Incidental Mutation 'IGL01393:Grm3'
ID 79279
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Grm3
Ensembl Gene ENSMUSG00000003974
Gene Name glutamate receptor, metabotropic 3
Synonyms mGluR3, mGlu3, 0710001G23Rik, Gprc1c
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01393
Quality Score
Status
Chromosome 5
Chromosomal Location 9535541-9775170 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 9639856 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 63 (D63G)
Ref Sequence ENSEMBL: ENSMUSP00000004076 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004076]
AlphaFold Q9QYS2
Predicted Effect probably benign
Transcript: ENSMUST00000004076
AA Change: D63G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000004076
Gene: ENSMUSG00000003974
AA Change: D63G

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 67 473 4.8e-102 PFAM
Pfam:NCD3G 505 555 2.4e-14 PFAM
Pfam:7tm_3 588 825 4.7e-62 PFAM
low complexity region 849 861 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a targeted mutation display normal morphology, clinical chemistry, hematology, and behavior. Mice homozygous for a knock-out allele exhibit altered neuroprotection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930474N05Rik G A 14: 35,818,379 (GRCm39) V126I possibly damaging Het
A630073D07Rik G T 6: 132,603,577 (GRCm39) Q60K unknown Het
Alpk2 A G 18: 65,440,779 (GRCm39) S205P possibly damaging Het
Ang4 T A 14: 52,001,670 (GRCm39) I93L probably benign Het
Arpin A G 7: 79,581,588 (GRCm39) V44A possibly damaging Het
Atxn3 A T 12: 101,899,306 (GRCm39) C263* probably null Het
Cd209f T C 8: 4,153,154 (GRCm39) N260S probably damaging Het
Cdh20 A G 1: 104,861,969 (GRCm39) R50G probably benign Het
Cracd T C 5: 77,006,818 (GRCm39) S1060P unknown Het
Csmd3 C T 15: 48,320,995 (GRCm39) V272I possibly damaging Het
Dst A T 1: 34,206,706 (GRCm39) Y1136F possibly damaging Het
Fam20c A G 5: 138,793,026 (GRCm39) Y420C probably damaging Het
Fancd2 T A 6: 113,554,321 (GRCm39) probably benign Het
Fat2 T C 11: 55,160,135 (GRCm39) D3326G probably benign Het
Filip1l A G 16: 57,392,586 (GRCm39) N820S probably damaging Het
Gm26566 G A 4: 88,640,581 (GRCm39) probably benign Het
Gm4792 A G 10: 94,134,304 (GRCm39) L22P unknown Het
Gpat2 A G 2: 127,274,571 (GRCm39) E386G probably damaging Het
Hdc A G 2: 126,436,581 (GRCm39) V430A probably benign Het
Hnf4a T C 2: 163,393,492 (GRCm39) probably benign Het
Il2ra A G 2: 11,687,865 (GRCm39) D215G probably damaging Het
Kctd3 T C 1: 188,732,487 (GRCm39) I74V probably benign Het
Kctd5 A T 17: 24,278,292 (GRCm39) probably null Het
Lrsam1 A T 2: 32,845,185 (GRCm39) probably benign Het
Mblac1 A G 5: 138,193,036 (GRCm39) N126S possibly damaging Het
Mmrn1 T A 6: 60,937,692 (GRCm39) probably benign Het
Mpp3 A T 11: 101,916,304 (GRCm39) L16Q probably damaging Het
Mrgprb1 C A 7: 48,097,754 (GRCm39) A53S possibly damaging Het
