Incidental Mutation 'I2288:Olfr1152'
ID7909
Institutional Source Beutler Lab
Gene Symbol Olfr1152
Ensembl Gene ENSMUSG00000045225
Gene Nameolfactory receptor 1152
SynonymsMOR177-12, GA_x6K02T2Q125-49372426-49373358
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.128) question?
Stock #I2288 (G3) of strain 633
Quality Score
Status Validated
Chromosome2
Chromosomal Location87866492-87874156 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 87868135 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Asparagine at position 48 (I48N)
Ref Sequence ENSEMBL: ENSMUSP00000151045 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051058] [ENSMUST00000213308]
Predicted Effect probably damaging
Transcript: ENSMUST00000051058
AA Change: I48N

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000054645
Gene: ENSMUSG00000045225
AA Change: I48N

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 4e-46 PFAM
Pfam:7tm_1 40 290 1e-13 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000121994
Predicted Effect probably damaging
Transcript: ENSMUST00000213308
AA Change: I48N

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 89.9%
  • 3x: 84.8%
Validation Efficiency 71% (138/195)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam3 A T 8: 24,684,661 I696N probably damaging Het
Adgra1 T C 7: 139,852,579 I111T probably damaging Het
Adgrv1 A G 13: 81,437,524 L4607P probably damaging Het
Alppl2 A T 1: 87,088,176 M284K possibly damaging Het
Arfgef1 T C 1: 10,173,253 K1024E probably damaging Het
Arid2 T C 15: 96,369,511 V624A possibly damaging Het
Babam1 G A 8: 71,397,823 R32Q probably damaging Het
Camk1g C T 1: 193,351,106 probably benign Homo
Cfap44 C A 16: 44,449,138 Y1168* probably null Het
Clasp1 A G 1: 118,565,229 H1168R probably benign Het
Crkl A G 16: 17,483,748 T289A probably damaging Het
Dlec1 A G 9: 119,143,601 D1464G probably damaging Het
Dmxl2 A T 9: 54,401,793 H1891Q probably damaging Het
Dnah10 G A 5: 124,730,100 A150T probably benign Het
Dnah8 A G 17: 30,663,454 T667A probably benign Het
Fpr-rs3 A T 17: 20,624,495 L128Q probably damaging Het
Fxn C T 19: 24,262,067 probably benign Homo
Golgb1 A G 16: 36,898,542 H270R probably benign Het
Gramd1b T C 9: 40,306,805 I572V probably damaging Het
Iqch A T 9: 63,500,890 I664K probably benign Het
Kcnn2 T A 18: 45,675,273 probably benign Het
Lrp1b A T 2: 41,122,932 I2001K probably damaging Het
Lrrc40 T A 3: 158,052,789 I277K probably damaging Het
Myo1e A G 9: 70,342,097 E493G possibly damaging Homo
Nrcam C A 12: 44,564,315 H567Q probably benign Homo
Olfr1350 A T 7: 6,570,819 Y276F probably damaging Homo
Olfr653 T C 7: 104,580,386 C247R probably damaging Het
Parvg C A 15: 84,328,780 probably benign Het
Ripk4 A G 16: 97,748,145 V237A probably benign Het
Spam1 A G 6: 24,796,478 I143V probably benign Het
Synj2 A G 17: 6,022,267 probably benign Het
Taar4 A G 10: 23,960,920 T143A probably benign Het
Ttc12 T A 9: 49,470,258 M138L possibly damaging Het
Ttll9 A G 2: 152,972,339 probably benign Het
Usp34 T A 11: 23,432,473 probably benign Homo
Utrn A G 10: 12,421,640 Y675H probably damaging Het
Other mutations in Olfr1152
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01418:Olfr1152 APN 2 87868465 missense probably benign 0.00
IGL01618:Olfr1152 APN 2 87868144 missense probably damaging 0.96
IGL02326:Olfr1152 APN 2 87868675 missense probably damaging 1.00
IGL03162:Olfr1152 APN 2 87868140 missense probably benign 0.00
IGL03189:Olfr1152 APN 2 87868215 missense possibly damaging 0.76
R0761:Olfr1152 UTSW 2 87868536 missense possibly damaging 0.88
R1558:Olfr1152 UTSW 2 87868115 missense probably damaging 1.00
R1938:Olfr1152 UTSW 2 87868461 missense probably benign 0.01
R3810:Olfr1152 UTSW 2 87868401 missense probably damaging 1.00
R3812:Olfr1152 UTSW 2 87868401 missense probably damaging 1.00
R4728:Olfr1152 UTSW 2 87868435 missense probably benign 0.13
R4928:Olfr1152 UTSW 2 87868230 missense probably benign 0.32
R5172:Olfr1152 UTSW 2 87868827 missense probably benign 0.20
R5174:Olfr1152 UTSW 2 87868411 missense possibly damaging 0.79
R6147:Olfr1152 UTSW 2 87868717 missense probably benign 0.03
R6195:Olfr1152 UTSW 2 87868560 missense possibly damaging 0.63
R6233:Olfr1152 UTSW 2 87868560 missense possibly damaging 0.63
R6541:Olfr1152 UTSW 2 87868294 missense probably benign 0.11
R7507:Olfr1152 UTSW 2 87868369 missense probably damaging 1.00
Posted On2012-11-13