Incidental Mutation 'IGL01394:Foxred2'
ID 79349
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Foxred2
Ensembl Gene ENSMUSG00000016552
Gene Name FAD-dependent oxidoreductase domain containing 2
Synonyms D15Bwg0759e, A430097D04Rik, LOC239554
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01394
Quality Score
Status
Chromosome 15
Chromosomal Location 77824722-77840922 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 77839820 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 157 (T157A)
Ref Sequence ENSEMBL: ENSMUSP00000016696 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000016696] [ENSMUST00000100484] [ENSMUST00000117725]
AlphaFold Q3USW5
Predicted Effect probably benign
Transcript: ENSMUST00000016696
AA Change: T157A

PolyPhen 2 Score 0.296 (Sensitivity: 0.91; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000016696
Gene: ENSMUSG00000016552
AA Change: T157A

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:Pyr_redox_2 22 243 2.9e-11 PFAM
Pfam:Pyr_redox_3 25 240 9.3e-35 PFAM
Pfam:NAD_binding_8 26 84 3.3e-6 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000100484
SMART Domains Protein: ENSMUSP00000098053
Gene: ENSMUSG00000016554

DomainStartEndE-ValueType
Pfam:eIF-3_zeta 4 521 6.3e-220 PFAM
low complexity region 530 547 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000117725
AA Change: T157A

PolyPhen 2 Score 0.215 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000113403
Gene: ENSMUSG00000016552
AA Change: T157A

