Incidental Mutation 'IGL01397:Nphs1'
| ID |
79478 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Nphs1
|
| Ensembl Gene |
ENSMUSG00000006649 |
| Gene Name |
nephrosis 1, nephrin |
| Synonyms |
nephrin |
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
IGL01397
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
30157740-30186648 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 30186089 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 1240
(D1240G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000006825
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000006825]
[ENSMUST00000126297]
|
| AlphaFold |
Q9QZS7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000006825
AA Change: D1240G
PolyPhen 2
Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
|
| SMART Domains |
Protein: ENSMUSP00000006825
Gene: ENSMUSG00000006649
AA Change: D1240G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
36 |
N/A |
INTRINSIC |
|
IG
|
52 |
146 |
1.38e-6 |
SMART |
|
Pfam:C2-set_2
|
152 |
242 |
4.1e-20 |
PFAM |
|
IG
|
264 |
351 |
9.86e-3 |
SMART |
|
IG_like
|
360 |
452 |
2.73e1 |
SMART |
|
IG
|
464 |
556 |
2.99e-2 |
SMART |
|
IG_like
|
572 |
644 |
8.9e-1 |
SMART |
|
IG
|
667 |
751 |
1.32e-3 |
SMART |
|
IG
|
760 |
849 |
7.3e-6 |
SMART |
|
IGc2
|
868 |
941 |
5.4e-9 |
SMART |
|
FN3
|
955 |
1036 |
1.01e-11 |
SMART |
|
transmembrane domain
|
1078 |
1100 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000123880
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000126297
AA Change: D1226G
PolyPhen 2
Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000116500
Gene: ENSMUSG00000006649
AA Change: D1226G
| Domain | Start | End | E-Value | Type |
|---|
|
IG
|
38 |
132 |
1.38e-6 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000131004
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000149086
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000208689
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.[provided by RefSeq, Oct 2009]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit severe proteinuria associated with kidney defects and die soon after birth. Heterozygotes exhibit fusion of one-third of glomerular foot processes. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 47 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acoxl |
A |
C |
2: 127,876,811 (GRCm39) |
T436P |
possibly damaging |
Het |
| Afap1 |
T |
A |
5: 36,126,052 (GRCm39) |
V349E |
probably damaging |
Het |
| Arfgef1 |
C |
T |
1: 10,229,796 (GRCm39) |
V1302I |
probably benign |
Het |
| Atp11a |
T |
A |
8: 12,862,321 (GRCm39) |
W58R |
probably damaging |
Het |
| Brpf3 |
A |
T |
17: 29,036,606 (GRCm39) |
K670N |
probably benign |
Het |
| Cd4 |
G |
A |
6: 124,856,341 (GRCm39) |
T50I |
probably benign |
Het |
| Cenpp |
T |
C |
13: 49,794,759 (GRCm39) |
D136G |
probably damaging |
Het |
| Cep85 |
T |
C |
4: 133,883,517 (GRCm39) |
E124G |
probably damaging |
Het |
| Crybb3 |
T |
C |
5: 113,227,701 (GRCm39) |
E40G |
probably damaging |
Het |
| Dennd2d |
G |
T |
3: 106,394,365 (GRCm39) |
|
probably null |
Het |
| Dhx34 |
A |
G |
7: 15,944,468 (GRCm39) |
L582P |
probably damaging |
Het |
| Dst |
A |
G |
1: 34,296,825 (GRCm39) |
K5738R |
probably damaging |
Het |
| Eif4g1 |
T |
A |
16: 20,498,425 (GRCm39) |
L328Q |
probably damaging |
Het |
| Eya4 |
T |
C |
10: 23,015,897 (GRCm39) |
K357E |
probably benign |
Het |
| F8 |
A |
G |
X: 74,423,145 (GRCm39) |
S25P |
probably benign |
Het |
| Fgd2 |
A |
G |
17: 29,586,949 (GRCm39) |
E293G |
probably damaging |
Het |
| Foxi1 |
T |
A |
11: 34,157,599 (GRCm39) |
Q142L |
probably damaging |
Het |
| Gfm1 |
A |
G |
3: 67,350,991 (GRCm39) |
E316G |
