Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01382:Vmn2r24'

78896

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r24

Ensembl Gene

ENSMUSG00000072780

Gene Name

vomeronasal 2, receptor 24

Synonyms

EG243628

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.055) question?

Stock #

IGL01382

Quality Score

Status

Chromosome

Chromosomal Location

123755930-123793239 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 123763938 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 272 (T272A)

Ref Sequence

ENSEMBL: ENSMUSP00000074602 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000075095]

AlphaFold

D3YUI0

Predicted Effect

possibly damaging
Transcript: ENSMUST00000075095
AA Change: T272A

PolyPhen 2 Score 0.620 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000074602
Gene: ENSMUSG00000072780
AA Change: T272A

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	82	469	1.6e-32	PFAM
Pfam:NCD3G	518	571	1.1e-22	PFAM
Pfam:7tm_3	602	839	1.1e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ap5z1	G	T	5: 142,458,006 (GRCm39)	R393L	probably benign	Het
Arhgap21	G	T	2: 20,860,511 (GRCm39)	P1128T	probably damaging	Het
Atp12a	T	G	14: 56,617,412 (GRCm39)	C567W	probably damaging	Het
Bcat2	C	A	7: 45,237,684 (GRCm39)	R312S	probably damaging	Het
Cacna1g	T	A	11: 94,356,684 (GRCm39)	T151S	probably damaging	Het
Chid1	G	A	7: 141,110,166 (GRCm39)	T53M	probably damaging	Het
Dis3l2	A	G	1: 86,784,925 (GRCm39)	D272G	probably benign	Het
Entrep3	T	C	3: 89,095,733 (GRCm39)	S596P	probably damaging	Het
Ephx4	A	G	5: 107,577,585 (GRCm39)	E303G	probably damaging	Het
Fsd1	C	T	17: 56,303,733 (GRCm39)	S491F	probably damaging	Het
Gm9843	A	T	16: 76,200,460 (GRCm39)		noncoding transcript	Het
Gnb1l	T	C	16: 18,362,950 (GRCm39)	F11S	probably damaging	Het
Ipmk	C	T	10: 71,212,596 (GRCm39)	T186M	probably damaging	Het
Jph1	T	C	1: 17,086,380 (GRCm39)	T381A	probably damaging	Het
Kbtbd8	T	A	6: 95,099,211 (GRCm39)	I163K	probably damaging	Het
Kif18a	T	A	2: 109,127,111 (GRCm39)	Y348*	probably null	Het
Lrrc37a	T	A	11: 103,389,581 (GRCm39)	D1948V	probably damaging	Het
Mc4r	A	G	18: 66,992,864 (GRCm39)	I83T	probably damaging	Het
Myh8	A	T	11: 67,192,799 (GRCm39)	E1530V	probably damaging	Het
Naip6	C	T	13: 100,436,364 (GRCm39)	E720K	possibly damaging	Het
Ncor2	T	A	5: 125,132,837 (GRCm39)	Q50L	probably damaging	Het
Or5p70	G	A	7: 107,994,452 (GRCm39)	V42M	probably benign	Het
Or9s15	A	G	1: 92,524,922 (GRCm39)	Y227C	possibly damaging	Het
Plxnd1	A	T	6: 115,937,488 (GRCm39)	M1575K	probably damaging	Het
Ptprg	T	G	14: 12,237,797 (GRCm38)	M643R	probably benign	Het
Reck	T	A	4: 43,940,662 (GRCm39)	C824S	probably damaging	Het
Rpgrip1	C	T	14: 52,382,934 (GRCm39)	T689I	possibly damaging	Het
Ruvbl2	A	T	7: 45,072,161 (GRCm39)	S358T	probably benign	Het
Sec14l3	G	T	11: 4,018,104 (GRCm39)	C128F	probably damaging	Het
Serpinf2	C	T	11: 75,328,863 (GRCm39)		probably benign	Het
Sez6l	C	T	5: 112,573,487 (GRCm39)	V842I	probably benign	Het
Tm6sf2	A	G	8: 70,531,018 (GRCm39)	Y257C	probably damaging	Het
Tmpo	T	C	10: 91,001,912 (GRCm39)	D99G	probably damaging	Het
Tulp3	A	C	6: 128,302,033 (GRCm39)	N329K	probably damaging	Het
Vmn1r7	T	A	6: 57,001,708 (GRCm39)	D184V	probably damaging	Het
Vmn2r93	T	A	17: 18,533,578 (GRCm39)	L494*	probably null	Het
Wdr18	T	C	10: 79,801,106 (GRCm39)	L173P	probably damaging	Het
Zfp663	T	A	2: 165,200,935 (GRCm39)	Y33F	probably damaging	Het
Zmiz2	T	A	11: 6,353,781 (GRCm39)		probably null	Het

