Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01393:Mrgprb1'

79295

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mrgprb1

Ensembl Gene

ENSMUSG00000070547

Gene Name

MAS-related GPR, member B1

Synonyms

MrgB1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.050) question?

Stock #

IGL01393

Quality Score

Status

Chromosome

Chromosomal Location

48444113-48456342 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 48448006 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Serine at position 53 (A53S)

Ref Sequence

ENSEMBL: ENSMUSP00000091946 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094384] [ENSMUST00000188095] [ENSMUST00000188918]

AlphaFold

Q3UG61

Predicted Effect

possibly damaging
Transcript: ENSMUST00000094384
AA Change: A53S

PolyPhen 2 Score 0.483 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000091946
Gene: ENSMUSG00000070547
AA Change: A53S

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	50	227	5.5e-11	PFAM
Pfam:7tm_1	59	290	4.3e-10	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000188095

Predicted Effect

probably benign
Transcript: ENSMUST00000188918
AA Change: A53S

PolyPhen 2 Score 0.136 (Sensitivity: 0.92; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000140432
Gene: ENSMUSG00000070547
AA Change: A53S

Domain	Start	End	E-Value	Type
SCOP:d1l9ha_	23	84	3e-6	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930474N05Rik	G	A	14: 36,096,422 (GRCm38)	V126I	possibly damaging	Het
A630073D07Rik	G	T	6: 132,626,614 (GRCm38)	Q60K	unknown	Het
Alpk2	A	G	18: 65,307,708 (GRCm38)	S205P	possibly damaging	Het
Ang4	T	A	14: 51,764,213 (GRCm38)	I93L	probably benign	Het
Arpin	A	G	7: 79,931,840 (GRCm38)	V44A	possibly damaging	Het
Atxn3	A	T	12: 101,933,047 (GRCm38)	C263*	probably null	Het
C530008M17Rik	T	C	5: 76,858,971 (GRCm38)	S1060P	unknown	Het
Cd209f	T	C	8: 4,103,154 (GRCm38)	N260S	probably damaging	Het
Cdh20	A	G	1: 104,934,244 (GRCm38)	R50G	probably benign	Het
Csmd3	C	T	15: 48,457,599 (GRCm38)	V272I	possibly damaging	Het
Dst	A	T	1: 34,167,625 (GRCm38)	Y1136F	possibly damaging	Het
Fam20c	A	G	5: 138,807,271 (GRCm38)	Y420C	probably damaging	Het
Fancd2	T	A	6: 113,577,360 (GRCm38)		probably benign	Het
Fat2	T	C	11: 55,269,309 (GRCm38)	D3326G	probably benign	Het
Filip1l	A	G	16: 57,572,223 (GRCm38)	N820S	probably damaging	Het
Gm26566	G	A	4: 88,722,344 (GRCm38)		probably benign	Het
Gm4792	A	G	10: 94,298,442 (GRCm38)	L22P	unknown	Het
Gpat2	A	G	2: 127,432,651 (GRCm38)	E386G	probably damaging	Het
Grm3	T	C	5: 9,589,856 (GRCm38)	D63G	probably benign	Het
Hdc	A	G	2: 126,594,661 (GRCm38)	V430A	probably benign	Het
Hnf4a	T	C	2: 163,551,572 (GRCm38)		probably benign	Het
Il2ra	A	G	2: 11,683,054 (GRCm38)	D215G	probably damaging	Het
Kctd3	T	C	1: 189,000,290 (GRCm38)	I74V	probably benign	Het
Kctd5	A	T	17: 24,059,318 (GRCm38)		probably null	Het
Lrsam1	A	T	2: 32,955,173 (GRCm38)		probably benign	Het
Mblac1	A	G	5: 138,194,774 (GRCm38)	N126S	possibly damaging	Het
Mmrn1	T	A	6: 60,960,708 (GRCm38)		probably benign	Het
Mpp3	A	T	11: 102,025,478 (GRCm38)	L16Q	probably damaging	Het
Nbea	C	A	3: 56,005,308 (GRCm38)	M1019I	probably benign	Het
Nlrp5	A	G	7: 23,404,174 (GRCm38)	K22R	probably null	Het
Olfr1298	A	G	2: 111,645,256 (GRCm38)	V247A	probably damaging	Het
Olfr350	G	A	2: 36,850,541 (GRCm38)	R165Q	probably benign	Het
Olfr700	C	T	7: 106,806,435 (GRCm38)	G9E	probably benign	Het
Pard6b	T	A	2: 168,087,378 (GRCm38)	S35T	probably benign	Het
Peli1	T	C	11: 21,147,400 (GRCm38)	V215A	probably benign	Het
Pkp4	A	T	2: 59,347,925 (GRCm38)	D1003V	probably damaging	Het
Pot1a	G	A	6: 25,744,631 (GRCm38)	R625*	probably null	Het
Ppp1r16a	T	C	15: 76,694,544 (GRCm38)	S483P	probably benign	Het
Prpf8	C	A	11: 75,494,295 (GRCm38)	A794D	possibly damaging	Het
Prrg3	T	C	X: 71,967,517 (GRCm38)	V210A	probably benign	Het
Rev1	A	G	1: 38,092,063 (GRCm38)	V168A	probably damaging	Het
Sez6l	G	T	5: 112,438,395 (GRCm38)		probably benign	Het
Spag17	A	G	3: 100,027,610 (GRCm38)	T711A	possibly damaging	Het
Spice1	A	G	16: 44,366,630 (GRCm38)	I163M	probably benign	Het
Tex13c1	C	T	X: 43,591,356 (GRCm38)	A66V	probably damaging	Het
Tmem132d	A	T	5: 127,784,638 (GRCm38)	S806R	probably benign	Het
Tnc	A	G	4: 64,014,054 (GRCm38)		probably benign	Het
Tpbg	T	A	9: 85,844,092 (GRCm38)	V38E	unknown	Het
Unc13c	T	A	9: 73,540,270 (GRCm38)	I1883F	probably benign	Het
Vmn2r61	A	C	7: 42,266,834 (GRCm38)	Q290H	probably benign	Het
Vps39	A	G	2: 120,350,238 (GRCm38)		probably benign	Het
Zfp369	T	C	13: 65,294,474 (GRCm38)	V294A	possibly damaging	Het
Zfp821	T	A	8: 109,709,478 (GRCm38)		probably benign	Het
Zfp941	C	T	7: 140,811,928 (GRCm38)	G506E	probably damaging	Het

