Incidental Mutation 'IGL01376:Olfr1084'
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ID78712
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1084
Ensembl Gene ENSMUSG00000110804
Gene Nameolfactory receptor 1084
SynonymsGA_x6K02T2Q125-48121788-48120847, MOR192-2, MOR192-3
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.342) question?
Stock #IGL01376
Quality Score
Status
Chromosome2
Chromosomal Location86638765-86639725 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 86639609 bp
ZygosityHeterozygous
Amino Acid Change Valine to Glycine at position 33 (V33G)
Gene Model predicted gene model for transcript(s): [ENSMUST00000216851]
Predicted Effect probably benign
Transcript: ENSMUST00000099880
AA Change: V33G

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000097465
Gene: ENSMUSG00000075177
AA Change: V33G

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 5.9e-48 PFAM
Pfam:7tm_1 41 290 7.6e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216851
AA Change: V33G

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010300C02Rik A G 1: 37,628,344 L207P probably damaging Het
4930568D16Rik A T 2: 35,355,628 I61K probably benign Het
Acot12 A G 13: 91,784,671 Y521C probably damaging Het
Anxa7 T C 14: 20,460,456 N313D probably benign Het
Cdk14 T C 5: 5,010,839 I327M probably damaging Het
Clca3b T C 3: 144,826,051 N664S possibly damaging Het
Cpb1 A C 3: 20,270,324 L62R probably benign Het
Eef2 G A 10: 81,178,049 probably benign Het
Enox1 T C 14: 77,251,843 probably benign Het
Esco1 A T 18: 10,594,892 C131* probably null Het
Etv1 A T 12: 38,857,040 D347V probably damaging Het
Fat1 A G 8: 45,026,841 I2975V probably benign Het
Ghsr A G 3: 27,371,828 E11G probably benign Het
Gins4 T C 8: 23,227,327 D166G probably benign Het
Iglv2 G T 16: 19,260,565 H62N possibly damaging Het
Irf2bp1 T C 7: 19,006,027 S531P possibly damaging Het
Lrig3 T A 10: 125,994,466 F144L probably benign Het
Magi1 C T 6: 94,283,093 R77Q possibly damaging Het
Mlkl A G 8: 111,319,747 L298P probably damaging Het
Ndc1 T C 4: 107,375,197 L193P probably damaging Het
Npas3 A T 12: 54,044,586 T308S probably benign Het
Nt5dc3 A T 10: 86,834,164 Q541L probably benign Het
Olfr1115 T C 2: 87,252,873 V312A possibly damaging Het
Parp10 G T 15: 76,241,677 T437K probably benign Het
Phf3 A G 1: 30,830,485 V494A possibly damaging Het
Prpf8 C A 11: 75,494,295 A794D possibly damaging Het
Sars2 T A 7: 28,749,883 Y307N probably damaging Het
Serping1 A T 2: 84,770,185 V271E probably damaging Het
Sgpl1 G A 10: 61,114,070 P117S probably damaging Het
Slc38a1 A C 15: 96,585,556 L297R probably damaging Het
Strbp A G 2: 37,645,651 M15T probably damaging Het
Tdp2 A G 13: 24,836,949 probably null Het
Tex10 T C 4: 48,456,740 Y657C possibly damaging Het
Xrcc4 A T 13: 90,062,050 S92T probably benign Het
Other mutations in Olfr1084
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01132:Olfr1084 APN 2 86639166 missense probably benign 0.01
IGL01387:Olfr1084 APN 2 86639250 missense probably benign 0.03
IGL01549:Olfr1084 APN 2 86639361 missense probably benign 0.29
IGL01549:Olfr1084 APN 2 86639532 missense possibly damaging 0.95
IGL01572:Olfr1084 APN 2 86638939 missense possibly damaging 0.92
IGL02084:Olfr1084 APN 2 86639636 missense possibly damaging 0.89
IGL02289:Olfr1084 APN 2 86639519 missense probably damaging 1.00
IGL02422:Olfr1084 APN 2 86639216 missense probably damaging 0.99
IGL02691:Olfr1084 APN 2 86638838 missense probably damaging 1.00
IGL02829:Olfr1084 APN 2 86639255 missense possibly damaging 0.60
IGL02859:Olfr1084 APN 2 86639648 missense probably benign 0.01
R0441:Olfr1084 UTSW 2 86639330 missense probably damaging 1.00
R0546:Olfr1084 UTSW 2 86639229 missense possibly damaging 0.86
R1186:Olfr1084 UTSW 2 86639463 missense probably damaging 1.00
R4465:Olfr1084 UTSW 2 86639134 missense probably benign 0.28
R4554:Olfr1084 UTSW 2 86638779 missense possibly damaging 0.74
R4670:Olfr1084 UTSW 2 86639168 missense possibly damaging 0.95
R4945:Olfr1084 UTSW 2 86639489 missense probably damaging 0.99
R5348:Olfr1084 UTSW 2 86638806 missense probably benign 0.39
R5888:Olfr1084 UTSW 2 86639144 missense probably damaging 0.98
R7001:Olfr1084 UTSW 2 86639151 missense probably benign 0.20
R7258:Olfr1084 UTSW 2 86639001 nonsense probably null
R7526:Olfr1084 UTSW 2 86639669 missense possibly damaging 0.93
R7646:Olfr1084 UTSW 2 86639169 missense probably damaging 1.00
Posted On2013-11-05