Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01383:Vmn2r109'

78924

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r109

Ensembl Gene

ENSMUSG00000090572

Gene Name

vomeronasal 2, receptor 109

Synonyms

EG627814

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.064) question?

Stock #

IGL01383

Quality Score

Status

Chromosome

Chromosomal Location

20540517-20564756 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 20541121 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 658 (V658A)

Ref Sequence

ENSEMBL: ENSMUSP00000132641 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167093]

AlphaFold

K7N747

Predicted Effect

possibly damaging
Transcript: ENSMUST00000167093
AA Change: V658A

PolyPhen 2 Score 0.886 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000132641
Gene: ENSMUSG00000090572
AA Change: V658A

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	467	1.4e-35	PFAM
Pfam:NCD3G	510	563	3.1e-21	PFAM
Pfam:7tm_3	596	831	7.4e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930555G01Rik	C	A	14: 5,051,570		probably null	Het
4931409K22Rik	A	T	5: 24,548,294	N453K	probably benign	Het
Abca9	A	C	11: 110,113,293		probably benign	Het
Aox2	T	A	1: 58,294,305	M227K	probably benign	Het
Asb5	T	A	8: 54,550,509	L22H	probably damaging	Het
Atrx	T	C	X: 105,802,075	D2309G	probably damaging	Het
Cand1	T	A	10: 119,208,167	T1074S	probably damaging	Het
Ccdc114	T	C	7: 45,939,700	S179P	probably damaging	Het
Cep97	T	C	16: 55,911,607	E534G	probably damaging	Het
Cftr	C	A	6: 18,226,041	N329K	probably benign	Het
Clec7a	T	C	6: 129,472,640	T16A	probably damaging	Het
Col1a1	G	A	11: 94,945,525	R674H	probably damaging	Het
Csf2rb2	T	C	15: 78,297,043	S50G	possibly damaging	Het
Eepd1	A	G	9: 25,482,482	D14G	probably damaging	Het
Fsd1	C	T	17: 55,996,733	S491F	probably damaging	Het
Gm13103	T	G	4: 143,846,532		probably benign	Het
Grin1	C	A	2: 25,296,967	R694L	possibly damaging	Het
Gtf3c1	A	G	7: 125,699,500	I151T	probably damaging	Het
Havcr2	T	C	11: 46,469,548	S152P	probably damaging	Het
Hvcn1	T	C	5: 122,237,703	V15A	probably damaging	Het
Map3k10	C	T	7: 27,657,999	V785M	probably benign	Het
Mis18bp1	T	C	12: 65,148,989	N667S	probably benign	Het
Mup3	A	C	4: 62,085,959	Y106D	probably damaging	Het
Mypn	G	T	10: 63,135,797	N821K	probably damaging	Het
Olfr1386	T	A	11: 49,471,053	W301R	probably benign	Het
Olfr152	A	G	2: 87,782,873	D111G	possibly damaging	Het
Olfr209	A	T	16: 59,361,953	N88K	probably benign	Het
Olfr547	A	G	7: 102,534,933	Y62C	probably benign	Het
Pcdhb10	A	T	18: 37,413,275	H468L	probably benign	Het
Prp2	C	A	6: 132,599,878	P43T	unknown	Het
Psg26	A	G	7: 18,480,254	V161A	possibly damaging	Het
Rab17	T	G	1: 90,960,093	D115A	probably damaging	Het
Rrp1b	T	C	17: 32,058,578	F611L	probably damaging	Het
Skor1	T	A	9: 63,146,556	T44S	probably benign	Het
Spaca5	T	C	X: 21,068,486		probably benign	Het
Tatdn3	G	A	1: 191,055,381		probably benign	Het
Tbk1	T	C	10: 121,576,279	D118G	probably damaging	Het
Tnfsf13b	T	C	8: 10,031,528	F230S	probably damaging	Het
Tnrc6c	T	C	11: 117,714,257	S73P	probably benign	Het
Vmn2r116	C	T	17: 23,401,601	L770F	probably damaging	Het
Wwp2	T	A	8: 107,533,291		probably null	Het

