Incidental Mutation 'IGL01380:Suv39h2'
ID 78842
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Suv39h2
Ensembl Gene ENSMUSG00000026646
Gene Name suppressor of variegation 3-9 2
Synonyms Suv39h histone methyltransferase, 4930507K23Rik, D2Ertd544e, KMT1B
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01380
Quality Score
Status
Chromosome 2
Chromosomal Location 3455815-3475031 bp(-) (GRCm38)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 3464259 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000125485 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027956] [ENSMUST00000060618] [ENSMUST00000061852] [ENSMUST00000100463] [ENSMUST00000115066] [ENSMUST00000127540]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000027956
SMART Domains Protein: ENSMUSP00000027956
Gene: ENSMUSG00000026646

DomainStartEndE-ValueType
low complexity region 2 47 N/A INTRINSIC
CHROMO 117 169 2.44e-11 SMART
Pfam:Pre-SET 212 309 4.4e-18 PFAM
SET 317 446 4.05e-41 SMART
PostSET 461 477 7.05e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000060618
SMART Domains Protein: ENSMUSP00000054169
Gene: ENSMUSG00000026646

DomainStartEndE-ValueType
low complexity region 2 47 N/A INTRINSIC
SET 70 226 6.61e-23 SMART
PostSET 241 257 7.05e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000061852
SMART Domains Protein: ENSMUSP00000054300
Gene: ENSMUSG00000026648

DomainStartEndE-ValueType
Lactamase_B 10 193 7.78e0 SMART
Pfam:DRMBL 239 345 1.6e-22 PFAM
low complexity region 383 400 N/A INTRINSIC
low complexity region 463 477 N/A INTRINSIC
low complexity region 593 601 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000100458
SMART Domains Protein: ENSMUSP00000098026
Gene: ENSMUSG00000026646

DomainStartEndE-ValueType
CHROMO 6 67 2e-7 SMART
Pfam:Pre-SET 110 207 1.3e-17 PFAM
SET 215 344 4.05e-41 SMART
PostSET 359 375 7.05e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000100463
SMART Domains Protein: ENSMUSP00000098031
Gene: ENSMUSG00000026648

DomainStartEndE-ValueType
Lactamase_B 10 193 7.78e0 SMART
Pfam:DRMBL 239 345 6.5e-23 PFAM
low complexity region 476 484 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000115066
SMART Domains Protein: ENSMUSP00000110718
Gene: ENSMUSG00000026648

DomainStartEndE-ValueType
Blast:Lactamase_B 25 70 1e-19 BLAST
Pfam:DRMBL 109 215 1.1e-22 PFAM
low complexity region 253 270 N/A INTRINSIC
low complexity region 333 347 N/A INTRINSIC
low complexity region 463 471 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000127540
SMART Domains Protein: ENSMUSP00000125485
Gene: ENSMUSG00000026646

