Incidental Mutation 'IGL01386:Tcim'
ID 79045
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tcim
Ensembl Gene ENSMUSG00000056313
Gene Name transcriptional and immune response regulator
Synonyms 1810011O10Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.232) question?
Stock # IGL01386
Quality Score
Status
Chromosome 8
Chromosomal Location 24927188-24928962 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 24928705 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 70 (I70F)
Ref Sequence ENSEMBL: ENSMUSP00000058631 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052622]
AlphaFold Q9D915
Predicted Effect probably benign
Transcript: ENSMUST00000052622
AA Change: I70F

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000058631
Gene: ENSMUSG00000056313
AA Change: I70F

DomainStartEndE-ValueType
Pfam:TC1 10 85 5.2e-40 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181338
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit myeloid and lymphoid hyperplasia, an increased number of small-sized red blood cells, increased hematopoietic stem cell number, and enhanced hematopoietic activity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actn1 T C 12: 80,240,446 (GRCm39) R214G probably benign Het
Cacna1e T A 1: 154,348,123 (GRCm39) K817N probably benign Het
Cyp3a16 A G 5: 145,377,244 (GRCm39) F448L probably damaging Het
Dpp6 T A 5: 27,869,760 (GRCm39) probably null Het
Eif2ak3 C T 6: 70,869,710 (GRCm39) T799M probably damaging Het
Erbb4 A T 1: 68,383,090 (GRCm39) S302R probably damaging Het
Fam217a T A 13: 35,099,632 (GRCm39) probably benign Het
Flt4 C A 11: 49,528,162 (GRCm39) A995D probably benign Het
Fpr-rs7 G A 17: 20,334,454 (GRCm39) S12L probably damaging Het
Fsd1 C T 17: 56,303,733 (GRCm39) S491F probably damaging Het
Hpcal4 T C 4: 123,083,035 (GRCm39) probably null Het
Intu A T 3: 40,647,017 (GRCm39) D630V probably damaging Het
Jak3 A G 8: 72,136,933 (GRCm39) D703G probably damaging Het
Lama4 A G 10: 38,887,060 (GRCm39) I122V probably benign Het
Mrpl11 A C 19: 5,013,409 (GRCm39) K92T probably null Het
Mtarc2 A G 1: 184,551,413 (GRCm39) probably benign Het
Mylk A G 16: 34,791,610 (GRCm39) probably null Het
Or52ab4 A T 7: 102,987,974 (GRCm39) K238* probably null Het
Parpbp A C 10: 87,975,848 (GRCm39) Y88* probably null Het
Plod2 G A 9: 92,488,655 (GRCm39) R627Q probably damaging Het
Rapsn G T 2: 90,867,144 (GRCm39) A149S probably damaging Het
Ripk3 T G 14: 56,023,484 (GRCm39) Q109P probably damaging Het
Scaf11 T C 15: 96,318,361 (GRCm39) D401G probably damaging Het
Serpine2 G A 1: 79,779,268 (GRCm39) T150I probably damaging Het
Sh2d6 T A 6: 72,495,945 (GRCm39) T98S probably benign Het
Slc28a1 G T 7: 80,814,427 (GRCm39) A513S probably benign Het
Tanc2 T C 11: 105,777,207 (GRCm39) F795S probably damaging Het
Thbd G A 2: 148,249,602 (GRCm39) Q89* probably null Het
Tmem115 C T 9: 107,411,859 (GRCm39) T61I probably damaging Het
Tsc2 A T 17: 24,832,259 (GRCm39) V650E probably damaging Het
Tubgcp6 A T 15: 88,992,199 (GRCm39) Y595* probably null Het
Uroc1 C T 6: 90,323,747 (GRCm39) A398V probably damaging Het
Vmn1r31 T C 6: 58,449,587 (GRCm39) T93A probably benign Het
Vmn2r113 A G 17: 23,175,024 (GRCm39) E545G possibly damaging Het
Vps13a A G 19: 16,678,516 (GRCm39) V1155A possibly damaging Het
Zfp667 A G 7: 6,307,869 (GRCm39) H179R probably benign Het
Other mutations in Tcim
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01937:Tcim APN 8 24,928,892 (GRCm39) missense probably benign
IGL01945:Tcim APN 8 24,928,892 (GRCm39) missense probably benign
R0464:Tcim UTSW 8 24,928,644 (GRCm39) missense probably damaging 1.00
R0519:Tcim UTSW 8 24,928,651 (GRCm39) missense possibly damaging 0.80
R2322:Tcim UTSW 8 24,928,726 (GRCm39) missense probably damaging 1.00
R3766:Tcim UTSW 8 24,928,765 (GRCm39) missense probably damaging 0.98
R4623:Tcim UTSW 8 24,928,725 (GRCm39) missense probably damaging 1.00
R6242:Tcim UTSW 8 24,928,911 (GRCm39) start codon destroyed probably null 0.90
R9195:Tcim UTSW 8 24,928,878 (GRCm39) missense probably damaging 0.99
Posted On 2013-11-05