Incidental Mutation 'R0815:Vmn2r94'
ID 78594
Institutional Source Beutler Lab
Gene Symbol Vmn2r94
Ensembl Gene ENSMUSG00000090417
Gene Name vomeronasal 2, receptor 94
Synonyms EG665227
MMRRC Submission 038995-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R0815 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 18461384-18498018 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 18477973 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Proline at position 146 (Q146P)
Ref Sequence ENSEMBL: ENSMUSP00000156288 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000172190] [ENSMUST00000231457] [ENSMUST00000231815]
AlphaFold E9PZK8
Predicted Effect probably damaging
Transcript: ENSMUST00000172190
AA Change: Q146P

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000126386
Gene: ENSMUSG00000090417
AA Change: Q146P

DomainStartEndE-ValueType
Pfam:ANF_receptor 42 425 1.7e-35 PFAM
Pfam:NCD3G 469 522 3.5e-21 PFAM
Pfam:7tm_3 553 790 1.7e-51 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000231457
Predicted Effect probably damaging
Transcript: ENSMUST00000231815
AA Change: Q146P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 96.5%
  • 20x: 91.3%
Validation Efficiency 97% (58/60)
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 A G 12: 118,865,184 (GRCm39) probably benign Het
Abcf2 A T 5: 24,772,268 (GRCm39) Y487N probably damaging Het
Adcy4 T C 14: 56,021,056 (GRCm39) Y27C probably damaging Het
Atp2a2 T C 5: 122,609,299 (GRCm39) I188V probably benign Het
Cacna1s A T 1: 136,040,695 (GRCm39) I1231F possibly damaging Het
Capn7 T A 14: 31,091,714 (GRCm39) C704S possibly damaging Het
Celsr2 G T 3: 108,308,617 (GRCm39) T1770K possibly damaging Het
Chmp7 C T 14: 69,956,899 (GRCm39) M336I probably benign Het
Cul9 T C 17: 46,848,748 (GRCm39) probably null Het
Dpp10 A G 1: 123,360,658 (GRCm39) probably null Het
Dscaml1 A G 9: 45,656,372 (GRCm39) I1571V probably benign Het
Eif3j2 T A 18: 43,610,036 (GRCm39) Y259F probably benign Het
Erc2 A C 14: 27,747,105 (GRCm39) N345T probably benign Het
Fbxo21 T C 5: 118,133,573 (GRCm39) probably benign Het
Frmd8 A T 19: 5,915,084 (GRCm39) probably benign Het
Gfm1 T C 3: 67,381,928 (GRCm39) S705P probably damaging Het
Gucy1b2 T C 14: 62,656,511 (GRCm39) D282G probably benign Het
H2-Ab1 T C 17: 34,486,328 (GRCm39) I129T probably damaging Het
H2-M10.3 T A 17: 36,677,582 (GRCm39) Y232F probably damaging Het
Lipm A T 19: 34,096,161 (GRCm39) T326S probably benign Het
Lrrc8c T C 5: 105,756,400 (GRCm39) L725P probably damaging Het
Map3k19 A G 1: 127,762,375 (GRCm39) probably benign Het
Med31 T A 11: 72,104,657 (GRCm39) N50I probably damaging Het
Myo15b T G 11: 115,757,162 (GRCm39) probably benign Het
Nemp1 T C 10: 127,528,893 (GRCm39) L199S probably damaging Het
Nod2 G A 8: 89,399,290 (GRCm39) probably benign Het
Oga C T 19: 45,771,425 (GRCm39) A49T probably benign Het
Or2ak6 A G 11: 58,593,435 (GRCm39) R303G possibly damaging Het
Or5b21 A G 19: 12,840,008 (GRCm39) I290V probably benign Het
Parva G A 7: 112,167,071 (GRCm39) V215M probably damaging Het
Phf1 T C 17: 27,156,114 (GRCm39) probably benign Het
Plscr1l1 A T 9: 92,233,140 (GRCm39) I88L possibly damaging Het
Ppp1r12c G T 7: 4,489,365 (GRCm39) Q240K probably damaging Het
Ralgapa1 A T 12: 55,809,466 (GRCm39) Y436* probably null Het
