Incidental Mutation 'IGL01385:Olfr1330'
ID79002
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1330
Ensembl Gene ENSMUSG00000073768
Gene Nameolfactory receptor 1330
SynonymsGA_x6K02T2QD9B-18644371-18643424, MOR259-8
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.079) question?
Stock #IGL01385
Quality Score
Status
Chromosome4
Chromosomal Location118888597-118899597 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 118893551 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Serine at position 156 (L156S)
Ref Sequence ENSEMBL: ENSMUSP00000101968 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094830] [ENSMUST00000105035] [ENSMUST00000106361]
Predicted Effect probably benign
Transcript: ENSMUST00000094830
AA Change: L156S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000092425
Gene: ENSMUSG00000073768
AA Change: L156S

DomainStartEndE-ValueType
Pfam:7tm_4 34 310 1.2e-53 PFAM
Pfam:7TM_GPCR_Srsx 38 308 1.4e-6 PFAM
Pfam:7tm_1 44 293 1.6e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000105035
AA Change: L156S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000100652
Gene: ENSMUSG00000073768
AA Change: L156S

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 38 307 6.4e-8 PFAM
Pfam:7tm_1 44 293 2.9e-31 PFAM
Pfam:7tm_4 142 286 6.7e-46 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106361
AA Change: L156S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000101968
Gene: ENSMUSG00000073768
AA Change: L156S

DomainStartEndE-ValueType
Pfam:7tm_4 33 309 6.1e-56 PFAM
Pfam:7tm_1 43 292 3.9e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215186
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216386
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700016C15Rik G A 1: 177,741,074 G46R probably benign Het
Ablim1 A T 19: 57,068,914 S292R probably damaging Het
Adamts19 A G 18: 58,972,779 T749A probably damaging Het
Agap2 A T 10: 127,087,996 I747F unknown Het
Arhgap35 T A 7: 16,564,474 N222I probably damaging Het
Atp10b A G 11: 43,234,429 E1074G probably damaging Het
Brd3 T C 2: 27,464,089 T4A possibly damaging Het
Col6a6 A G 9: 105,783,666 S415P probably damaging Het
Dennd2a A G 6: 39,523,136 V165A probably damaging Het
Dnm1l T A 16: 16,341,453 E95V probably damaging Het
Dock9 A G 14: 121,580,583 Y1609H possibly damaging Het
Esm1 A C 13: 113,216,682 E166A possibly damaging Het
F2rl2 A C 13: 95,701,328 I294L probably benign Het
Gstt3 A G 10: 75,774,988 S187P probably benign Het
Katna1 T C 10: 7,752,810 C268R probably damaging Het
Mbd5 T A 2: 49,250,221 C66S possibly damaging Het
Naa35 G A 13: 59,601,066 E167K probably damaging Het
Osbpl2 A G 2: 180,137,080 N2S probably benign Het
Parp6 T C 9: 59,630,612 probably benign Het
Pcdhb5 T A 18: 37,322,214 V549E probably benign Het
Pcnx4 T C 12: 72,573,746 L780P probably damaging Het
Plcb3 A T 19: 6,957,908 D851E probably benign Het
Ppfia2 A G 10: 106,913,699 S1149G probably damaging Het
Prkca A G 11: 107,978,352 V469A probably damaging Het
Ryr1 A T 7: 29,056,985 V3468D probably damaging Het
Stxbp4 A G 11: 90,540,248 V412A possibly damaging Het
Vmn1r238 G T 18: 3,122,770 Q215K possibly damaging Het
Wdr11 A G 7: 129,607,913 M482V probably benign Het
Wdr72 T C 9: 74,179,506 probably benign Het
Xirp2 T C 2: 67,509,677 L754P probably damaging Het
Zmym6 G A 4: 127,124,106 G1135S probably benign Het
Other mutations in Olfr1330
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01642:Olfr1330 APN 4 118893461 missense probably damaging 1.00
R0402:Olfr1330 UTSW 4 118893229 missense possibly damaging 0.95
R0418:Olfr1330 UTSW 4 118893251 missense possibly damaging 0.51
R0646:Olfr1330 UTSW 4 118893490 missense probably damaging 0.96
R1075:Olfr1330 UTSW 4 118893205 missense probably damaging 1.00
R1743:Olfr1330 UTSW 4 118893526 missense probably benign
R1950:Olfr1330 UTSW 4 118893340 missense probably benign 0.22
R2265:Olfr1330 UTSW 4 118893874 missense probably damaging 1.00
R2268:Olfr1330 UTSW 4 118893874 missense probably damaging 1.00
R2269:Olfr1330 UTSW 4 118893874 missense probably damaging 1.00
R4648:Olfr1330 UTSW 4 118893950 missense possibly damaging 0.84
R5635:Olfr1330 UTSW 4 118893635 missense probably benign 0.31
R6881:Olfr1330 UTSW 4 118893107 missense probably damaging 1.00
R7351:Olfr1330 UTSW 4 118893836 missense probably benign 0.05
R7412:Olfr1330 UTSW 4 118893130 missense possibly damaging 0.83
Posted On2013-11-05