Incidental Mutation 'IGL01376:Iglv2'
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ID78719
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Iglv2
Ensembl Gene ENSMUSG00000076940
Gene Nameimmunoglobulin lambda variable 2
Synonyms
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL01376
Quality Score
Status
Chromosome16
Chromosomal Location19260403-19260844 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 19260565 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Asparagine at position 62 (H62N)
Ref Sequence ENSEMBL: ENSMUSP00000100466 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103752] [ENSMUST00000197518]
Predicted Effect possibly damaging
Transcript: ENSMUST00000103752
AA Change: H62N

PolyPhen 2 Score 0.605 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000100466
Gene: ENSMUSG00000076940
AA Change: H62N

DomainStartEndE-ValueType
low complexity region 5 18 N/A INTRINSIC
IGv 35 110 9.84e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000197518
AA Change: H63N

PolyPhen 2 Score 0.154 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000142646
Gene: ENSMUSG00000076940
AA Change: H63N

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
IGv 36 111 9.84e-12 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010300C02Rik A G 1: 37,628,344 L207P probably damaging Het
4930568D16Rik A T 2: 35,355,628 I61K probably benign Het
Acot12 A G 13: 91,784,671 Y521C probably damaging Het
Anxa7 T C 14: 20,460,456 N313D probably benign Het
Cdk14 T C 5: 5,010,839 I327M probably damaging Het
Clca3b T C 3: 144,826,051 N664S possibly damaging Het
Cpb1 A C 3: 20,270,324 L62R probably benign Het
Eef2 G A 10: 81,178,049 probably benign Het
Enox1 T C 14: 77,251,843 probably benign Het
Esco1 A T 18: 10,594,892 C131* probably null Het
Etv1 A T 12: 38,857,040 D347V probably damaging Het
Fat1 A G 8: 45,026,841 I2975V probably benign Het
Ghsr A G 3: 27,371,828 E11G probably benign Het
Gins4 T C 8: 23,227,327 D166G probably benign Het
Irf2bp1 T C 7: 19,006,027 S531P possibly damaging Het
Lrig3 T A 10: 125,994,466 F144L probably benign Het
Magi1 C T 6: 94,283,093 R77Q possibly damaging Het
Mlkl A G 8: 111,319,747 L298P probably damaging Het
Ndc1 T C 4: 107,375,197 L193P probably damaging Het
Npas3 A T 12: 54,044,586 T308S probably benign Het
Nt5dc3 A T 10: 86,834,164 Q541L probably benign Het
Olfr1084 A C 2: 86,639,609 V33G probably benign Het
Olfr1115 T C 2: 87,252,873 V312A possibly damaging Het
Parp10 G T 15: 76,241,677 T437K probably benign Het
Phf3 A G 1: 30,830,485 V494A possibly damaging Het
Prpf8 C A 11: 75,494,295 A794D possibly damaging Het
Sars2 T A 7: 28,749,883 Y307N probably damaging Het
Serping1 A T 2: 84,770,185 V271E probably damaging Het
Sgpl1 G A 10: 61,114,070 P117S probably damaging Het
Slc38a1 A C 15: 96,585,556 L297R probably damaging Het
Strbp A G 2: 37,645,651 M15T probably damaging Het
Tdp2 A G 13: 24,836,949 probably null Het
Tex10 T C 4: 48,456,740 Y657C possibly damaging Het
Xrcc4 A T 13: 90,062,050 S92T probably benign Het
Other mutations in Iglv2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00557:Iglv2 APN 16 19260797 critical splice donor site probably benign
R3831:Iglv2 UTSW 16 19260843 start codon destroyed probably null 0.53
R3832:Iglv2 UTSW 16 19260843 start codon destroyed probably null 0.53
R3833:Iglv2 UTSW 16 19260843 start codon destroyed probably null 0.53
R7195:Iglv2 UTSW 16 19260510 missense not run
Posted On2013-11-05