Incidental Mutation 'IGL01395:Tas2r135'
ID 79376
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tas2r135
Ensembl Gene ENSMUSG00000056203
Gene Name taste receptor, type 2, member 135
Synonyms mt2r38, Tas2r35
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # IGL01395
Quality Score
Chromosome 6
Chromosomal Location 42382463-42383428 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 42382846 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 128 (C128*)
Ref Sequence ENSEMBL: ENSMUSP00000070247 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057398] [ENSMUST00000070178]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000057398
SMART Domains Protein: ENSMUSP00000057910
Gene: ENSMUSG00000046652

Pfam:TAS2R 1 293 6.7e-68 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000070178
AA Change: C128*
SMART Domains Protein: ENSMUSP00000070247
Gene: ENSMUSG00000056203
AA Change: C128*

Pfam:TAS2R 22 320 1.3e-63 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afg3l2 C T 18: 67,575,880 (GRCm39) R52H probably benign Het
Alg8 T A 7: 97,027,383 (GRCm39) Y84N possibly damaging Het
B3gnt4 T A 5: 123,649,131 (GRCm39) F165L probably damaging Het
Calcrl T C 2: 84,198,919 (GRCm39) I157V probably benign Het
Clpx T C 9: 65,209,133 (GRCm39) S83P probably benign Het
Col7a1 G A 9: 108,812,980 (GRCm39) probably benign Het
Cttn A G 7: 144,011,464 (GRCm39) V115A probably damaging Het
Dcaf1 G A 9: 106,735,361 (GRCm39) V770I possibly damaging Het
Ddx19a A G 8: 111,717,164 (GRCm39) probably benign Het
Dennd6a T A 14: 26,338,056 (GRCm39) Y175* probably null Het
Dhx58 C T 11: 100,594,752 (GRCm39) G48D probably damaging Het
Dnah8 T A 17: 30,854,979 (GRCm39) F178I probably benign Het
Eif5b T C 1: 38,076,339 (GRCm39) I629T probably damaging Het
Frrs1 A G 3: 116,694,654 (GRCm39) I492V probably benign Het
Gm16505 G A 13: 3,411,242 (GRCm39) noncoding transcript Het
Golga4 G A 9: 118,364,441 (GRCm39) G259D probably damaging Het
Gpatch8 T C 11: 102,371,534 (GRCm39) H668R unknown Het
Gucy2c G T 6: 136,675,027 (GRCm39) Q1019K probably damaging Het
Hivep2 T C 10: 14,008,544 (GRCm39) probably null Het
Jph2 T C 2: 163,181,847 (GRCm39) N439S probably benign Het
Knl1 T A 2: 118,902,047 (GRCm39) D1249E probably damaging Het
Lrrc37a A G 11: 103,394,687 (GRCm39) V246A probably benign Het
Mast1 T C 8: 85,639,444 (GRCm39) D1295G possibly damaging Het
Mical2 T A 7: 111,922,792 (GRCm39) M599K probably damaging Het
Nr3c2 T C 8: 77,635,477 (GRCm39) S193P possibly damaging Het
Nr4a2 T A 2: 57,002,165 (GRCm39) Q33L probably damaging Het
Nrap A T 19: 56,350,225 (GRCm39) M514K probably damaging Het
Or1d2 T C 11: 74,255,713 (GRCm39) F73L probably damaging Het
Or5ac16 T A 16: 59,022,460 (GRCm39) T110S possibly damaging Het
Or9i2 A T 19: 13,816,316 (GRCm39) S74T probably damaging Het
Pde5a T C 3: 122,611,604 (GRCm39) I514T probably benign Het
Plxna4 A G 6: 32,216,368 (GRCm39) V569A probably damaging Het
Ppm1k T C 6: 57,490,943 (GRCm39) H324R probably benign Het
Prdm5 A G 6: 65,847,374 (GRCm39) H155R possibly damaging Het
Prpf19 C T 19: 10,878,375 (GRCm39) T287I probably damaging Het
Prpf8 C A 11: 75,385,121 (GRCm39) A794D possibly damaging Het
Pygb C A 2: 150,643,503 (GRCm39) Q97K probably benign Het
Rab27b T C 18: 70,118,288 (GRCm39) K210E probably benign Het
Rttn T G 18: 89,147,894 (GRCm39) N2182K possibly damaging Het
Rusc1 T C 3: 88,999,728 (GRCm39) Q18R probably damaging Het
Stat4 C T 1: 52,051,033 (GRCm39) R31W probably damaging Het
Tm9sf3 T C 19: 41,244,715 (GRCm39) E54G probably damaging Het
Tmx1 A T 12: 70,507,251 (GRCm39) probably null Het
Tnrc6c T A 11: 117,613,939 (GRCm39) V859E probably benign Het
Uggt1 T C 1: 36,194,158 (GRCm39) D1360G probably damaging Het
Other mutations in Tas2r135
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01357:Tas2r135 APN 6 42,383,078 (GRCm39) missense probably benign 0.00
IGL02479:Tas2r135 APN 6 42,382,685 (GRCm39) nonsense probably null
IGL02526:Tas2r135 APN 6 42,383,214 (GRCm39) missense probably damaging 1.00
IGL02806:Tas2r135 APN 6 42,383,382 (GRCm39) missense probably benign 0.00
IGL02982:Tas2r135 APN 6 42,383,187 (GRCm39) missense probably benign
IGL03057:Tas2r135 APN 6 42,378,061 (GRCm39) unclassified probably benign
R0057:Tas2r135 UTSW 6 42,383,354 (GRCm39) missense probably benign 0.07
R0104:Tas2r135 UTSW 6 42,383,258 (GRCm39) missense possibly damaging 0.79
R1412:Tas2r135 UTSW 6 42,382,768 (GRCm39) missense probably benign 0.00
R4517:Tas2r135 UTSW 6 42,383,013 (GRCm39) missense probably benign
R4629:Tas2r135 UTSW 6 42,383,160 (GRCm39) missense probably benign 0.03
R5788:Tas2r135 UTSW 6 42,382,531 (GRCm39) missense probably damaging 1.00
R6021:Tas2r135 UTSW 6 42,383,321 (GRCm39) missense probably damaging 1.00
R6586:Tas2r135 UTSW 6 42,382,952 (GRCm39) missense probably benign 0.18
R7180:Tas2r135 UTSW 6 42,382,685 (GRCm39) nonsense probably null
R7458:Tas2r135 UTSW 6 42,382,881 (GRCm39) missense possibly damaging 0.95
R7850:Tas2r135 UTSW 6 42,383,072 (GRCm39) missense probably benign
R9113:Tas2r135 UTSW 6 42,383,315 (GRCm39) missense probably benign 0.00
Z1176:Tas2r135 UTSW 6 42,383,168 (GRCm39) missense probably benign 0.03
Posted On 2013-11-05