Incidental Mutation 'IGL01399:Gpr149'
| ID |
79577 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Gpr149
|
| Ensembl Gene |
ENSMUSG00000043441 |
| Gene Name |
G protein-coupled receptor 149 |
| Synonyms |
PGR10, 9630018L10Rik, R35, Ieda |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.074)
|
| Stock # |
IGL01399
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
3 |
| Chromosomal Location |
62436851-62512861 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 62511852 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Glutamine
at position 49
(L49Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000060893
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000058535]
|
| AlphaFold |
Q3UVY1 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000058535
AA Change: L49Q
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000060893
Gene: ENSMUSG00000043441
AA Change: L49Q
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
52 |
363 |
7.2e-7 |
PFAM |
|
coiled coil region
|
694 |
730 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000149007
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Female mice homozygous for a knock-out allele exhibit increased fertility with increased litter size and frequency. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 44 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Apol11b |
G |
A |
15: 77,522,219 (GRCm39) |
T26M |
probably damaging |
Het |
| Asic4 |
T |
A |
1: 75,445,790 (GRCm39) |
N206K |
possibly damaging |
Het |
| Bsn |
A |
G |
9: 107,984,386 (GRCm39) |
Y3223H |
unknown |
Het |
| Btaf1 |
C |
T |
19: 36,977,570 (GRCm39) |
R1463* |
probably null |
Het |
| Ccdc146 |
A |
G |
5: 21,499,611 (GRCm39) |
I857T |
possibly damaging |
Het |
| Ccnf |
G |
A |
17: 24,443,986 (GRCm39) |
S594L |
probably damaging |
Het |
| Chd5 |
T |
C |
4: 152,441,144 (GRCm39) |
W195R |
probably damaging |
Het |
| Cntn1 |
A |
G |
15: 92,203,025 (GRCm39) |
Y769C |
probably damaging |
Het |
| Cwc22 |
T |
C |
2: 77,747,408 (GRCm39) |
E435G |
probably benign |
Het |
| Dct |
A |
G |
14: 118,273,890 (GRCm39) |
F339S |
probably damaging |
Het |
| Ddx54 |
G |
T |
5: 120,761,968 (GRCm39) |
E554* |
probably null |
Het |
| Dock3 |
G |
T |
9: 106,870,670 (GRCm39) |
S581R |
probably benign |
Het |
| Dst |
A |
G |
1: 34,156,598 (GRCm39) |
H176R |
probably benign |
Het |
| Emc8 |
A |
G |
8: 121,385,745 (GRCm39) |
M123T |
probably damaging |
Het |
| Evc |
T |
A |
5: 37,490,357 (GRCm39) |
D55V |
probably damaging |
Het |
| Gm5424 |
A |
G |
10: 61,907,272 (GRCm39) |
|
noncoding transcript |
Het |
| Hcfc1 |
C |
T |
X: 72,993,515 (GRCm39) |
V1217I |
possibly damaging |
Het |
| Hoxa4 |
G |
T |
6: 52,167,393 (GRCm39) |
Q263K |
probably damaging |
Het |
| Ift172 |
T |
C |
5: 31,423,592 (GRCm39) |
E790G |
probably benign |
Het |
| Ipp |
A |
G |
4: 116,372,384 (GRCm39) |
N138D |
probably damaging |
Het |
| Isg20 |
A |
T |
7: 78,569,836 (GRCm39) |
T158S |
possibly damaging |
Het |
| Klf17 |
A |
G |
4: 117,616,356 (GRCm39) |
F325S |
probably damaging |
Het |
| Lilrb4a |
T |
C |
10: 51,370,161 (GRCm39) |
L233P |
probably benign |
Het |
| Malrd1 |
G |
A |
2: 16,106,768 (GRCm39) |
|
probably null |
Het |
| Myh9 |
A |
T |
15: 77,651,470 (GRCm39) |
L1544Q |
probably damaging |
Het |
| Nexmif |
T |
A |
X: 103,130,786 (GRCm39) |
D377V |
probably damaging |
Het |
| Nobox |
T |
C |
6: 43,280,972 (GRCm39) |
T501A |
probably benign |
Het |
| Noc3l |
T |
C |
19: 38,804,099 (GRCm39) |
D93G |
possibly damaging |
Het |
| Nrcam |
G |
T |
12: 44,622,667 (GRCm39) |
A938S |
probably benign |
Het |
| Nup205 |
T |
C |
6: 35,196,624 (GRCm39) |
I1120T |
possibly damaging |
Het |
| Or5b96 |
A |
T |
19: 12,867,803 (GRCm39) |
M46K |
probably benign |
Het |
| Or5h18 |
C |
T |
16: 58,847,629 (GRCm39) |
V214I |
probably benign |
Het |
| Ptpn3 |
T |
C |
4: 57,225,775 (GRCm39) |
D480G |
probably benign |
Het |
| Selenof |
C |
T |
3: 144,302,669 (GRCm39) |
T148I |
probably damaging |
Het |
| Sgce |
C |
A |
6: 4,746,997 (GRCm39) |
G31V |
probably damaging |
Het |
| Slc35e1 |
C |
A |
8: 73,238,534 (GRCm39) |
A325S |
probably damaging |
Het |
| Slc4a4 |
A |
G |
5: 89,376,794 (GRCm39) |
D1016G |
probably damaging |
Het |
| Synj2 |
T |
G |
17: 6,060,046 (GRCm39) |
C149W |
probably damaging |
Het |
