1)
Quality Score 138
Status Validated
Chromosome 16
Chromosomal Location 17362329-17379111 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 17376254 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000155867 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023441] [ENSMUST00000023442] [ENSMUST00000065125] [ENSMUST00000100123] [ENSMUST00000171002] [ENSMUST00000232637] [ENSMUST00000231806]
AlphaFold Q14BP6
Predicted Effect probably benign
Transcript: ENSMUST00000023441
SMART Domains Protein: ENSMUSP00000023441
Gene: ENSMUSG00000022758

DomainStartEndE-ValueType
low complexity region 12 18 N/A INTRINSIC
Pfam:P2X_receptor 25 385 7.9e-139 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000023442
SMART Domains Protein: ENSMUSP00000023442
Gene: ENSMUSG00000022759

DomainStartEndE-ValueType
LRR 71 103 3.9e0 SMART
LRR 104 131 1.04e-3 SMART
LRR 132 159 1.14e1 SMART
LRR 160 187 7.78e-3 SMART
LRR 188 215 3.9e0 SMART
LRR 216 243 7.89e-1 SMART
LRR 244 271 6.78e-3 SMART
LRR 272 299 5.51e-1 SMART
low complexity region 342 355 N/A INTRINSIC
Predicted Effect
SMART Domains Protein: ENSMUSP00000070127
Gene: ENSMUSG00000022759

DomainStartEndE-ValueType
LRR 71 103 3.9e0 SMART
LRR 104 131 1.04e-3 SMART
LRR 132 159 1.14e1 SMART
LRR 160 187 7.78e-3 SMART
LRR 188 215 3.9e0 SMART
LRR 216 243 7.89e-1 SMART
LRR 244 271 6.78e-3 SMART
LRR 272 299 5.51e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000100123
SMART Domains Protein: ENSMUSP00000097699
Gene: ENSMUSG00000022759

DomainStartEndE-ValueType
LRR 71 103 3.9e0 SMART
LRR 104 131 1.04e-3 SMART
LRR 132 159 1.14e1 SMART
LRR 160 187 7.78e-3 SMART
LRR 188 215 3.9e0 SMART
LRR 216 243 7.89e-1 SMART
LRR 244 271 6.78e-3 SMART
LRR 272 299 5.51e-1 SMART
LRR 300 327 4.16e0 SMART
low complexity region 374 387 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138839
Predicted Effect probably benign
Transcript: ENSMUST00000171002
SMART Domains Protein: ENSMUSP00000132727
Gene: ENSMUSG00000022758

