Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01386:Fpr-rs7'

79036

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fpr-rs7

Ensembl Gene

ENSMUSG00000071276

Gene Name

formyl peptide receptor, related sequence 7

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.110) question?

Stock #

IGL01386

Quality Score

Status

Chromosome

Chromosomal Location

20113210-20114226 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 20114192 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Leucine at position 12 (S12L)

Ref Sequence

ENSEMBL: ENSMUSP00000093297 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095637]

AlphaFold

Q71MR7

Predicted Effect

probably damaging
Transcript: ENSMUST00000095637
AA Change: S12L

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000093297
Gene: ENSMUSG00000071276
AA Change: S12L

Domain	Start	End	E-Value	Type
Pfam:7tm_1	43	297	1.2e-38	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000176711

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actn1	T	C	12: 80,193,672	R214G	probably benign	Het
Cacna1e	T	A	1: 154,472,377	K817N	probably benign	Het
Cyp3a16	A	G	5: 145,440,434	F448L	probably damaging	Het
Dpp6	T	A	5: 27,664,762		probably null	Het
Eif2ak3	C	T	6: 70,892,726	T799M	probably damaging	Het
Erbb4	A	T	1: 68,343,931	S302R	probably damaging	Het
Fam217a	T	A	13: 34,915,649		probably benign	Het
Flt4	C	A	11: 49,637,335	A995D	probably benign	Het
Fsd1	C	T	17: 55,996,733	S491F	probably damaging	Het
Hpcal4	T	C	4: 123,189,242		probably null	Het
Intu	A	T	3: 40,692,587	D630V	probably damaging	Het
Jak3	A	G	8: 71,684,289	D703G	probably damaging	Het
Lama4	A	G	10: 39,011,064	I122V	probably benign	Het
Marc2	A	G	1: 184,819,216		probably benign	Het
Mrpl11	A	C	19: 4,963,381	K92T	probably null	Het
Mylk	A	G	16: 34,971,240		probably null	Het
Olfr599	A	T	7: 103,338,767	K238*	probably null	Het
Parpbp	A	C	10: 88,139,986	Y88*	probably null	Het
Plod2	G	A	9: 92,606,602	R627Q	probably damaging	Het
Rapsn	G	T	2: 91,036,799	A149S	probably damaging	Het
Ripk3	T	G	14: 55,786,027	Q109P	probably damaging	Het
Scaf11	T	C	15: 96,420,480	D401G	probably damaging	Het
Serpine2	G	A	1: 79,801,551	T150I	probably damaging	Het
Sh2d6	T	A	6: 72,518,962	T98S	probably benign	Het
Slc28a1	G	T	7: 81,164,679	A513S	probably benign	Het
Tanc2	T	C	11: 105,886,381	F795S	probably damaging	Het
Tcim	T	A	8: 24,438,689	I70F	probably benign	Het
Thbd	G	A	2: 148,407,682	Q89*	probably null	Het
Tmem115	C	T	9: 107,534,660	T61I	probably damaging	Het
Tsc2	A	T	17: 24,613,285	V650E	probably damaging	Het
Tubgcp6	A	T	15: 89,107,996	Y595*	probably null	Het
Uroc1	C	T	6: 90,346,765	A398V	probably damaging	Het
Vmn1r31	T	C	6: 58,472,602	T93A	probably benign	Het
Vmn2r113	A	G	17: 22,956,050	E545G	possibly damaging	Het
Vps13a	A	G	19: 16,701,152	V1155A	possibly damaging	Het
Zfp667	A	G	7: 6,304,870	H179R	probably benign	Het

Other mutations in Fpr-rs7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00332:Fpr-rs7	APN	17	20113218	nonsense	probably null
IGL02293:Fpr-rs7	APN	17	20113970	missense	probably benign	0.01
IGL03303:Fpr-rs7	APN	17	20113739	missense	possibly damaging	0.55
R0731:Fpr-rs7	UTSW	17	20113854	missense	probably benign	0.00
R0826:Fpr-rs7	UTSW	17	20113626	missense	probably benign	0.01
R1439:Fpr-rs7	UTSW	17	20113607	missense	probably benign	0.10
R1590:Fpr-rs7	UTSW	17	20113416	missense	probably benign	0.05
R1778:Fpr-rs7	UTSW	17	20114015	missense	probably damaging	1.00
R4715:Fpr-rs7	UTSW	17	20113428	missense	probably benign	0.00
R4744:Fpr-rs7	UTSW	17	20114003	missense	probably benign	0.17
R4921:Fpr-rs7	UTSW	17	20113820	missense	possibly damaging	0.70
R5540:Fpr-rs7	UTSW	17	20114094	missense	probably damaging	1.00
R5677:Fpr-rs7	UTSW	17	20114103	missense	probably benign
R5959:Fpr-rs7	UTSW	17	20113749	missense	probably benign	0.01
R6042:Fpr-rs7	UTSW	17	20113215	missense	probably benign	0.00
R7921:Fpr-rs7	UTSW	17	20113405	missense	probably benign	0.03
R7984:Fpr-rs7	UTSW	17	20113409	missense	probably benign	0.01
R8137:Fpr-rs7	UTSW	17	20113793	missense	possibly damaging	0.49
R8172:Fpr-rs7	UTSW	17	20114181	missense	probably benign	0.04
R8762:Fpr-rs7	UTSW	17	20113527	missense	probably benign	0.07
R9134:Fpr-rs7	UTSW	17	20114063	missense	probably damaging	1.00
Z1176:Fpr-rs7	UTSW	17	20113393	missense	probably benign	0.02

Posted On

2013-11-05