Other mutations in Vmn2r24

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00954:Vmn2r24	APN	6	123,792,596 (GRCm39)	missense	probably damaging	1.00
IGL01592:Vmn2r24	APN	6	123,764,445 (GRCm39)	missense	probably benign	0.30
IGL01754:Vmn2r24	APN	6	123,781,120 (GRCm39)	missense	probably damaging	1.00
IGL01939:Vmn2r24	APN	6	123,764,404 (GRCm39)	missense	probably benign
IGL02140:Vmn2r24	APN	6	123,757,631 (GRCm39)	missense	probably damaging	0.98
IGL02272:Vmn2r24	APN	6	123,763,843 (GRCm39)	missense	possibly damaging	0.94
IGL02568:Vmn2r24	APN	6	123,792,812 (GRCm39)	missense	probably benign	0.36
IGL02748:Vmn2r24	APN	6	123,793,057 (GRCm39)	missense	possibly damaging	0.90
IGL03022:Vmn2r24	APN	6	123,755,967 (GRCm39)	missense	probably damaging	0.99
IGL03343:Vmn2r24	APN	6	123,793,070 (GRCm39)	missense	probably damaging	1.00
R0357:Vmn2r24	UTSW	6	123,792,369 (GRCm39)	frame shift	probably null
R0453:Vmn2r24	UTSW	6	123,757,350 (GRCm39)	critical splice acceptor site	probably null
R0538:Vmn2r24	UTSW	6	123,793,012 (GRCm39)	missense	probably benign	0.32
R0607:Vmn2r24	UTSW	6	123,763,893 (GRCm39)	missense	probably benign
R1381:Vmn2r24	UTSW	6	123,763,692 (GRCm39)	missense	probably damaging	1.00
R1589:Vmn2r24	UTSW	6	123,783,479 (GRCm39)	splice site	probably benign
R1848:Vmn2r24	UTSW	6	123,793,183 (GRCm39)	missense	probably damaging	1.00
R2035:Vmn2r24	UTSW	6	123,793,019 (GRCm39)	missense	probably damaging	1.00
R2077:Vmn2r24	UTSW	6	123,792,358 (GRCm39)	missense	probably damaging	1.00
R2122:Vmn2r24	UTSW	6	123,792,353 (GRCm39)	missense	possibly damaging	0.81
R2145:Vmn2r24	UTSW	6	123,755,972 (GRCm39)	missense	probably benign
R2483:Vmn2r24	UTSW	6	123,792,997 (GRCm39)	missense	probably damaging	1.00
R2512:Vmn2r24	UTSW	6	123,763,985 (GRCm39)	missense	probably benign	0.01
R3001:Vmn2r24	UTSW	6	123,781,231 (GRCm39)	missense	probably benign	0.00
R3002:Vmn2r24	UTSW	6	123,781,231 (GRCm39)	missense	probably benign	0.00
R3236:Vmn2r24	UTSW	6	123,755,984 (GRCm39)	nonsense	probably null
R3623:Vmn2r24	UTSW	6	123,792,997 (GRCm39)	missense	probably damaging	1.00
R3624:Vmn2r24	UTSW	6	123,792,997 (GRCm39)	missense	probably damaging	1.00
R3835:Vmn2r24	UTSW	6	123,764,412 (GRCm39)	missense	probably benign	0.33
R4074:Vmn2r24	UTSW	6	123,764,374 (GRCm39)	missense	possibly damaging	0.92
R4075:Vmn2r24	UTSW	6	123,764,374 (GRCm39)	missense	possibly damaging	0.92
R4812:Vmn2r24	UTSW	6	123,756,144 (GRCm39)	missense	probably benign	0.00
R4825:Vmn2r24	UTSW	6	123,792,739 (GRCm39)	missense	probably benign	0.02
R5351:Vmn2r24	UTSW	6	123,793,223 (GRCm39)	missense	possibly damaging	0.80
