Incidental Mutation 'IGL01388:Olfr918'
ID79112
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr918
Ensembl Gene ENSMUSG00000046150
Gene Nameolfactory receptor 918
SynonymsGA_x6K02T2PVTD-32375756-32374818, MOR164-3
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.352) question?
Stock #IGL01388
Quality Score
Status
Chromosome9
Chromosomal Location38669861-38674601 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) A to T at 38673083 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Stop codon at position 120 (Y120*)
Ref Sequence ENSEMBL: ENSMUSP00000150182 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055099] [ENSMUST00000215461]
Predicted Effect probably null
Transcript: ENSMUST00000055099
AA Change: Y133*
SMART Domains Protein: ENSMUSP00000057210
Gene: ENSMUSG00000046150
AA Change: Y133*

DomainStartEndE-ValueType
transmembrane domain 9 31 N/A INTRINSIC
Pfam:7tm_4 44 319 6.5e-48 PFAM
Pfam:7tm_1 54 301 3.9e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213750
Predicted Effect probably null
Transcript: ENSMUST00000215461
AA Change: Y120*
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216579
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap28 T G 17: 67,853,039 probably benign Het
Ces2b A C 8: 104,834,604 probably benign Het
Col20a1 T A 2: 181,003,471 M924K probably benign Het
Commd4 G A 9: 57,155,989 probably benign Het
Ctnna3 A G 10: 63,504,107 E24G possibly damaging Het
Cyp2a22 C T 7: 26,937,792 R189H probably benign Het
Gm20426 T C 6: 90,178,712 probably benign Het
Gm3839 T C 14: 11,281,836 D33G probably damaging Het
Gm6802 T G 12: 19,490,545 noncoding transcript Het
Igkv8-21 A G 6: 70,315,169 S30P probably benign Het
Lig4 A G 8: 9,973,586 Y65H probably damaging Het
Mpzl1 T C 1: 165,605,767 D105G probably benign Het
Myo10 A G 15: 25,736,617 I451V possibly damaging Het
Nos2 G T 11: 78,957,452 V1062L probably damaging Het
Oas2 A G 5: 120,748,592 S170P probably damaging Het
Olfr1131 T A 2: 87,628,629 H55Q probably benign Het
Olfr348 G T 2: 36,787,355 V277L probably benign Het
Olfr970 A G 9: 39,820,002 D121G probably damaging Het
Pcdh7 T C 5: 57,720,204 L367P probably damaging Het
Pde3a A G 6: 141,459,738 T439A probably damaging Het
Plekhm2 T C 4: 141,642,001 Y124C probably damaging Het
Ppp4r4 T A 12: 103,576,849 W155R probably damaging Het
Prl7c1 C A 13: 27,776,215 A115S probably damaging Het
Psg25 T C 7: 18,529,665 I78V possibly damaging Het
Ptpn9 T A 9: 57,036,718 V292E probably benign Het
Ptprs G A 17: 56,421,261 R908C probably damaging Het
Rps6ka1 C T 4: 133,871,964 V51I probably damaging Het
Scube1 T C 15: 83,620,131 I492V probably benign Het
Trappc2 G A X: 166,449,779 probably benign Het
Ubr4 T C 4: 139,460,243 V739A possibly damaging Het
Unc79 T C 12: 103,169,759 probably benign Het
Vmn2r27 G A 6: 124,223,832 P389S possibly damaging Het
Wipi2 T A 5: 142,661,043 F212I possibly damaging Het
Other mutations in Olfr918
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00958:Olfr918 APN 9 38673024 missense probably benign 0.01
IGL01516:Olfr918 APN 9 38672863 missense probably benign 0.09
IGL02121:Olfr918 APN 9 38673415 missense probably damaging 0.98
IGL02209:Olfr918 APN 9 38673046 missense possibly damaging 0.84
IGL02256:Olfr918 APN 9 38673480 start codon destroyed probably null
IGL02517:Olfr918 APN 9 38672913 missense probably damaging 1.00
IGL02648:Olfr918 APN 9 38673016 missense probably benign
IGL02747:Olfr918 APN 9 38673084 missense probably benign 0.11
IGL02971:Olfr918 APN 9 38673268 missense probably damaging 0.96
E0370:Olfr918 UTSW 9 38672561 missense probably damaging 0.99
R0616:Olfr918 UTSW 9 38673480 start codon destroyed probably null
R2173:Olfr918 UTSW 9 38672944 missense probably benign 0.03
R2989:Olfr918 UTSW 9 38672535 missense probably benign
R3430:Olfr918 UTSW 9 38673139 missense probably damaging 1.00
R3809:Olfr918 UTSW 9 38672863 missense probably benign 0.09
R4688:Olfr918 UTSW 9 38673363 missense probably damaging 1.00
R4702:Olfr918 UTSW 9 38673480 start codon destroyed probably null
R5548:Olfr918 UTSW 9 38673304 missense probably benign 0.00
R5590:Olfr918 UTSW 9 38672965 missense probably damaging 1.00
R6082:Olfr918 UTSW 9 38672570 missense probably damaging 1.00
R6214:Olfr918 UTSW 9 38673214 missense probably benign 0.13
R6215:Olfr918 UTSW 9 38673214 missense probably benign 0.13
R6893:Olfr918 UTSW 9 38673059 missense possibly damaging 0.95
R7215:Olfr918 UTSW 9 38673447 missense probably benign 0.05
R7624:Olfr918 UTSW 9 38672623 missense probably benign 0.18
R7862:Olfr918 UTSW 9 38673328 missense probably benign 0.01
R8116:Olfr918 UTSW 9 38673168 missense possibly damaging 0.93
Posted On2013-11-05