Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01391:Vmn2r16'

79191

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r16

Ensembl Gene

ENSMUSG00000092080

Gene Name

vomeronasal 2, receptor 16

Synonyms

EG384220

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.117) question?

Stock #

IGL01391

Quality Score

Status

Chromosome

Chromosomal Location

109330381-109364481 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 109363761 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glutamic Acid at position 611 (D611E)

Ref Sequence

ENSEMBL: ENSMUSP00000127838 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165180]

AlphaFold

A0A3B2WCY4

Predicted Effect

possibly damaging
Transcript: ENSMUST00000165180
AA Change: D611E

PolyPhen 2 Score 0.502 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000127838
Gene: ENSMUSG00000092080
AA Change: D611E

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:ANF_receptor	76	425	2.3e-28	PFAM
Pfam:NCD3G	509	563	8.2e-19	PFAM
Pfam:7tm_3	596	831	3.5e-56	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ap3m2	T	A	8: 22,799,647	I147F	probably benign	Het
Areg	T	A	5: 91,141,095	S87T	probably damaging	Het
Arid1b	T	A	17: 5,318,858		probably benign	Het
Arl6ip6	A	G	2: 53,192,144	R8G	probably benign	Het
Brms1	A	G	19: 5,046,695	E135G	possibly damaging	Het
Ccser1	A	G	6: 61,638,521		probably benign	Het
Dock3	A	T	9: 106,907,234	M258K	possibly damaging	Het
Epb41l4a	T	G	18: 33,801,625	D562A	possibly damaging	Het
Etaa1	G	A	11: 17,946,005	T704I	probably damaging	Het
Fer1l4	T	A	2: 156,036,456	H972L	probably damaging	Het
Foxn1	A	G	11: 78,361,494	M356T	probably damaging	Het
Gfral	C	A	9: 76,164,825	G388*	probably null	Het
Gm10436	C	T	12: 88,178,455	V34I	possibly damaging	Het
Gm12258	A	G	11: 58,848,694	T3A	probably benign	Het
Hoxa5	T	C	6: 52,204,331	N7S	probably damaging	Het
Itgb4	T	C	11: 115,990,920	L765P	probably damaging	Het
Jchain	C	T	5: 88,521,524	C90Y	probably damaging	Het
Klhl40	A	G	9: 121,778,917	Y381C	probably damaging	Het
Lhx6	A	T	2: 36,103,465	C74S	probably benign	Het
Magel2	A	G	7: 62,380,884	S1179G	unknown	Het
Mapre3	T	C	5: 30,864,897	I236T	probably damaging	Het
Mcf2l	A	T	8: 13,014,010		probably null	Het
Med13	A	T	11: 86,328,497	H374Q	probably benign	Het
Meioc	A	G	11: 102,674,287	Y187C	probably benign	Het
Myh1	G	A	11: 67,217,863	M1368I	probably benign	Het
Olfr304	A	T	7: 86,386,000	I220N	possibly damaging	Het
Olfr921	A	G	9: 38,775,530	I92V	probably damaging	Het
Phrf1	T	C	7: 141,262,481	Y1501H	probably damaging	Het
Pigb	T	C	9: 73,022,291	T337A	probably damaging	Het
Pls1	T	C	9: 95,773,698	K334E	probably benign	Het
Rab3b	T	C	4: 108,940,802	C226R	probably damaging	Het
Ryr2	A	T	13: 11,556,685	I4889N	possibly damaging	Het
Serpinb1a	G	A	13: 32,845,415	S210L	probably benign	Het
Slc52a3	A	G	2: 152,007,602	I390V	probably benign	Het
Slc6a7	C	A	18: 61,003,310	A340S	probably damaging	Het
Tcaf3	T	C	6: 42,593,681	Y379C	probably damaging	Het
Tex261	A	G	6: 83,771,240	V180A	probably benign	Het
Tnnt1	C	T	7: 4,514,212		probably null	Het
Ttn	T	C	2: 76,968,503	T476A	possibly damaging	Het
Vcan	A	G	13: 89,704,169	S891P	probably benign	Het
Vmn2r68	T	C	7: 85,237,611	T32A	probably benign	Het
Vwde	T	G	6: 13,190,527	S522R	probably benign	Het
Wdr3	G	A	3: 100,146,789		probably benign	Het
Wfs1	G	T	5: 36,971,563	Q288K	probably benign	Het
Zfp142	A	G	1: 74,579,540	V120A	probably damaging	Het
Zfp672	A	G	11: 58,317,366	F43S	probably damaging	Het
Znhit3	A	T	11: 84,911,457		probably benign	Het

