Incidental Mutation 'IGL01391:Zfp672'
ID79198
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp672
Ensembl Gene ENSMUSG00000049755
Gene Namezinc finger protein 672
Synonyms4930511N19Rik, 4930488P06Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.116) question?
Stock #IGL01391
Quality Score
Status
Chromosome11
Chromosomal Location58315114-58330339 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 58317366 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Serine at position 43 (F43S)
Ref Sequence ENSEMBL: ENSMUSP00000114561 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049353] [ENSMUST00000057836] [ENSMUST00000064786] [ENSMUST00000108829] [ENSMUST00000153510] [ENSMUST00000155662] [ENSMUST00000186859]
Predicted Effect probably benign
Transcript: ENSMUST00000049353
SMART Domains Protein: ENSMUSP00000131896
Gene: ENSMUSG00000037243

DomainStartEndE-ValueType
low complexity region 10 23 N/A INTRINSIC
low complexity region 94 110 N/A INTRINSIC
low complexity region 159 175 N/A INTRINSIC
low complexity region 193 204 N/A INTRINSIC
low complexity region 215 232 N/A INTRINSIC
ZnF_C2H2 327 352 4.11e-2 SMART
ZnF_C2H2 358 382 2.05e-2 SMART
ZnF_C2H2 388 410 1.69e-3 SMART
ZnF_C2H2 416 438 1.69e-3 SMART
ZnF_C2H2 447 470 6.23e-2 SMART
low complexity region 502 520 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000057836
AA Change: F43S

PolyPhen 2 Score 0.533 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000060088
Gene: ENSMUSG00000049755
AA Change: F43S

DomainStartEndE-ValueType
ZnF_C2H2 15 37 4.17e-3 SMART
ZnF_C2H2 43 65 8.75e0 SMART
ZnF_C2H2 71 93 1.18e-2 SMART
ZnF_C2H2 100 123 1.76e-1 SMART
ZnF_C2H2 129 151 1.59e1 SMART
ZnF_C2H2 167 189 4.47e-3 SMART
ZnF_C2H2 202 224 9.58e-3 SMART
ZnF_C2H2 230 252 7.37e-4 SMART
ZnF_C2H2 258 280 3.16e-3 SMART
ZnF_C2H2 286 308 1.45e-2 SMART
ZnF_C2H2 314 336 4.01e-5 SMART
ZnF_C2H2 342 364 5.5e-3 SMART
ZnF_C2H2 370 392 1.12e-3 SMART
ZnF_C2H2 398 420 6.67e-2 SMART
low complexity region 421 441 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000064786
AA Change: F43S

PolyPhen 2 Score 0.533 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000070567
Gene: ENSMUSG00000049755
AA Change: F43S

DomainStartEndE-ValueType
ZnF_C2H2 15 37 4.17e-3 SMART
ZnF_C2H2 43 65 8.75e0 SMART
ZnF_C2H2 71 93 1.18e-2 SMART
ZnF_C2H2 100 123 1.76e-1 SMART
ZnF_C2H2 129 151 1.59e1 SMART
ZnF_C2H2 167 189 4.47e-3 SMART
ZnF_C2H2 202 224 9.58e-3 SMART
ZnF_C2H2 230 252 7.37e-4 SMART
ZnF_C2H2 258 280 3.16e-3 SMART
ZnF_C2H2 286 308 1.45e-2 SMART
ZnF_C2H2 314 336 4.01e-5 SMART
ZnF_C2H2 342 364 5.5e-3 SMART
ZnF_C2H2 370 392 1.12e-3 SMART
ZnF_C2H2 398 420 6.67e-2 SMART
low complexity region 421 441 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000108829
AA Change: F43S

PolyPhen 2 Score 0.533 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000104457
Gene: ENSMUSG00000049755
AA Change: F43S

