Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01374:Vmn2r117'

78654

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r117

Ensembl Gene

ENSMUSG00000091407

Gene Name

vomeronasal 2, receptor 117

Synonyms

EG619788, V2Rp6

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

IGL01374

Quality Score

Status

Chromosome

Chromosomal Location

23678649-23698571 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 23697356 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 112 (Y112C)

Ref Sequence

ENSEMBL: ENSMUSP00000126885 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171996]

AlphaFold

K7N6V1

Predicted Effect

possibly damaging
Transcript: ENSMUST00000171996
AA Change: Y112C

PolyPhen 2 Score 0.458 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000126885
Gene: ENSMUSG00000091407
AA Change: Y112C

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	471	2.6e-28	PFAM
Pfam:NCD3G	512	565	5e-20	PFAM
Pfam:7tm_3	595	833	8.2e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933402N03Rik	T	C	7: 130,747,830 (GRCm39)	H54R	probably benign	Het
Acsl6	T	C	11: 54,229,245 (GRCm39)	V359A	probably damaging	Het
Aldh3a2	C	T	11: 61,139,828 (GRCm39)	V435I	probably benign	Het
Atm	A	T	9: 53,443,024 (GRCm39)	S80T	possibly damaging	Het
Atp8b4	A	T	2: 126,225,577 (GRCm39)		probably benign	Het
Atxn1	T	C	13: 45,721,903 (GRCm39)		probably benign	Het
Chd3	T	C	11: 69,250,806 (GRCm39)	E641G	probably damaging	Het
Clpb	T	C	7: 101,422,335 (GRCm39)	V346A	probably damaging	Het
Ctnnbl1	T	A	2: 157,678,613 (GRCm39)		probably null	Het
Cyp2b19	C	T	7: 26,458,504 (GRCm39)	P73L	probably benign	Het
Dcc	T	C	18: 71,507,624 (GRCm39)	Y916C	probably damaging	Het
Fat4	A	G	3: 38,941,647 (GRCm39)	N180S	probably damaging	Het
Foxi1	A	C	11: 34,157,984 (GRCm39)	C14G	probably damaging	Het
Fut4	G	T	9: 14,662,786 (GRCm39)	F169L	probably benign	Het
Grip1	T	C	10: 119,885,273 (GRCm39)	S748P	probably benign	Het
Hnrnpr	T	C	4: 136,054,729 (GRCm39)		probably benign	Het
Ifnz	G	A	4: 88,701,578 (GRCm39)		probably benign	Het
Krt28	A	G	11: 99,262,294 (GRCm39)	V232A	probably benign	Het
Lyar	C	A	5: 38,385,391 (GRCm39)		probably null	Het
Manba	G	A	3: 135,260,541 (GRCm39)	W575*	probably null	Het
Morc3	T	A	16: 93,641,101 (GRCm39)	D44E	probably damaging	Het
Mrc2	T	A	11: 105,238,469 (GRCm39)	Y1205*	probably null	Het
Myh2	A	T	11: 67,068,250 (GRCm39)	T293S	probably benign	Het
Nlrp10	T	A	7: 108,523,788 (GRCm39)	K564I	possibly damaging	Het
Nuak1	A	G	10: 84,210,532 (GRCm39)	S519P	probably damaging	Het
Or12k5	T	C	2: 36,894,942 (GRCm39)	H228R	probably benign	Het
Or9m2	T	C	2: 87,820,892 (GRCm39)	F146L	probably benign	Het
Padi2	T	A	4: 140,660,496 (GRCm39)	N325K	probably damaging	Het
Pcdhb19	A	T	18: 37,631,042 (GRCm39)	Y279F	probably damaging	Het
Phldb1	A	G	9: 44,607,464 (GRCm39)	L1247P	probably damaging	Het
Rmdn3	A	G	2: 118,984,428 (GRCm39)	V108A	probably damaging	Het
Slc22a5	A	G	11: 53,758,490 (GRCm39)	F437L	probably benign	Het
Slc3a2	C	T	19: 8,690,701 (GRCm39)		probably null	Het
Slc5a3	T	A	16: 91,874,006 (GRCm39)	M21K	probably benign	Het
Spink5	T	A	18: 44,122,471 (GRCm39)	F312Y	possibly damaging	Het
Stab1	T	C	14: 30,869,032 (GRCm39)	Y1531C	probably damaging	Het
Tln2	C	A	9: 67,169,205 (GRCm39)	A433S	probably damaging	Het
Usp24	C	T	4: 106,237,296 (GRCm39)	L1076F	possibly damaging	Het
Vmn2r16	C	T	5: 109,478,283 (GRCm39)	L13F	probably benign	Het
Vmn2r76	T	C	7: 85,874,857 (GRCm39)	M707V	probably benign	Het
Zmym4	A	T	4: 126,762,750 (GRCm39)	F1358I	probably damaging	Het