Other mutations in Vmn2r16

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01116:Vmn2r16	APN	5	109340428	missense	probably damaging	1.00
IGL01374:Vmn2r16	APN	5	109330417	missense	probably benign	0.00
IGL01419:Vmn2r16	APN	5	109362401	splice site	probably benign
IGL01634:Vmn2r16	APN	5	109340311	missense	probably benign	0.00
IGL01845:Vmn2r16	APN	5	109363896	missense	probably damaging	1.00
IGL01875:Vmn2r16	APN	5	109330411	missense	probably benign	0.01
IGL01910:Vmn2r16	APN	5	109340085	missense	probably damaging	1.00
IGL02217:Vmn2r16	APN	5	109339810	missense	probably damaging	0.98
IGL02327:Vmn2r16	APN	5	109340121	missense	probably benign	0.01
IGL02491:Vmn2r16	APN	5	109339837	nonsense	probably null
IGL02531:Vmn2r16	APN	5	109340268	missense	probably damaging	0.99
IGL02680:Vmn2r16	APN	5	109340082	missense	probably benign	0.44
IGL02884:Vmn2r16	APN	5	109360891	missense	possibly damaging	0.94
IGL03084:Vmn2r16	APN	5	109330426	missense	probably damaging	0.99
IGL03096:Vmn2r16	APN	5	109339885	missense	probably damaging	0.99
IGL03355:Vmn2r16	APN	5	109363714	missense	possibly damaging	0.74
R0280:Vmn2r16	UTSW	5	109340139	missense	possibly damaging	0.88
R0594:Vmn2r16	UTSW	5	109363896	missense	probably damaging	1.00
R1016:Vmn2r16	UTSW	5	109339888	missense	probably damaging	1.00
R1109:Vmn2r16	UTSW	5	109339786	missense	probably damaging	0.98
R1248:Vmn2r16	UTSW	5	109360777	missense	probably benign	0.10
R1626:Vmn2r16	UTSW	5	109363577	missense	probably damaging	1.00
R1909:Vmn2r16	UTSW	5	109363987	missense	probably benign	0.01
R1929:Vmn2r16	UTSW	5	109339258	missense	possibly damaging	0.92
R1982:Vmn2r16	UTSW	5	109364024	missense	probably benign	0.01
R3038:Vmn2r16	UTSW	5	109339333	missense	probably damaging	1.00
R3437:Vmn2r16	UTSW	5	109330496	missense	probably damaging	0.99
R3734:Vmn2r16	UTSW	5	109330414	missense	probably benign	0.11
R3820:Vmn2r16	UTSW	5	109362277	missense	probably benign	0.36
R3873:Vmn2r16	UTSW	5	109340311	missense	probably benign	0.33
R4165:Vmn2r16	UTSW	5	109330561	missense	possibly damaging	0.80
R4373:Vmn2r16	UTSW	5	109363801	missense	probably damaging	1.00
R4575:Vmn2r16	UTSW	5	109363799	missense	possibly damaging	0.81
R4576:Vmn2r16	UTSW	5	109363799	missense	possibly damaging	0.81
R4578:Vmn2r16	UTSW	5	109363799	missense	possibly damaging	0.81
R4637:Vmn2r16	UTSW	5	109330414	missense	probably benign	0.00
R4696:Vmn2r16	UTSW	5	109339302	missense	probably benign	0.01
R5026:Vmn2r16	UTSW	5	109360856	nonsense	probably null
R5180:Vmn2r16	UTSW	5	109330525	missense	probably benign	0.01
R5433:Vmn2r16	UTSW	5	109363842	missense	probably damaging	1.00
R5955:Vmn2r16	UTSW	5	109363747	missense	possibly damaging	0.78
R5958:Vmn2r16	UTSW	5	109362287	missense	possibly damaging	0.81
R6353:Vmn2r16	UTSW	5	109340253	missense	probably benign	0.33
R6389:Vmn2r16	UTSW	5	109330478	missense	probably benign	0.19
R6819:Vmn2r16	UTSW	5	109340546	missense	probably benign	0.04
R6994:Vmn2r16	UTSW	5	109340103	missense	probably damaging	1.00
R7061:Vmn2r16	UTSW	5	109363754	missense	probably damaging	0.99
R7063:Vmn2r16	UTSW	5	109363784	missense	probably damaging	1.00
R7220:Vmn2r16	UTSW	5	109360906	missense	probably damaging	0.97
R7268:Vmn2r16	UTSW	5	109340465	nonsense	probably null
R7420:Vmn2r16	UTSW	5	109363870	missense	probably damaging	0.96
R7591:Vmn2r16	UTSW	5	109362357	missense	probably damaging	0.99
R7644:Vmn2r16	UTSW	5	109339971	missense	probably damaging	1.00
R7939:Vmn2r16	UTSW	5	109339839	missense	possibly damaging	0.79
R7977:Vmn2r16	UTSW	5	109340149	missense	probably damaging	1.00
R7987:Vmn2r16	UTSW	5	109340149	missense	probably damaging	1.00
R8023:Vmn2r16	UTSW	5	109340406	nonsense	probably null
R8427:Vmn2r16	UTSW	5	109340272	missense	probably benign	0.03
R8436:Vmn2r16	UTSW	5	109363783	missense	probably damaging	1.00
R8475:Vmn2r16	UTSW	5	109339207	missense	probably benign	0.01
R8554:Vmn2r16	UTSW	5	109364131	missense	probably benign	0.13
R8771:Vmn2r16	UTSW	5	109340365	missense	probably benign	0.00
R8774:Vmn2r16	UTSW	5	109340365	missense	probably benign	0.00
R8774-TAIL:Vmn2r16	UTSW	5	109340365	missense	probably benign	0.00
R8775:Vmn2r16	UTSW	5	109340365	missense	probably benign	0.00
R8775-TAIL:Vmn2r16	UTSW	5	109340365	missense	probably benign	0.00
R8777:Vmn2r16	UTSW	5	109340365	missense	probably benign	0.00
R8777-TAIL:Vmn2r16	UTSW	5	109340365	missense	probably benign	0.00
R8825:Vmn2r16	UTSW	5	109339153	missense	probably benign	0.41
R8865:Vmn2r16	UTSW	5	109340044	missense	probably benign	0.33
R8900:Vmn2r16	UTSW	5	109363753	missense	probably benign	0.04
R9365:Vmn2r16	UTSW	5	109340198	missense	probably damaging	0.99
R9683:Vmn2r16	UTSW	5	109363811	missense	probably damaging	1.00
X0027:Vmn2r16	UTSW	5	109339309	missense	probably damaging	1.00
Z1088:Vmn2r16	UTSW	5	109340515	missense	probably benign	0.03
Z1088:Vmn2r16	UTSW	5	109363913	frame shift	probably null
Z1177:Vmn2r16	UTSW	5	109339998	missense	possibly damaging	0.79

Posted On

2013-11-05