Other mutations in Vmn2r109

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01313:Vmn2r109	APN	17	20550157	missense	probably damaging	1.00
IGL01469:Vmn2r109	APN	17	20541409	missense	probably damaging	1.00
IGL01762:Vmn2r109	APN	17	20554392	missense	probably benign
IGL01864:Vmn2r109	APN	17	20541134	missense	probably benign	0.28
IGL02028:Vmn2r109	APN	17	20541080	missense	probably benign	0.28
IGL02074:Vmn2r109	APN	17	20554341	missense	probably benign	0.05
IGL02162:Vmn2r109	APN	17	20554160	missense	probably benign	0.01
IGL02474:Vmn2r109	APN	17	20540888	missense	probably benign
IGL02490:Vmn2r109	APN	17	20540984	missense	possibly damaging	0.78
IGL02604:Vmn2r109	APN	17	20540701	missense	probably damaging	1.00
IGL02669:Vmn2r109	APN	17	20554256	missense	possibly damaging	0.64
IGL02705:Vmn2r109	APN	17	20553800	missense	probably benign
IGL02745:Vmn2r109	APN	17	20541250	missense	probably damaging	0.99
PIT4142001:Vmn2r109	UTSW	17	20554577	critical splice acceptor site	probably null
R0389:Vmn2r109	UTSW	17	20541074	missense	probably damaging	1.00
R0470:Vmn2r109	UTSW	17	20552886	missense	probably benign	0.06
R0570:Vmn2r109	UTSW	17	20540675	missense	probably damaging	0.99
R0855:Vmn2r109	UTSW	17	20541408	nonsense	probably null
R0882:Vmn2r109	UTSW	17	20554580	splice site	probably benign
R1241:Vmn2r109	UTSW	17	20555241	missense	possibly damaging	0.86
R1587:Vmn2r109	UTSW	17	20540740	missense	probably damaging	1.00
R1931:Vmn2r109	UTSW	17	20553810	nonsense	probably null
R1957:Vmn2r109	UTSW	17	20564707	missense	probably benign	0.11
R1962:Vmn2r109	UTSW	17	20553923	missense	probably damaging	0.99
R2020:Vmn2r109	UTSW	17	20541186	nonsense	probably null
R2073:Vmn2r109	UTSW	17	20564712	missense	probably benign	0.00
R2436:Vmn2r109	UTSW	17	20554536	missense	probably damaging	0.99
R3123:Vmn2r109	UTSW	17	20540986	missense	probably damaging	1.00
R3839:Vmn2r109	UTSW	17	20554442	missense	probably damaging	1.00
R4019:Vmn2r109	UTSW	17	20553812	missense	probably benign
R4428:Vmn2r109	UTSW	17	20553024	missense	probably benign
R4584:Vmn2r109	UTSW	17	20554558	nonsense	probably null
R4652:Vmn2r109	UTSW	17	20541394	missense	probably damaging	1.00
R4708:Vmn2r109	UTSW	17	20541343	missense	probably damaging	0.97
R4823:Vmn2r109	UTSW	17	20553891	missense	probably damaging	1.00
R4831:Vmn2r109	UTSW	17	20541232	missense	probably benign	0.01
R4907:Vmn2r109	UTSW	17	20550086	missense	probably damaging	1.00
R5011:Vmn2r109	UTSW	17	20555189	missense	probably damaging	1.00
R5296:Vmn2r109	UTSW	17	20554341	missense	possibly damaging	0.90
R5600:Vmn2r109	UTSW	17	20540927	missense	probably damaging	1.00
R5602:Vmn2r109	UTSW	17	20540671	missense	possibly damaging	0.94
R5652:Vmn2r109	UTSW	17	20540519	makesense	probably null
R5702:Vmn2r109	UTSW	17	20554145	missense	probably benign	0.42
R5706:Vmn2r109	UTSW	17	20554305	missense	probably benign	0.16
R5714:Vmn2r109	UTSW	17	20552859	missense	probably damaging	1.00
R5832:Vmn2r109	UTSW	17	20541056	missense	probably benign	0.10
R6008:Vmn2r109	UTSW	17	20540719	missense	probably damaging	1.00
R6334:Vmn2r109	UTSW	17	20541178	missense	probably benign	0.18
R6377:Vmn2r109	UTSW	17	20564534	critical splice donor site	probably null
R6738:Vmn2r109	UTSW	17	20554523	missense	possibly damaging	0.52
R6857:Vmn2r109	UTSW	17	20540670	missense	probably benign	0.45
R6953:Vmn2r109	UTSW	17	20540711	missense	possibly damaging	0.95
R7108:Vmn2r109	UTSW	17	20564744	missense	probably benign	0.03
R7229:Vmn2r109	UTSW	17	20540963	missense	possibly damaging	0.80
R7238:Vmn2r109	UTSW	17	20541074	missense	probably damaging	1.00
R7244:Vmn2r109	UTSW	17	20540683	missense	possibly damaging	0.70
R7292:Vmn2r109	UTSW	17	20541438	missense	probably benign	0.05
R7354:Vmn2r109	UTSW	17	20540781	missense	probably damaging	1.00
R7357:Vmn2r109	UTSW	17	20541274	missense	probably damaging	1.00
R7522:Vmn2r109	UTSW	17	20554403	missense	probably benign	0.11
R7596:Vmn2r109	UTSW	17	20540680	missense	probably damaging	0.98
R7728:Vmn2r109	UTSW	17	20552855	missense	probably damaging	0.99
R7859:Vmn2r109	UTSW	17	20541174	missense	probably damaging	1.00
R7871:Vmn2r109	UTSW	17	20540520	missense	probably benign	0.08
R8113:Vmn2r109	UTSW	17	20554467	missense	probably benign	0.01
R8153:Vmn2r109	UTSW	17	20564707	missense	probably benign	0.11
R8977:Vmn2r109	UTSW	17	20554269	missense	possibly damaging	0.96
Z1176:Vmn2r109	UTSW	17	20552994	missense	probably benign	0.00

Posted On

2013-11-05