| Tecpr1 |
A |
G |
5: 144,145,411 (GRCm39) |
|
probably null |
Het |
| Utp20 |
A |
G |
10: 88,594,164 (GRCm39) |
|
probably null |
Het |
| Vmn2r63 |
T |
A |
7: 42,553,543 (GRCm39) |
K571M |
probably damaging |
Het |
| Wdr53 |
A |
G |
16: 32,070,718 (GRCm39) |
D21G |
possibly damaging |
Het |
| Zbtb3 |
T |
C |
19: 8,780,819 (GRCm39) |
L144S |
probably damaging |
Het |
| Zfp185 |
T |
A |
X: 72,043,654 (GRCm39) |
S154T |
probably damaging |
Het |
|
| Other mutations in Gpr149 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00330:Gpr149
|
APN |
3 |
62,438,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01339:Gpr149
|
APN |
3 |
62,511,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01954:Gpr149
|
APN |
3 |
62,438,348 (GRCm39) |
missense |
probably benign |
0.36 |
|
IGL02115:Gpr149
|
APN |
3 |
62,502,336 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02218:Gpr149
|
APN |
3 |
62,437,952 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL02592:Gpr149
|
APN |
3 |
62,511,231 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL03393:Gpr149
|
APN |
3 |
62,511,366 (GRCm39) |
missense |
probably benign |
0.15 |
|
R0578:Gpr149
|
UTSW |
3 |
62,510,110 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1173:Gpr149
|
UTSW |
3 |
62,511,888 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1174:Gpr149
|
UTSW |
3 |
62,511,888 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1175:Gpr149
|
UTSW |
3 |
62,511,888 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1432:Gpr149
|
UTSW |
3 |
62,438,439 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1484:Gpr149
|
UTSW |
3 |
62,502,592 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1972:Gpr149
|
UTSW |
3 |
62,438,216 (GRCm39) |
missense |
probably benign |
0.39 |
|
R1973:Gpr149
|
UTSW |
3 |
62,438,216 (GRCm39) |
missense |
probably benign |
0.39 |
|
R2180:Gpr149
|
UTSW |
3 |
62,511,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2241:Gpr149
|
UTSW |
3 |
62,511,474 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3118:Gpr149
|
UTSW |
3 |
62,502,443 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3547:Gpr149
|
UTSW |
3 |
62,502,549 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3548:Gpr149
|
UTSW |
3 |
62,502,549 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4206:Gpr149
|
UTSW |
3 |
62,511,924 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4332:Gpr149
|
UTSW |
3 |
62,511,794 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4531:Gpr149
|
UTSW |
3 |
62,510,099 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4557:Gpr149
|
UTSW |
3 |
62,511,918 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4557:Gpr149
|
UTSW |
3 |
62,438,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4593:Gpr149
|
UTSW |
3 |
62,510,151 (GRCm39) |
intron |
probably benign |
|
|
R5397:Gpr149
|
UTSW |
3 |
62,438,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6592:Gpr149
|
UTSW |
3 |
62,437,961 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6642:Gpr149
|
UTSW |
3 |
62,437,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6845:Gpr149
|
UTSW |
3 |
62,511,942 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R7303:Gpr149
|
UTSW |
3 |
62,502,491 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R7659:Gpr149
|
UTSW |
3 |
62,511,256 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7682:Gpr149
|
UTSW |
3 |
62,438,160 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7803:Gpr149
|
UTSW |
3 |
62,438,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7904:Gpr149
|
UTSW |
3 |
62,502,356 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7943:Gpr149
|
UTSW |
3 |
62,438,132 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8844:Gpr149
|
UTSW |
3 |
62,502,572 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8919:Gpr149
|
UTSW |
3 |
62,438,478 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9043:Gpr149
|
UTSW |
3 |
62,511,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9209:Gpr149
|
UTSW |
3 |
62,511,093 (GRCm39) |
missense |
probably benign |
0.40 |
|
Z1177:Gpr149
|
UTSW |
3 |
62,511,380 (GRCm39) |
frame shift |
probably null |
|
|
Z1190:Gpr149
|
UTSW |
3 |
62,511,972 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
| Posted On |
2013-11-05 |
Incidental Mutation