Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01396:Actl11'

79440

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Actl11

Ensembl Gene

ENSMUSG00000066368

Gene Name

actin-like 11

Synonyms

4921517D21Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

IGL01396

Quality Score

Status

Chromosome

Chromosomal Location

107805668-107809660 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 107805964 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 96 (S96P)

Ref Sequence

ENSEMBL: ENSMUSP00000082150 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000085073]

AlphaFold

Q9D5V1

Predicted Effect

possibly damaging
Transcript: ENSMUST00000085073
AA Change: S96P

PolyPhen 2 Score 0.713 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000082150
Gene: ENSMUSG00000066368
AA Change: S96P

Domain	Start	End	E-Value	Type
low complexity region	223	239	N/A	INTRINSIC
low complexity region	301	309	N/A	INTRINSIC
low complexity region	374	391	N/A	INTRINSIC
low complexity region	492	507	N/A	INTRINSIC
low complexity region	697	710	N/A	INTRINSIC
ACTIN	858	1207	4.26e-81	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310003L06Rik	T	A	5: 88,120,649 (GRCm39)	Y469N	probably benign	Het
Ankrd13b	T	A	11: 77,363,198 (GRCm39)		probably null	Het
Apobec4	T	A	1: 152,632,017 (GRCm39)	I15K	probably damaging	Het
Arhgef28	G	T	13: 98,090,401 (GRCm39)	D1039E	probably damaging	Het
Atp1a1	C	T	3: 101,498,769 (GRCm39)	G175R	probably damaging	Het
AU040320	T	A	4: 126,763,171 (GRCm39)		probably benign	Het
Bcl9l	G	A	9: 44,418,121 (GRCm39)	R653H	probably damaging	Het
Ccdc141	T	A	2: 76,958,669 (GRCm39)	I144L	possibly damaging	Het
Cdh20	C	T	1: 104,875,154 (GRCm39)	T312I	possibly damaging	Het
Cdh23	C	T	10: 60,220,848 (GRCm39)	V1297I	possibly damaging	Het
Cfap57	T	C	4: 118,467,792 (GRCm39)	Y315C	probably damaging	Het
Chd8	A	G	14: 52,442,044 (GRCm39)		probably benign	Het
Cog5	A	G	12: 31,944,095 (GRCm39)	D660G	probably benign	Het
Cps1	T	C	1: 67,196,945 (GRCm39)	I332T	probably damaging	Het
Csgalnact2	T	C	6: 118,103,288 (GRCm39)	T225A	probably damaging	Het
Dchs1	A	G	7: 105,421,490 (GRCm39)	L310P	probably damaging	Het
Dgki	T	C	6: 36,977,025 (GRCm39)	N695S	probably damaging	Het
Gas7	T	A	11: 67,543,740 (GRCm39)		probably null	Het
Gm21286	T	C	4: 60,794,323 (GRCm39)		noncoding transcript	Het
Gm4799	C	T	10: 82,790,518 (GRCm39)		noncoding transcript	Het
Hdac4	T	C	1: 91,887,196 (GRCm39)		probably benign	Het
Hif1a	T	A	12: 73,987,307 (GRCm39)	S467T	probably benign	Het
Ier5	A	G	1: 154,974,296 (GRCm39)	V294A	probably damaging	Het
Ifna11	T	C	4: 88,738,314 (GRCm39)	V40A	probably benign	Het
Itga9	T	C	9: 118,436,191 (GRCm39)		probably benign	Het
Lbx1	G	T	19: 45,222,670 (GRCm39)	Q118K	probably benign	Het
Lta	A	T	17: 35,423,061 (GRCm39)		probably null	Het
Matr3	A	G	18: 35,721,442 (GRCm39)	Y471C	probably damaging	Het
Nrg2	A	T	18: 36,178,905 (GRCm39)		probably benign	Het
Or4c103	C	T	2: 88,513,575 (GRCm39)	C167Y	probably damaging	Het
Or4k51	T	C	2: 111,584,848 (GRCm39)	F85L	probably benign	Het
Or4k51	T	A	2: 111,584,948 (GRCm39)	M118K	probably damaging	Het
Or5l13	G	T	2: 87,780,207 (GRCm39)	F123L	probably damaging	Het
Patl1	A	G	19: 11,901,247 (GRCm39)	K299R	probably damaging	Het
Pdgfrb	A	G	18: 61,205,736 (GRCm39)	E574G	probably damaging	Het
Phf3	G	A	1: 30,843,386 (GRCm39)	Q1858*	probably null	Het
Prkca	T	C	11: 107,905,148 (GRCm39)	K197E	possibly damaging	Het
Psmc6	C	A	14: 45,581,124 (GRCm39)	Q307K	probably benign	Het
Rasa1	T	C	13: 85,406,561 (GRCm39)	I181V	probably benign	Het
Scel	A	G	14: 103,845,530 (GRCm39)		probably benign	Het
Scn5a	A	T	9: 119,363,770 (GRCm39)	S457T	probably damaging	Het
Sesn3	A	G	9: 14,232,374 (GRCm39)	T216A	probably benign	Het
Slc25a21	A	G	12: 57,205,974 (GRCm39)	V19A	probably benign	Het
Slc34a1	A	G	13: 55,550,546 (GRCm39)	T81A	probably damaging	Het
Slc35a5	A	G	16: 44,971,866 (GRCm39)	Y117H	probably damaging	Het
Sptbn4	A	G	7: 27,114,196 (GRCm39)	V569A	probably benign	Het
Sqle	A	G	15: 59,195,723 (GRCm39)	Y333C	probably damaging	Het
Svep1	T	C	4: 58,068,552 (GRCm39)	E3078G	possibly damaging	Het
Tacc2	T	A	7: 130,360,919 (GRCm39)	I2737N	probably damaging	Het
Tet3	A	T	6: 83,346,620 (GRCm39)	Y1272*	probably null	Het
Tnr	G	T	1: 159,724,594 (GRCm39)	R1095L	possibly damaging	Het
Vmn1r184	T	C	7: 25,966,862 (GRCm39)	S203P	probably damaging	Het
Vmn2r94	A	G	17: 18,477,301 (GRCm39)	L370P	probably damaging	Het
Xrcc5	A	G	1: 72,393,404 (GRCm39)	H559R	probably benign	Het