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:Pyr_redox_2 23 478 3.4e-9 PFAM
Pfam:Pyr_redox_3 25 240 6.2e-37 PFAM
Pfam:NAD_binding_8 26 90 4.8e-7 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129045
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229824
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933402N03Rik G A 7: 130,747,960 (GRCm39) Q11* probably null Het
Acot5 T C 12: 84,122,262 (GRCm39) I282T probably benign Het
Adcy2 A G 13: 69,130,521 (GRCm39) V122A probably damaging Het
Aldh16a1 A C 7: 44,794,937 (GRCm39) S511A probably benign Het
Arid3b T C 9: 57,702,317 (GRCm39) E480G probably damaging Het
Baz2a T C 10: 127,954,514 (GRCm39) V723A possibly damaging Het
Bmpr1b A G 3: 141,568,742 (GRCm39) probably null Het
Ccdc83 T C 7: 89,873,209 (GRCm39) E382G probably damaging Het
Cfap46 A G 7: 139,246,895 (GRCm39) Y349H probably damaging Het
Clpx T C 9: 65,217,495 (GRCm39) V21A probably damaging Het
Clstn1 A G 4: 149,719,239 (GRCm39) N356S possibly damaging Het
Ctnnd1 A G 2: 84,435,600 (GRCm39) probably benign Het
Dock1 A G 7: 134,367,945 (GRCm39) N505S probably benign Het
Eaf2 G A 16: 36,630,928 (GRCm39) P82S probably damaging Het
Fbxw26 T C 9: 109,547,057 (GRCm39) Y456C probably benign Het
Fscb A T 12: 64,520,578 (GRCm39) I296K possibly damaging Het
Gad1-ps A G 10: 99,281,424 (GRCm39) noncoding transcript Het
Golgb1 A G 16: 36,751,926 (GRCm39) E3120G probably damaging Het
Ift140 A G 17: 25,313,676 (GRCm39) D1369G probably benign Het
Kcnk13 T C 12: 100,027,921 (GRCm39) V332A probably benign Het
Lama3 T A 18: 12,664,983 (GRCm39) D661E probably null Het
Lum A T 10: 97,404,834 (GRCm39) D243V probably damaging Het
Mgat4c A G 10: 102,220,975 (GRCm39) T86A possibly damaging Het
Mpdz A T 4: 81,210,728 (GRCm39) V1706D possibly damaging Het
Myrfl T C 10: 116,658,592 (GRCm39) Q455R probably benign Het
Or6k2 T C 1: 173,986,423 (GRCm39) F28S probably damaging Het
Or8c20 T A 9: 38,261,101 (GRCm39) S241T possibly damaging Het
Papolg G A 11: 23,817,235 (GRCm39) T654I probably benign Het
Pappa2 G A 1: 158,592,674 (GRCm39) probably benign Het
Plekhh2 C T 17: 84,864,858 (GRCm39) T82I probably benign Het
Prrc2a A G 17: 35,372,080 (GRCm39) V1773A probably benign Het
Psmb8 G T 17: 34,419,703 (GRCm39) V186L probably damaging Het
Rin3 T C 12: 102,339,862 (GRCm39) V604A probably damaging Het
Rtn1 T C 12: 72,355,190 (GRCm39) D252G probably benign Het
Sdk1 C T 5: 141,598,970 (GRCm39) H212Y probably benign Het
Slc5a5 G T 8: 71,342,032 (GRCm39) Y307* probably null Het
Slc9a9 T A 9: 95,005,090 (GRCm39) L499Q probably benign Het
Snx8 C A 5: 140,337,934 (GRCm39) G237V probably benign Het
Spata18 T A 5: 73,836,688 (GRCm39) probably null Het
Stard9 A G 2: 120,536,808 (GRCm39) E417G possibly damaging Het
Ubr5 T C 15: 38,009,875 (GRCm39) D1034G possibly damaging Het
Upf2 A G 2: 6,045,024 (GRCm39) probably null Het
Xrcc6 A G 15: 81,909,862 (GRCm39) K89R possibly damaging Het
Yeats2 T C 16: 19,980,782 (GRCm39) V237A probably damaging Het
Zdhhc6 A G 19: 55,298,324 (GRCm39) W178R probably benign Het
Zfp280b C A 10: 75,875,497 (GRCm39) Q459K probably damaging Het
Zfp811 C A 17: 33,016,794 (GRCm39) K414N probably damaging Het
Other mutations in Foxred2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01479:Foxred2 APN 15 77,836,489 (GRCm39) splice site probably null
IGL01748:Foxred2 APN 15 77,836,546 (GRCm39) missense probably damaging 1.00
IGL02160:Foxred2 APN 15 77,839,850 (GRCm39) missense probably benign 0.03
IGL02328:Foxred2 APN 15 77,840,032 (GRCm39) missense probably damaging 1.00
IGL02630:Foxred2 APN 15 77,831,362 (GRCm39) missense probably benign 0.05
IGL02672:Foxred2 APN 15 77,829,777 (GRCm39) critical splice donor site probably null
soma UTSW 15 77,837,558 (GRCm39) missense possibly damaging 0.78
R0271:Foxred2 UTSW 15 77,827,590 (GRCm39) missense possibly damaging 0.68
R1386:Foxred2 UTSW 15 77,832,721 (GRCm39) critical splice acceptor site probably null
R1581:Foxred2 UTSW 15 77,839,961 (GRCm39) missense possibly damaging 0.94
R4399:Foxred2 UTSW 15 77,839,880 (GRCm39) missense probably benign 0.06
R4399:Foxred2 UTSW 15 77,837,558 (GRCm39) missense possibly damaging 0.78
R4528:Foxred2 UTSW 15 77,827,449 (GRCm39) missense probably benign 0.01
R4937:Foxred2 UTSW 15 77,840,035 (GRCm39) missense probably damaging 1.00
R5165:Foxred2 UTSW 15 77,840,212 (GRCm39) missense probably damaging 1.00
R5318:Foxred2 UTSW 15 77,836,598 (GRCm39) missense probably benign 0.00
R5893:Foxred2 UTSW 15 77,831,344 (GRCm39) missense probably damaging 1.00
R6336:Foxred2 UTSW 15 77,839,964 (GRCm39) missense probably damaging 0.99
R6370:Foxred2 UTSW 15 77,827,506 (GRCm39) missense probably benign 0.01
R6426:Foxred2 UTSW 15 77,837,508 (GRCm39) missense probably damaging 1.00
R6826:Foxred2 UTSW 15 77,831,285 (GRCm39) missense probably benign 0.01
R6891:Foxred2 UTSW 15 77,839,909 (GRCm39) missense probably damaging 1.00
R6934:Foxred2 UTSW 15 77,836,530 (GRCm39) nonsense probably null
R7193:Foxred2 UTSW 15 77,836,230 (GRCm39) missense probably damaging 1.00
R7821:Foxred2 UTSW 15 77,827,550 (GRCm39) missense probably benign 0.01
R8401:Foxred2 UTSW 15 77,836,191 (GRCm39) missense probably damaging 0.98
R8540:Foxred2 UTSW 15 77,836,212 (GRCm39) missense probably damaging 1.00
R8844:Foxred2 UTSW 15 77,832,677 (GRCm39) missense probably benign 0.00
R8916:Foxred2 UTSW 15 77,837,514 (GRCm39) missense probably damaging 1.00
R8963:Foxred2 UTSW 15 77,829,805 (GRCm39) missense probably benign 0.20
R9104:Foxred2 UTSW 15 77,836,517 (GRCm39) missense probably damaging 1.00
R9153:Foxred2 UTSW 15 77,839,787 (GRCm39) critical splice donor site probably null
R9205:Foxred2 UTSW 15 77,836,206 (GRCm39) missense probably damaging 1.00
R9612:Foxred2 UTSW 15 77,836,206 (GRCm39) missense probably damaging 1.00
Z1088:Foxred2 UTSW 15 77,836,203 (GRCm39) missense probably damaging 1.00
Posted On 2013-11-05