Incidental Mutation 'IGL01393:Zfp941'
ID79297
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp941
Ensembl Gene ENSMUSG00000060314
Gene Namezinc finger protein 941
SynonymsBC066028
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.070) question?
Stock #IGL01393
Quality Score
Status
Chromosome7
Chromosomal Location140807449-140822178 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 140811928 bp
ZygosityHeterozygous
Amino Acid Change Glycine to Glutamic Acid at position 506 (G506E)
Ref Sequence ENSEMBL: ENSMUSP00000079482 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080651] [ENSMUST00000106052] [ENSMUST00000150053]
Predicted Effect probably damaging
Transcript: ENSMUST00000080651
AA Change: G506E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000079482
Gene: ENSMUSG00000060314
AA Change: G506E

DomainStartEndE-ValueType
KRAB 4 65 3.88e-21 SMART
ZnF_C2H2 339 361 1.26e-2 SMART
ZnF_C2H2 367 389 1.12e-3 SMART
ZnF_C2H2 395 417 7.78e-3 SMART
ZnF_C2H2 423 445 1.12e-3 SMART
ZnF_C2H2 451 471 1.16e1 SMART
ZnF_C2H2 500 522 2.57e-3 SMART
ZnF_C2H2 528 550 7.9e-4 SMART
ZnF_C2H2 556 578 6.42e-4 SMART
ZnF_C2H2 584 606 1.38e-3 SMART
ZnF_C2H2 612 634 3.69e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000106052
AA Change: G506E

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000101667
Gene: ENSMUSG00000060314
AA Change: G506E