DomainStartEndE-ValueType
ZnF_C2H2 15 37 4.17e-3 SMART
ZnF_C2H2 43 65 8.75e0 SMART
ZnF_C2H2 71 93 1.18e-2 SMART
ZnF_C2H2 100 123 1.76e-1 SMART
ZnF_C2H2 129 151 1.59e1 SMART
ZnF_C2H2 167 189 4.47e-3 SMART
ZnF_C2H2 202 224 9.58e-3 SMART
ZnF_C2H2 230 252 7.37e-4 SMART
ZnF_C2H2 258 280 3.16e-3 SMART
ZnF_C2H2 286 308 1.45e-2 SMART
ZnF_C2H2 314 336 4.01e-5 SMART
ZnF_C2H2 342 364 5.5e-3 SMART
ZnF_C2H2 370 392 1.12e-3 SMART
ZnF_C2H2 398 420 6.67e-2 SMART
low complexity region 421 441 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130217
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135097
Predicted Effect probably benign
Transcript: ENSMUST00000153510
SMART Domains Protein: ENSMUSP00000126674
Gene: ENSMUSG00000037243

DomainStartEndE-ValueType
low complexity region 10 23 N/A INTRINSIC
low complexity region 94 110 N/A INTRINSIC
low complexity region 159 175 N/A INTRINSIC
low complexity region 193 204 N/A INTRINSIC
low complexity region 215 232 N/A INTRINSIC
ZnF_C2H2 327 352 4.11e-2 SMART
ZnF_C2H2 358 382 2.05e-2 SMART
ZnF_C2H2 388 410 1.69e-3 SMART
ZnF_C2H2 416 438 1.69e-3 SMART
ZnF_C2H2 447 470 6.23e-2 SMART
low complexity region 502 520 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000155662
AA Change: F43S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000114561
Gene: ENSMUSG00000049755
AA Change: F43S

DomainStartEndE-ValueType
ZnF_C2H2 15 37 4.17e-3 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000186859
AA Change: F43S

PolyPhen 2 Score 0.873 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000140236
Gene: ENSMUSG00000049755
AA Change: F43S

