Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01393:Zfp369'

79284

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp369

Ensembl Gene

ENSMUSG00000021514

Gene Name

zinc finger protein 369

Synonyms

B930030B22Rik, NRIF2, D230020H11Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.092) question?

Stock #

IGL01393

Quality Score

Status

Chromosome

Chromosomal Location

65426628-65452035 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 65442288 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 294 (V294A)

Ref Sequence

ENSEMBL: ENSMUSP00000119114 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000126879] [ENSMUST00000130799]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000126879
AA Change: V294A

PolyPhen 2 Score 0.845 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000119114
Gene: ENSMUSG00000021514
AA Change: V294A

Domain	Start	End	E-Value	Type
KRAB	35	95	7.13e-20	SMART
SCAN	178	289	2.57e-39	SMART
KRAB	300	367	1.63e-14	SMART
low complexity region	440	452	N/A	INTRINSIC
ZnF_C2H2	701	723	5.42e-2	SMART
ZnF_C2H2	729	751	4.79e-3	SMART
ZnF_C2H2	757	779	1.47e-3	SMART
ZnF_C2H2	785	807	2.43e-4	SMART
ZnF_C2H2	813	835	6.88e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000130799
AA Change: V294A

PolyPhen 2 Score 0.044 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000116221
Gene: ENSMUSG00000021514
AA Change: V294A

Domain	Start	End	E-Value	Type
KRAB	35	95	7.13e-20	SMART
SCAN	178	289	2.57e-39	SMART
KRAB	300	354	3.54e-15	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000221365

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930474N05Rik	G	A	14: 35,818,379 (GRCm39)	V126I	possibly damaging	Het
A630073D07Rik	G	T	6: 132,603,577 (GRCm39)	Q60K	unknown	Het
Alpk2	A	G	18: 65,440,779 (GRCm39)	S205P	possibly damaging	Het
Ang4	T	A	14: 52,001,670 (GRCm39)	I93L	probably benign	Het
Arpin	A	G	7: 79,581,588 (GRCm39)	V44A	possibly damaging	Het
Atxn3	A	T	12: 101,899,306 (GRCm39)	C263*	probably null	Het
Cd209f	T	C	8: 4,153,154 (GRCm39)	N260S	probably damaging	Het
Cdh20	A	G	1: 104,861,969 (GRCm39)	R50G	probably benign	Het
Cracd	T	C	5: 77,006,818 (GRCm39)	S1060P	unknown	Het
Csmd3	C	T	15: 48,320,995 (GRCm39)	V272I	possibly damaging	Het
Dst	A	T	1: 34,206,706 (GRCm39)	Y1136F	possibly damaging	Het
Fam20c	A	G	5: 138,793,026 (GRCm39)	Y420C	probably damaging	Het
Fancd2	T	A	6: 113,554,321 (GRCm39)		probably benign	Het
Fat2	T	C	11: 55,160,135 (GRCm39)	D3326G	probably benign	Het
Filip1l	A	G	16: 57,392,586 (GRCm39)	N820S	probably damaging	Het
Gm26566	G	A	4: 88,640,581 (GRCm39)		probably benign	Het
Gm4792	A	G	10: 94,134,304 (GRCm39)	L22P	unknown	Het
Gpat2	A	G	2: 127,274,571 (GRCm39)	E386G	probably damaging	Het
Grm3	T	C	5: 9,639,856 (GRCm39)	D63G	probably benign	Het
Hdc	A	G	2: 126,436,581 (GRCm39)	V430A	probably benign	Het
Hnf4a	T	C	2: 163,393,492 (GRCm39)		probably benign	Het
Il2ra	A	G	2: 11,687,865 (GRCm39)	D215G	probably damaging	Het
Kctd3	T	C	1: 188,732,487 (GRCm39)	I74V	probably benign	Het
Kctd5	A	T	17: 24,278,292 (GRCm39)		probably null	Het
Lrsam1	A	T	2: 32,845,185 (GRCm39)		probably benign	Het
Mblac1	A	G	5: 138,193,036 (GRCm39)	N126S	possibly damaging	Het
Mmrn1	T	A	6: 60,937,692 (GRCm39)		probably benign	Het
Mpp3	A	T	11: 101,916,304 (GRCm39)	L16Q	probably damaging	Het
Mrgprb1	C	A	7: 48,097,754 (GRCm39)	A53S	possibly damaging	Het
Nbea	C	A	3: 55,912,729 (GRCm39)	M1019I	probably benign	Het
Nlrp5	A	G	7: 23,103,599 (GRCm39)	K22R	probably null	Het
Or1j4	G	A	2: 36,740,553 (GRCm39)	R165Q	probably benign	Het
Or2ag18	C	T	7: 106,405,642 (GRCm39)	G9E	probably benign	Het
Or4k48	A	G	2: 111,475,601 (GRCm39)	V247A	probably damaging	Het
Pard6b	T	A	2: 167,929,298 (GRCm39)	S35T	probably benign	Het
Peli1	T	C	11: 21,097,400 (GRCm39)	V215A	probably benign	Het
Pkp4	A	T	2: 59,178,269 (GRCm39)	D1003V	probably damaging	Het
Pot1a	G	A	6: 25,744,630 (GRCm39)	R625*	probably null	Het
Ppp1r16a	T	C	15: 76,578,744 (GRCm39)	S483P	probably benign	Het
Prpf8	C	A	11: 75,385,121 (GRCm39)	A794D	possibly damaging	Het
Prrg3	T	C	X: 71,011,123 (GRCm39)	V210A	probably benign	Het
Rev1	A	G	1: 38,131,144 (GRCm39)	V168A	probably damaging	Het
Sez6l	G	T	5: 112,586,261 (GRCm39)		probably benign	Het
Spag17	A	G	3: 99,934,926 (GRCm39)	T711A	possibly damaging	Het
Spice1	A	G	16: 44,186,993 (GRCm39)	I163M	probably benign	Het
Tex13c1	C	T	X: 42,680,233 (GRCm39)	A66V	probably damaging	Het
Tmem132d	A	T	5: 127,861,702 (GRCm39)	S806R	probably benign	Het
Tnc	A	G	4: 63,932,291 (GRCm39)		probably benign	Het
Tpbg	T	A	9: 85,726,145 (GRCm39)	V38E	unknown	Het
Unc13c	T	A	9: 73,447,552 (GRCm39)	I1883F	probably benign	Het
Vmn2r61	A	C	7: 41,916,258 (GRCm39)	Q290H	probably benign	Het
Vps39	A	G	2: 120,180,719 (GRCm39)		probably benign	Het
Zfp821	T	A	8: 110,436,110 (GRCm39)		probably benign	Het
Zfp941	C	T	7: 140,391,841 (GRCm39)	G506E	probably damaging	Het

