Incidental Mutation 'IGL01390:Prl7d1'
ID 79177
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prl7d1
Ensembl Gene ENSMUSG00000021348
Gene Name prolactin family 7, subfamily d, member 1
Synonyms Plfr, PRP, PLF-RP
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01390
Quality Score
Status
Chromosome 13
Chromosomal Location 27706337-27716736 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 27710166 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 140 (V140A)
Ref Sequence ENSEMBL: ENSMUSP00000153033 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021776] [ENSMUST00000224026]
AlphaFold P04769
Predicted Effect possibly damaging
Transcript: ENSMUST00000021776
AA Change: V139A

PolyPhen 2 Score 0.889 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000021776
Gene: ENSMUSG00000021348
AA Change: V139A

DomainStartEndE-ValueType
Pfam:Hormone_1 17 240 1.1e-78 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000224026
AA Change: V140A

PolyPhen 2 Score 0.910 (Sensitivity: 0.81; Specificity: 0.94)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp6v0a1 A G 11: 101,043,802 K565R probably benign Het
Cacna2d3 T C 14: 28,943,591 T158A possibly damaging Het
Ccdc129 C T 6: 55,897,998 P311L probably benign Het
Dnah5 A G 15: 28,411,540 D3685G probably benign Het
Dock1 T C 7: 134,745,047 I236T possibly damaging Het
Dock6 A G 9: 21,803,045 V1803A probably damaging Het
Epb41 T C 4: 132,003,737 I178V probably benign Het
Gm10110 C A 14: 89,898,241 noncoding transcript Het
Hist1h2ac T C 13: 23,683,516 probably benign Het
Hoxb7 A C 11: 96,287,011 N95T probably benign Het
Ikzf2 C A 1: 69,570,642 C116F probably damaging Het
Ints8 A T 4: 11,218,679 probably benign Het
Man2a1 T C 17: 64,710,705 Y649H probably benign Het
Mcm8 T C 2: 132,838,078 probably benign Het
Msi1 T A 5: 115,438,721 D137E possibly damaging Het
Olfr1037 T C 2: 86,085,640 I46V probably benign Het
Pde6c A G 19: 38,161,928 Y507C probably benign Het
Rb1 T A 14: 73,294,999 I132F probably benign Het
Rgl1 A G 1: 152,571,588 probably benign Het
Rpl18a G T 8: 70,895,510 probably benign Het
Sf3b1 T C 1: 54,987,429 I1274V probably benign Het
Slc9a3 A C 13: 74,150,761 I100L probably benign Het
Sorcs3 T A 19: 48,790,131 Y996N probably damaging Het
Sra1 A G 18: 36,670,081 L37P probably damaging Het
Stim1 A G 7: 102,427,162 Q440R possibly damaging Het
Tacc3 C T 5: 33,668,061 probably benign Het
Tas2r104 T A 6: 131,685,485 Y87F probably benign Het
Tbl2 T C 5: 135,156,363 probably benign Het
Vsig10l C T 7: 43,466,465 S410F probably damaging Het
Other mutations in Prl7d1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01735:Prl7d1 APN 13 27714389 missense possibly damaging 0.83
IGL02139:Prl7d1 APN 13 27712083 missense probably damaging 1.00
PIT4305001:Prl7d1 UTSW 13 27714337 missense possibly damaging 0.90
PIT4531001:Prl7d1 UTSW 13 27710178 missense probably damaging 1.00
R0555:Prl7d1 UTSW 13 27712055 missense probably benign 0.13
R0625:Prl7d1 UTSW 13 27710140 missense probably benign 0.10
R0631:Prl7d1 UTSW 13 27710182 missense probably benign 0.32
R0837:Prl7d1 UTSW 13 27714338 missense probably benign 0.06
R1403:Prl7d1 UTSW 13 27709197 missense possibly damaging 0.89
R1403:Prl7d1 UTSW 13 27709197 missense possibly damaging 0.89
R1459:Prl7d1 UTSW 13 27709257 missense possibly damaging 0.81
R1643:Prl7d1 UTSW 13 27712131 missense possibly damaging 0.53
R1691:Prl7d1 UTSW 13 27709382 missense probably damaging 0.97
R2016:Prl7d1 UTSW 13 27710173 missense probably damaging 1.00
R3873:Prl7d1 UTSW 13 27716668 start codon destroyed probably null 0.92
R3874:Prl7d1 UTSW 13 27716668 start codon destroyed probably null 0.92
R5251:Prl7d1 UTSW 13 27709244 missense probably benign 0.33
R5275:Prl7d1 UTSW 13 27709247 missense probably damaging 0.99
R5295:Prl7d1 UTSW 13 27709247 missense probably damaging 0.99
R5398:Prl7d1 UTSW 13 27710074 missense probably damaging 1.00
R6798:Prl7d1 UTSW 13 27709397 critical splice acceptor site probably null
R6818:Prl7d1 UTSW 13 27714471 missense probably benign 0.07
R6825:Prl7d1 UTSW 13 27710142 missense probably benign 0.01
R7478:Prl7d1 UTSW 13 27710185 nonsense probably null
R7795:Prl7d1 UTSW 13 27709280 missense probably damaging 1.00
R7995:Prl7d1 UTSW 13 27710071 missense probably benign
R8193:Prl7d1 UTSW 13 27709247 missense
R9313:Prl7d1 UTSW 13 27709199 missense probably benign
R9424:Prl7d1 UTSW 13 27710202 missense probably benign 0.00
R9430:Prl7d1 UTSW 13 27714377 missense possibly damaging 0.80
Posted On 2013-11-05