DomainStartEndE-ValueType
ZnF_C2H2 15 37 1.8e-5 SMART
ZnF_C2H2 43 65 3.6e-2 SMART
ZnF_C2H2 71 90 6.1e-1 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ap3m2 T A 8: 22,799,647 I147F probably benign Het
Areg T A 5: 91,141,095 S87T probably damaging Het
Arid1b T A 17: 5,318,858 probably benign Het
Arl6ip6 A G 2: 53,192,144 R8G probably benign Het
Brms1 A G 19: 5,046,695 E135G possibly damaging Het
Ccser1 A G 6: 61,638,521 probably benign Het
Dock3 A T 9: 106,907,234 M258K possibly damaging Het
Epb41l4a T G 18: 33,801,625 D562A possibly damaging Het
Etaa1 G A 11: 17,946,005 T704I probably damaging Het
Fer1l4 T A 2: 156,036,456 H972L probably damaging Het
Foxn1 A G 11: 78,361,494 M356T probably damaging Het
Gfral C A 9: 76,164,825 G388* probably null Het
Gm10436 C T 12: 88,178,455 V34I possibly damaging Het
Gm12258 A G 11: 58,848,694 T3A probably benign Het
Hoxa5 T C 6: 52,204,331 N7S probably damaging Het
Itgb4 T C 11: 115,990,920 L765P probably damaging Het
Jchain C T 5: 88,521,524 C90Y probably damaging Het
Klhl40 A G 9: 121,778,917 Y381C probably damaging Het
Lhx6 A T 2: 36,103,465 C74S probably benign Het
Magel2 A G 7: 62,380,884 S1179G unknown Het
Mapre3 T C 5: 30,864,897 I236T probably damaging Het
Mcf2l A T 8: 13,014,010 probably null Het
Med13 A T 11: 86,328,497 H374Q probably benign Het
Meioc A G 11: 102,674,287 Y187C probably benign Het
Myh1 G A 11: 67,217,863 M1368I probably benign Het
Olfr304 A T 7: 86,386,000 I220N possibly damaging Het
Olfr921 A G 9: 38,775,530 I92V probably damaging Het
Phrf1 T C 7: 141,262,481 Y1501H probably damaging Het
Pigb T C 9: 73,022,291 T337A probably damaging Het
Pls1 T C 9: 95,773,698 K334E probably benign Het
Rab3b T C 4: 108,940,802 C226R probably damaging Het
Ryr2 A T 13: 11,556,685 I4889N possibly damaging Het
Serpinb1a G A 13: 32,845,415 S210L probably benign Het
Slc52a3 A G 2: 152,007,602 I390V probably benign Het
Slc6a7 C A 18: 61,003,310 A340S probably damaging Het
Tcaf3 T C 6: 42,593,681 Y379C probably damaging Het
Tex261 A G 6: 83,771,240 V180A probably benign Het
Tnnt1 C T 7: 4,514,212 probably null Het
Ttn T C 2: 76,968,503 T476A possibly damaging Het
Vcan A G 13: 89,704,169 S891P probably benign Het
Vmn2r16 T A 5: 109,363,761 D611E possibly damaging Het
Vmn2r68 T C 7: 85,237,611 T32A probably benign Het
Vwde T G 6: 13,190,527 S522R probably benign Het
Wdr3 G A 3: 100,146,789 probably benign Het
Wfs1 G T 5: 36,971,563 Q288K probably benign Het
Zfp142 A G 1: 74,579,540 V120A probably damaging Het
Znhit3 A T 11: 84,911,457 probably benign Het
Other mutations in Zfp672
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0326:Zfp672 UTSW 11 58316347 missense possibly damaging 0.86
R1485:Zfp672 UTSW 11 58329569 intron probably benign
R1664:Zfp672 UTSW 11 58317312 missense probably damaging 0.99
R1667:Zfp672 UTSW 11 58316095 missense possibly damaging 0.53
R1853:Zfp672 UTSW 11 58316964 missense probably benign
R2074:Zfp672 UTSW 11 58316636 missense possibly damaging 0.71
R3817:Zfp672 UTSW 11 58316636 missense possibly damaging 0.71
R4623:Zfp672 UTSW 11 58316455 missense probably benign 0.34
R4745:Zfp672 UTSW 11 58329498 intron probably benign
R5157:Zfp672 UTSW 11 58316851 missense possibly damaging 0.86
R5240:Zfp672 UTSW 11 58329701 intron probably benign
R5510:Zfp672 UTSW 11 58316630 nonsense probably null
R6207:Zfp672 UTSW 11 58317523 start gained probably benign
R6279:Zfp672 UTSW 11 58317268 missense probably damaging 0.99
R6300:Zfp672 UTSW 11 58317268 missense probably damaging 0.99
R6432:Zfp672 UTSW 11 58316932 missense possibly damaging 0.53
R6438:Zfp672 UTSW 11 58316737 missense probably benign 0.07
R7777:Zfp672 UTSW 11 58317255 missense possibly damaging 0.71
R8401:Zfp672 UTSW 11 58316802 missense probably benign 0.28
R8489:Zfp672 UTSW 11 58329855 intron probably benign
R8826:Zfp672 UTSW 11 58329764 missense
R8858:Zfp672 UTSW 11 58317319 missense possibly damaging 0.91
RF012:Zfp672 UTSW 11 58316112 missense probably benign
Z1186:Zfp672 UTSW 11 58329626 missense unknown
Z1186:Zfp672 UTSW 11 58329960 intron probably benign
Z1187:Zfp672 UTSW 11 58329626 missense unknown
Z1188:Zfp672 UTSW 11 58329626 missense unknown
Z1189:Zfp672 UTSW 11 58329626 missense unknown
Z1190:Zfp672 UTSW 11 58329626 missense unknown
Z1191:Zfp672 UTSW 11 58329626 missense unknown
Z1191:Zfp672 UTSW 11 58329960 intron probably benign
Z1192:Zfp672 UTSW 11 58329626 missense unknown
Posted On2013-11-05