Nbea C A 3: 55,912,729 (GRCm39) M1019I probably benign Het
Nlrp5 A G 7: 23,103,599 (GRCm39) K22R probably null Het
Or1j4 G A 2: 36,740,553 (GRCm39) R165Q probably benign Het
Or2ag18 C T 7: 106,405,642 (GRCm39) G9E probably benign Het
Or4k48 A G 2: 111,475,601 (GRCm39) V247A probably damaging Het
Pard6b T A 2: 167,929,298 (GRCm39) S35T probably benign Het
Peli1 T C 11: 21,097,400 (GRCm39) V215A probably benign Het
Pkp4 A T 2: 59,178,269 (GRCm39) D1003V probably damaging Het
Pot1a G A 6: 25,744,630 (GRCm39) R625* probably null Het
Ppp1r16a T C 15: 76,578,744 (GRCm39) S483P probably benign Het
Prpf8 C A 11: 75,385,121 (GRCm39) A794D possibly damaging Het
Prrg3 T C X: 71,011,123 (GRCm39) V210A probably benign Het
Rev1 A G 1: 38,131,144 (GRCm39) V168A probably damaging Het
Sez6l G T 5: 112,586,261 (GRCm39) probably benign Het
Spag17 A G 3: 99,934,926 (GRCm39) T711A possibly damaging Het
Spice1 A G 16: 44,186,993 (GRCm39) I163M probably benign Het
Tex13c1 C T X: 42,680,233 (GRCm39) A66V probably damaging Het
Tmem132d A T 5: 127,861,702 (GRCm39) S806R probably benign Het
Tnc A G 4: 63,932,291 (GRCm39) probably benign Het
Tpbg T A 9: 85,726,145 (GRCm39) V38E unknown Het
Unc13c T A 9: 73,447,552 (GRCm39) I1883F probably benign Het
Vmn2r61 A C 7: 41,916,258 (GRCm39) Q290H probably benign Het
Vps39 A G 2: 120,180,719 (GRCm39) probably benign Het
Zfp369 T C 13: 65,442,288 (GRCm39) V294A possibly damaging Het
Zfp821 T A 8: 110,436,110 (GRCm39) probably benign Het
Zfp941 C T 7: 140,391,841 (GRCm39) G506E probably damaging Het
Other mutations in Grm3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00495:Grm3 APN 5 9,562,290 (GRCm39) missense probably benign
IGL01398:Grm3 APN 5 9,535,762 (GRCm39) unclassified probably benign
IGL01825:Grm3 APN 5 9,561,600 (GRCm39) missense probably damaging 1.00
IGL01966:Grm3 APN 5 9,561,486 (GRCm39) missense probably damaging 0.98
IGL02367:Grm3 APN 5 9,561,660 (GRCm39) missense probably damaging 1.00
IGL02526:Grm3 APN 5 9,639,847 (GRCm39) missense probably damaging 1.00
IGL02972:Grm3 APN 5 9,562,410 (GRCm39) missense probably damaging 1.00
IGL03356:Grm3 APN 5 9,562,206 (GRCm39) missense possibly damaging 0.89
BB002:Grm3 UTSW 5 9,639,880 (GRCm39) missense probably benign 0.09
BB012:Grm3 UTSW 5 9,639,880 (GRCm39) missense probably benign 0.09
R0032:Grm3 UTSW 5 9,561,452 (GRCm39) splice site probably null
R0032:Grm3 UTSW 5 9,561,452 (GRCm39) splice site probably null
R0389:Grm3 UTSW 5 9,554,794 (GRCm39) missense probably damaging 1.00
R0455:Grm3 UTSW 5 9,562,477 (GRCm39) missense probably benign
R0538:Grm3 UTSW 5 9,562,446 (GRCm39) missense possibly damaging 0.95
R0553:Grm3 UTSW 5 9,620,048 (GRCm39) missense probably benign 0.16
R1124:Grm3 UTSW 5 9,620,297 (GRCm39) missense probably benign
R1163:Grm3 UTSW 5 9,620,738 (GRCm39) missense probably benign 0.34
R1440:Grm3 UTSW 5 9,639,958 (GRCm39) missense probably benign
