Incidental Mutation 'IGL01380:Lrrc74a'
ID 78808
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lrrc74a
Ensembl Gene ENSMUSG00000059114
Gene Name leucine rich repeat containing 74A
Synonyms Gm6772, Lrrc74
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # IGL01380
Quality Score
Status
Chromosome 12
Chromosomal Location 86781143-86810571 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 86808496 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 425 (M425L)
Ref Sequence ENSEMBL: ENSMUSP00000152661 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095527] [ENSMUST00000222180] [ENSMUST00000223308]
AlphaFold A0A1Y7VMD6
Predicted Effect probably benign
Transcript: ENSMUST00000095527
AA Change: M425L

PolyPhen 2 Score 0.383 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000093183
Gene: ENSMUSG00000059114
AA Change: M425L

DomainStartEndE-ValueType
Blast:LRR 87 116 9e-7 BLAST
LRR 117 144 4.17e-3 SMART
LRR 145 172 3.16e-3 SMART
LRR 174 201 1.92e-2 SMART
LRR 202 229 3.07e-1 SMART
LRR 230 257 1.03e-2 SMART
LRR 258 285 1.64e-1 SMART
LRR 286 313 2.03e0 SMART
LRR 314 341 1.11e1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000222180
Predicted Effect possibly damaging
Transcript: ENSMUST00000223308
AA Change: M425L

