Incidental Mutation 'IGL01389:Lyg1'
| ID |
79154 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Lyg1
|
| Ensembl Gene |
ENSMUSG00000026085 |
| Gene Name |
lysozyme G-like 1 |
| Synonyms |
2300002O18Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.051)
|
| Stock # |
IGL01389
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
1 |
| Chromosomal Location |
37985819-37996840 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 37989011 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Proline to Serine
at position 70
(P70S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000110544
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027254]
[ENSMUST00000114894]
|
| AlphaFold |
Q9D7Q0 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000027254
AA Change: P70S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000027254
Gene: ENSMUSG00000026085
AA Change: P70S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
SCOP:d153l__
|
23 |
197 |
1e-47 |
SMART |
|
PDB:154L|A
|
24 |
197 |
2e-48 |
PDB |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000114894
AA Change: P70S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000110544
Gene: ENSMUSG00000026085
AA Change: P70S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
SCOP:d153l__
|
23 |
197 |
8e-48 |
SMART |
|
PDB:154L|A
|
24 |
197 |
1e-48 |
PDB |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000129513
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000144184
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 26 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ccdc163 |
T |
C |
4: 116,568,503 (GRCm39) |
|
probably benign |
Het |
| Ceacam5 |
T |
G |
7: 17,481,300 (GRCm39) |
V349G |
probably damaging |
Het |
| Ces2e |
T |
A |
8: 105,656,197 (GRCm39) |
D169E |
probably benign |
Het |
| Cfh |
G |
T |
1: 140,082,377 (GRCm39) |
T150K |
probably benign |
Het |
| Chrd |
A |
G |
16: 20,559,975 (GRCm39) |
M859V |
possibly damaging |
Het |
| Clca3a2 |
C |
T |
3: 144,783,629 (GRCm39) |
|
probably null |
Het |
| Crocc |
T |
C |
4: 140,749,423 (GRCm39) |
E1536G |
probably damaging |
Het |
| Dhx57 |
A |
G |
17: 80,588,652 (GRCm39) |
V67A |
probably benign |
Het |
| Dock11 |
T |
C |
X: 35,256,701 (GRCm39) |
V576A |
probably benign |
Het |
| Ighv1-85 |
A |
G |
12: 115,963,671 (GRCm39) |
S110P |
probably damaging |
Het |
| Numbl |
T |
G |
7: 26,980,472 (GRCm39) |
F485V |
possibly damaging |
Het |
| Or4x6 |
A |
T |
2: 89,949,412 (GRCm39) |
C177S |
probably damaging |
Het |
| Pclo |
A |
G |
5: 14,764,535 (GRCm39) |
E1051G |
probably damaging |
Het |
| Pdzd2 |
T |
C |
15: 12,374,712 (GRCm39) |
S1808G |
possibly damaging |
Het |
| Rad51b |
T |
A |
12: 79,349,327 (GRCm39) |
H54Q |
probably benign |
Het |
| Rbbp7 |
T |
C |
X: 161,552,939 (GRCm39) |
|
probably benign |
Het |
| Rhbdl2 |
G |
T |
4: 123,723,450 (GRCm39) |
V285L |
probably benign |
Het |
| Slc22a16 |
T |
A |
10: 40,461,131 (GRCm39) |
M311K |
probably damaging |
Het |
| Slc22a21 |
A |
G |
11: 53,870,407 (GRCm39) |
S93P |
probably damaging |
Het |
| Stt3b |
T |
C |
9: 115,082,968 (GRCm39) |
E488G |
probably benign |
Het |
| Tas2r108 |
A |
G |
6: 40,470,866 (GRCm39) |
H114R |
possibly damaging |
Het |
| Tcaim |
A |
G |
9: 122,643,627 (GRCm39) |
E109G |
possibly damaging |
Het |
| Tsc22d2 |
A |
G |
3: 58,323,659 (GRCm39) |
T184A |
probably damaging |
Het |
| Vmn2r2 |
G |
T |
3: 64,024,430 (GRCm39) |
T717N |
probably damaging |
Het |
| Vps25 |
C |
T |
11: 101,144,861 (GRCm39) |
Q20* |
probably null |
Het |
| Xiap |
T |
C |
X: 41,183,429 (GRCm39) |
F52L |
probably damaging |
Het |
|
| Other mutations in Lyg1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL03095:Lyg1
|
APN |
1 |
37,989,849 (GRCm39) |
splice site |
probably benign |
|
|
R0411:Lyg1
|
UTSW |
1 |
37,988,977 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1171:Lyg1
|
UTSW |
1 |
37,986,305 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2126:Lyg1
|
UTSW |
1 |
37,989,755 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3715:Lyg1
|
UTSW |
1 |
37,989,759 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3744:Lyg1
|
UTSW |
1 |
37,988,923 (GRCm39) |
missense |
probably benign |
0.37 |
|
R4660:Lyg1
|
UTSW |
1 |
37,985,942 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R5040:Lyg1
|
UTSW |
1 |
37,989,892 (GRCm39) |
intron |
probably benign |
|
|
R5769:Lyg1
|
UTSW |
1 |
37,989,831 (GRCm39) |
missense |
unknown |
|
|
R5792:Lyg1
|
UTSW |
1 |
37,986,348 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5800:Lyg1
|
UTSW |
1 |
37,986,034 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7318:Lyg1
|
UTSW |
1 |
37,988,936 (GRCm39) |
missense |
probably benign |
0.44 |
|
R8323:Lyg1
|
UTSW |
1 |
37,989,018 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8463:Lyg1
|
UTSW |
1 |
37,988,922 (GRCm39) |
nonsense |
probably null |
|
|
Z1176:Lyg1
|
UTSW |
1 |
37,986,258 (GRCm39) |
missense |
probably null |
1.00 |
|
| Posted On |
2013-11-05 |
Incidental Mutation