DomainStartEndE-ValueType
KRAB 4 65 3.88e-21 SMART
ZnF_C2H2 339 361 1.26e-2 SMART
ZnF_C2H2 367 389 1.12e-3 SMART
ZnF_C2H2 395 417 7.78e-3 SMART
ZnF_C2H2 423 445 1.12e-3 SMART
ZnF_C2H2 451 471 1.16e1 SMART
ZnF_C2H2 500 522 2.57e-3 SMART
ZnF_C2H2 528 550 7.9e-4 SMART
ZnF_C2H2 556 578 6.42e-4 SMART
ZnF_C2H2 584 606 1.38e-3 SMART
ZnF_C2H2 612 634 3.69e-4 SMART
ZnF_C2H2 640 662 2.99e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000150053
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930474N05Rik G A 14: 36,096,422 V126I possibly damaging Het
A630073D07Rik G T 6: 132,626,614 Q60K unknown Het
Alpk2 A G 18: 65,307,708 S205P possibly damaging Het
Ang4 T A 14: 51,764,213 I93L probably benign Het
Arpin A G 7: 79,931,840 V44A possibly damaging Het
Atxn3 A T 12: 101,933,047 C263* probably null Het
C530008M17Rik T C 5: 76,858,971 S1060P unknown Het
Cd209f T C 8: 4,103,154 N260S probably damaging Het
Cdh20 A G 1: 104,934,244 R50G probably benign Het
Csmd3 C T 15: 48,457,599 V272I possibly damaging Het
Dst A T 1: 34,167,625 Y1136F possibly damaging Het
Fam20c A G 5: 138,807,271 Y420C probably damaging Het
Fancd2 T A 6: 113,577,360 probably benign Het
Fat2 T C 11: 55,269,309 D3326G probably benign Het
Filip1l A G 16: 57,572,223 N820S probably damaging Het
Gm26566 G A 4: 88,722,344 probably benign Het
Gm4792 A G 10: 94,298,442 L22P unknown Het
Gpat2 A G 2: 127,432,651 E386G probably damaging Het
Grm3 T C 5: 9,589,856 D63G probably benign Het
Hdc A G 2: 126,594,661 V430A probably benign Het
Hnf4a T C 2: 163,551,572 probably benign Het
Il2ra A G 2: 11,683,054 D215G probably damaging Het
Kctd3 T C 1: 189,000,290 I74V probably benign Het
Kctd5 A T 17: 24,059,318 probably null Het
Lrsam1 A T 2: 32,955,173 probably benign Het
Mblac1 A G 5: 138,194,774 N126S possibly damaging Het
Mmrn1 T A 6: 60,960,708 probably benign Het
Mpp3 A T 11: 102,025,478 L16Q probably damaging Het
Mrgprb1 C A 7: 48,448,006 A53S possibly damaging Het
Nbea C A 3: 56,005,308 M1019I probably benign Het
Nlrp5 A G 7: 23,404,174 K22R probably null Het
Olfr1298 A G 2: 111,645,256 V247A probably damaging Het
Olfr350 G A 2: 36,850,541 R165Q probably benign Het
Olfr700 C T 7: 106,806,435 G9E probably benign Het
Pard6b T A 2: 168,087,378 S35T probably benign Het
Peli1 T C 11: 21,147,400 V215A probably benign Het
Pkp4 A T 2: 59,347,925 D1003V probably damaging Het
Pot1a G A 6: 25,744,631 R625* probably null Het
Ppp1r16a T C 15: 76,694,544 S483P probably benign Het
Prpf8 C A 11: 75,494,295 A794D possibly damaging Het
Prrg3 T C X: 71,967,517 V210A probably benign Het
Rev1 A G 1: 38,092,063 V168A probably damaging Het
Sez6l G T 5: 112,438,395 probably benign Het
Spag17 A G 3: 100,027,610 T711A possibly damaging Het
Spice1 A G 16: 44,366,630 I163M probably benign Het
Tex13c1 C T X: 43,591,356 A66V probably damaging Het
Tmem132d A T 5: 127,784,638 S806R probably benign Het
Tnc A G 4: 64,014,054 probably benign Het
Tpbg T A 9: 85,844,092 V38E unknown Het
Unc13c T A 9: 73,540,270 I1883F probably benign Het
Vmn2r61 A C 7: 42,266,834 Q290H probably benign Het
Vps39 A G 2: 120,350,238 probably benign Het
Zfp369 T C 13: 65,294,474 V294A possibly damaging Het
Zfp821 T A 8: 109,709,478 probably benign Het
Other mutations in Zfp941
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02399:Zfp941 APN 7 140812699 missense probably benign 0.37
IGL03202:Zfp941 APN 7 140813053 missense probably benign 0.02
R0025:Zfp941 UTSW 7 140813272 missense probably benign 0.01
R0025:Zfp941 UTSW 7 140813272 missense probably benign 0.01
R0226:Zfp941 UTSW 7 140813275 missense probably damaging 1.00
R0945:Zfp941 UTSW 7 140811664 missense probably damaging 0.99
R1455:Zfp941 UTSW 7 140812774 missense probably benign 0.29
R1581:Zfp941 UTSW 7 140812120 missense probably benign 0.03
R2474:Zfp941 UTSW 7 140811471 missense probably damaging 1.00
R4052:Zfp941 UTSW 7 140812427 missense possibly damaging 0.81
R4576:Zfp941 UTSW 7 140811590 nonsense probably null
R4604:Zfp941 UTSW 7 140812211 missense probably damaging 1.00
R5170:Zfp941 UTSW 7 140812957 unclassified probably benign
R5311:Zfp941 UTSW 7 140811959 nonsense probably null
R5505:Zfp941 UTSW 7 140811917 missense probably benign 0.03
R5549:Zfp941 UTSW 7 140808108 missense possibly damaging 0.46
R5566:Zfp941 UTSW 7 140812766 missense probably benign 0.01
R5723:Zfp941 UTSW 7 140812850 unclassified probably benign
R5736:Zfp941 UTSW 7 140813060 missense probably benign 0.01
R5861:Zfp941 UTSW 7 140812139 missense probably damaging 1.00
R6041:Zfp941 UTSW 7 140812245 nonsense probably null
R6058:Zfp941 UTSW 7 140812097 missense probably damaging 1.00
R6226:Zfp941 UTSW 7 140812485 missense probably benign 0.01
R6488:Zfp941 UTSW 7 140812750 missense probably benign 0.37
R6824:Zfp941 UTSW 7 140812699 missense probably benign 0.37
R7356:Zfp941 UTSW 7 140812115 missense possibly damaging 0.66
R7554:Zfp941 UTSW 7 140812057 missense possibly damaging 0.69
Z1177:Zfp941 UTSW 7 140812186 missense possibly damaging 0.53
Posted On2013-11-05