PolyPhen 2 Score 0.617 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2fm1 A G 3: 59,840,053 (GRCm39) T42A probably benign Het
Abcc10 C A 17: 46,634,948 (GRCm39) V352L possibly damaging Het
Ankrd44 A T 1: 54,766,724 (GRCm39) M488K probably benign Het
Ano8 A G 8: 71,933,453 (GRCm39) probably benign Het
Atp2a1 T A 7: 126,047,942 (GRCm39) M623L possibly damaging Het
Atxn10 G T 15: 85,260,896 (GRCm39) E214* probably null Het
Btla A C 16: 45,070,716 (GRCm39) D225A probably benign Het
C030048H21Rik G A 2: 26,146,659 (GRCm39) Q1218* probably null Het
Cacna1a A G 8: 85,285,746 (GRCm39) Y750C probably damaging Het
Ccdc15 A T 9: 37,187,853 (GRCm39) probably benign Het
Ccdc18 T A 5: 108,328,753 (GRCm39) I724N probably damaging Het
Cluh T A 11: 74,556,772 (GRCm39) F937L probably benign Het
Clybl G T 14: 122,616,761 (GRCm39) A259S probably benign Het
Cyp4f39 T G 17: 32,700,832 (GRCm39) I167S probably damaging Het
Dchs1 T A 7: 105,411,418 (GRCm39) D1566V probably damaging Het
Dnah3 C T 7: 119,525,787 (GRCm39) A3867T probably damaging Het
Dtwd1 T A 2: 126,001,847 (GRCm39) L189Q probably benign Het
Dusp10 T C 1: 183,801,211 (GRCm39) I326T possibly damaging Het
Eaf1 T A 14: 31,219,767 (GRCm39) probably benign Het
Eif3c C T 7: 126,163,585 (GRCm39) probably benign Het
Fam169a C T 13: 97,228,459 (GRCm39) T44M probably damaging Het
Fam184a T C 10: 53,570,782 (GRCm39) probably benign Het
Fam25a C T 14: 34,075,655 (GRCm39) A46T probably null Het
Gckr A G 5: 31,456,977 (GRCm39) probably benign Het
Gfra2 G T 14: 71,204,586 (GRCm39) probably benign Het
Gm8237 A T 14: 5,863,703 (GRCm38) probably null Het
H2-Eb2 G T 17: 34,554,783 (GRCm39) L228F probably benign Het
Igf2r T C 17: 12,914,261 (GRCm39) N1736S probably benign Het
Izumo1 T G 7: 45,276,519 (GRCm39) S361A probably benign Het
Klri1 T C 6: 129,675,761 (GRCm39) I170V probably benign Het
L3mbtl2 C T 15: 81,555,326 (GRCm39) A193V possibly damaging Het
Lats1 T A 10: 7,567,544 (GRCm39) M105K possibly damaging Het
Lrpprc T C 17: 85,030,158 (GRCm39) D1080G probably benign Het
Mfsd13a G T 19: 46,356,347 (GRCm39) D151Y probably damaging Het
Mst1 G A 9: 107,961,787 (GRCm39) E640K probably damaging Het
Napsa T C 7: 44,236,098 (GRCm39) V379A probably damaging Het
Or1e16 A T 11: 73,286,017 (GRCm39) M277K probably damaging Het
Or55b4 C T 7: 102,133,592 (GRCm39) C245Y probably damaging Het
Or7c19 C A 8: 85,957,775 (GRCm39) S217Y probably damaging Het
Or7c19 A T 8: 85,957,958 (GRCm39) Y278F possibly damaging Het
Otop3 T C 11: 115,237,237 (GRCm39) V567A probably damaging Het
Oxsr1 A T 9: 119,089,167 (GRCm39) probably benign Het
Pak2 A T 16: 31,860,362 (GRCm39) V167E probably benign Het
Pcdhb16 A G 18: 37,612,498 (GRCm39) H486R probably benign Het
Plekha5 C T 6: 140,516,042 (GRCm39) probably benign Het
Rbm6 T C 9: 107,665,548 (GRCm39) D616G probably damaging Het
Sf3b1 T C 1: 55,027,108 (GRCm39) Y1249C probably damaging Het
Sipa1l3 T C 7: 29,030,797 (GRCm39) H534R possibly damaging Het
Slco1c1 T C 6: 141,485,777 (GRCm39) Y136H probably damaging Het
Smarca4 A G 9: 21,590,369 (GRCm39) M1333V probably benign Het
Smc4 A G 3: 68,933,161 (GRCm39) D54G probably damaging Het
Spag5 T A 11: 78,195,443 (GRCm39) V250E possibly damaging Het
Stxbp4 A G 11: 90,512,475 (GRCm39) probably benign Het
Suv39h2 T A 2: 3,465,296 (GRCm39) probably benign Het
Taar8b T A 10: 23,968,005 (GRCm39) H63L probably damaging Het
Tex2 G A 11: 106,435,141 (GRCm39) Q264* probably null Het
Thnsl2 A C 6: 71,115,740 (GRCm39) S156A probably benign Het
Tmtc4 G T 14: 123,163,366 (GRCm39) probably benign Het
Usp25 T C 16: 76,890,566 (GRCm39) L758P probably benign Het
Zfyve1 G A 12: 83,599,281 (GRCm39) R144C probably damaging Het
Zpld1 A G 16: 55,072,133 (GRCm39) V42A probably damaging Het
Other mutations in Lrrc74a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01370:Lrrc74a APN 12 86,801,204 (GRCm39) missense probably damaging 1.00
IGL01715:Lrrc74a APN 12 86,801,189 (GRCm39) missense probably benign 0.05
IGL01832:Lrrc74a APN 12 86,808,488 (GRCm39) missense probably benign 0.00
IGL01953:Lrrc74a APN 12 86,788,494 (GRCm39) missense probably damaging 1.00
IGL02218:Lrrc74a APN 12 86,795,822 (GRCm39) missense probably benign 0.15
IGL02637:Lrrc74a APN 12 86,788,521 (GRCm39) nonsense probably null
IGL03397:Lrrc74a APN 12 86,805,312 (GRCm39) missense probably benign 0.39
R0201:Lrrc74a UTSW 12 86,808,547 (GRCm39) splice site probably benign
R0360:Lrrc74a UTSW 12 86,784,569 (GRCm39) missense probably damaging 1.00
R0403:Lrrc74a UTSW 12 86,787,753 (GRCm39) missense probably damaging 1.00
R0729:Lrrc74a UTSW 12 86,792,353 (GRCm39) nonsense probably null
R1675:Lrrc74a UTSW 12 86,787,800 (GRCm39) missense probably damaging 1.00
R1774:Lrrc74a UTSW 12 86,795,827 (GRCm39) missense probably damaging 1.00
R1818:Lrrc74a UTSW 12 86,784,484 (GRCm39) missense probably damaging 1.00
R4688:Lrrc74a UTSW 12 86,784,472 (GRCm39) nonsense probably null
R6023:Lrrc74a UTSW 12 86,805,380 (GRCm39) missense probably damaging 1.00
R6190:Lrrc74a UTSW 12 86,783,263 (GRCm39) missense probably benign 0.01
R6226:Lrrc74a UTSW 12 86,795,231 (GRCm39) missense possibly damaging 0.87
R6247:Lrrc74a UTSW 12 86,805,330 (GRCm39) missense probably damaging 1.00
R7275:Lrrc74a UTSW 12 86,787,753 (GRCm39) missense probably damaging 1.00
R7631:Lrrc74a UTSW 12 86,795,884 (GRCm39) missense probably damaging 1.00
R7857:Lrrc74a UTSW 12 86,788,485 (GRCm39) missense probably benign 0.00
R8172:Lrrc74a UTSW 12 86,788,530 (GRCm39) missense probably damaging 1.00
R8715:Lrrc74a UTSW 12 86,805,239 (GRCm39) missense probably damaging 1.00
R8717:Lrrc74a UTSW 12 86,783,253 (GRCm39) missense probably damaging 0.99
R9080:Lrrc74a UTSW 12 86,795,908 (GRCm39) missense possibly damaging 0.87
R9612:Lrrc74a UTSW 12 86,805,345 (GRCm39) missense possibly damaging 0.84
X0024:Lrrc74a UTSW 12 86,795,819 (GRCm39) missense probably damaging 1.00
Posted On 2013-11-05