Incidental Mutation 'K2124:Cep89'
ID 7918
Institutional Source Beutler Lab
Gene Symbol Cep89
Ensembl Gene ENSMUSG00000023072
Gene Name centrosomal protein 89
Synonyms Ccdc123, 2610507L03Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.177) question?
Stock # K2124 of strain 613
Quality Score
Status Validated
Chromosome 7
Chromosomal Location 35096460-35138114 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 35120397 bp (GRCm39)
Zygosity Homozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000145618 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079414] [ENSMUST00000141704] [ENSMUST00000206230]
AlphaFold Q9CZX2
Predicted Effect probably benign
Transcript: ENSMUST00000079414
SMART Domains Protein: ENSMUSP00000078383
Gene: ENSMUSG00000023072

DomainStartEndE-ValueType
low complexity region 27 62 N/A INTRINSIC
low complexity region 181 190 N/A INTRINSIC
coiled coil region 252 291 N/A INTRINSIC
coiled coil region 372 598 N/A INTRINSIC
coiled coil region 670 732 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000141704
SMART Domains Protein: ENSMUSP00000121393
Gene: ENSMUSG00000023072

DomainStartEndE-ValueType
low complexity region 27 62 N/A INTRINSIC
low complexity region 181 190 N/A INTRINSIC
coiled coil region 252 291 N/A INTRINSIC
coiled coil region 372 598 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148166
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152020
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155137
Predicted Effect probably benign
Transcript: ENSMUST00000206230
Coding Region Coverage
  • 1x: 88.1%
  • 3x: 81.9%
Validation Efficiency 96% (194/202)
Allele List at MGI

All alleles(5) : Gene trapped(5)

Other mutations in this stock
Total: 5 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Itih3 T C 14: 30,634,644 (GRCm39) N121S probably benign Het
Mmrn1 A T 6: 60,953,017 (GRCm39) N433Y possibly damaging Het
Slc28a2b A T 2: 122,355,634 (GRCm39) T609S probably benign Homo
Stra6l T A 4: 45,870,770 (GRCm39) probably benign Homo
Tgs1 C T 4: 3,595,547 (GRCm39) S572L probably benign Het
Other mutations in Cep89
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00784:Cep89 APN 7 35,105,132 (GRCm39) missense possibly damaging 0.92
IGL01546:Cep89 APN 7 35,120,325 (GRCm39) missense probably damaging 1.00
IGL02001:Cep89 APN 7 35,102,432 (GRCm39) splice site probably benign
IGL02141:Cep89 APN 7 35,120,349 (GRCm39) missense probably damaging 1.00
IGL02468:Cep89 APN 7 35,102,577 (GRCm39) missense probably benign 0.35
IGL02507:Cep89 APN 7 35,134,990 (GRCm39) missense probably damaging 1.00
IGL02612:Cep89 APN 7 35,124,080 (GRCm39) critical splice acceptor site probably null
IGL03324:Cep89 APN 7 35,124,078 (GRCm39) intron probably benign
IGL03396:Cep89 APN 7 35,128,603 (GRCm39) missense probably benign 0.05
3-1:Cep89 UTSW 7 35,124,147 (GRCm39) missense probably damaging 0.99
FR4304:Cep89 UTSW 7 35,109,066 (GRCm39) utr 3 prime probably benign
FR4976:Cep89 UTSW 7 35,109,066 (GRCm39) utr 3 prime probably benign
R0127:Cep89 UTSW 7 35,127,687 (GRCm39) missense possibly damaging 0.92
R0416:Cep89 UTSW 7 35,115,827 (GRCm39) unclassified probably benign
R0609:Cep89 UTSW 7 35,134,955 (GRCm39) missense probably damaging 1.00
R1442:Cep89 UTSW 7 35,117,636 (GRCm39) splice site probably benign
R1468:Cep89 UTSW 7 35,120,388 (GRCm39) splice site probably null
R1468:Cep89 UTSW 7 35,120,388 (GRCm39) splice site probably null
R1661:Cep89 UTSW 7 35,117,105 (GRCm39) missense possibly damaging 0.66
R3981:Cep89 UTSW 7 35,137,808 (GRCm39) missense probably damaging 1.00
R4414:Cep89 UTSW 7 35,115,822 (GRCm39) unclassified probably benign
R4700:Cep89 UTSW 7 35,137,862 (GRCm39) missense probably benign 0.05
R4963:Cep89 UTSW 7 35,102,577 (GRCm39) missense probably benign 0.35
R4968:Cep89 UTSW 7 35,109,055 (GRCm39) missense possibly damaging 0.90
R4972:Cep89 UTSW 7 35,131,977 (GRCm39) missense probably damaging 1.00
R5578:Cep89 UTSW 7 35,109,067 (GRCm39) unclassified probably benign
R5767:Cep89 UTSW 7 35,117,070 (GRCm39) missense probably damaging 1.00
R5809:Cep89 UTSW 7 35,117,151 (GRCm39) missense probably damaging 0.97
R5890:Cep89 UTSW 7 35,128,587 (GRCm39) missense probably damaging 0.99
R6290:Cep89 UTSW 7 35,119,688 (GRCm39) missense probably damaging 1.00
R6361:Cep89 UTSW 7 35,097,472 (GRCm39) missense probably damaging 1.00
R6627:Cep89 UTSW 7 35,127,172 (GRCm39) missense possibly damaging 0.90
R7272:Cep89 UTSW 7 35,137,888 (GRCm39) missense probably benign 0.03
R7340:Cep89 UTSW 7 35,129,353 (GRCm39) missense probably damaging 0.97
R7341:Cep89 UTSW 7 35,129,353 (GRCm39) missense probably damaging 0.97
R7347:Cep89 UTSW 7 35,129,353 (GRCm39) missense probably damaging 0.97
R7348:Cep89 UTSW 7 35,129,353 (GRCm39) missense probably damaging 0.97
R7365:Cep89 UTSW 7 35,129,353 (GRCm39) missense probably damaging 0.97
R7366:Cep89 UTSW 7 35,129,353 (GRCm39) missense probably damaging 0.97
R7394:Cep89 UTSW 7 35,129,353 (GRCm39) missense probably damaging 0.97
R7399:Cep89 UTSW 7 35,137,803 (GRCm39) missense probably damaging 1.00
R7422:Cep89 UTSW 7 35,127,672 (GRCm39) missense probably damaging 1.00
R7792:Cep89 UTSW 7 35,129,353 (GRCm39) missense probably damaging 0.97
R7793:Cep89 UTSW 7 35,129,353 (GRCm39) missense probably damaging 0.97
R7819:Cep89 UTSW 7 35,131,968 (GRCm39) missense probably benign 0.07
R7860:Cep89 UTSW 7 35,113,570 (GRCm39) missense possibly damaging 0.63
R7899:Cep89 UTSW 7 35,129,353 (GRCm39) missense probably damaging 0.97
R8336:Cep89 UTSW 7 35,127,141 (GRCm39) nonsense probably null
R8669:Cep89 UTSW 7 35,128,602 (GRCm39) missense probably benign 0.04
R8974:Cep89 UTSW 7 35,097,493 (GRCm39) missense probably damaging 0.99
R9580:Cep89 UTSW 7 35,102,538 (GRCm39) missense possibly damaging 0.63
V7732:Cep89 UTSW 7 35,102,523 (GRCm39) missense probably damaging 1.00
Z1177:Cep89 UTSW 7 35,096,506 (GRCm39) unclassified probably benign
Posted On 2012-11-15