Ralgapa1 C A 12: 55,829,562 (GRCm39) probably benign Het
Rbm11 C T 16: 75,393,525 (GRCm39) R74C probably damaging Het
Robo3 A G 9: 37,333,479 (GRCm39) V744A probably damaging Het
Rsbn1 T G 3: 103,861,469 (GRCm39) S522A probably damaging Het
Scel T A 14: 103,823,916 (GRCm39) S381R possibly damaging Het
Sec31b G A 19: 44,506,612 (GRCm39) Q909* probably null Het
Slc38a11 T A 2: 65,184,124 (GRCm39) I176L possibly damaging Het
Slc39a4 C T 15: 76,496,839 (GRCm39) D574N probably damaging Het
Slc44a1 T G 4: 53,536,421 (GRCm39) V199G possibly damaging Het
Sltm A G 9: 70,469,190 (GRCm39) T150A probably benign Het
Son C A 16: 91,452,372 (GRCm39) A373D probably damaging Het
Sp140 C T 1: 85,547,772 (GRCm39) probably benign Het
Speg A G 1: 75,392,036 (GRCm39) Y1606C probably damaging Het
Srgap1 A T 10: 121,621,379 (GRCm39) V1061D probably damaging Het
Stat5a A G 11: 100,765,908 (GRCm39) probably null Het
Supt4a T A 11: 87,628,409 (GRCm39) probably benign Het
Teddm1b A G 1: 153,750,638 (GRCm39) K149R possibly damaging Het
Thnsl2 A T 6: 71,111,208 (GRCm39) L220* probably null Het
Tinf2 G A 14: 55,917,566 (GRCm39) P308S probably benign Het
Tmem131l A G 3: 83,847,879 (GRCm39) S329P probably benign Het
Tnf T C 17: 35,420,120 (GRCm39) probably benign Het
Upp2 A G 2: 58,661,568 (GRCm39) T144A probably benign Het
Zfhx4 T A 3: 5,310,375 (GRCm39) S919R possibly damaging Het
Other mutations in Vmn2r94
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01396:Vmn2r94 APN 17 18,477,301 (GRCm39) missense probably damaging 1.00
IGL01676:Vmn2r94 APN 17 18,477,272 (GRCm39) missense probably benign
IGL01687:Vmn2r94 APN 17 18,473,574 (GRCm39) missense possibly damaging 0.64
IGL02113:Vmn2r94 APN 17 18,477,937 (GRCm39) missense probably damaging 0.99
IGL02408:Vmn2r94 APN 17 18,473,523 (GRCm39) missense probably benign 0.01
IGL02451:Vmn2r94 APN 17 18,478,453 (GRCm39) missense possibly damaging 0.95
IGL02755:Vmn2r94 APN 17 18,464,761 (GRCm39) missense probably benign 0.01
IGL02822:Vmn2r94 APN 17 18,463,882 (GRCm39) missense probably benign 0.00
IGL02868:Vmn2r94 APN 17 18,464,316 (GRCm39) missense possibly damaging 0.75
IGL03008:Vmn2r94 APN 17 18,477,908 (GRCm39) missense probably benign 0.05
R0112:Vmn2r94 UTSW 17 18,463,866 (GRCm39) missense probably benign
R0371:Vmn2r94 UTSW 17 18,477,556 (GRCm39) missense probably benign 0.11
R0413:Vmn2r94 UTSW 17 18,464,080 (GRCm39) missense probably damaging 0.98
R0627:Vmn2r94 UTSW 17 18,477,427 (GRCm39) missense probably damaging 1.00
R0737:Vmn2r94 UTSW 17 18,497,695 (GRCm39) nonsense probably null
R0863:Vmn2r94 UTSW 17 18,477,973 (GRCm39) missense probably damaging 1.00
R1125:Vmn2r94 UTSW 17 18,477,717 (GRCm39) missense probably damaging 1.00
R1276:Vmn2r94 UTSW 17 18,477,344 (GRCm39) missense possibly damaging 0.47
R1491:Vmn2r94 UTSW 17 18,477,965 (GRCm39) missense probably damaging 1.00
R1500:Vmn2r94 UTSW 17 18,477,242 (GRCm39) missense probably benign 0.07
R1610:Vmn2r94 UTSW 17 18,463,995 (GRCm39) missense probably damaging 1.00
R1664:Vmn2r94 UTSW 17 18,464,406 (GRCm39) missense probably damaging 0.99
R1716:Vmn2r94 UTSW 17 18,477,635 (GRCm39) missense probably benign 0.01
R1843:Vmn2r94 UTSW 17 18,464,732 (GRCm39) missense probably benign 0.01
R1882:Vmn2r94 UTSW 17 18,464,476 (GRCm39) missense probably benign 0.07