Other mutations in Vmn2r117

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Vmn2r117	APN	17	23,698,520 (GRCm39)	missense	probably benign
IGL00990:Vmn2r117	APN	17	23,696,814 (GRCm39)	missense	probably damaging	1.00
IGL00990:Vmn2r117	APN	17	23,694,403 (GRCm39)	missense	probably damaging	1.00
IGL01078:Vmn2r117	APN	17	23,696,778 (GRCm39)	missense	probably damaging	1.00
IGL01139:Vmn2r117	APN	17	23,696,778 (GRCm39)	missense	probably damaging	1.00
IGL01779:Vmn2r117	APN	17	23,696,215 (GRCm39)	missense	probably benign	0.00
IGL02283:Vmn2r117	APN	17	23,694,356 (GRCm39)	missense	probably damaging	0.99
IGL02527:Vmn2r117	APN	17	23,696,199 (GRCm39)	missense	possibly damaging	0.65
IGL02612:Vmn2r117	APN	17	23,678,758 (GRCm39)	missense	possibly damaging	0.91
IGL02887:Vmn2r117	APN	17	23,694,552 (GRCm39)	splice site	probably benign
IGL03167:Vmn2r117	APN	17	23,696,681 (GRCm39)	missense	probably damaging	1.00
R0315:Vmn2r117	UTSW	17	23,679,139 (GRCm39)	missense	probably benign	0.11
R0610:Vmn2r117	UTSW	17	23,694,488 (GRCm39)	missense	probably benign	0.00
R0747:Vmn2r117	UTSW	17	23,694,477 (GRCm39)	nonsense	probably null
R1411:Vmn2r117	UTSW	17	23,679,527 (GRCm39)	missense	probably damaging	1.00
R1471:Vmn2r117	UTSW	17	23,697,447 (GRCm39)	missense	probably benign	0.00
R1853:Vmn2r117	UTSW	17	23,696,429 (GRCm39)	missense	probably damaging	0.99
R1925:Vmn2r117	UTSW	17	23,697,363 (GRCm39)	missense	probably benign	0.00
R1940:Vmn2r117	UTSW	17	23,696,454 (GRCm39)	missense	probably damaging	1.00
R2005:Vmn2r117	UTSW	17	23,696,618 (GRCm39)	missense	probably damaging	1.00
R2082:Vmn2r117	UTSW	17	23,679,230 (GRCm39)	missense	possibly damaging	0.55
R2698:Vmn2r117	UTSW	17	23,678,885 (GRCm39)	missense	probably damaging	0.98
R2972:Vmn2r117	UTSW	17	23,678,830 (GRCm39)	missense	probably damaging	1.00
R2973:Vmn2r117	UTSW	17	23,678,830 (GRCm39)	missense	probably damaging	1.00
R2974:Vmn2r117	UTSW	17	23,678,830 (GRCm39)	missense	probably damaging	1.00
R3160:Vmn2r117	UTSW	17	23,679,352 (GRCm39)	missense	probably damaging	1.00
R3161:Vmn2r117	UTSW	17	23,679,352 (GRCm39)	missense	probably damaging	1.00
R3162:Vmn2r117	UTSW	17	23,679,352 (GRCm39)	missense	probably damaging	1.00
R3847:Vmn2r117	UTSW	17	23,679,389 (GRCm39)	missense	probably damaging	0.97
R3848:Vmn2r117	UTSW	17	23,679,389 (GRCm39)	missense	probably damaging	0.97
R4082:Vmn2r117	UTSW	17	23,679,080 (GRCm39)	missense	probably benign	0.00
R4320:Vmn2r117	UTSW	17	23,698,487 (GRCm39)	frame shift	probably null
R4560:Vmn2r117	UTSW	17	23,678,851 (GRCm39)	missense	probably damaging	1.00
R4658:Vmn2r117	UTSW	17	23,697,390 (GRCm39)	missense	probably benign	0.01