Other mutations in Actl11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01081:Actl11	APN	9	107,806,181 (GRCm39)	missense	possibly damaging	0.49
IGL01622:Actl11	APN	9	107,805,775 (GRCm39)	missense	probably benign	0.03
IGL01623:Actl11	APN	9	107,805,775 (GRCm39)	missense	probably benign	0.03
IGL01660:Actl11	APN	9	107,806,247 (GRCm39)	missense	probably benign
IGL01912:Actl11	APN	9	107,806,844 (GRCm39)	missense	probably damaging	0.98
IGL02002:Actl11	APN	9	107,806,529 (GRCm39)	missense	probably benign	0.08
IGL02266:Actl11	APN	9	107,808,382 (GRCm39)	missense	possibly damaging	0.76
IGL02535:Actl11	APN	9	107,807,136 (GRCm39)	missense	possibly damaging	0.71
IGL02692:Actl11	APN	9	107,806,507 (GRCm39)	missense	probably benign	0.06
IGL02744:Actl11	APN	9	107,807,061 (GRCm39)	missense	probably benign	0.04
IGL02864:Actl11	APN	9	107,806,186 (GRCm39)	missense	probably benign	0.25
IGL03037:Actl11	APN	9	107,807,294 (GRCm39)	missense	probably damaging	0.99
IGL03085:Actl11	APN	9	107,806,749 (GRCm39)	missense	probably damaging	0.98
R0167:Actl11	UTSW	9	107,806,969 (GRCm39)	missense	probably damaging	1.00
R0304:Actl11	UTSW	9	107,806,967 (GRCm39)	missense	probably damaging	1.00
R0959:Actl11	UTSW	9	107,808,434 (GRCm39)	missense	probably damaging	1.00
R1499:Actl11	UTSW	9	107,808,682 (GRCm39)	missense	probably damaging	1.00
R1616:Actl11	UTSW	9	107,809,135 (GRCm39)	missense	probably benign	0.39
R1694:Actl11	UTSW	9	107,807,207 (GRCm39)	missense	probably damaging	1.00
R1927:Actl11	UTSW	9	107,806,736 (GRCm39)	missense	possibly damaging	0.88
R2081:Actl11	UTSW	9	107,807,396 (GRCm39)	missense	probably benign
R2939:Actl11	UTSW	9	107,808,409 (GRCm39)	missense	possibly damaging	0.84
R3427:Actl11	UTSW	9	107,806,969 (GRCm39)	missense	probably damaging	1.00
R4812:Actl11	UTSW	9	107,808,329 (GRCm39)	missense	probably damaging	0.99
R4843:Actl11	UTSW	9	107,806,691 (GRCm39)	missense	possibly damaging	0.61
R4972:Actl11	UTSW	9	107,807,155 (GRCm39)	missense	probably benign	0.07
R4989:Actl11	UTSW	9	107,808,615 (GRCm39)	missense	probably damaging	1.00
R4996:Actl11	UTSW	9	107,808,934 (GRCm39)	missense	possibly damaging	0.77
R5320:Actl11	UTSW	9	107,808,203 (GRCm39)	missense	possibly damaging	0.73
R5546:Actl11	UTSW	9	107,806,832 (GRCm39)	missense	probably benign	0.00
R5810:Actl11	UTSW	9	107,806,420 (GRCm39)	missense	probably benign	0.23
R6302:Actl11	UTSW	9	107,806,772 (GRCm39)	missense	probably benign	0.12
R6412:Actl11	UTSW	9	107,807,116 (GRCm39)	missense	probably benign	0.01
R6835:Actl11	UTSW	9	107,807,761 (GRCm39)	missense	probably benign
R6891:Actl11	UTSW	9	107,806,346 (GRCm39)	missense	probably benign	0.03
R7195:Actl11	UTSW	9	107,806,069 (GRCm39)	nonsense	probably null
R7212:Actl11	UTSW	9	107,805,856 (GRCm39)	missense	probably damaging	0.99
R8478:Actl11	UTSW	9	107,805,844 (GRCm39)	missense	possibly damaging	0.81
R8670:Actl11	UTSW	9	107,805,959 (GRCm39)	missense	possibly damaging	0.76
R8683:Actl11	UTSW	9	107,806,065 (GRCm39)	missense	probably benign	0.15
R9114:Actl11	UTSW	9	107,808,509 (GRCm39)	missense	possibly damaging	0.62
R9233:Actl11	UTSW	9	107,807,900 (GRCm39)	missense	possibly damaging	0.91
R9280:Actl11	UTSW	9	107,808,573 (GRCm39)	missense	probably damaging	1.00
R9361:Actl11	UTSW	9	107,805,824 (GRCm39)	missense	probably damaging	1.00
R9565:Actl11	UTSW	9	107,808,121 (GRCm39)	missense	possibly damaging	0.92
X0024:Actl11	UTSW	9	107,807,704 (GRCm39)	missense	probably benign	0.01
Z1176:Actl11	UTSW	9	107,808,899 (GRCm39)	missense	probably benign	0.20

Posted On

2013-11-05