probably benign |
Het |
| Glb1l3 |
C |
T |
9: 26,736,491 (GRCm39) |
D524N |
probably benign |
Het |
| Heatr5a |
A |
T |
12: 51,941,152 (GRCm39) |
V1366D |
possibly damaging |
Het |
| Idh1 |
T |
C |
1: 65,207,754 (GRCm39) |
T142A |
possibly damaging |
Het |
| Lamc1 |
C |
A |
1: 153,126,880 (GRCm39) |
G422V |
probably damaging |
Het |
| Lars1 |
A |
T |
18: 42,361,094 (GRCm39) |
H691Q |
probably damaging |
Het |
| Ltbp2 |
T |
C |
12: 84,837,042 (GRCm39) |
Y1259C |
probably damaging |
Het |
| Muc19 |
T |
A |
15: 91,778,498 (GRCm39) |
|
noncoding transcript |
Het |
| Or3a1b |
T |
A |
11: 74,012,590 (GRCm39) |
N158K |
probably damaging |
Het |
| Or5w1 |
A |
T |
2: 87,487,249 (GRCm39) |
N5K |
probably damaging |
Het |
| Pabir2 |
G |
A |
X: 52,349,088 (GRCm39) |
T121I |
probably damaging |
Het |
| Parp14 |
T |
C |
16: 35,679,098 (GRCm39) |
N290S |
probably benign |
Het |
| Pex5l |
G |
A |
3: 33,006,746 (GRCm39) |
T541I |
probably damaging |
Het |
| Plch1 |
A |
C |
3: 63,639,150 (GRCm39) |
|
probably null |
Het |
| Ppp4r3b |
C |
T |
11: 29,163,594 (GRCm39) |
A722V |
probably benign |
Het |
| Ptges3 |
T |
C |
10: 127,906,069 (GRCm39) |
S85P |
probably benign |
Het |
| R3hdm2 |
C |
T |
10: 127,294,719 (GRCm39) |
R201W |
probably damaging |
Het |
| Rcan2 |
C |
A |
17: 44,147,359 (GRCm39) |
Q66K |
possibly damaging |
Het |
| Skint4 |
A |
G |
4: 111,977,207 (GRCm39) |
N199S |
possibly damaging |
Het |
| Smc4 |
A |
G |
3: 68,938,877 (GRCm39) |
T951A |
probably benign |
Het |
| Smg1 |
A |
T |
7: 117,762,444 (GRCm39) |
|
probably benign |
Het |
| Snx30 |
T |
C |
4: 59,894,526 (GRCm39) |
V368A |
probably benign |
Het |
| Spata31d1a |
C |
T |
13: 59,849,552 (GRCm39) |
A859T |
probably damaging |
Het |
| Tg |
G |
A |
15: 66,567,941 (GRCm39) |
|
probably benign |
Het |
| Tmem132b |
T |
C |
5: 125,775,792 (GRCm39) |
V422A |
probably benign |
Het |
| Tnxb |
T |
C |
17: 34,933,647 (GRCm39) |
S2356P |
probably damaging |
Het |
| Vmn1r122 |
A |
G |
7: 20,867,707 (GRCm39) |
V116A |
possibly damaging |
Het |
| Washc2 |
A |
G |
6: 116,224,959 (GRCm39) |
D683G |
probably benign |
Het |
| Wdr35 |
C |
A |
12: 9,058,550 (GRCm39) |
T580K |
probably benign |
Het |
| Wwc2 |
T |
A |
8: 48,321,311 (GRCm39) |
N601I |
unknown |
Het |
|
| Other mutations in Nphs1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00160:Nphs1
|
APN |
7 |
30,181,976 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
IGL00927:Nphs1
|
APN |
7 |
30,160,164 (GRCm39) |
unclassified |
probably benign |
|
|
IGL00976:Nphs1
|
APN |
7 |
30,160,110 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL01465:Nphs1
|
APN |
7 |
30,186,139 (GRCm39) |
makesense |
probably null |
|
|
IGL01889:Nphs1
|
APN |
7 |
30,159,936 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02383:Nphs1
|
APN |
7 |
30,181,060 (GRCm39) |
splice site |
probably benign |
|
|
R0020:Nphs1
|
UTSW |
7 |
30,162,633 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0485:Nphs1
|
UTSW |
7 |
30,166,940 (GRCm39) |
missense |
probably benign |
|
|
R1024:Nphs1
|
UTSW |
7 |
30,173,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1115:Nphs1
|
UTSW |
7 |
30,180,803 (GRCm39) |
splice site |
probably benign |
|
|
R1144:Nphs1
|
UTSW |
7 |
30,181,103 (GRCm39) |
splice site |
probably benign |
|
|
R1289:Nphs1
|
UTSW |
7 |
30,170,603 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1317:Nphs1
|
UTSW |
7 |
30,181,256 (GRCm39) |
splice site |
probably benign |
|
|
R1617:Nphs1
|
UTSW |
7 |
30,181,956 (GRCm39) |
missense |
probably benign |
|
|
R1756:Nphs1
|
UTSW |
7 |
30,160,959 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1937:Nphs1
|
UTSW |
7 |