R1635:Grm3 UTSW 5 9,561,520 (GRCm39) missense probably damaging 1.00
R1734:Grm3 UTSW 5 9,639,742 (GRCm39) missense probably benign 0.00
R1895:Grm3 UTSW 5 9,562,123 (GRCm39) missense probably damaging 1.00
R1926:Grm3 UTSW 5 9,554,881 (GRCm39) missense probably damaging 0.98
R1940:Grm3 UTSW 5 9,561,682 (GRCm39) missense probably damaging 1.00
R1946:Grm3 UTSW 5 9,562,123 (GRCm39) missense probably damaging 1.00
R2004:Grm3 UTSW 5 9,639,793 (GRCm39) missense possibly damaging 0.57
R2005:Grm3 UTSW 5 9,639,793 (GRCm39) missense possibly damaging 0.57
R2006:Grm3 UTSW 5 9,639,793 (GRCm39) missense possibly damaging 0.57
R3116:Grm3 UTSW 5 9,620,752 (GRCm39) missense probably damaging 1.00
R4083:Grm3 UTSW 5 9,562,054 (GRCm39) missense probably benign
R4537:Grm3 UTSW 5 9,562,083 (GRCm39) missense probably benign 0.02
R4855:Grm3 UTSW 5 9,620,047 (GRCm39) missense probably damaging 0.98
R5060:Grm3 UTSW 5 9,620,167 (GRCm39) missense probably damaging 0.99
R5093:Grm3 UTSW 5 9,639,766 (GRCm39) missense probably benign 0.01
R5419:Grm3 UTSW 5 9,620,233 (GRCm39) missense probably damaging 1.00
R5525:Grm3 UTSW 5 9,554,872 (GRCm39) missense probably damaging 1.00
R5642:Grm3 UTSW 5 9,620,536 (GRCm39) missense probably benign 0.21
R5804:Grm3 UTSW 5 9,620,155 (GRCm39) missense probably benign 0.33
R5915:Grm3 UTSW 5 9,561,927 (GRCm39) missense probably damaging 1.00
R5966:Grm3 UTSW 5 9,561,930 (GRCm39) missense probably damaging 0.98
R6151:Grm3 UTSW 5 9,561,556 (GRCm39) missense probably damaging 1.00
R6419:Grm3 UTSW 5 9,620,201 (GRCm39) missense probably damaging 1.00
R7267:Grm3 UTSW 5 9,639,581 (GRCm39) missense probably benign 0.00
R7555:Grm3 UTSW 5 9,620,000 (GRCm39) missense probably benign 0.00
R7657:Grm3 UTSW 5 9,561,452 (GRCm39) splice site probably null
R7925:Grm3 UTSW 5 9,639,880 (GRCm39) missense probably benign 0.09
R8032:Grm3 UTSW 5 9,562,272 (GRCm39) missense probably benign 0.11
R8227:Grm3 UTSW 5 9,620,242 (GRCm39) missense possibly damaging 0.65
R8462:Grm3 UTSW 5 9,562,365 (GRCm39) missense probably benign
R8500:Grm3 UTSW 5 9,561,726 (GRCm39) missense probably benign 0.21
R8696:Grm3 UTSW 5 9,562,311 (GRCm39) missense probably damaging 1.00
R8807:Grm3 UTSW 5 9,561,499 (GRCm39) missense probably damaging 1.00
R8828:Grm3 UTSW 5 9,554,725 (GRCm39) missense probably benign 0.00
R8876:Grm3 UTSW 5 9,561,580 (GRCm39) missense probably damaging 1.00
R8896:Grm3 UTSW 5 9,562,483 (GRCm39) missense possibly damaging 0.91
R9035:Grm3 UTSW 5 9,620,464 (GRCm39) missense probably damaging 0.99
R9779:Grm3 UTSW 5 9,561,656 (GRCm39) missense possibly damaging 0.74
X0020:Grm3 UTSW 5 9,562,195 (GRCm39) missense probably damaging 1.00
X0025:Grm3 UTSW 5 9,535,790 (GRCm39) missense probably damaging 1.00
X0026:Grm3 UTSW 5 9,562,238 (GRCm39) nonsense probably null
Z1088:Grm3 UTSW 5 9,620,183 (GRCm39) missense probably damaging 0.97
Posted On 2013-11-05