Incidental Mutation 'IGL01383:Olfr152'
ID78934
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr152
Ensembl Gene ENSMUSG00000068816
Gene Nameolfactory receptor 152
SynonymsV1, MOR181-1, GA_x6K02T2Q125-49283184-49284128, Olfr4-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.157) question?
Stock #IGL01383
Quality Score
Status
Chromosome2
Chromosomal Location87779483-87784572 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 87782873 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 111 (D111G)
Ref Sequence ENSEMBL: ENSMUSP00000150778 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090709] [ENSMUST00000105210] [ENSMUST00000215394]
Predicted Effect possibly damaging
Transcript: ENSMUST00000090709
AA Change: D113G

PolyPhen 2 Score 0.915 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000088211
Gene: ENSMUSG00000068816
AA Change: D113G

DomainStartEndE-ValueType
Pfam:7tm_4 35 312 4.3e-49 PFAM
Pfam:7tm_1 45 314 7.9e-22 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000105210
AA Change: D111G

PolyPhen 2 Score 0.915 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000100845
Gene: ENSMUSG00000068816
AA Change: D111G

DomainStartEndE-ValueType
Pfam:7tm_1 43 292 6.4e-28 PFAM
Pfam:7tm_4 141 285 1.3e-46 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213624
Predicted Effect possibly damaging
Transcript: ENSMUST00000215394
AA Change: D111G

PolyPhen 2 Score 0.915 (Sensitivity: 0.81; Specificity: 0.94)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930555G01Rik C A 14: 5,051,570 probably null Het
4931409K22Rik A T 5: 24,548,294 N453K probably benign Het
Abca9 A C 11: 110,113,293 probably benign Het
Aox2 T A 1: 58,294,305 M227K probably benign Het
Asb5 T A 8: 54,550,509 L22H probably damaging Het
Atrx T C X: 105,802,075 D2309G probably damaging Het
Cand1 T A 10: 119,208,167 T1074S probably damaging Het
Ccdc114 T C 7: 45,939,700 S179P probably damaging Het
Cep97 T C 16: 55,911,607 E534G probably damaging Het
Cftr C A 6: 18,226,041 N329K probably benign Het
Clec7a T C 6: 129,472,640 T16A probably damaging Het
Col1a1 G A 11: 94,945,525 R674H probably damaging Het
Csf2rb2 T C 15: 78,297,043 S50G possibly damaging Het
Eepd1 A G 9: 25,482,482 D14G probably damaging Het
Fsd1 C T 17: 55,996,733 S491F probably damaging Het
Gm13103 T G 4: 143,846,532 probably benign Het
Grin1 C A 2: 25,296,967 R694L possibly damaging Het
Gtf3c1 A G 7: 125,699,500 I151T probably damaging Het
Havcr2 T C 11: 46,469,548 S152P probably damaging Het
Hvcn1 T C 5: 122,237,703 V15A probably damaging Het
Map3k10 C T 7: 27,657,999 V785M probably benign Het
Mis18bp1 T C 12: 65,148,989 N667S probably benign Het
Mup3 A C 4: 62,085,959 Y106D probably damaging Het
Mypn G T 10: 63,135,797 N821K probably damaging Het
Olfr1386 T A 11: 49,471,053 W301R probably benign Het
Olfr209 A T 16: 59,361,953 N88K probably benign Het
Olfr547 A G 7: 102,534,933 Y62C probably benign Het
Pcdhb10 A T 18: 37,413,275 H468L probably benign Het
Prp2 C A 6: 132,599,878 P43T unknown Het
Psg26 A G 7: 18,480,254 V161A possibly damaging Het
Rab17 T G 1: 90,960,093 D115A probably damaging Het
Rrp1b T C 17: 32,058,578 F611L probably damaging Het
Skor1 T A 9: 63,146,556 T44S probably benign Het
Spaca5 T C X: 21,068,486 probably benign Het
Tatdn3 G A 1: 191,055,381 probably benign Het
Tbk1 T C 10: 121,576,279 D118G probably damaging Het
Tnfsf13b T C 8: 10,031,528 F230S probably damaging Het
Tnrc6c T C 11: 117,714,257 S73P probably benign Het
Vmn2r109 A G 17: 20,541,121 V658A possibly damaging Het
Vmn2r116 C T 17: 23,401,601 L770F probably damaging Het
Wwp2 T A 8: 107,533,291 probably null Het
Other mutations in Olfr152
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00951:Olfr152 APN 2 87782539 missense probably benign
IGL01124:Olfr152 APN 2 87783376 missense probably benign 0.01
IGL01501:Olfr152 APN 2 87783136 missense possibly damaging 0.85
IGL02279:Olfr152 APN 2 87783232 missense probably damaging 0.99
R0141:Olfr152 UTSW 2 87782705 missense possibly damaging 0.74
R0212:Olfr152 UTSW 2 87783482 missense unknown
R0492:Olfr152 UTSW 2 87782822 missense probably damaging 1.00
R1611:Olfr152 UTSW 2 87782624 missense probably benign 0.38
R1697:Olfr152 UTSW 2 87782585 missense possibly damaging 0.95
R3606:Olfr152 UTSW 2 87783207 missense probably benign 0.26
R4583:Olfr152 UTSW 2 87783221 missense possibly damaging 0.76
R4646:Olfr152 UTSW 2 87783221 missense possibly damaging 0.76
R4648:Olfr152 UTSW 2 87783221 missense possibly damaging 0.76
R4853:Olfr152 UTSW 2 87783182 missense probably benign 0.04
R6102:Olfr152 UTSW 2 87782848 missense probably damaging 1.00
R6154:Olfr152 UTSW 2 87782756 missense possibly damaging 0.94
R7637:Olfr152 UTSW 2 87783434 missense probably damaging 1.00
Z1088:Olfr152 UTSW 2 87782628 missense probably damaging 1.00
Z1176:Olfr152 UTSW 2 87783024 missense probably damaging 1.00
Posted On2013-11-05