30,173,798 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2144:Nphs1
|
UTSW |
7 |
30,160,395 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2256:Nphs1
|
UTSW |
7 |
30,167,417 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2257:Nphs1
|
UTSW |
7 |
30,167,417 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2277:Nphs1
|
UTSW |
7 |
30,166,989 (GRCm39) |
nonsense |
probably null |
|
|
R3104:Nphs1
|
UTSW |
7 |
30,166,965 (GRCm39) |
nonsense |
probably null |
|
|
R3106:Nphs1
|
UTSW |
7 |
30,166,965 (GRCm39) |
nonsense |
probably null |
|
|
R3151:Nphs1
|
UTSW |
7 |
30,159,665 (GRCm39) |
missense |
probably benign |
|
|
R3765:Nphs1
|
UTSW |
7 |
30,170,635 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4078:Nphs1
|
UTSW |
7 |
30,166,945 (GRCm39) |
nonsense |
probably null |
|
|
R4397:Nphs1
|
UTSW |
7 |
30,181,390 (GRCm39) |
splice site |
probably null |
|
|
R4635:Nphs1
|
UTSW |
7 |
30,167,432 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4650:Nphs1
|
UTSW |
7 |
30,181,895 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4811:Nphs1
|
UTSW |
7 |
30,159,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4850:Nphs1
|
UTSW |
7 |
30,162,657 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R5272:Nphs1
|
UTSW |
7 |
30,181,067 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5327:Nphs1
|
UTSW |
7 |
30,163,250 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5681:Nphs1
|
UTSW |
7 |
30,186,050 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5865:Nphs1
|
UTSW |
7 |
30,173,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5975:Nphs1
|
UTSW |
7 |
30,165,540 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6186:Nphs1
|
UTSW |
7 |
30,165,059 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6198:Nphs1
|
UTSW |
7 |
30,167,340 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6353:Nphs1
|
UTSW |
7 |
30,173,969 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7405:Nphs1
|
UTSW |
7 |
30,162,253 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7647:Nphs1
|
UTSW |
7 |
30,181,390 (GRCm39) |
splice site |
probably null |
|
|
R7767:Nphs1
|
UTSW |
7 |
30,162,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8132:Nphs1
|
UTSW |
7 |
30,181,478 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8485:Nphs1
|
UTSW |
7 |
30,165,598 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8678:Nphs1
|
UTSW |
7 |
30,163,284 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8890:Nphs1
|
UTSW |
7 |
30,162,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8946:Nphs1
|
UTSW |
7 |
30,162,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9133:Nphs1
|
UTSW |
7 |
30,160,092 (GRCm39) |
nonsense |
probably null |
|
|
R9159:Nphs1
|
UTSW |
7 |
30,165,026 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9347:Nphs1
|
UTSW |
7 |
30,170,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9547:Nphs1
|
UTSW |
7 |
30,180,875 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9548:Nphs1
|
UTSW |
7 |
30,180,875 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9607:Nphs1
|
UTSW |
7 |
30,163,012 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9626:Nphs1
|
UTSW |
7 |
30,166,991 (GRCm39) |
missense |
probably benign |
0.16 |
|
R9720:Nphs1
|
UTSW |
7 |
30,165,499 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9733:Nphs1
|
UTSW |
7 |
30,166,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0028:Nphs1
|
UTSW |
7 |
30,166,929 (GRCm39) |
missense |
probably null |
0.01 |
|
Z1177:Nphs1
|
UTSW |
7 |
30,170,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1186:Nphs1
|
UTSW |
7 |
30,159,775 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2013-11-05 |
Incidental Mutation