Other mutations in Zfp369

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00969:Zfp369	APN	13	65,445,074 (GRCm39)	missense	probably benign	0.41
IGL02277:Zfp369	APN	13	65,432,746 (GRCm39)	missense	probably damaging	1.00
IGL02986:Zfp369	APN	13	65,428,095 (GRCm39)	missense	probably damaging	1.00
IGL02992:Zfp369	APN	13	65,442,265 (GRCm39)	missense	possibly damaging	0.50
IGL03170:Zfp369	APN	13	65,442,224 (GRCm39)	missense	probably damaging	0.99
IGL03351:Zfp369	APN	13	65,443,967 (GRCm39)	missense	possibly damaging	0.95
R0136:Zfp369	UTSW	13	65,445,016 (GRCm39)	missense	probably benign	0.08
R0600:Zfp369	UTSW	13	65,444,248 (GRCm39)	missense	probably damaging	0.97
R0646:Zfp369	UTSW	13	65,445,362 (GRCm39)	missense	probably damaging	1.00
R1190:Zfp369	UTSW	13	65,440,107 (GRCm39)	missense	probably damaging	0.99
R1191:Zfp369	UTSW	13	65,439,776 (GRCm39)	nonsense	probably null
R1528:Zfp369	UTSW	13	65,439,979 (GRCm39)	missense	probably damaging	1.00
R1934:Zfp369	UTSW	13	65,444,965 (GRCm39)	missense	probably damaging	1.00
R2168:Zfp369	UTSW	13	65,444,762 (GRCm39)	missense	probably benign	0.01
R4386:Zfp369	UTSW	13	65,444,806 (GRCm39)	missense	probably benign	0.00
R4928:Zfp369	UTSW	13	65,444,614 (GRCm39)	missense	possibly damaging	0.91
R5127:Zfp369	UTSW	13	65,426,847 (GRCm39)	start gained	probably benign
R5549:Zfp369	UTSW	13	65,445,194 (GRCm39)	missense	probably damaging	1.00
R5740:Zfp369	UTSW	13	65,444,581 (GRCm39)	missense	probably benign
R5743:Zfp369	UTSW	13	65,443,494 (GRCm39)	missense	probably benign	0.02
R5840:Zfp369	UTSW	13	65,445,092 (GRCm39)	missense	possibly damaging	0.46
R6351:Zfp369	UTSW	13	65,444,044 (GRCm39)	missense	possibly damaging	0.83
R7248:Zfp369	UTSW	13	65,443,931 (GRCm39)	missense	probably damaging	0.98
R7288:Zfp369	UTSW	13	65,432,832 (GRCm39)	critical splice donor site	probably null
R7314:Zfp369	UTSW	13	65,439,918 (GRCm39)	missense	probably damaging	0.97
R7470:Zfp369	UTSW	13	65,439,960 (GRCm39)	missense	probably benign	0.12
R7508:Zfp369	UTSW	13	65,427,087 (GRCm39)	missense	unknown
R7796:Zfp369	UTSW	13	65,444,029 (GRCm39)	missense	probably benign
R7886:Zfp369	UTSW	13	65,439,868 (GRCm39)	missense	possibly damaging	0.95
R8425:Zfp369	UTSW	13	65,444,489 (GRCm39)	missense	possibly damaging	0.96
R8671:Zfp369	UTSW	13	65,444,095 (GRCm39)	missense	possibly damaging	0.92
R8868:Zfp369	UTSW	13	65,445,082 (GRCm39)	missense	possibly damaging	0.60
R8918:Zfp369	UTSW	13	65,443,529 (GRCm39)	nonsense	probably null
R8921:Zfp369	UTSW	13	65,444,044 (GRCm39)	missense	possibly damaging	0.92
R9201:Zfp369	UTSW	13	65,444,396 (GRCm39)	missense	probably benign	0.07
R9236:Zfp369	UTSW	13	65,445,010 (GRCm39)	missense	probably benign	0.08
R9443:Zfp369	UTSW	13	65,444,347 (GRCm39)	missense	possibly damaging	0.93
Z1177:Zfp369	UTSW	13	65,439,974 (GRCm39)	missense	probably benign	0.00

Posted On

2013-11-05