Mutagenetix > Incidental Mutation

Incidental Mutation 'I2288:Taar4'

7892

Institutional Source

Beutler Lab

Gene Symbol

Taar4

Ensembl Gene

ENSMUSG00000069707

Gene Name

trace amine-associated receptor 4

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.126) question?

Stock #

I2288 (G3) of strain 633

Quality Score

Status

Validated

Chromosome

Chromosomal Location

23836392-23837435 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 23836818 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 143 (T143A)

Ref Sequence

ENSEMBL: ENSMUSP00000090330 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000092660]

AlphaFold

Q5QD15

Predicted Effect

probably benign
Transcript: ENSMUST00000092660
AA Change: T143A

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000090330
Gene: ENSMUSG00000069707
AA Change: T143A

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	44	328	9.2e-11	PFAM
Pfam:7tm_1	50	313	4.6e-63	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 89.9%
3x: 84.8%

Validation Efficiency

71% (138/195)

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired olfactory response and aversion to PEA and puma urine. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam3	A	T	8: 25,174,677 (GRCm39)	I696N	probably damaging	Het
Adgra1	T	C	7: 139,432,495 (GRCm39)	I111T	probably damaging	Het
Adgrv1	A	G	13: 81,585,643 (GRCm39)	L4607P	probably damaging	Het
Alppl2	A	T	1: 87,015,898 (GRCm39)	M284K	possibly damaging	Het
Arfgef1	T	C	1: 10,243,478 (GRCm39)	K1024E	probably damaging	Het
Arid2	T	C	15: 96,267,392 (GRCm39)	V624A	possibly damaging	Het
Babam1	G	A	8: 71,850,467 (GRCm39)	R32Q	probably damaging	Het
Camk1g	C	T	1: 193,033,414 (GRCm39)		probably benign	Homo
Cfap44	C	A	16: 44,269,501 (GRCm39)	Y1168*	probably null	Het
Clasp1	A	G	1: 118,492,959 (GRCm39)	H1168R	probably benign	Het
Crkl	A	G	16: 17,301,612 (GRCm39)	T289A	probably damaging	Het
Dlec1	A	G	9: 118,972,669 (GRCm39)	D1464G	probably damaging	Het
Dmxl2	A	T	9: 54,309,077 (GRCm39)	H1891Q	probably damaging	Het
Dnah10	G	A	5: 124,807,164 (GRCm39)	A150T	probably benign	Het
Dnah8	A	G	17: 30,882,428 (GRCm39)	T667A	probably benign	Het
Fpr-rs3	A	T	17: 20,844,757 (GRCm39)	L128Q	probably damaging	Het
Fxn	C	T	19: 24,239,431 (GRCm39)		probably benign	Homo
Golgb1	A	G	16: 36,718,904 (GRCm39)	H270R	probably benign	Het
Gramd1b	T	C	9: 40,218,101 (GRCm39)	I572V	probably damaging	Het
Iqch	A	T	9: 63,408,172 (GRCm39)	I664K	probably benign	Het
Kcnn2	T	A	18: 45,808,340 (GRCm39)		probably benign	Het
Lrp1b	A	T	2: 41,012,944 (GRCm39)	I2001K	probably damaging	Het
Lrrc40	T	A	3: 157,758,426 (GRCm39)	I277K	probably damaging	Het
Myo1e	A	G	9: 70,249,379 (GRCm39)	E493G	possibly damaging	Homo
Nrcam	C	A	12: 44,611,098 (GRCm39)	H567Q	probably benign	Homo
Or52d3	T	C	7: 104,229,593 (GRCm39)	C247R	probably damaging	Het
Or5bw2	A	T	7: 6,573,818 (GRCm39)	Y276F	probably damaging	Homo
Or5w19	T	A	2: 87,698,479 (GRCm39)	I48N	probably damaging	Het
Parvg	C	A	15: 84,212,981 (GRCm39)		probably benign	Het
Ripk4	A	G	16: 97,549,345 (GRCm39)	V237A	probably benign	Het
Spam1	A	G	6: 24,796,477 (GRCm39)	I143V	probably benign	Het
Synj2	A	G	17: 6,072,542 (GRCm39)		probably benign	Het
Ttc12	T	A	9: 49,381,558 (GRCm39)	M138L	possibly damaging	Het
Ttll9	A	G	2: 152,814,259 (GRCm39)		probably benign	Het
Usp34	T	A	11: 23,382,473 (GRCm39)		probably benign	Homo
Utrn	A	G	10: 12,297,384 (GRCm39)	Y675H	probably damaging	Het

Other mutations in Taar4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02576:Taar4	APN	10	23,836,909 (GRCm39)	missense	probably damaging	1.00
IGL03202:Taar4	APN	10	23,836,692 (GRCm39)	missense	probably damaging	1.00
R0103:Taar4	UTSW	10	23,837,304 (GRCm39)	missense	probably damaging	1.00
R0103:Taar4	UTSW	10	23,837,304 (GRCm39)	missense	probably damaging	1.00
R0514:Taar4	UTSW	10	23,836,780 (GRCm39)	missense	probably damaging	1.00
R1222:Taar4	UTSW	10	23,837,230 (GRCm39)	missense	probably benign	0.05
R1248:Taar4	UTSW	10	23,836,936 (GRCm39)	missense	possibly damaging	0.95
R1514:Taar4	UTSW	10	23,836,510 (GRCm39)	missense	possibly damaging	0.71
R1921:Taar4	UTSW	10	23,837,239 (GRCm39)	missense	probably damaging	1.00
R2074:Taar4	UTSW	10	23,837,071 (GRCm39)	missense	probably benign	0.18
R2354:Taar4	UTSW	10	23,836,912 (GRCm39)	missense	probably damaging	1.00
R2392:Taar4	UTSW	10	23,837,172 (GRCm39)	missense	possibly damaging	0.94
R2698:Taar4	UTSW	10	23,837,328 (GRCm39)	missense	probably damaging	1.00
R3902:Taar4	UTSW	10	23,836,913 (GRCm39)	missense	probably damaging	1.00
R4688:Taar4	UTSW	10	23,836,731 (GRCm39)	missense	probably damaging	1.00
R5495:Taar4	UTSW	10	23,837,181 (GRCm39)	missense	possibly damaging	0.95
R5595:Taar4	UTSW	10	23,836,639 (GRCm39)	missense	probably damaging	1.00
R5773:Taar4	UTSW	10	23,837,056 (GRCm39)	missense	probably damaging	1.00
R7403:Taar4	UTSW	10	23,836,957 (GRCm39)	missense	probably damaging	1.00
R7581:Taar4	UTSW	10	23,837,052 (GRCm39)	missense	probably damaging	0.97
R7736:Taar4	UTSW	10	23,836,897 (GRCm39)	missense	probably damaging	1.00
R7859:Taar4	UTSW	10	23,837,032 (GRCm39)	missense	probably benign	0.35
R8676:Taar4	UTSW	10	23,836,801 (GRCm39)	missense	possibly damaging	0.56

Posted On

2012-11-13