R1936:Vmn2r94 UTSW 17 18,464,554 (GRCm39) nonsense probably null
R2273:Vmn2r94 UTSW 17 18,477,593 (GRCm39) missense probably benign 0.00
R2508:Vmn2r94 UTSW 17 18,477,736 (GRCm39) missense probably benign 0.32
R3436:Vmn2r94 UTSW 17 18,478,650 (GRCm39) splice site probably benign
R3917:Vmn2r94 UTSW 17 18,464,620 (GRCm39) missense probably benign
R3968:Vmn2r94 UTSW 17 18,478,647 (GRCm39) missense possibly damaging 0.95
R3969:Vmn2r94 UTSW 17 18,478,647 (GRCm39) missense possibly damaging 0.95
R4257:Vmn2r94 UTSW 17 18,464,433 (GRCm39) missense probably damaging 1.00
R4271:Vmn2r94 UTSW 17 18,463,940 (GRCm39) missense probably damaging 1.00
R4349:Vmn2r94 UTSW 17 18,464,605 (GRCm39) missense probably benign 0.01
R4436:Vmn2r94 UTSW 17 18,478,645 (GRCm39) missense probably damaging 1.00
R4603:Vmn2r94 UTSW 17 18,477,647 (GRCm39) missense probably benign 0.33
R4821:Vmn2r94 UTSW 17 18,477,293 (GRCm39) missense probably benign 0.02
R5288:Vmn2r94 UTSW 17 18,464,728 (GRCm39) missense probably damaging 1.00
R5725:Vmn2r94 UTSW 17 18,476,489 (GRCm39) missense possibly damaging 0.88
R5735:Vmn2r94 UTSW 17 18,464,066 (GRCm39) missense probably damaging 1.00
R6066:Vmn2r94 UTSW 17 18,477,695 (GRCm39) missense probably damaging 0.99
R6124:Vmn2r94 UTSW 17 18,464,321 (GRCm39) missense probably benign 0.01
R6189:Vmn2r94 UTSW 17 18,477,996 (GRCm39) missense probably benign 0.25
R6245:Vmn2r94 UTSW 17 18,478,385 (GRCm39) missense probably damaging 1.00
R6574:Vmn2r94 UTSW 17 18,476,421 (GRCm39) missense probably damaging 1.00
R7236:Vmn2r94 UTSW 17 18,477,811 (GRCm39) missense possibly damaging 0.49
R7317:Vmn2r94 UTSW 17 18,463,882 (GRCm39) missense probably benign 0.00
R7398:Vmn2r94 UTSW 17 18,477,603 (GRCm39) missense probably benign 0.00
R7399:Vmn2r94 UTSW 17 18,464,765 (GRCm39) critical splice acceptor site probably null
R7478:Vmn2r94 UTSW 17 18,477,767 (GRCm39) missense probably benign
R8099:Vmn2r94 UTSW 17 18,477,659 (GRCm39) missense probably benign 0.00
R8189:Vmn2r94 UTSW 17 18,478,618 (GRCm39) missense probably damaging 1.00
R8217:Vmn2r94 UTSW 17 18,463,986 (GRCm39) missense probably damaging 1.00
R8303:Vmn2r94 UTSW 17 18,464,433 (GRCm39) missense probably damaging 1.00
R8543:Vmn2r94 UTSW 17 18,463,984 (GRCm39) missense possibly damaging 0.45
R8684:Vmn2r94 UTSW 17 18,497,912 (GRCm39) start gained probably benign
R8889:Vmn2r94 UTSW 17 18,464,335 (GRCm39) missense possibly damaging 0.83
R8892:Vmn2r94 UTSW 17 18,464,335 (GRCm39) missense possibly damaging 0.83
R9282:Vmn2r94 UTSW 17 18,497,751 (GRCm39) missense possibly damaging 0.89
R9526:Vmn2r94 UTSW 17 18,477,261 (GRCm39) missense probably benign
R9647:Vmn2r94 UTSW 17 18,463,884 (GRCm39) missense probably benign 0.00
R9748:Vmn2r94 UTSW 17 18,463,989 (GRCm39) missense probably benign 0.21
R9789:Vmn2r94 UTSW 17 18,464,038 (GRCm39) missense probably damaging 1.00
RF014:Vmn2r94 UTSW 17 18,473,549 (GRCm39) nonsense probably null
X0011:Vmn2r94 UTSW 17 18,464,710 (GRCm39) missense possibly damaging 0.76
X0028:Vmn2r94 UTSW 17 18,464,237 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTTCATGACCCAGACAATCCATGTCAA -3'
(R):5'- GCCCAAATTGGGACATTGCTTCAAC -3'

Sequencing Primer
(F):5'- CCAGAAGCTTGTAAAATATGCAGTCC -3'
(R):5'- CTGAGCAAGTCCTTGAAACTTAC -3'
Posted On 2013-10-16