Incidental Mutation 'IGL01383:Prp2'
ID78948
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prp2
Ensembl Gene ENSMUSG00000058295
Gene Nameproline rich protein 2
SynonymsMP14
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL01383
Quality Score
Status
Chromosome6
Chromosomal Location132595913-132601236 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 132599878 bp
ZygosityHeterozygous
Amino Acid Change Proline to Threonine at position 43 (P43T)
Ref Sequence ENSEMBL: ENSMUSP00000135942 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076061] [ENSMUST00000178961]
Predicted Effect unknown
Transcript: ENSMUST00000076061
AA Change: P43T
SMART Domains Protein: ENSMUSP00000075435
Gene: ENSMUSG00000058295
AA Change: P43T

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
low complexity region 24 44 N/A INTRINSIC
low complexity region 49 299 N/A INTRINSIC
low complexity region 302 316 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000178961
AA Change: P43T
SMART Domains Protein: ENSMUSP00000135942
Gene: ENSMUSG00000058295
AA Change: P43T

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
low complexity region 24 44 N/A INTRINSIC
low complexity region 49 299 N/A INTRINSIC
low complexity region 302 316 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The expression of this gene is dramatically induced in the parotid and submandibular glands of mice by beta-adrenergic stimulation. The encoded protein serves an important dental function by protecting mice against toxic dietary polyphenols such as tannins and influence the visco-elastic properties of the mucus. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 6. [provided by RefSeq, Nov 2015]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930555G01Rik C A 14: 5,051,570 probably null Het
4931409K22Rik A T 5: 24,548,294 N453K probably benign Het
Abca9 A C 11: 110,113,293 probably benign Het
Aox2 T A 1: 58,294,305 M227K probably benign Het
Asb5 T A 8: 54,550,509 L22H probably damaging Het
Atrx T C X: 105,802,075 D2309G probably damaging Het
Cand1 T A 10: 119,208,167 T1074S probably damaging Het
Ccdc114 T C 7: 45,939,700 S179P probably damaging Het
Cep97 T C 16: 55,911,607 E534G probably damaging Het
Cftr C A 6: 18,226,041 N329K probably benign Het
Clec7a T C 6: 129,472,640 T16A probably damaging Het
Col1a1 G A 11: 94,945,525 R674H probably damaging Het
Csf2rb2 T C 15: 78,297,043 S50G possibly damaging Het
Eepd1 A G 9: 25,482,482 D14G probably damaging Het
Fsd1 C T 17: 55,996,733 S491F probably damaging Het
Gm13103 T G 4: 143,846,532 probably benign Het
Grin1 C A 2: 25,296,967 R694L possibly damaging Het
Gtf3c1 A G 7: 125,699,500 I151T probably damaging Het
Havcr2 T C 11: 46,469,548 S152P probably damaging Het
Hvcn1 T C 5: 122,237,703 V15A probably damaging Het
Map3k10 C T 7: 27,657,999 V785M probably benign Het
Mis18bp1 T C 12: 65,148,989 N667S probably benign Het
Mup3 A C 4: 62,085,959 Y106D probably damaging Het
Mypn G T 10: 63,135,797 N821K probably damaging Het
Olfr1386 T A 11: 49,471,053 W301R probably benign Het
Olfr152 A G 2: 87,782,873 D111G possibly damaging Het
Olfr209 A T 16: 59,361,953 N88K probably benign Het
Olfr547 A G 7: 102,534,933 Y62C probably benign Het
Pcdhb10 A T 18: 37,413,275 H468L probably benign Het
Psg26 A G 7: 18,480,254 V161A possibly damaging Het
Rab17 T G 1: 90,960,093 D115A probably damaging Het
Rrp1b T C 17: 32,058,578 F611L probably damaging Het
Skor1 T A 9: 63,146,556 T44S probably benign Het
Spaca5 T C X: 21,068,486 probably benign Het
Tatdn3 G A 1: 191,055,381 probably benign Het
Tbk1 T C 10: 121,576,279 D118G probably damaging Het
Tnfsf13b T C 8: 10,031,528 F230S probably damaging Het
Tnrc6c T C 11: 117,714,257 S73P probably benign Het
Vmn2r109 A G 17: 20,541,121 V658A possibly damaging Het
Vmn2r116 C T 17: 23,401,601 L770F probably damaging Het
Wwp2 T A 8: 107,533,291 probably null Het
Other mutations in Prp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02951:Prp2 APN 6 132599825 missense unknown
PIT4458001:Prp2 UTSW 6 132600547 missense unknown
R2034:Prp2 UTSW 6 132595984 synonymous probably null
R2432:Prp2 UTSW 6 132599911 missense unknown
R5283:Prp2 UTSW 6 132600643 missense unknown
R7761:Prp2 UTSW 6 132600343 nonsense probably null
R7877:Prp2 UTSW 6 132595965 missense unknown
R7960:Prp2 UTSW 6 132595965 missense unknown
R8033:Prp2 UTSW 6 132600428 missense unknown
R8062:Prp2 UTSW 6 132600688 missense unknown
RF005:Prp2 UTSW 6 132600501 small deletion probably benign
RF016:Prp2 UTSW 6 132600512 small deletion probably benign
RF039:Prp2 UTSW 6 132600501 small deletion probably benign
RF052:Prp2 UTSW 6 132600512 small deletion probably benign
RF054:Prp2 UTSW 6 132600521 frame shift probably null
RF057:Prp2 UTSW 6 132600530 frame shift probably null
X0053:Prp2 UTSW 6 132600596 missense unknown
Z1176:Prp2 UTSW 6 132600237 missense unknown
Z1177:Prp2 UTSW 6 132595970 missense unknown
Posted On2013-11-05