DomainStartEndE-ValueType
low complexity region 2 47 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149932
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Less than 5% of mice either heterozygous or homozygous for a reporter/null allele develop late-onset B cell lymphomas. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc10 C A 17: 46,324,022 (GRCm38) V352L possibly damaging Het
Ankrd44 A T 1: 54,727,565 (GRCm38) M488K probably benign Het
Ano8 A G 8: 71,480,809 (GRCm38) probably benign Het
Atp2a1 T A 7: 126,448,770 (GRCm38) M623L possibly damaging Het
Atxn10 G T 15: 85,376,695 (GRCm38) E214* probably null Het
Btla A C 16: 45,250,353 (GRCm38) D225A probably benign Het
C030048H21Rik G A 2: 26,256,647 (GRCm38) Q1218* probably null Het
C130079G13Rik A G 3: 59,932,632 (GRCm38) T42A probably benign Het
Cacna1a A G 8: 84,559,117 (GRCm38) Y750C probably damaging Het
Ccdc15 A T 9: 37,276,557 (GRCm38) probably benign Het
Ccdc18 T A 5: 108,180,887 (GRCm38) I724N probably damaging Het
Cluh T A 11: 74,665,946 (GRCm38) F937L probably benign Het
Clybl G T 14: 122,379,349 (GRCm38) A259S probably benign Het
Cyp4f39 T G 17: 32,481,858 (GRCm38) I167S probably damaging Het
Dchs1 T A 7: 105,762,211 (GRCm38) D1566V probably damaging Het
Dnah3 C T 7: 119,926,564 (GRCm38) A3867T probably damaging Het
Dtwd1 T A 2: 126,159,927 (GRCm38) L189Q probably benign Het
Dusp10 T C 1: 184,069,014 (GRCm38) I326T possibly damaging Het
Eaf1 T A 14: 31,497,810 (GRCm38) probably benign Het
Eif3c C T 7: 126,564,413 (GRCm38) probably benign Het
Fam169a C T 13: 97,091,951 (GRCm38) T44M probably damaging Het
Fam184a T C 10: 53,694,686 (GRCm38) probably benign Het
Fam25c C T 14: 34,353,698 (GRCm38) A46T probably null Het
Gckr A G 5: 31,299,633 (GRCm38) probably benign Het
Gfra2 G T 14: 70,967,146 (GRCm38) probably benign Het
Gm8237 A T 14: 5,863,703 (GRCm38) probably null Het
H2-Eb2 G T 17: 34,335,809 (GRCm38) L228F probably benign Het
Igf2r T C 17: 12,695,374 (GRCm38) N1736S probably benign Het
Izumo1 T G 7: 45,627,095 (GRCm38) S361A probably benign Het
Klri1 T C 6: 129,698,798 (GRCm38) I170V probably benign Het
L3mbtl2 C T 15: 81,671,125 (GRCm38) A193V possibly damaging Het
Lats1 T A 10: 7,691,780 (GRCm38) M105K possibly damaging Het
Lrpprc T C 17: 84,722,730 (GRCm38) D1080G probably benign Het
Lrrc74a A T 12: 86,761,722 (GRCm38) M425L possibly damaging Het
Mfsd13a G T 19: 46,367,908 (GRCm38) D151Y probably damaging Het
Mst1 G A 9: 108,084,588 (GRCm38) E640K probably damaging Het
Napsa T C 7: 44,586,674 (GRCm38) V379A probably damaging Het
Olfr1 A T 11: 73,395,191 (GRCm38) M277K probably damaging Het
Olfr371 A T 8: 85,231,329 (GRCm38) Y278F possibly damaging Het
Olfr371 C A 8: 85,231,146 (GRCm38) S217Y probably damaging Het
Olfr544 C T 7: 102,484,385 (GRCm38) C245Y probably damaging Het
Otop3 T C 11: 115,346,411 (GRCm38) V567A probably damaging Het
Oxsr1 A T 9: 119,260,101 (GRCm38) probably benign Het
Pak2 A T 16: 32,041,544 (GRCm38) V167E probably benign Het
Pcdhb16 A G 18: 37,479,445 (GRCm38) H486R probably benign Het
Plekha5 C T 6: 140,570,316 (GRCm38) probably benign Het
Rbm6 T C 9: 107,788,349 (GRCm38) D616G probably damaging Het
Sf3b1 T C 1: 54,987,949 (GRCm38) Y1249C probably damaging Het
Sipa1l3 T C 7: 29,331,372 (GRCm38) H534R possibly damaging Het
Slco1c1 T C 6: 141,540,051 (GRCm38) Y136H probably damaging Het
Smarca4 A G 9: 21,679,073 (GRCm38) M1333V probably benign Het
Smc4 A G 3: 69,025,828 (GRCm38) D54G probably damaging Het
Spag5 T A 11: 78,304,617 (GRCm38) V250E possibly damaging Het
Stxbp4 A G 11: 90,621,649 (GRCm38) probably benign Het
Taar8b T A 10: 24,092,107 (GRCm38) H63L probably damaging Het
Tex2 G A 11: 106,544,315 (GRCm38) Q264* probably null Het
Thnsl2 A C 6: 71,138,756 (GRCm38) S156A probably benign Het
Tmtc4 G T 14: 122,925,954 (GRCm38) probably benign Het
Usp25 T C 16: 77,093,678 (GRCm38) L758P probably benign Het
Zfyve1 G A 12: 83,552,507 (GRCm38) R144C probably damaging Het
Zpld1 A G 16: 55,251,770 (GRCm38) V42A probably damaging Het
Other mutations in Suv39h2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03408:Suv39h2 APN 2 3,459,876 (GRCm38) missense probably damaging 1.00
R0060:Suv39h2 UTSW 2 3,464,916 (GRCm38) missense probably damaging 1.00
R0060:Suv39h2 UTSW 2 3,464,916 (GRCm38) missense probably damaging 1.00
R0511:Suv39h2 UTSW 2 3,472,579 (GRCm38) missense probably damaging 0.99
R1892:Suv39h2 UTSW 2 3,459,768 (GRCm38) missense probably damaging 1.00
R1919:Suv39h2 UTSW 2 3,464,316 (GRCm38) missense probably damaging 1.00
R3888:Suv39h2 UTSW 2 3,464,808 (GRCm38) missense probably benign 0.09
R5583:Suv39h2 UTSW 2 3,474,853 (GRCm38) unclassified probably benign
R6770:Suv39h2 UTSW 2 3,472,551 (GRCm38) missense possibly damaging 0.52
R6801:Suv39h2 UTSW 2 3,464,421 (GRCm38) missense probably benign 0.16
R7607:Suv39h2 UTSW 2 3,474,829 (GRCm38) missense unknown
R7914:Suv39h2 UTSW 2 3,464,416 (GRCm38) nonsense probably null
R9557:Suv39h2 UTSW 2 3,474,414 (GRCm38) missense
R9781:Suv39h2 UTSW 2 3,462,594 (GRCm38) missense probably benign 0.01
X0062:Suv39h2 UTSW 2 3,464,785 (GRCm38) missense probably benign
Posted On 2013-11-05