R5665:Vmn2r24	UTSW	6	123,763,938 (GRCm39)	missense	possibly damaging	0.62
R5790:Vmn2r24	UTSW	6	123,792,499 (GRCm39)	missense	probably benign
R5808:Vmn2r24	UTSW	6	123,792,597 (GRCm39)	nonsense	probably null
R5879:Vmn2r24	UTSW	6	123,764,226 (GRCm39)	missense	possibly damaging	0.89
R5923:Vmn2r24	UTSW	6	123,792,751 (GRCm39)	missense	probably damaging	0.96
R5969:Vmn2r24	UTSW	6	123,755,981 (GRCm39)	missense	probably benign	0.00
R6050:Vmn2r24	UTSW	6	123,792,691 (GRCm39)	missense	probably damaging	1.00
R6171:Vmn2r24	UTSW	6	123,764,205 (GRCm39)	missense	probably damaging	0.98
R6174:Vmn2r24	UTSW	6	123,793,236 (GRCm39)	missense	probably benign	0.00
R6356:Vmn2r24	UTSW	6	123,783,368 (GRCm39)	missense	possibly damaging	0.93
R6562:Vmn2r24	UTSW	6	123,757,386 (GRCm39)	missense	probably benign	0.01
R6563:Vmn2r24	UTSW	6	123,781,137 (GRCm39)	missense	possibly damaging	0.86
R6584:Vmn2r24	UTSW	6	123,792,764 (GRCm39)	missense	possibly damaging	0.53
R6630:Vmn2r24	UTSW	6	123,763,981 (GRCm39)	missense	probably benign	0.00
R6803:Vmn2r24	UTSW	6	123,755,960 (GRCm39)	missense	possibly damaging	0.64
R6864:Vmn2r24	UTSW	6	123,756,117 (GRCm39)	missense	possibly damaging	0.89
R7252:Vmn2r24	UTSW	6	123,764,191 (GRCm39)	missense	possibly damaging	0.90
R7369:Vmn2r24	UTSW	6	123,792,638 (GRCm39)	missense	probably damaging	0.99
R7646:Vmn2r24	UTSW	6	123,793,169 (GRCm39)	missense	probably benign	0.20
R7799:Vmn2r24	UTSW	6	123,757,422 (GRCm39)	missense	probably benign	0.00
R7803:Vmn2r24	UTSW	6	123,757,438 (GRCm39)	missense	probably benign	0.00
R7959:Vmn2r24	UTSW	6	123,755,949 (GRCm39)	missense	possibly damaging	0.86
R8215:Vmn2r24	UTSW	6	123,756,077 (GRCm39)	missense	probably benign	0.10
R8796:Vmn2r24	UTSW	6	123,757,500 (GRCm39)	missense	probably benign
R9172:Vmn2r24	UTSW	6	123,783,432 (GRCm39)	missense	probably damaging	1.00
R9300:Vmn2r24	UTSW	6	123,793,030 (GRCm39)	missense	possibly damaging	0.46
R9369:Vmn2r24	UTSW	6	123,792,357 (GRCm39)	missense	probably damaging	1.00
R9375:Vmn2r24	UTSW	6	123,792,542 (GRCm39)	missense	probably damaging	1.00
R9523:Vmn2r24	UTSW	6	123,763,950 (GRCm39)	missense	possibly damaging	0.89
R9546:Vmn2r24	UTSW	6	123,764,266 (GRCm39)	missense	probably damaging	0.98
RF006:Vmn2r24	UTSW	6	123,783,378 (GRCm39)	missense	probably damaging	1.00
RF016:Vmn2r24	UTSW	6	123,781,174 (GRCm39)	missense	probably benign	0.04
X0023:Vmn2r24	UTSW	6	123,764,359 (GRCm39)	missense	probably damaging	0.99
Z1088:Vmn2r24	UTSW	6	123,781,155 (GRCm39)	missense	probably benign	0.00
Z1177:Vmn2r24	UTSW	6	123,763,719 (GRCm39)	missense	probably benign	0.00

Posted On

2013-11-05