R4881:Vmn2r117	UTSW	17	23,696,859 (GRCm39)	missense	probably damaging	1.00
R4908:Vmn2r117	UTSW	17	23,678,812 (GRCm39)	missense	probably damaging	1.00
R4910:Vmn2r117	UTSW	17	23,698,487 (GRCm39)	frame shift	probably null
R5078:Vmn2r117	UTSW	17	23,679,122 (GRCm39)	missense	probably damaging	1.00
R5327:Vmn2r117	UTSW	17	23,696,848 (GRCm39)	nonsense	probably null
R5774:Vmn2r117	UTSW	17	23,696,176 (GRCm39)	missense	probably damaging	0.98
R6014:Vmn2r117	UTSW	17	23,698,535 (GRCm39)	missense	probably damaging	0.97
R6390:Vmn2r117	UTSW	17	23,679,088 (GRCm39)	missense	possibly damaging	0.95
R6520:Vmn2r117	UTSW	17	23,679,193 (GRCm39)	missense	probably damaging	0.99
R6674:Vmn2r117	UTSW	17	23,679,023 (GRCm39)	nonsense	probably null
R6736:Vmn2r117	UTSW	17	23,697,282 (GRCm39)	missense	probably damaging	0.99
R6909:Vmn2r117	UTSW	17	23,698,479 (GRCm39)	missense	possibly damaging	0.67
R6913:Vmn2r117	UTSW	17	23,698,537 (GRCm39)	missense	probably damaging	0.99
R7220:Vmn2r117	UTSW	17	23,696,177 (GRCm39)	missense	probably damaging	1.00
R7260:Vmn2r117	UTSW	17	23,694,359 (GRCm39)	missense	probably benign	0.06
R7440:Vmn2r117	UTSW	17	23,694,539 (GRCm39)	missense	probably benign	0.26
R7443:Vmn2r117	UTSW	17	23,679,319 (GRCm39)	missense	probably damaging	1.00
R7443:Vmn2r117	UTSW	17	23,679,107 (GRCm39)	missense	probably benign	0.25
R7449:Vmn2r117	UTSW	17	23,678,869 (GRCm39)	missense	probably damaging	1.00
R7644:Vmn2r117	UTSW	17	23,696,265 (GRCm39)	missense	probably damaging	0.98
R7914:Vmn2r117	UTSW	17	23,679,100 (GRCm39)	missense	possibly damaging	0.95
R8001:Vmn2r117	UTSW	17	23,698,381 (GRCm39)	missense	possibly damaging	0.89
R8029:Vmn2r117	UTSW	17	23,696,744 (GRCm39)	missense	probably benign	0.00
R8340:Vmn2r117	UTSW	17	23,679,511 (GRCm39)	missense	probably benign	0.01
R8519:Vmn2r117	UTSW	17	23,698,442 (GRCm39)	missense	probably benign
R8723:Vmn2r117	UTSW	17	23,696,343 (GRCm39)	missense	probably damaging	1.00
R8914:Vmn2r117	UTSW	17	23,679,143 (GRCm39)	missense	probably benign	0.02
R9010:Vmn2r117	UTSW	17	23,679,445 (GRCm39)	missense	probably benign	0.10
R9129:Vmn2r117	UTSW	17	23,678,918 (GRCm39)	nonsense	probably null
R9244:Vmn2r117	UTSW	17	23,696,589 (GRCm39)	missense	probably damaging	0.98
R9464:Vmn2r117	UTSW	17	23,696,578 (GRCm39)	missense	probably benign	0.23
R9620:Vmn2r117	UTSW	17	23,697,450 (GRCm39)	missense	probably damaging	0.97
V5622:Vmn2r117	UTSW	17	23,698,479 (GRCm39)	missense	possibly damaging	0.67
V5622:Vmn2r117	UTSW	17	23,696,814 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r117	UTSW	17	23,678,740 (GRCm39)	missense	probably benign	0.00

Posted On

2013-11-05