Mutagenetix > Incidental Mutation

Incidental Mutation 'R0010:Zfp608'

7945

Institutional Source

Beutler Lab

Gene Symbol

Zfp608

Ensembl Gene

ENSMUSG00000052713

Gene Name

zinc finger protein 608

Synonyms

4932417D18Rik

MMRRC Submission

038305-MU

Accession Numbers

Is this an essential gene?

Probably essential (E-score: 0.915) question?

Stock #

R0010 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

54888045-54990180 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 54895214 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000068192 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000064763]

AlphaFold

Q56A10

Predicted Effect

probably benign
Transcript: ENSMUST00000064763

SMART Domains

Protein: ENSMUSP00000068192
Gene: ENSMUSG00000052713

Domain	Start	End	E-Value	Type
low complexity region	51	61	N/A	INTRINSIC
low complexity region	150	184	N/A	INTRINSIC
low complexity region	214	234	N/A	INTRINSIC
low complexity region	252	266	N/A	INTRINSIC
low complexity region	309	326	N/A	INTRINSIC
low complexity region	428	445	N/A	INTRINSIC
low complexity region	459	471	N/A	INTRINSIC
ZnF_C2H2	552	577	1.86e0	SMART
low complexity region	624	636	N/A	INTRINSIC
low complexity region	706	718	N/A	INTRINSIC
low complexity region	734	773	N/A	INTRINSIC
low complexity region	807	822	N/A	INTRINSIC
low complexity region	833	846	N/A	INTRINSIC
low complexity region	934	956	N/A	INTRINSIC
coiled coil region	1028	1054	N/A	INTRINSIC
low complexity region	1182	1193	N/A	INTRINSIC
low complexity region	1255	1268	N/A	INTRINSIC
low complexity region	1439	1450	N/A	INTRINSIC
low complexity region	1458	1466	N/A	INTRINSIC
low complexity region	1486	1502	N/A	INTRINSIC

Coding Region Coverage

1x: 79.6%
3x: 70.9%
10x: 47.0%
20x: 26.4%

Validation Efficiency

91% (78/86)

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrl3	C	T	5: 81,792,403	A1320V	possibly damaging	Het
Ahrr	G	A	13: 74,283,024		probably benign	Het
BC037034	T	C	5: 138,260,293		probably null	Het
Cd74	A	T	18: 60,809,071	H124L	probably benign	Het
Cdk5rap2	T	C	4: 70,243,459	E270G	probably benign	Het
Cldnd1	T	A	16: 58,731,259		probably benign	Het
Dennd4a	T	C	9: 64,896,715	L1112P	probably benign	Het
Evc2	T	A	5: 37,417,449	L1016Q	probably damaging	Het
Fam135b	T	C	15: 71,622,032	K16R	probably damaging	Het
Frem1	T	C	4: 83,000,098	I536V	probably benign	Het
Ginm1	T	C	10: 7,775,374		probably benign	Het
Glrb	A	T	3: 80,860,315		probably benign	Het
Glt6d1	C	A	2: 25,794,727		probably null	Het
Gm10320	T	C	13: 98,489,546	Y110C	probably damaging	Het
Intu	T	C	3: 40,654,272		probably benign	Het
Ltbp1	A	G	17: 75,363,391	T1476A	probably damaging	Het
Mcoln2	C	T	3: 146,183,561	T374M	probably damaging	Het
Mitf	A	G	6: 97,807,281	K33R	probably benign	Het
Nlgn1	G	T	3: 25,435,842		probably benign	Het
Nup133	A	T	8: 123,904,579	I1072N	probably damaging	Het
Rock1	T	A	18: 10,084,380	D951V	probably damaging	Het
Scgb2b26	T	A	7: 33,944,349	E55D	probably damaging	Het
Scn8a	T	C	15: 101,013,573	V958A	probably damaging	Het
Sgk1	G	A	10: 21,997,438		probably null	Het
Shprh	C	T	10: 11,151,931	T94I	probably benign	Het
Smg1	A	T	7: 118,171,859		probably benign	Het
Spta1	G	A	1: 174,217,943	V1556I	probably benign	Het
Trappc4	G	A	9: 44,405,231		probably benign	Het
Txlna	T	G	4: 129,629,086	D487A	probably benign	Het
Ube2d2b	T	C	5: 107,830,636	F51S	possibly damaging	Het
Wdfy3	T	C	5: 101,848,349	T3234A	probably damaging	Het
Zbtb41	T	G	1: 139,423,530	V127G	probably damaging	Het

