Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01383:Prp2'

78948

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Prp2

Ensembl Gene

ENSMUSG00000058295

Gene Name

proline rich protein 2

Synonyms

MP14

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL01383

Quality Score

Status

Chromosome

Chromosomal Location

132572874-132577665 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 132576841 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Proline to Threonine at position 43 (P43T)

Ref Sequence

ENSEMBL: ENSMUSP00000135942 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000076061] [ENSMUST00000178961]

AlphaFold

no structure available at present

Predicted Effect

unknown
Transcript: ENSMUST00000076061
AA Change: P43T

SMART Domains

Protein: ENSMUSP00000075435
Gene: ENSMUSG00000058295
AA Change: P43T

Domain	Start	End	E-Value	Type
signal peptide	1	16	N/A	INTRINSIC
low complexity region	24	44	N/A	INTRINSIC
low complexity region	49	299	N/A	INTRINSIC
low complexity region	302	316	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000178961
AA Change: P43T

SMART Domains

Protein: ENSMUSP00000135942
Gene: ENSMUSG00000058295
AA Change: P43T

Domain	Start	End	E-Value	Type
signal peptide	1	16	N/A	INTRINSIC
low complexity region	24	44	N/A	INTRINSIC
low complexity region	49	299	N/A	INTRINSIC
low complexity region	302	316	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The expression of this gene is dramatically induced in the parotid and submandibular glands of mice by beta-adrenergic stimulation. The encoded protein serves an important dental function by protecting mice against toxic dietary polyphenols such as tannins and influence the visco-elastic properties of the mucus. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 6. [provided by RefSeq, Nov 2015]

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930555G01Rik	C	A	14: 5,051,570 (GRCm38)		probably null	Het
Abca9	A	C	11: 110,004,119 (GRCm39)		probably benign	Het
Aox1	T	A	1: 58,333,464 (GRCm39)	M227K	probably benign	Het
Asb5	T	A	8: 55,003,544 (GRCm39)	L22H	probably damaging	Het
Atrx	T	C	X: 104,845,681 (GRCm39)	D2309G	probably damaging	Het
Cand1	T	A	10: 119,044,072 (GRCm39)	T1074S	probably damaging	Het
Cep97	T	C	16: 55,731,970 (GRCm39)	E534G	probably damaging	Het
Cftr	C	A	6: 18,226,040 (GRCm39)	N329K	probably benign	Het
Clec7a	T	C	6: 129,449,603 (GRCm39)	T16A	probably damaging	Het
Col1a1	G	A	11: 94,836,351 (GRCm39)	R674H	probably damaging	Het
Csf2rb2	T	C	15: 78,181,243 (GRCm39)	S50G	possibly damaging	Het
Eepd1	A	G	9: 25,393,778 (GRCm39)	D14G	probably damaging	Het
Fsd1	C	T	17: 56,303,733 (GRCm39)	S491F	probably damaging	Het
Grin1	C	A	2: 25,186,979 (GRCm39)	R694L	possibly damaging	Het
Gtf3c1	A	G	7: 125,298,672 (GRCm39)	I151T	probably damaging	Het
Havcr2	T	C	11: 46,360,375 (GRCm39)	S152P	probably damaging	Het
Hvcn1	T	C	5: 122,375,766 (GRCm39)	V15A	probably damaging	Het
Iqca1l	A	T	5: 24,753,292 (GRCm39)	N453K	probably benign	Het
Map3k10	C	T	7: 27,357,424 (GRCm39)	V785M	probably benign	Het
Mis18bp1	T	C	12: 65,195,763 (GRCm39)	N667S	probably benign	Het
Mup3	A	C	4: 62,004,196 (GRCm39)	Y106D	probably damaging	Het
Mypn	G	T	10: 62,971,576 (GRCm39)	N821K	probably damaging	Het
Odad1	T	C	7: 45,589,124 (GRCm39)	S179P	probably damaging	Het
Or2y1c	T	A	11: 49,361,880 (GRCm39)	W301R	probably benign	Het
Or52b4	A	G	7: 102,184,140 (GRCm39)	Y62C	probably benign	Het
Or5ac25	A	T	16: 59,182,316 (GRCm39)	N88K	probably benign	Het
Or5i1	A	G	2: 87,613,217 (GRCm39)	D111G	possibly damaging	Het
Pcdhb10	A	T	18: 37,546,328 (GRCm39)	H468L	probably benign	Het
Pramel27	T	G	4: 143,573,102 (GRCm39)		probably benign	Het
Psg26	A	G	7: 18,214,179 (GRCm39)	V161A	possibly damaging	Het
Rab17	T	G	1: 90,887,815 (GRCm39)	D115A	probably damaging	Het
Rrp1b	T	C	17: 32,277,552 (GRCm39)	F611L	probably damaging	Het
Skor1	T	A	9: 63,053,838 (GRCm39)	T44S	probably benign	Het
Spaca5	T	C	X: 20,934,725 (GRCm39)		probably benign	Het
Tatdn3	G	A	1: 190,787,578 (GRCm39)		probably benign	Het
Tbk1	T	C	10: 121,412,184 (GRCm39)	D118G	probably damaging	Het
Tnfsf13b	T	C	8: 10,081,528 (GRCm39)	F230S	probably damaging	Het
Tnrc6c	T	C	11: 117,605,083 (GRCm39)	S73P	probably benign	Het
Vmn2r109	A	G	17: 20,761,383 (GRCm39)	V658A	possibly damaging	Het
Vmn2r116	C	T	17: 23,620,575 (GRCm39)	L770F	probably damaging	Het
Wwp2	T	A	8: 108,259,923 (GRCm39)		probably null	Het

