Incidental Mutation 'R0815:Fbxo21'
ID 78565
Institutional Source Beutler Lab
Gene Symbol Fbxo21
Ensembl Gene ENSMUSG00000032898
Gene Name F-box protein 21
Synonyms 2810425J22Rik
MMRRC Submission 038995-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.204) question?
Stock # R0815 (G1)
Quality Score 211
Status Validated
Chromosome 5
Chromosomal Location 118114835-118148263 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 118133573 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000143873 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035579] [ENSMUST00000202447]
AlphaFold Q8VDH1
Predicted Effect probably benign
Transcript: ENSMUST00000035579
SMART Domains Protein: ENSMUSP00000035506
Gene: ENSMUSG00000032898

DomainStartEndE-ValueType
low complexity region 15 24 N/A INTRINSIC
Blast:FBOX 33 73 6e-8 BLAST
Pfam:Transglut_core2 215 390 3e-43 PFAM
low complexity region 482 491 N/A INTRINSIC
YccV-like 500 597 8.22e-39 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000201611
Predicted Effect probably benign
Transcript: ENSMUST00000202447
SMART Domains Protein: ENSMUSP00000143873
Gene: ENSMUSG00000032898

DomainStartEndE-ValueType
low complexity region 15 24 N/A INTRINSIC
Blast:FBOX 33 73 6e-8 BLAST
Pfam:Transglut_core2 215 390 3e-43 PFAM
low complexity region 482 491 N/A INTRINSIC
YccV-like 500 597 8.22e-39 SMART
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 96.5%
  • 20x: 91.3%
Validation Efficiency 97% (58/60)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 A G 12: 118,865,184 (GRCm39) probably benign Het
Abcf2 A T 5: 24,772,268 (GRCm39) Y487N probably damaging Het
Adcy4 T C 14: 56,021,056 (GRCm39) Y27C probably damaging Het
Atp2a2 T C 5: 122,609,299 (GRCm39) I188V probably benign Het
Cacna1s A T 1: 136,040,695 (GRCm39) I1231F possibly damaging Het
Capn7 T A 14: 31,091,714 (GRCm39) C704S possibly damaging Het
Celsr2 G T 3: 108,308,617 (GRCm39) T1770K possibly damaging Het
Chmp7 C T 14: 69,956,899 (GRCm39) M336I probably benign Het
Cul9 T C 17: 46,848,748 (GRCm39) probably null Het
Dpp10 A G 1: 123,360,658 (GRCm39) probably null Het
Dscaml1 A G 9: 45,656,372 (GRCm39) I1571V probably benign Het
Eif3j2 T A 18: 43,610,036 (GRCm39) Y259F probably benign Het
Erc2 A C 14: 27,747,105 (GRCm39) N345T probably benign Het
Frmd8 A T 19: 5,915,084 (GRCm39) probably benign Het
Gfm1 T C 3: 67,381,928 (GRCm39) S705P probably damaging Het
Gucy1b2 T C 14: 62,656,511 (GRCm39) D282G probably benign Het
H2-Ab1 T C 17: 34,486,328 (GRCm39) I129T probably damaging Het
H2-M10.3 T A 17: 36,677,582 (GRCm39) Y232F probably damaging Het
Lipm A T 19: 34,096,161 (GRCm39) T326S probably benign Het
Lrrc8c T C 5: 105,756,400 (GRCm39) L725P probably damaging Het
Map3k19 A G 1: 127,762,375 (GRCm39) probably benign Het
Med31 T A 11: 72,104,657 (GRCm39) N50I probably damaging Het
Myo15b T G 11: 115,757,162 (GRCm39) probably benign Het
Nemp1 T C 10: 127,528,893 (GRCm39) L199S probably damaging Het
Nod2 G A 8: 89,399,290 (GRCm39) probably benign Het
Oga C T 19: 45,771,425 (GRCm39) A49T probably benign Het
Or2ak6 A G 11: 58,593,435 (GRCm39) R303G possibly damaging Het
Or5b21 A G 19: 12,840,008 (GRCm39) I290V probably benign Het
Parva G A 7: 112,167,071 (GRCm39) V215M probably damaging Het
Phf1 T C 17: 27,156,114 (GRCm39) probably benign Het
Plscr1l1 A T 9: 92,233,140 (GRCm39) I88L possibly damaging Het
Ppp1r12c G T 7: 4,489,365 (GRCm39) Q240K probably damaging Het
Ralgapa1 A T 12: 55,809,466 (GRCm39) Y436* probably null Het
Ralgapa1 C A 12: 55,829,562 (GRCm39) probably benign Het
Rbm11 C T 16: 75,393,525 (GRCm39) R74C probably damaging Het
Robo3 A G 9: 37,333,479 (GRCm39) V744A probably damaging Het
Rsbn1 T G 3: 103,861,469 (GRCm39) S522A probably damaging Het
Scel T A 14: 103,823,916 (GRCm39) S381R possibly damaging Het
Sec31b G A 19: 44,506,612 (GRCm39) Q909* probably null Het