Other mutations in Zfp608

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00500:Zfp608	APN	18	54988333	missense	probably benign
IGL00920:Zfp608	APN	18	54889831	missense	probably benign	0.00
IGL01088:Zfp608	APN	18	54898087	missense	probably benign	0.03
IGL01447:Zfp608	APN	18	54899011	missense	possibly damaging	0.75
IGL01534:Zfp608	APN	18	54898932	missense	probably damaging	0.99
IGL01547:Zfp608	APN	18	54894449	critical splice donor site	probably null
IGL01933:Zfp608	APN	18	54987799	missense	probably benign
IGL01998:Zfp608	APN	18	54891818	missense	probably damaging	0.99
IGL02167:Zfp608	APN	18	54988224	missense	probably damaging	1.00
IGL02266:Zfp608	APN	18	54897581	missense	probably benign	0.08
IGL02335:Zfp608	APN	18	54897437	nonsense	probably null
IGL02455:Zfp608	APN	18	54899333	missense	probably damaging	1.00
IGL02612:Zfp608	APN	18	54898201	missense	probably damaging	1.00
IGL02900:Zfp608	APN	18	54946793	missense	probably damaging	1.00
PIT4243001:Zfp608	UTSW	18	54898024	missense	probably damaging	1.00
PIT4519001:Zfp608	UTSW	18	54946711	missense	possibly damaging	0.71
R0005:Zfp608	UTSW	18	54895520	missense	possibly damaging	0.88
R0010:Zfp608	UTSW	18	54895214	splice site	probably benign
R0064:Zfp608	UTSW	18	54898816	missense	probably benign
R0401:Zfp608	UTSW	18	54898994	missense	probably benign
R0722:Zfp608	UTSW	18	54900234	missense	probably damaging	1.00
R1351:Zfp608	UTSW	18	54898391	missense	probably benign	0.00
R1512:Zfp608	UTSW	18	54946666	missense	probably damaging	1.00
R1554:Zfp608	UTSW	18	54898054	missense	probably damaging	1.00
R1622:Zfp608	UTSW	18	54988294	missense	probably benign	0.07
R1669:Zfp608	UTSW	18	54987739	missense	probably benign	0.09
R1690:Zfp608	UTSW	18	54987634	missense	possibly damaging	0.62
R1721:Zfp608	UTSW	18	54899249	missense	probably benign
R1826:Zfp608	UTSW	18	54898576	missense	probably benign	0.03
R1864:Zfp608	UTSW	18	54897911	missense	probably benign	0.00
R1952:Zfp608	UTSW	18	54897779	nonsense	probably null
R2049:Zfp608	UTSW	18	54895565	missense	probably damaging	1.00
R2051:Zfp608	UTSW	18	54988314	missense	probably benign
R2168:Zfp608	UTSW	18	54898053	nonsense	probably null
R2218:Zfp608	UTSW	18	54987684	missense	probably benign	0.14
R2283:Zfp608	UTSW	18	54988374	missense	probably damaging	1.00
R2399:Zfp608	UTSW	18	54897902	missense	probably damaging	1.00
R2520:Zfp608	UTSW	18	54988506	missense	possibly damaging	0.92
R2961:Zfp608	UTSW	18	54898472	missense	possibly damaging	0.60
R4074:Zfp608	UTSW	18	54898108	missense	probably damaging	1.00
R4076:Zfp608	UTSW	18	54898108	missense	probably damaging	1.00
R4206:Zfp608	UTSW	18	54988195	missense	probably damaging	1.00
R4756:Zfp608	UTSW	18	54894472	missense	probably damaging	1.00
R4771:Zfp608	UTSW	18	54988300	missense	probably benign
R4820:Zfp608	UTSW	18	54987684	missense	probably benign	0.14
R4825:Zfp608	UTSW	18	54897969	missense	probably benign	0.01
R4912:Zfp608	UTSW	18	54946591	missense	probably damaging	1.00
R4975:Zfp608	UTSW	18	54889890	missense	probably damaging	1.00
R5138:Zfp608	UTSW	18	54891799	missense	probably damaging	1.00
R5192:Zfp608	UTSW	18	54898497	missense	probably damaging	1.00
R5557:Zfp608	UTSW	18	54987870	missense	possibly damaging	0.81
R5624:Zfp608	UTSW	18	54898272	missense	probably damaging	1.00
R5818:Zfp608	UTSW	18	54895396	missense	probably benign	0.02
R5840:Zfp608	UTSW	18	54898906	missense	probably damaging	1.00
R5992:Zfp608	UTSW	18	54899248	missense	probably benign	0.15
R6106:Zfp608	UTSW	18	54987872	missense	possibly damaging	0.54
R6174:Zfp608	UTSW	18	54988544	start gained	probably benign
R6181:Zfp608	UTSW	18	54895628	missense	possibly damaging	0.56
R6517:Zfp608	UTSW	18	54899078	missense	possibly damaging	0.94
R6567:Zfp608	UTSW	18	54897556	missense	probably damaging	1.00
R6668:Zfp608	UTSW	18	54898019	missense	probably damaging	1.00
R6920:Zfp608	UTSW	18	54988265	missense	probably damaging	1.00
R7061:Zfp608	UTSW	18	54987997	missense	probably benign
R7074:Zfp608	UTSW	18	54897382	missense	possibly damaging	0.69
R7087:Zfp608	UTSW	18	54899397	missense	probably damaging	1.00
R7391:Zfp608	UTSW	18	54897547	missense	possibly damaging	0.49
R7600:Zfp608	UTSW	18	54988020	missense	probably damaging	1.00
R7723:Zfp608	UTSW	18	54897601	missense	probably damaging	1.00
R8054:Zfp608	UTSW	18	54899546	missense	probably benign	0.28
R8236:Zfp608	UTSW	18	54899209	missense	probably damaging	1.00
R8260:Zfp608	UTSW	18	54897749	missense	possibly damaging	0.60
R8732:Zfp608	UTSW	18	54988000	missense	probably benign	0.06
R8781:Zfp608	UTSW	18	54898729	missense	probably damaging	1.00
R8851:Zfp608	UTSW	18	54899122	missense	possibly damaging	0.94
R8940:Zfp608	UTSW	18	54900229	missense	possibly damaging	0.93
R9051:Zfp608	UTSW	18	54899194	missense	probably damaging	1.00
R9091:Zfp608	UTSW	18	54899118	missense	probably damaging	1.00
R9092:Zfp608	UTSW	18	54898576	missense	probably benign	0.03
R9236:Zfp608	UTSW	18	54899282	missense	probably benign	0.39
R9270:Zfp608	UTSW	18	54899118	missense	probably damaging	1.00
R9283:Zfp608	UTSW	18	54897841	missense	possibly damaging	0.50
R9288:Zfp608	UTSW	18	54900269	missense	probably benign	0.39
R9463:Zfp608	UTSW	18	54897202	missense	probably damaging	1.00

Posted On

2012-11-20