DomainStartEndE-ValueType
low complexity region 12 18 N/A INTRINSIC
Pfam:P2X_receptor 25 197 1e-65 PFAM
Pfam:P2X_receptor 185 362 7e-63 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000232637
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232230
Predicted Effect probably benign
Transcript: ENSMUST00000231806
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.4%
  • 20x: 94.7%
Validation Efficiency 95% (37/39)
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adprh C A 16: 38,266,150 (GRCm39) A331S probably benign Het
Atp4b T G 8: 13,440,098 (GRCm39) T83P probably damaging Het
Ccdc177 T C 12: 80,806,253 (GRCm39) E7G probably damaging Het
Cercam G T 2: 29,761,079 (GRCm39) R126L probably damaging Het
Cpb1 C T 3: 20,306,107 (GRCm39) probably benign Het
Dnah7a T C 1: 53,543,238 (GRCm39) M2311V probably benign Het
Dnah9 C A 11: 65,896,002 (GRCm39) V2458L probably benign Het
Dnajb6 T C 5: 29,990,020 (GRCm39) probably benign Het
Dst A G 1: 34,202,301 (GRCm39) T210A probably damaging Het
Gfpt1 T C 6: 87,030,847 (GRCm39) probably benign Het
Grin1 C T 2: 25,188,460 (GRCm39) D429N probably benign Het
Iqck T C 7: 118,499,111 (GRCm39) probably null Het
Itgb5 A G 16: 33,764,571 (GRCm39) I359V probably benign Het
Lemd3 T C 10: 120,814,988 (GRCm39) T82A probably benign Het
Mitf A T 6: 97,980,869 (GRCm39) I246F possibly damaging Het
Msgn1 C T 12: 11,258,525 (GRCm39) R142Q probably damaging Het
Myh8 C A 11: 67,174,326 (GRCm39) probably benign Het
Nacad C A 11: 6,551,158 (GRCm39) V678L probably benign Het
Nomo1 A G 7: 45,725,596 (GRCm39) probably benign Het
Ofcc1 C T 13: 40,362,305 (GRCm39) G206R probably benign Het
Or1s2 T A 19: 13,758,556 (GRCm39) D191E probably damaging Het
Or4c100 A T 2: 88,356,572 (GRCm39) Y215F probably damaging Het
Or4l15 C A 14: 50,198,503 (GRCm39) V9L probably benign Het
Or6d13 A G 6: 116,518,226 (GRCm39) T271A probably benign Het
Pcdh15 T A 10: 74,338,598 (GRCm39) V1068E probably damaging Het
Plat A G 8: 23,262,273 (GRCm39) Y99C probably damaging Het
Potefam1 G A 2: 111,028,450 (GRCm39) T42I possibly damaging Het
Rasl10b G A 11: 83,308,665 (GRCm39) probably null Het
Rbm25 T C 12: 83,707,150 (GRCm39) probably benign Het
Scaf11 T C 15: 96,316,570 (GRCm39) D998G probably damaging Het
Serpinb6a A G 13: 34,119,684 (GRCm39) probably benign Het
Spef2 T C 15: 9,687,899 (GRCm39) I507M probably benign Het
Srebf2 T A 15: 82,061,790 (GRCm39) probably null Het
Stimate C T 14: 30,584,842 (GRCm39) R56C probably damaging Het
Tert T C 13: 73,792,504 (GRCm39) C924R probably damaging Het
Usp19 T C 9: 108,371,000 (GRCm39) S221P probably benign Het
Xkr4 C T 1: 3,741,469 (GRCm39) A35T possibly damaging Het
Zbtb14 C A 17: 69,695,497 (GRCm39) F398L probably damaging Het
Other mutations in Lrrc74b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01810:Lrrc74b APN 16 17,363,422 (GRCm39) missense probably benign 0.00
IGL02402:Lrrc74b APN 16 17,376,028 (GRCm39) splice site probably benign
P0043:Lrrc74b UTSW 16 17,376,023 (GRCm39) splice site probably benign
R0131:Lrrc74b UTSW 16 17,371,016 (GRCm39) missense probably damaging 1.00
R0131:Lrrc74b UTSW 16 17,371,016 (GRCm39) missense probably damaging 1.00
R0132:Lrrc74b UTSW 16 17,371,016 (GRCm39) missense probably damaging 1.00
R1463:Lrrc74b UTSW 16 17,377,737 (GRCm39) missense probably benign 0.00
R1681:Lrrc74b UTSW 16 17,377,617 (GRCm39) missense probably damaging 1.00
R1938:Lrrc74b UTSW 16 17,371,058 (GRCm39) missense probably benign 0.41
R4790:Lrrc74b UTSW 16 17,367,717 (GRCm39) missense probably damaging 1.00
R5428:Lrrc74b UTSW 16 17,376,125 (GRCm39) missense probably damaging 0.99
R6198:Lrrc74b UTSW 16 17,366,650 (GRCm39) missense probably damaging 0.96
R7910:Lrrc74b UTSW 16 17,376,213 (GRCm39) nonsense probably null
R8233:Lrrc74b UTSW 16 17,376,089 (GRCm39) missense probably benign 0.00
R8957:Lrrc74b UTSW 16 17,378,976 (GRCm39) missense probably benign 0.09
R9030:Lrrc74b UTSW 16 17,367,640 (GRCm39) critical splice donor site probably null
X0063:Lrrc74b UTSW 16 17,371,072 (GRCm39) missense probably benign 0.05
Z1177:Lrrc74b UTSW 16 17,376,036 (GRCm39) missense probably damaging 1.00
Z1177:Lrrc74b UTSW 16 17,376,032 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- CCATGACTGCCCAGACTTTGTTACC -3'
(R):5'- TGCTACCACAGCATTCTTCACAGAC -3'

Sequencing Primer
(F):5'- TTACCTGCCAGGTCATTGAG -3'
(R):5'- TCTTCACAGACAGTCATGGAGTG -3'
Posted On 2013-10-16