Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01384:Pla2g2c'

78973

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Pla2g2c

Ensembl Gene

ENSMUSG00000028750

Gene Name

phospholipase A2, group IIC

Synonyms

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01384

Quality Score

Status

Chromosome

Chromosomal Location

138452636-138471886 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 138471012 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Arginine at position 131 (K131R)

Ref Sequence

ENSEMBL: ENSMUSP00000101434 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000030530] [ENSMUST00000105808] [ENSMUST00000124660]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000030530
AA Change: K131R

PolyPhen 2 Score 0.158 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000030530
Gene: ENSMUSG00000028750
AA Change: K131R

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
PA2c	21	143	1.83e-50	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000105808
AA Change: K131R

PolyPhen 2 Score 0.158 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000101434
Gene: ENSMUSG00000028750
AA Change: K131R

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
PA2c	21	143	1.83e-50	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000124660

SMART Domains

Protein: ENSMUSP00000124341
Gene: ENSMUSG00000028750

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
PA2c	21	128	1.4e-37	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932414N04Rik	A	G	2: 68,575,749 (GRCm39)	R683G	possibly damaging	Het
Abca9	A	G	11: 110,036,463 (GRCm39)	S549P	probably damaging	Het
Adgrd1	T	C	5: 129,174,273 (GRCm39)	S17P	possibly damaging	Het
Ankrd36	C	A	11: 5,578,348 (GRCm39)	H546N	probably benign	Het
Aopep	C	T	13: 63,338,290 (GRCm39)		probably benign	Het
Bivm	T	G	1: 44,165,907 (GRCm39)	I119S	possibly damaging	Het
Ccdc88a	G	T	11: 29,453,915 (GRCm39)	D1693Y	probably damaging	Het
Clcn6	G	A	4: 148,103,423 (GRCm39)	R242C	probably damaging	Het
Clec4a2	A	C	6: 123,104,947 (GRCm39)	K79T	probably damaging	Het
Cspp1	G	A	1: 10,186,905 (GRCm39)	R129H	probably damaging	Het
Cyp2c40	A	T	19: 39,801,027 (GRCm39)	M47K	probably benign	Het
Dmxl1	A	G	18: 49,990,401 (GRCm39)	D280G	probably benign	Het
Fbxo38	A	G	18: 62,655,487 (GRCm39)	S400P	probably damaging	Het
Fsd1	C	T	17: 56,303,733 (GRCm39)	S491F	probably damaging	Het
Gen1	T	C	12: 11,305,242 (GRCm39)	I184M	probably benign	Het
Gm9949	A	T	18: 62,317,089 (GRCm39)		probably benign	Het
Grtp1	A	T	8: 13,229,629 (GRCm39)	V253E	probably damaging	Het
Irag1	A	G	7: 110,525,708 (GRCm39)	V148A	possibly damaging	Het
Lamb1	T	A	12: 31,370,930 (GRCm39)	M1327K	probably benign	Het
Lrp2	T	A	2: 69,313,846 (GRCm39)	D2295V	probably damaging	Het
Lrp2	T	C	2: 69,284,156 (GRCm39)	D3874G	probably null	Het
Muc5b	A	T	7: 141,400,555 (GRCm39)	I509F	unknown	Het
Mug1	A	C	6: 121,826,433 (GRCm39)		probably benign	Het
Myh7	A	T	14: 55,208,916 (GRCm39)	L1903Q	probably damaging	Het
Mylk	G	T	16: 34,759,322 (GRCm39)	A1229S	probably benign	Het
Myorg	G	T	4: 41,498,151 (GRCm39)	A493E	probably damaging	Het
Ncam1	A	T	9: 49,421,152 (GRCm39)	I721N	possibly damaging	Het
Or8b101	T	A	9: 38,020,858 (GRCm39)	I287N	probably damaging	Het
Rpgrip1l	A	T	8: 92,000,268 (GRCm39)	I557N	probably benign	Het
Sirpb1b	T	A	3: 15,613,789 (GRCm39)	N98Y	probably damaging	Het
Stab1	A	G	14: 30,872,365 (GRCm39)	V1182A	probably benign	Het
Tagap1	T	C	17: 7,224,282 (GRCm39)	D138G	probably benign	Het
Tiam2	T	A	17: 3,477,477 (GRCm39)	F567I	probably benign	Het
Ush2a	A	T	1: 188,285,425 (GRCm39)	D1987V	possibly damaging	Het
Vmn1r36	A	T	6: 66,693,446 (GRCm39)	I37N	probably damaging	Het
Wif1	A	T	10: 120,920,855 (GRCm39)	T226S	possibly damaging	Het
Zfp428	A	G	7: 24,210,167 (GRCm39)	D22G	possibly damaging	Het
Zfp521	A	T	18: 13,976,980 (GRCm39)	N1144K	probably benign	Het

Other mutations in Pla2g2c

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02219:Pla2g2c	APN	4	138,463,319 (GRCm39)	missense	probably damaging	1.00
IGL03087:Pla2g2c	APN	4	138,458,923 (GRCm39)	missense	probably benign	0.03
R0047:Pla2g2c	UTSW	4	138,470,901 (GRCm39)	splice site	probably benign
R0047:Pla2g2c	UTSW	4	138,470,901 (GRCm39)	splice site	probably benign
R4491:Pla2g2c	UTSW	4	138,461,719 (GRCm39)	critical splice donor site	probably null
R4817:Pla2g2c	UTSW	4	138,461,645 (GRCm39)	missense	probably damaging	1.00
R5257:Pla2g2c	UTSW	4	138,458,856 (GRCm39)	start gained	probably benign
R5360:Pla2g2c	UTSW	4	138,461,656 (GRCm39)	missense	possibly damaging	0.54
R6777:Pla2g2c	UTSW	4	138,470,976 (GRCm39)	missense	probably benign	0.02
R7346:Pla2g2c	UTSW	4	138,461,650 (GRCm39)	missense	probably damaging	1.00
R7447:Pla2g2c	UTSW	4	138,458,927 (GRCm39)	missense	probably benign	0.39
R9083:Pla2g2c	UTSW	4	138,463,378 (GRCm39)	missense	probably benign	0.04
R9500:Pla2g2c	UTSW	4	138,461,689 (GRCm39)	nonsense	probably null
R9744:Pla2g2c	UTSW	4	138,470,972 (GRCm39)	missense	probably damaging	1.00
Z1088:Pla2g2c	UTSW	4	138,461,597 (GRCm39)	missense	probably damaging	0.99

Posted On

2013-11-05