Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01396:Vmn1r184'

79455

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r184

Ensembl Gene

ENSMUSG00000046130

Gene Name

vomeronasal 1 receptor, 184

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.057) question?

Stock #

IGL01396

Quality Score

Status

Chromosome

Chromosomal Location

25966256-25967200 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 25966862 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 203 (S203P)

Ref Sequence

ENSEMBL: ENSMUSP00000154576 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057123] [ENSMUST00000227230] [ENSMUST00000227232] [ENSMUST00000227534] [ENSMUST00000227790] [ENSMUST00000228145] [ENSMUST00000228369]

AlphaFold

E9Q2N4

Predicted Effect

probably damaging
Transcript: ENSMUST00000057123
AA Change: S203P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000061885
Gene: ENSMUSG00000046130
AA Change: S203P

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	308	1.7e-7	PFAM
Pfam:V1R	35	297	7.5e-31	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000227230
AA Change: S203P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000227232
AA Change: S203P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000227534
AA Change: S203P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000227790
AA Change: S203P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000228145
AA Change: S203P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000228369
AA Change: S203P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310003L06Rik	T	A	5: 88,120,649 (GRCm39)	Y469N	probably benign	Het
Actl11	T	C	9: 107,805,964 (GRCm39)	S96P	possibly damaging	Het
Ankrd13b	T	A	11: 77,363,198 (GRCm39)		probably null	Het
Apobec4	T	A	1: 152,632,017 (GRCm39)	I15K	probably damaging	Het
Arhgef28	G	T	13: 98,090,401 (GRCm39)	D1039E	probably damaging	Het
Atp1a1	C	T	3: 101,498,769 (GRCm39)	G175R	probably damaging	Het
AU040320	T	A	4: 126,763,171 (GRCm39)		probably benign	Het
Bcl9l	G	A	9: 44,418,121 (GRCm39)	R653H	probably damaging	Het
Ccdc141	T	A	2: 76,958,669 (GRCm39)	I144L	possibly damaging	Het
Cdh20	C	T	1: 104,875,154 (GRCm39)	T312I	possibly damaging	Het
Cdh23	C	T	10: 60,220,848 (GRCm39)	V1297I	possibly damaging	Het
Cfap57	T	C	4: 118,467,792 (GRCm39)	Y315C	probably damaging	Het
Chd8	A	G	14: 52,442,044 (GRCm39)		probably benign	Het
Cog5	A	G	12: 31,944,095 (GRCm39)	D660G	probably benign	Het
Cps1	T	C	1: 67,196,945 (GRCm39)	I332T	probably damaging	Het
Csgalnact2	T	C	6: 118,103,288 (GRCm39)	T225A	probably damaging	Het
Dchs1	A	G	7: 105,421,490 (GRCm39)	L310P	probably damaging	Het
Dgki	T	C	6: 36,977,025 (GRCm39)	N695S	probably damaging	Het
Gas7	T	A	11: 67,543,740 (GRCm39)		probably null	Het
Gm21286	T	C	4: 60,794,323 (GRCm39)		noncoding transcript	Het
Gm4799	C	T	10: 82,790,518 (GRCm39)		noncoding transcript	Het
Hdac4	T	C	1: 91,887,196 (GRCm39)		probably benign	Het
Hif1a	T	A	12: 73,987,307 (GRCm39)	S467T	probably benign	Het
Ier5	A	G	1: 154,974,296 (GRCm39)	V294A	probably damaging	Het
Ifna11	T	C	4: 88,738,314 (GRCm39)	V40A	probably benign	Het
Itga9	T	C	9: 118,436,191 (GRCm39)		probably benign	Het
Lbx1	G	T	19: 45,222,670 (GRCm39)	Q118K	probably benign	Het
Lta	A	T	17: 35,423,061 (GRCm39)		probably null	Het
Matr3	A	G	18: 35,721,442 (GRCm39)	Y471C	probably damaging	Het
Nrg2	A	T	18: 36,178,905 (GRCm39)		probably benign	Het
Or4c103	C	T	2: 88,513,575 (GRCm39)	C167Y	probably damaging	Het
Or4k51	T	C	2: 111,584,848 (GRCm39)	F85L	probably benign	Het
Or4k51	T	A	2: 111,584,948 (GRCm39)	M118K	probably damaging	Het
Or5l13	G	T	2: 87,780,207 (GRCm39)	F123L	probably damaging	Het
Patl1	A	G	19: 11,901,247 (GRCm39)	K299R	probably damaging	Het
Pdgfrb	A	G	18: 61,205,736 (GRCm39)	E574G	probably damaging	Het
Phf3	G	A	1: 30,843,386 (GRCm39)	Q1858*	probably null	Het
Prkca	T	C	11: 107,905,148 (GRCm39)	K197E	possibly damaging	Het
Psmc6	C	A	14: 45,581,124 (GRCm39)	Q307K	probably benign	Het
Rasa1	T	C	13: 85,406,561 (GRCm39)	I181V	probably benign	Het
Scel	A	G	14: 103,845,530 (GRCm39)		probably benign	Het
Scn5a	A	T	9: 119,363,770 (GRCm39)	S457T	probably damaging	Het
Sesn3	A	G	9: 14,232,374 (GRCm39)	T216A	probably benign	Het
Slc25a21	A	G	12: 57,205,974 (GRCm39)	V19A	probably benign	Het
Slc34a1	A	G	13: 55,550,546 (GRCm39)	T81A	probably damaging	Het
Slc35a5	A	G	16: 44,971,866 (GRCm39)	Y117H	probably damaging	Het
Sptbn4	A	G	7: 27,114,196 (GRCm39)	V569A	probably benign	Het
Sqle	A	G	15: 59,195,723 (GRCm39)	Y333C	probably damaging	Het
Svep1	T	C	4: 58,068,552 (GRCm39)	E3078G	possibly damaging	Het
Tacc2	T	A	7: 130,360,919 (GRCm39)	I2737N	probably damaging	Het
Tet3	A	T	6: 83,346,620 (GRCm39)	Y1272*	probably null	Het
Tnr	G	T	1: 159,724,594 (GRCm39)	R1095L	possibly damaging	Het
Vmn2r94	A	G	17: 18,477,301 (GRCm39)	L370P	probably damaging	Het
Xrcc5	A	G	1: 72,393,404 (GRCm39)	H559R	probably benign	Het