Other mutations in Mrgprb1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00540:Mrgprb1	APN	7	48,447,543 (GRCm38)	missense	probably damaging	0.99
IGL01141:Mrgprb1	APN	7	48,448,027 (GRCm38)	missense	probably benign	0.36
IGL02430:Mrgprb1	APN	7	48,447,661 (GRCm38)	missense	possibly damaging	0.95
IGL02485:Mrgprb1	APN	7	48,447,717 (GRCm38)	missense	possibly damaging	0.88
R0026:Mrgprb1	UTSW	7	48,447,204 (GRCm38)	missense	possibly damaging	0.66
R0051:Mrgprb1	UTSW	7	48,447,214 (GRCm38)	missense	probably benign	0.01
R0789:Mrgprb1	UTSW	7	48,456,184 (GRCm38)	splice site	probably benign
R1223:Mrgprb1	UTSW	7	48,447,687 (GRCm38)	missense	possibly damaging	0.61
R1327:Mrgprb1	UTSW	7	48,447,429 (GRCm38)	missense	possibly damaging	0.87
R1456:Mrgprb1	UTSW	7	48,448,029 (GRCm38)	missense	probably damaging	0.98
R1561:Mrgprb1	UTSW	7	48,447,125 (GRCm38)	splice site	probably null
R1567:Mrgprb1	UTSW	7	48,447,453 (GRCm38)	missense	probably damaging	0.97
R2030:Mrgprb1	UTSW	7	48,447,328 (GRCm38)	missense	possibly damaging	0.83
R2165:Mrgprb1	UTSW	7	48,447,322 (GRCm38)	missense	probably benign	0.00
R2885:Mrgprb1	UTSW	7	48,447,721 (GRCm38)	missense	probably damaging	1.00
R3108:Mrgprb1	UTSW	7	48,447,328 (GRCm38)	missense	possibly damaging	0.93
R3919:Mrgprb1	UTSW	7	48,448,081 (GRCm38)	missense	probably benign	0.03
R4021:Mrgprb1	UTSW	7	48,447,123 (GRCm38)	missense	possibly damaging	0.95
R4613:Mrgprb1	UTSW	7	48,447,708 (GRCm38)	missense	possibly damaging	0.91
R4809:Mrgprb1	UTSW	7	48,447,991 (GRCm38)	missense	possibly damaging	0.89
R5249:Mrgprb1	UTSW	7	48,447,477 (GRCm38)	missense	possibly damaging	0.91
R5425:Mrgprb1	UTSW	7	48,447,971 (GRCm38)	missense	possibly damaging	0.81
R5555:Mrgprb1	UTSW	7	48,447,775 (GRCm38)	missense	probably benign	0.06
R5595:Mrgprb1	UTSW	7	48,447,684 (GRCm38)	missense	probably damaging	0.99
R5982:Mrgprb1	UTSW	7	48,447,820 (GRCm38)	missense	probably benign	0.01
R6746:Mrgprb1	UTSW	7	48,447,897 (GRCm38)	missense	possibly damaging	0.82
R7066:Mrgprb1	UTSW	7	48,447,676 (GRCm38)	missense	probably benign	0.27
R7141:Mrgprb1	UTSW	7	48,447,687 (GRCm38)	missense	possibly damaging	0.61
R7633:Mrgprb1	UTSW	7	48,447,583 (GRCm38)	missense	probably benign	0.01
R8072:Mrgprb1	UTSW	7	48,448,147 (GRCm38)	nonsense	probably null
R8080:Mrgprb1	UTSW	7	48,446,910 (GRCm38)	splice site	probably null
R8112:Mrgprb1	UTSW	7	48,447,934 (GRCm38)	missense	probably damaging	0.97
R8493:Mrgprb1	UTSW	7	48,447,573 (GRCm38)	missense	probably damaging	0.99
R8817:Mrgprb1	UTSW	7	48,447,322 (GRCm38)	missense	probably benign	0.01
R9135:Mrgprb1	UTSW	7	48,447,298 (GRCm38)	missense	possibly damaging	0.95

Posted On

2013-11-05