Other mutations in Prp2

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL02951:Prp2	APN	6	132,576,788 (GRCm39)	missense	unknown
PIT4458001:Prp2	UTSW	6	132,577,510 (GRCm39)	missense	unknown
R2034:Prp2	UTSW	6	132,572,947 (GRCm39)	splice site	probably null
R2432:Prp2	UTSW	6	132,576,874 (GRCm39)	missense	unknown
R5283:Prp2	UTSW	6	132,577,606 (GRCm39)	missense	unknown
R7761:Prp2	UTSW	6	132,577,306 (GRCm39)	nonsense	probably null
R7877:Prp2	UTSW	6	132,572,928 (GRCm39)	missense	unknown
R8033:Prp2	UTSW	6	132,577,391 (GRCm39)	missense	unknown
R8062:Prp2	UTSW	6	132,577,651 (GRCm39)	missense	unknown
R8695:Prp2	UTSW	6	132,576,932 (GRCm39)	missense	unknown
R8696:Prp2	UTSW	6	132,577,322 (GRCm39)	missense	unknown
R8938:Prp2	UTSW	6	132,577,581 (GRCm39)	missense	unknown
RF005:Prp2	UTSW	6	132,577,464 (GRCm39)	small deletion	probably benign
RF016:Prp2	UTSW	6	132,577,475 (GRCm39)	small deletion	probably benign
RF039:Prp2	UTSW	6	132,577,464 (GRCm39)	small deletion	probably benign
RF052:Prp2	UTSW	6	132,577,475 (GRCm39)	small deletion	probably benign
RF054:Prp2	UTSW	6	132,577,484 (GRCm39)	frame shift	probably null
RF057:Prp2	UTSW	6	132,577,493 (GRCm39)	frame shift	probably null
X0053:Prp2	UTSW	6	132,577,559 (GRCm39)	missense	unknown
Z1176:Prp2	UTSW	6	132,577,200 (GRCm39)	missense	unknown
Z1177:Prp2	UTSW	6	132,572,933 (GRCm39)	missense	unknown

Posted On

2013-11-05