Other mutations in Vmn1r184

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01411:Vmn1r184	APN	7	25,966,320 (GRCm39)	missense	probably benign	0.06
IGL02961:Vmn1r184	APN	7	25,967,075 (GRCm39)	missense	probably benign	0.27
IGL03271:Vmn1r184	APN	7	25,967,034 (GRCm39)	missense	probably benign
R0302:Vmn1r184	UTSW	7	25,966,968 (GRCm39)	missense	probably damaging	1.00
R0384:Vmn1r184	UTSW	7	25,967,076 (GRCm39)	missense	probably benign	0.41
R0591:Vmn1r184	UTSW	7	25,966,500 (GRCm39)	missense	probably damaging	0.98
R0620:Vmn1r184	UTSW	7	25,966,602 (GRCm39)	missense	possibly damaging	0.46
R1644:Vmn1r184	UTSW	7	25,966,670 (GRCm39)	missense	probably benign	0.00
R2304:Vmn1r184	UTSW	7	25,966,550 (GRCm39)	missense	probably damaging	1.00
R2329:Vmn1r184	UTSW	7	25,966,387 (GRCm39)	missense	probably damaging	1.00
R3522:Vmn1r184	UTSW	7	25,967,008 (GRCm39)	nonsense	probably null
R5020:Vmn1r184	UTSW	7	25,966,955 (GRCm39)	missense	possibly damaging	0.87
R5030:Vmn1r184	UTSW	7	25,966,881 (GRCm39)	missense	probably benign	0.25
R5049:Vmn1r184	UTSW	7	25,966,793 (GRCm39)	missense	possibly damaging	0.49
R5076:Vmn1r184	UTSW	7	25,966,346 (GRCm39)	missense	probably benign	0.00
R5213:Vmn1r184	UTSW	7	25,967,136 (GRCm39)	missense	probably damaging	0.99
R5554:Vmn1r184	UTSW	7	25,966,413 (GRCm39)	missense	probably damaging	1.00
R6146:Vmn1r184	UTSW	7	25,966,817 (GRCm39)	missense	probably benign	0.08
R6868:Vmn1r184	UTSW	7	25,966,727 (GRCm39)	missense	probably benign	0.00
R6937:Vmn1r184	UTSW	7	25,966,750 (GRCm39)	missense	probably benign	0.08
R6943:Vmn1r184	UTSW	7	25,966,563 (GRCm39)	missense	possibly damaging	0.77
R7190:Vmn1r184	UTSW	7	25,967,105 (GRCm39)	missense	probably damaging	1.00
R7239:Vmn1r184	UTSW	7	25,966,602 (GRCm39)	missense	possibly damaging	0.79
R7472:Vmn1r184	UTSW	7	25,966,824 (GRCm39)	missense	possibly damaging	0.82
R8258:Vmn1r184	UTSW	7	25,966,686 (GRCm39)	missense	probably benign	0.44
R8259:Vmn1r184	UTSW	7	25,966,686 (GRCm39)	missense	probably benign	0.44
R8911:Vmn1r184	UTSW	7	25,966,310 (GRCm39)	missense	possibly damaging	0.89
R9008:Vmn1r184	UTSW	7	25,967,177 (GRCm39)	missense	probably benign
R9159:Vmn1r184	UTSW	7	25,966,545 (GRCm39)	missense	possibly damaging	0.65
R9216:Vmn1r184	UTSW	7	25,966,703 (GRCm39)	missense	probably benign	0.00
R9548:Vmn1r184	UTSW	7	25,966,734 (GRCm39)	missense	probably benign	0.29
R9588:Vmn1r184	UTSW	7	25,966,347 (GRCm39)	missense	probably null	0.78
Z1177:Vmn1r184	UTSW	7	25,966,415 (GRCm39)	missense	possibly damaging	0.95

Posted On

2013-11-05