Slc38a11 T A 2: 65,184,124 (GRCm39) I176L possibly damaging Het
Slc39a4 C T 15: 76,496,839 (GRCm39) D574N probably damaging Het
Slc44a1 T G 4: 53,536,421 (GRCm39) V199G possibly damaging Het
Sltm A G 9: 70,469,190 (GRCm39) T150A probably benign Het
Son C A 16: 91,452,372 (GRCm39) A373D probably damaging Het
Sp140 C T 1: 85,547,772 (GRCm39) probably benign Het
Speg A G 1: 75,392,036 (GRCm39) Y1606C probably damaging Het
Srgap1 A T 10: 121,621,379 (GRCm39) V1061D probably damaging Het
Stat5a A G 11: 100,765,908 (GRCm39) probably null Het
Supt4a T A 11: 87,628,409 (GRCm39) probably benign Het
Teddm1b A G 1: 153,750,638 (GRCm39) K149R possibly damaging Het
Thnsl2 A T 6: 71,111,208 (GRCm39) L220* probably null Het
Tinf2 G A 14: 55,917,566 (GRCm39) P308S probably benign Het
Tmem131l A G 3: 83,847,879 (GRCm39) S329P probably benign Het
Tnf T C 17: 35,420,120 (GRCm39) probably benign Het
Upp2 A G 2: 58,661,568 (GRCm39) T144A probably benign Het
Vmn2r94 T G 17: 18,477,973 (GRCm39) Q146P probably damaging Het
Zfhx4 T A 3: 5,310,375 (GRCm39) S919R possibly damaging Het
Other mutations in Fbxo21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01721:Fbxo21 APN 5 118,126,855 (GRCm39) missense probably benign 0.04
IGL02131:Fbxo21 APN 5 118,140,155 (GRCm39) missense possibly damaging 0.76
IGL02156:Fbxo21 APN 5 118,132,733 (GRCm39) splice site probably benign
IGL02195:Fbxo21 APN 5 118,140,219 (GRCm39) missense probably damaging 1.00
IGL02702:Fbxo21 APN 5 118,138,575 (GRCm39) missense probably damaging 1.00
PIT1430001:Fbxo21 UTSW 5 118,115,931 (GRCm39) missense possibly damaging 0.68
R0008:Fbxo21 UTSW 5 118,146,078 (GRCm39) missense possibly damaging 0.63
R0055:Fbxo21 UTSW 5 118,138,555 (GRCm39) missense probably benign 0.12
R0055:Fbxo21 UTSW 5 118,138,555 (GRCm39) missense probably benign 0.12
R0089:Fbxo21 UTSW 5 118,146,208 (GRCm39) missense probably benign
R0101:Fbxo21 UTSW 5 118,133,521 (GRCm39) missense probably damaging 1.00
R0866:Fbxo21 UTSW 5 118,115,098 (GRCm39) missense probably benign 0.01
R1673:Fbxo21 UTSW 5 118,146,129 (GRCm39) missense probably benign 0.27
R2048:Fbxo21 UTSW 5 118,146,169 (GRCm39) missense probably damaging 1.00
R2063:Fbxo21 UTSW 5 118,115,031 (GRCm39) missense probably benign 0.45
R2161:Fbxo21 UTSW 5 118,133,451 (GRCm39) missense probably damaging 1.00
R2224:Fbxo21 UTSW 5 118,146,188 (GRCm39) missense probably damaging 1.00
R3872:Fbxo21 UTSW 5 118,138,394 (GRCm39) missense possibly damaging 0.70
R4750:Fbxo21 UTSW 5 118,138,533 (GRCm39) missense probably benign 0.10
R5807:Fbxo21 UTSW 5 118,114,933 (GRCm39) missense probably benign 0.01
R6075:Fbxo21 UTSW 5 118,126,948 (GRCm39) missense probably damaging 0.97
R6528:Fbxo21 UTSW 5 118,138,421 (GRCm39) missense probably benign 0.25
R7494:Fbxo21 UTSW 5 118,138,388 (GRCm39) missense possibly damaging 0.86
R7498:Fbxo21 UTSW 5 118,140,239 (GRCm39) critical splice donor site probably null
R7801:Fbxo21 UTSW 5 118,124,189 (GRCm39) missense probably damaging 0.96
R7857:Fbxo21 UTSW 5 118,126,878 (GRCm39) missense probably benign 0.21
R7944:Fbxo21 UTSW 5 118,146,212 (GRCm39) missense possibly damaging 0.89
R7945:Fbxo21 UTSW 5 118,146,212 (GRCm39) missense possibly damaging 0.89
R8116:Fbxo21 UTSW 5 118,128,919 (GRCm39) missense possibly damaging 0.70
R8354:Fbxo21 UTSW 5 118,133,479 (GRCm39) missense probably damaging 1.00
R8454:Fbxo21 UTSW 5 118,133,479 (GRCm39) missense probably damaging 1.00
R8751:Fbxo21 UTSW 5 118,140,127 (GRCm39) missense probably damaging 1.00
R9273:Fbxo21 UTSW 5 118,146,108 (GRCm39) missense probably damaging 1.00
R9483:Fbxo21 UTSW 5 118,127,272 (GRCm39) missense possibly damaging 0.52
Z1177:Fbxo21 UTSW 5 118,127,236 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- AGGGTCTGGGAATCGGAAACCTTG -3'
(R):5'- AGCATTGAGCACCTGTCTTGCC -3'

Sequencing Primer
(F):5'- TTGTAGACTTCCACTGAGAAAGCC -3'
(R):5'- ACCAACAGGCATTTCTGGTG -3'
Posted On 2013-10-16